Recreational spaces in the towns of Hungary

The study is an introduction to recreational spaces in Hungary and an attempt for their typifying in relation with the Hungarian urbanisation processes and trends. In the first half of the essay the division of the urban spaces of Hungary is done, together with the introduction of the birth of the recreational spaces. The essay is continued with the typifying of the recreational spaces, differentiating intra- and extra-urban recreational spaces, giving examples from Hungary. The essay is finished by the introduction of a recreational space within Pécs and one around the city, with a view to their role in the recreation of the inhabitants and the leisure time possibilities

For-Know Repository: How can global trends be used in foresight? Expert workshop

The EU Policy Lab at the Joint Research Centre (JRC) of the European Commission (EC) organised a one-day workshop to pilot a foresight policy-engagement tool based on a set of global megatrends. The workshop was also used to gather the experience and good practice of foresight practitioners in engaging policy-makers and other stakeholders in long-term and systems-thinking processes. The workshop was held on 18 November 2016, at the EC premises, Rue Science 29, Brussels, Belgium, This report documents and illustrates the activities that took place during the workshop, taking stock of the results to support further development of the FOR-KNOW project, which aims to establish a repository of megatrends and a tool for using such trends in policy-making mainly at European level. As such, it does not describe all the insights captured during the workshop, Content gathered during the workshop will be further developed and ultimately feed the online format of the FOR-KNOW repository and other dissemination products of the project. The first section provides information about the JRC, the project itself and its policy context. The second and third sections present the workshop purpose, participants and an illustrated guide to the workshop process including the participants' feedback before we conclude in section four.JRC.I.2-Foresight, Behavioural Insights and Design for Polic

How will standards facilitate new production systems in the context of EU innovation and competitiveness in 2025? ANNEXES

Standards are very important as they provide requirements, specifications, guidelines or characteristics that can be used consistently to ensure that materials, products, processes and services are fit for their purpose. They contribute to remove technical barriers to trade, leading to new markets and economic growth for industry. They also facilitate technology transfer and they contribute to ensure safety of products thereby affecting the daily life of citizens. This report ‘How will standards facilitate new production systems in the context of EU innovation and competitiveness in 2025?’ is the outcome of a foresight process looking at how standards and standardisation can become even more relevant policy tool supporting different European policies. The study has especially looked at the areas where Europe drives innovation, where the development of new products and processes could lead to new trade of goods, services and technologies. The foresight process has dealt with standardisation by using a holistic approach. It explored at how effective standards can be developed within a European industrial landscape vision able to contribute to jobs and growth in a sustainable manner. The report provides a clear overview of the evolution of the European production system and illustrates what are the drivers of change influencing the future production system. The Industrial Landscape Vision was used to identify the its implications on the European Standardisation System and it highlights priorities for the development of standards in the future.JRC.DDG.02-Foresight and Behavioural Insight

How will standards facilitate new production systems in the context of EU innovation and competitiveness in 2025?

Standards are very important as they provide requirements, specifications, guidelines or characteristics that can be used consistently to ensure that materials, products, processes and services are fit for their purpose. They contribute to remove technical barriers to trade, leading to new markets and economic growth for industry. They also facilitate technology transfer and they contribute to ensure safety of products thereby affecting the daily life of citizens. This report ‘How will standards facilitate new production systems in the context of EU innovation and competitiveness in 2025?’ is the outcome of a foresight process looking at how standards and standardisation can become even more relevant policy tool supporting different European policies. The study has especially looked at the areas where Europe drives innovation, where the development of new products and processes could lead to new trade of goods, services and technologies. The foresight process has dealt with standardisation by using a holistic approach. It explored at how effective standards can be developed within a European industrial landscape vision able to contribute to jobs and growth in a sustainable manner. The report provides a clear overview of the evolution of the European production system and illustrates what are the drivers of change influencing the future production system. The Industrial Landscape Vision was used to identify the its implications on the European Standardisation System and it highlights priorities for the development of standards in the future.JRC.DDG.02-Foresight and Behavioural Insight

CXCR7 Functions as a Scavenger for CXCL12 and CXCL11

CXCR7 (RDC1), the recently discovered second receptor for CXCL12, is phylogenetically closely related to chemokine receptors, but fails to couple to G-proteins and to induce typical chemokine receptor mediated cellular responses. The function of CXCR7 is controversial. Some studies suggest a signaling activity in mammalian cells and zebrafish embryos, while others indicate a decoy activity in fish. Here we investigated the two propositions in human tissues. We provide evidence and mechanistic insight that CXCR7 acts as specific scavenger for CXCL12 and CXCL11 mediating effective ligand internalization and targeting of the chemokine cargo for degradation. Consistently, CXCR7 continuously cycles between the plasma membrane and intracellular compartments in the absence and presence of ligand, both in mammalian cells and in zebrafish. In accordance with the proposed activity as a scavenger receptor CXCR7-dependent chemokine degradation does not become saturated with increasing ligand concentrations. Active CXCL12 sequestration by CXCR7 is demonstrated in adult mouse heart valves and human umbilical vein endothelium. The finding that CXCR7 specifically scavenges CXCL12 suggests a critical function of the receptor in modulating the activity of the ubiquitously expressed CXCR4 in development and tumor formation. Scavenger activity of CXCR7 might also be important for the fine tuning of the mobility of hematopoietic cells in the bone marrow and lymphoid organs

