An Intelligent Transportation System Application for Smartphones Based on Vehicle Position Advertising and Route Sharing in Vehicular Ad-Hoc Networks

[EN] Alerting drivers about incoming emergency vehicles and their routes can greatly improve their travel times in congested cities, while reducing the risk of accidents due to distractions. This paper contributes to this goal by proposing Messiah, an Android application capable of informing regular vehicles about incoming emergency vehicles like ambulances, police cars and fire brigades. This is made possible by creating a network of vehicles capable of directly communicating between them. The user can, therefore, take driving decisions in a timely manner by considering incoming alerts. Using the support of our GRCBox hardware, the application can rely on vehicular ad-hoc network communications in the 5 GHz band, being V2V (vehicle-to-vehicle) communication provided through a combination of Android-based smartphone and our GRCBox device. The application was tested in three different scenarios with different levels of obstruction, showing that it is capable of providing alerts up to 300 meters, and notifying vehicles within less than one secondThis work was partially supported by the "Ministerio de Economia y Competividad, Programa Estatal de Investigacion, Desarollo e Innovacion Orientada a los Retos de la Sociedad, Proyectos I+D+I 2014", Spain, under Grant Nos. TEC2014-52690-R and BES-2015-075988.Hadiwardoyo, SA.; Patra, S.; Tavares De Araujo Cesariny Calafate, CM.; Cano, J.; Manzoni, P. (2018). An Intelligent Transportation System Application for Smartphones Based on Vehicle Position Advertising and Route Sharing in Vehicular Ad-Hoc Networks. Journal of Computer Science and Technology. 33(2):249-262. https://doi.org/10.1007/s11390-018-1817-4S249262332Papadimitratos P, De La Fortelle A, Evenssen K, Brignolo R, Cosenza S. Vehicular communication systems: Enabling technologies, applications, and future outlook on intelligent transportation. IEEE Communications Magazine, 2009, 47(11): 84-95.Gerla M, Kleinrock L. Vehicular networks and the future of the mobile Internet. Computer Networks, 2011, 55(2): 457-469.Vegni A M, Loscrí V. A survey on vehicular social networks. IEEE Communications Surveys & Tutorials, 2015, 17(4): 2397-2419.Eze E C, Zhang S J, Liu E J. Vehicular ad hoc networks (VANETs): Current state, challenges, potentials and way forward. In Proc. the 20th Int. Conf. Automation and Computing, September 2014, pp.176-181.Qi L. Research on intelligent transportation system technologies and applications. In Proc. Workshop on Power Electronics and Intelligent Transportation System, August 2008, pp.529-531.Gozalvez J. First Google’s Android phone launched [Mobile Radio]. IEEE Vehicular Technology Magazine, 2008, 3(4): 3-69.Haklay M,Weber P. OpenStreetMap: User-generated street maps. IEEE Pervasive Computing, 2008, 7(4): 12-18.Hadiwardoyo S A, Patra S, Calafate C T, Cano J C, Manzoni P. An Android ITS driving safety application based on vehicle-to-vehicle (V2V) communications. In Proc. the 26th Int. Conf. Computer Communication and Networks, July 31-August 3, 2017.Eriksson J, Balakrishnan H, Madden S. Cabernet: Vehicular content delivery using WiFi. In Proc. the 14th ACM Int. Conf. Mobile Computing and Networking, September 2008, pp.199-210.Gerla M, Weng J T, Giordano E, Pau G. Vehicular testbeds-validating models and protocols before large scale deployment. In Proc. Int. Conf. Computing Networking and Communications, January 30-February 2, 2012, pp.665-669.Wahlström J, Skog I, Händel P. Smartphone-based vehicle telematics: A ten-year anniversary. IEEE Trans. Intelligent Transportation Systems, 2017, 18(10): 2802-2825.Whipple J, Arensman W, Boler M S. A public safety application of GPS-enabled smartphones and the Android operating system. In Proc. IEEE Int. Conf. Systems Man and Cybernetics, October 2009, pp.2059-2061.Meseguer J E, Calafate C T, Cano J C, Manzoni P. DrivingStyles: A smartphone application to assess driver behavior. In Proc. IEEE Symp. Computers and Communications, July 2013, pp.000535-000540.You C W, Lane N D, Chen F L, Wang