THE ROLE OF JOURNALIST IN COVID VACCINES 19 PERSUASIVE ADS: PERAN JURNALIS DALAM IKLAN PERSUASIF TERHADAP COVID-19

The purpose of this study was to find out the role of journalists in the Covid-19 pandemic and find out how to identify hoax news spread, especially on social media. This research object is a secondary research object, where the material used to earn data income in the form of written documents such as journals, articles and written news. The method that researchers use is observation list, where the author collects data through some existing written data to review and prove the truth of the research conducted. In this article researchers prove that a journalist is considered the most important role in delivering news accurately and vaktually. News is also spread through social media so that the public avoids hoax news that is easily spread in the general public. Hoax news is news that is uncertain or does not have the truth in the content of the news, for that as a society, as a society.Tujuan penelitian ini adalah untuk mengetahui peran jurnalis dalam masa pandemi Covid-19 dan mengetahui bagaimana cara mengidentifikasi berita hoax yang tersebar, khususnya di media sosial. Objek penelitian ini adalah objek penelitian sekunder, dimana bahan yang digunakan untuk memperoleh penghasilan data berupa dokumen-dokumen tertulis seperti jurnal, artikel dan berita tertulis. Metode yang peneliti gunakan adalah observasi list, dimana penulis mengumpulkan data melalui beberapa data tertulis yang telah ada untuk meninjau dan membuktikan kebenaran dari penelitian yang dilakukan. Dalam artikel ini peneliti membuktikan bahwa seorang jurnalis dianggap sebagai peran yang paling penting dalam menyampaikan berita secara akurat dan vaktual. Berita juga disebarkan melalui media sosial agar masyarakat terhindar dari berita hoax yang mudah tersebar di khalayak umum. Berita hoax adalah berita yang tidak pasti atau tidak mempunyai kebenaran dalam isi beritanya, untuk itu sebagai masyarakat, sebaiknya bisa memilah dan memilih mana berita yang hoax dan mana berita yang benar. Peran jurnalis dalam hal tersebut adalah mencari berita dengan sumber terpercaya dan didukung oleh fakta-fakta yang ada, sehingga menghasilkan informasi yang akurat dan dapat disebarkan ke khalayak umum

Refinement of the HIVAN1 Susceptibility Locus on Chr. 3A1-A3 via Generation of Sub-Congenic Strains

HIV-1 transgenic mice on the FVB/NJ background (TgFVB) represent a validated model of HIV-associated nephropathy (HIVAN). A major susceptibility locus, HIVAN1, was previously mapped to chromosome 3A1-A3 in a cross between TgFVB and CAST/EiJ (CAST) strains, and introgression of a 51.9 Mb segment encompassing HIVAN1 from CAST into TgFVB resulted in accelerated development of nephropathy. We generated three sub-congenic strains carrying CAST alleles in the proximal or distal regions of the HIVAN1 locus (Sub-II, 3.02–38.93 Mb; Sub-III, 38.45–55.1 Mb and Sub-IV, 47.7–55.1 Mb, build 38). At 5–10 weeks of age, histologic injury and proteinuria did not differ between HIV-1 transgenic Sub-II and TgFVB mice. In contrast, HIV-1 transgenic Sub-III and Sub-IV mice displayed up to 4.4 fold more histopathologic injury and 6-fold more albuminuria compared to TgFVB mice, similar in severity to the full-length congenic mice. The Sub-IV segment defines a maximal 7.4 Mb interval for HIVAN1, and encodes 31 protein coding genes: 15 genes have missense variants differentiating CAST from FVB, and 14 genes show differential renal expression. Of these, Frem1, Foxo1, and Setd7 have been implicated in the pathogenesis of nephropathy. HIVAN1 congenic kidneys are histologically normal without the HIV-1 transgene, yet their global transcriptome is enriched for molecular signatures of apoptosis, adenoviral infection, as well as genes repressed by histone H3 lysine 27 trimethylation, a histone modification associated with HIV-1 life cycle. These data refine HIVAN1to 7.4 Mb and identify latent molecular derangements that may predispose to nephropathy upon exposure to HIV-1