CXCR7 functions as a scavenger for CXCL12 and CXCL11

Background: CXCR7 (RDC1), the recently discovered second receptor for CXCL12, is phylogenetically closely related to chemokine receptors, but fails to couple to G-proteins and to induce typical chemokine receptor mediated cellular responses. The function of CXCR7 is controversial. Some studies suggest a signaling activity in mammalian cells and zebrafish embryos, while others indicate a decoy activity in fish. Here we investigated the two propositions in human tissues. Methodology/Principal Findings: We provide evidence and mechanistic insight that CXCR7 acts as specific scavenger for CXCL12 and CXCL11 mediating effective ligand internalization and targeting of the chemokine cargo for degradation. Consistently, CXCR7 continuously cycles between the plasma membrane and intracellular compartments in the absence and presence of ligand, both in mammalian cells and in zebrafish. In accordance with the proposed activity as a scavenger receptor CXCR7-dependent chemokine degradation does not become saturated with increasing ligand concentrations. Active CXCL12 sequestration by CXCR7 is demonstrated in adult mouse heart valves and human umbilical vein endothelium. Conclusions/Significance: The finding that CXCR7 specifically scavenges CXCL12 suggests a critical function of the receptor in modulating the activity of the ubiquitously expressed CXCR4 in development and tumor formation. Scavenger activity of CXCR7 might also be important for the fine tuning of the mobility of hematopoietic cells in the bone marrow and lymphoid organs

Gaps and challenges in the knowledge of migration and demography: Proposals for new approaches and solutions

This report is the result of the research carried out under Task 5 of DG JRC's Task Force on Migration and Demography. The report is structured following the four pillars outlined in the European Agenda on Migration. A few additional chapters are included to cover some aspects not explicitly touched on in the Agenda, but still considered to have a relevant role in migration and an impact on demographic trends. Contributions answered the following questions: 1. What are main points/findings/debates concerning the priority area/sub-category allocated to you? 2. How does the information gathered in question 1 relate to the scope and the structure of the European Agenda on Migration? 3. What current information and data is available, who is producing it and how? 4. What and where are the main gaps and challenges? 5. What are the solutions or approaches to address these gaps and challenges based upon your research? To complement this review, two Annexes were created: the first being an overview of the main gaps and challenges as well as the suggested solutions for the whole report (Annex 1), and the second being a preliminary inventory of available migration data and data sources (Annex 2).JRC.E.6-Demography, Migration and Governanc

No interaction between tDCS current strength and baseline performance: a conceptual replication

Several recent studies have reported non-linear effects of transcranial direct current stimulation (tDCS), which has been attributed to an interaction between the stimulation parameters (e.g., current strength, duration) and the neural state of the cortex being stimulated (e.g., indexed by baseline performance ability, age) (see Fertonani and Miniussi, 2016). We have recently described one such non-linear interaction between current strength and baseline performance on a visuospatial attention (landmark) task (Benwell et al., 2015). In this previous study, we induced a small overall rightward shift of spatial attention across 38 participants using bi-hemispheric tDCS applied for 20 min (concurrent left posterior parietal (P5) anode and right posterior parietal (P6) cathode) relative to a sham protocol. Importantly, this shift in bias was driven by a state-dependent interaction between current intensity and the discrimination sensitivity of the participant at baseline (pre-stimulation) for the landmark task. Individuals with high discrimination sensitivity (HDS) shifted rightward in response to low- (1 mA) but not high-intensity (2 mA) tDCS, whereas individuals with low discrimination sensitivity (LDS) shifted rightward with high- but not low-intensity stimulation. However, in Benwell et al. (2015) current strength was applied as a between-groups factor, where half of the participants received 1 mA and half received 2 mA tDCS, thus we were unable to compare high and low-intensity tDCS directly within each individual. Here we aimed to replicate these findings using a within-group design. Thirty young adults received 15 min of 1 and 2 mA tDCS, and a sham protocol, each on different days, to test the concept of an interaction between baseline performance and current strength. We found no overall rightward shift of spatial attention with either current strength, and no interaction between performance and current strength. These results provide further evidence of low replicability of non-invasive brain stimulation protocols, and the need for further attempts to replicate the key experimental findings within this field

No Interaction between tDCS Current Strength and Baseline Performance:A Conceptual Replication

Several recent studies have reported non-linear effects of transcranial direct current stimulation (tDCS), which has been attributed to an interaction between the stimulation parameters (e.g., current strength, duration) and the neural state of the cortex being stimulated (e.g., indexed by baseline performance ability, age) (see Fertonani and Miniussi, 2016). We have recently described one such non-linear interaction between current strength and baseline performance on a visuospatial attention (landmark) task (Benwell et al., 2015). In this previous study, we induced a small overall rightward shift of spatial attention across 38 participants using bi-hemispheric tDCS applied for 20 min (concurrent left posterior parietal (P5) anode and right posterior parietal (P6) cathode) relative to a sham protocol. Importantly, this shift in bias was driven by a state-dependent interaction between current intensity and the discrimination sensitivity of the participant at baseline (pre-stimulation) for the landmark task. Individuals with high discrimination sensitivity (HDS) shifted rightward in response to low- (1 mA) but not high-intensity (2 mA) tDCS, whereas individuals with low discrimination sensitivity (LDS) shifted rightward with high- but not low-intensity stimulation. However, in Benwell et al. (2015) current strength was applied as a between-groups factor, where half of the participants received 1 mA and half received 2 mA tDCS, thus we were unable to compare high and low-intensity tDCS directly within each individual. Here we aimed to replicate these findings using a within-group design. Thirty young adults received 15 min of 1 and 2 mA tDCS, and a sham protocol, each on different days, to test the concept of an interaction between baseline performance and current strength. We found no overall rightward shift of spatial attention with either current strength, and no interaction between performance and current strength. These results provide further evidence of low replicability of non-invasive brain stimulation protocols, and the need for further attempts to replicate the key experimental findings within this field