R, Chen Z Y, Bao T J, Montes-De-Oca M, Cheng Y T, Lin M, Torresani L, Campbell A T. CarSafe app: Alerting drowsy and distracted drivers using dual cameras on smartphones. In Proc. the 11th Annual Int. Conf. Mobile Systems Applications and Services, June 2013, pp.461-462.Patra S, Arnanz J H, Calafate C T, Cano J C, Manzoni P. EYES: A novel overtaking assistance system for vehicular networks. In Proc. the 14th Int. Conf. Ad-Hoc Networks and Wireless, June 2015, pp.375-389.Togneri M C, Deriaz M. On-board navigation system for smartphones. In Proc. Int. Conf. Indoor Positioning and Indoor Navigation, October 2013.Dancu A, Franjcic Z, Fjeld M. Smart flashlight: Map navigation using a bike-mounted projector. In Proc. the SIGCHI Conf. Human Factors in Computing Systems, April 2014, pp.3627-3630.Yamabe T, Ikegami S, Ishizaki A, Kitagami S, Kiyohara R. Car navigation user interface based on a smartphone. In Proc. the 7th Int. Conf. Mobile Computing and Ubiquitous Networking, January 2014, pp.85-86.Matsuyama S, Yamabe T, Takahashi N, Kiyohara R. Intelligent user interface of smartphones for on-vehicle information devices. Procedia Computer Science, 2014, 35: 1635-1643.Kovacevic B, Kovacevic M, Maruna T, Papp I. A java application programming interface for in-vehicle infotainment devices. IEEE Trans. Consumer Electronics, 2017, 63(1): 68-76.Liu R L, Liu H Z, Kwak D, Xiang Y, Borcea C, Nath B, Iftode L. Themis: A participatory navigation system for balanced traffic routing. In Proc. IEEE Vehicular Networking Conf., December 2014, pp.159-166.Liu R L, Liu H Z, Kwak D, Xiang Y, Borcea C, Nath B, Iftode L. Balanced traffic routing: Design, implementation, and evaluation. Ad Hoc Networks, 2016, 37: 14-28.Vochin M, Zoican S, Borcoci E. Intelligent system for vehicle navigation assistance. In Proc. World Conf. Information Systems and Technologies, April 2017, pp.142-148.Sha W J, Kwak D, Nath B, Iftode L. Social vehicle navigation: Integrating shared driving experience into vehicle navigation. In Proc. the 14th Workshop on Mobile Computing Systems and Applications, February 2013, Article No. 16.Kwak D, Liu R L, Kim D, Nath B, Iftode L. Seeing is believing: Sharing real-time visual traffic information via vehicular clouds. IEEE Access, 2016, 4: 3617-3631.Djajadi A, Putra R J. Inter-cars safety communication system based on Android smartphone. In Proc. IEEE Conf. Open Systems, October 2014, pp.12-17.Dorairaj P, Mohammed A, Grbic N. Location-Aware services using Android mobile operating platform for safety, emergency and health applications. In Mobile Health, Adibi S (ed.), Springer, 2015, pp.283-298.Dorairaj P, Ramamoorthy S, Ramalingam A K. Emergency based remote collateral tracking system using Google’s Android mobile platform. In Advances in Computer Science Engineering & Applications, Wyld D C, Zizka J, Nagamalai D (eds.), Springer, 2012, pp.391-403.Zulkafi A Z, Basri S, Jung L T, Ahmad R. Android based car alert system. In Proc. the 3rd Int. Conf. Computer and Information Sciences, August 2016, pp.501-506.Tornell S M, Calafate C T, Cano J C, Manzoni P, Fogue M, Martinez F J. Evaluating the feasibility of using smartphones for ITS safety applications. In Proc. the 77th IEEE Vehicular Technology Conf., June 2013.Tornell S M, Patra S, Calafate C T, Cano J C, Manzoni P. GRCBox: Extending smartphone connectivity in vehicular networks. International Journal of Distributed Sensor Networks, 2015, 2015: Article No. 5.Mirkovic J, Dietrich S, Dittrich D, Reiher P. Internet Denial of Service: Attack and Defense Mechanisms (Radia Perlman Computer Networking and Security). Prentice Hall PTR, 2004.Chen S, Xu J, Sezer E C, Gauriar P, Iyer R K. Non-control-data attacks are realistic threats. In Proc. the 14th Conf. USENIX Security Symp., July 31-August 5, 2005.Fung C K, Lee M C. A denial-of-service resistant public-key authentication and key establishment protocol. In Proc. the 21st IEEE Int. Performance Computing and Communications Conf., April 2002, pp.171-178.Abadi M, Budiu M, Erlingsson Ú, Ligatti J. Control-flow integrity. In Proc. the 12th ACM Conf. Computer and Communications Security, November 2005, pp.340-353