Case Report Of Malignant Lymphoma of the breast

Four cases of breast malignant lymphoma (BML) are discussed, diagnosed and managed. The issue of diagnosing BML, showed how different these 4 cases were, in particular in the imaging ultrasonography (USG). Generally, the USG of ductal carcinoma is irregular solid mass, while the USG of BML is compliant with cystic forms. Case 1 is 68 years old woman with left breast tumor. USG revealed hypoechoic lesion in the left breast with FNA result of malignant lymphoma, but still differential diagnosis with ductal carcinoma of the breast Mamma. Case 2 is a 52 years old woman who had left breast tumor. The USG revealed malignant lesion, left axilla node positive, although FNA result was ductal carcinoma, after simple mastectomy, the frozen section revealed malignant lymphoma. Case 3 is a 51 years old woman, USG of the left breast revealed malignant lesion, left axilla node positive, and excision biopsy revealed non-Hodgkins lymphoma diffuse large cell. Case 4 is a 51 years old woman, the USG revealed irregular hypoechoic lesions in both breasts and left supraclavicula node 5 mm. Core biopsy revealed bilateral breast non Hodgkins lymphoma subcutaneous, T-cell lymphoma. The therapeutic management of breast lymphoma is controversial and is not fully established yet. A strategy consisting of three cycles of CHOP followed by involved-field radiation therapy is reportedly superior to eight cycles of CHOP alone

Design of a compact planar transmission line for miniaturized rat-race coupler with harmonics suppression

This paper presents an elegant yet straightforward design procedure for a compact rat-race coupler (RRC) with an extended harmonic suppression. The coupler’s conventional λ /4 transmission lines (TLs) are replaced by a specialized TL that offers significant size reduction and harmonic elimination capabilities in the proposed approach. The design procedure is verified through the theoretical, circuit, and electromagnetic (EM) analyses, showing excellent agreement among different analyses and the measured results. The circuit and EM results show that the proposed TL replicates the same frequency behaviour of the conventional one at the design frequency of 1.8 GHz while enables harmonic suppression up to the 7th harmonic and a size reduction of 74%. According to the measured results, the RRC has a fractional bandwidth of 20%, with input insertion losses of around 0.2 dB and isolation level better than 35 dB. Furthermore, the total footprint of the proposed RRC is only 31.7 mm ×15.9 mm, corresponding to 0.28λ×0.14λ , where λ is the guided wavelength at 1.8 GHz.This work was supported in part by the Icelandic Centre for Research (RANNIS) Grant 206606051, and in part by the National Science Centre of Poland Grant 2017/37/B/ST7/00563

Learning Through Making with Project-Based Learning Approach In Online Learning Environment

As online and distance learning continue to gain prominence, exploring effective instructional approaches in these settings becomes increasingly important. This study examines the effectiveness of project-based learning (PBL) in an online and distance learning environment, specifically focusing on the concept of "learning through making." By emphasizing active and experiential learning, PBL can be adapted for distance and online settings to enhance student deeper learning and understanding. Moreover, project-based learning empowers students to take ownership of their education, enhances their creativity, and encourages self-directed learning, making it an ideal method to promote meaningful and engaging online learning experiences. In this study, a group of 39 Students participated in a two month project with an asynchronous online learning environment. The students were tasked with creating representative products relevant to their course material, namely Learning Innovation, aiming to apply their knowledge gained through asynchronous learning to real-world experiences. Data collection methods, including surveys, interviews, and artefact analysis, were used to assess the impact of Learning Through Making on students’ perception, self-efficacy, and motivation. The results indicate a significant improvement in self-efficacy and content retention as a result of learning through making in the online environment. The study suggests integrating project-based learning into online education as a pedagogical strategy to enhance student learning experiences. Digital tools and platforms play a crucial role in facilitating project progress and the creation of authentic and meaningful artefacts. However, further in-depth research and ongoing support are recommended to fully realize the potential of project-based learning in online environments. This study makes a notable contribution to the research on effective instructional approaches in digital education by exploring the potential of learning through making in the online learning environment. The findings offer actionable insights and recommendations for educators, instructional designers, and policymakers to create engaging online learning experiences that promote deeper learning and student succes

A Retrotransposon Insertion in the 5' Regulatory Domain of Ptf1a Results in Ectopic Gene Expression and Multiple Congenital Defects in Danforth’s Short Tail Mouse

Danforth's short tail mutant (Sd) mouse, first described in 1930, is a classic spontaneous mutant exhibiting defects of the axial skeleton, hindgut, and urogenital system. We used meiotic mapping in 1,497 segregants to localize the mutation to a 42.8-kb intergenic segment on chromosome 2. Resequencing of this region identified an 8.5-kb early retrotransposon (ETn) insertion within the highly conserved regulatory sequences upstream of Pancreas Specific Transcription Factor, 1a (Ptf1a). This mutation resulted in up to tenfold increased expression of Ptf1a as compared to wild-type embryos at E9.5 but no detectable changes in the expression levels of other neighboring genes. At E9.5, Sd mutants exhibit ectopic Ptf1a expression in embryonic progenitors of every organ that will manifest a developmental defect: the notochord, the hindgut, and the mesonephric ducts. Moreover, at E 8.5, Sd mutant mice exhibit ectopic Ptf1a expression in the lateral plate mesoderm, tail bud mesenchyme, and in the notochord, preceding the onset of visible defects such as notochord degeneration. The Sd heterozygote phenotype was not ameliorated by Ptf1a haploinsufficiency, further suggesting that the developmental defects result from ectopic expression of Ptf1a. These data identify disruption of the spatio-temporal pattern of Ptf1a expression as the unifying mechanism underlying the multiple congenital defects in Danforth's short tail mouse. This striking example of an enhancer mutation resulting in profound developmental defects suggests that disruption of conserved regulatory elements may also contribute to human malformation syndromes

IR-correlated 31 GHz radio emission from Orion East

Lynds dark cloud LDN1622 represents one of the best examples of anomalous dust emission, possibly originating from small spinning dust grains. We present Cosmic Background Imager (CBI) 31 GHz data of LDN1621, a diffuse dark cloud to the north of LDN1622 in a region known as Orion East. A broken ring with diameter g\approx 20 arcmin of diffuse emission is detected at 31 GHz, at \approx 20-30 mJy beam$^{-1}$ with an angular resolution of \approx 5 arcmin. The ring-like structure is highly correlated with Far Infra-Red emission at $12-100 \mu$m with correlation coefficients of r \approx 0.7-0.8, significant at $\sim10\sigma$. Multi-frequency data are used to place constraints on other components of emission that could be contributing to the 31 GHz flux. An analysis of the GB6 survey maps at 4.85 GHz yields a $3\sigma$ upper limit on free-free emission of 7.2 mJy beam$^{-1}$ (\la 30 per cent of the observed flux) at the CBI resolution. The bulk of the 31 GHz flux therefore appears to be mostly due to dust radiation. Aperture photometry, at an angular resolution of 13 arcmin and with an aperture of diameter 30 arcmin, allowed the use of IRAS maps and the {\it WMAP} 5-year W-band map at 93.5 GHz. A single modified blackbody model was fitted to the data to estimate the contribution from thermal dust, which amounts to \sim$10 per cent at 31 GHz. In this model, an excess of 1.52\pm 0.66 Jy (2.3\sigma) is seen at 31 GHz. Future high frequency$\sim$100-1000 GHz data, such as those from the {\it Planck} satellite, are required to accurately determine the thermal dust contribution at 31 GHz. Correlations with the IRAS$100 \mu$m gave a coupling coefficient of$18.1\pm4.4 \mu$K (MJy/sr)$^{-1}$, consistent with the values found for LDN1622.Comment: 8 pages, 3 figures, 3 tables, submitted to MNRA