A genetic association study of glutamine-encoding DNA sequence structures, somatic CAG expansion, and DNA repair gene variants, with Huntington disease clinical outcomes

BACKGROUND: Huntington disease (HD) is caused by an unstable CAG/CAA repeat expansion encoding a toxic polyglutamine tract. Here, we tested the hypotheses that HD outcomes are impacted by somatic expansion of, and polymorphisms within, the HTT CAG/CAA glutamine-encoding repeat, and DNA repair genes. METHODS: The sequence of the glutamine-encoding repeat and the proportion of somatic CAG expansions in blood DNA from participants inheriting 40 to 50 CAG repeats within the TRACK-HD and Enroll-HD cohorts were determined using high-throughput ultra-deep-sequencing. Candidate gene polymorphisms were genotyped using kompetitive allele-specific PCR (KASP). Genotypic associations were assessed using time-to-event and regression analyses. FINDINGS: Using data from 203 TRACK-HD and 531 Enroll-HD participants, we show that individuals with higher blood DNA somatic CAG repeat expansion scores have worse HD outcomes: a one-unit increase in somatic expansion score was associated with a Cox hazard ratio for motor onset of 3·05 (95% CI = 1·94 to 4·80, p = 1·3 × 10-6). We also show that individual-specific somatic expansion scores are associated with variants in FAN1 (pFDR = 4·8 × 10-6), MLH3 (pFDR = 8·0 × 10-4), MLH1 (pFDR = 0·004) and MSH3 (pFDR = 0·009). We also show that HD outcomes are best predicted by the number of pure CAGs rather than total encoded-glutamines. INTERPRETATION: These data establish pure CAG length, rather than encoded-glutamine, as the key inherited determinant of downstream pathophysiology. These findings have implications for HD diagnostics, and support somatic expansion as a mechanistic link for genetic modifiers of clinical outcomes, a driver of disease, and potential therapeutic target in HD and related repeat expansion disorders. FUNDING: CHDI Foundation

Search for CP violation in D0 and D+ decays

A high statistics sample of photoproduced charm particles from the FOCUS (E831) experiment at Fermilab has been used to search for CP violation in the Cabibbo suppressed decay modes D+ to K-K+pi+, D0 to K-K+ and D0 to pi-pi+. We have measured the following CP asymmetry parameters: A_CP(K-K+pi+) = +0.006 +/- 0.011 +/- 0.005, A_CP(K-K+) = -0.001 +/- 0.022 +/- 0.015 and A_CP(pi-pi+) = +0.048 +/- 0.039 +/- 0.025 where the first error is statistical and the second error is systematic. These asymmetries are consistent with zero with smaller errors than previous measurements.Comment: 12 pages, 4 figure

A Study of D0 --> K0(S) K0(S) X Decay Channels

Using data from the FOCUS experiment (FNAL-E831), we report on the decay of $D^0$ mesons into final states containing more than one $K^0_S$. We present evidence for two Cabibbo favored decay modes, $D^0\to K^0_SK^0_S K^- \pi^+$ and $D^0\to K^0_SK^0_S K^+ \pi^-$, and measure their combined branching fraction relative to $D^0\to \bar{K} ^0\pi^+\pi^-$ to be $\frac{\Gamma(D^0\to K^0_SK^0_SK^{\pm}\pi^{\mp})}{\Gamma(D^0\to \bar{K} ^0\pi^+\pi^-)}$ = 0.0106 $\pm$ 0.0019 $\pm$ 0.0010. Further, we report new measurements of $\frac{\Gamma(D^0\to K^0_SK^0_SK^0_S)}{\Gamma(D^0\to \bar{K} ^0\pi^+\pi^-)}$ = 0.0179 $\pm$ 0.0027 $\pm$ 0.0026, $\frac{\Gamma(D^0\to K^0\bar{K} ^0)}{\Gamma(D^0\to \bar{K} ^0\pi^+\pi^-)}$ = 0.0144 $\pm$ 0.0032 $\pm$ 0.0016, and $\frac{\Gamma(D^0\to K^0_SK^0_S\pi^+\pi^-)}{\Gamma(D^0\to \bar{K} ^0\pi^+\pi^-)}$ = 0.0208 $\pm$ 0.0035 $\pm$ 0.0021 where the first error is statistical and the second is systematic.Comment: 11 pages, 3 figures, typos correcte

Improving the Efficiency of Physical Examination Services

The objective of our project was to improve the efficiency of the physical examination screening service of a large hospital system. We began with a detailed simulation model to explore the relationships between four performance measures and three decision factors. We then attempted to identify the optimal physician inquiry starting time by solving a goal-programming problem, where the objective function includes multiple goals. One of our simulation results shows that the proposed optimal physician inquiry starting time decreased patient wait times by 50% without increasing overall physician utilization

Filming a live cell by scanning electrochemical microscopy: label-free imaging of the dynamic morphology in real time

The morphology of a live cell reflects the organization of the cytoskeleton and the healthy status of the cell. We established a label-free platform for monitoring the changing morphology of live cells in real time based on scanning electrochemical microscopy (SECM). The dynamic morphology of a live human bladder cancer cell (T24) was revealed by time-lapse SECM with dissolved oxygen in the medium solution as the redox mediator. Detailed local movements of cell membrane were presented by time-lapse cross section lines extracted from time-lapse SECM. Vivid dynamic morphology is presented by a movie made of time-lapse SECM images. The morphological change of the T24 cell by non-physiological temperature is in consistence with the morphological feature of early apoptosis. To obtain dynamic cellular morphology with other methods is difficult. The non-invasive nature of SECM combined with high resolution realized filming the movements of live cells

Molecular Characterizations of a Novel Putative DNA-Binding Protein LvDBP23 in Marine Shrimp L. vannamei Tissues and Molting Stages

Litopenaeus Vannamei, well known as pacific white shrimp, is the most popular shrimp in the world shrimp market. Identification and characterization of shrimp muscle regulatory genes are not only important for shrimp genetic improvement, but also facilitate comparative genomic tools for understanding of muscle development and regeneration.A novel mRNA encoding for a putative DNA-binding protein LvDBP23 was identified from Litopenaeus vannamei abdominal muscle cDNA library. The LvDBP23 cDNA contains 639 nucleotides of protein-coding sequence with deduced 212 amino acids of predicted molecular mass 23.32 kDa with glycine-rich domain at amino acid position 94-130. The mRNA sequence is successfully used for producing LvDBP23 recombinant protein in sf9 insect cell expression system. The expression of LvDBP23 mRNA is presented in abdominal muscle and swimming leg muscle, as well as other tissues including intestine, lymphoid and gill. The mRNA expression has the highest level in abdominal muscle in all tested tissues. LVDBP23 transcript during the molt cycle is highly expressed in the intermolt stage. In vitro nucleic acid-binding assays reveal that LvDBP23 protein can bind to both ssDNA and dsDNA, indicating its possible role of regulation of gene transcription.We are the first to report a DNA-binding protein identified from the abdominal muscle tissue of marine shrimp L. Vannamei. Its high-level specific expression during the intermot stage suggests its role in the regulation of muscle buildup during the growth phase of shrimp molt cycle

Accuracy of biplane x-ray imaging combined with model-based tracking for measuring in-vivo patellofemoral joint motion

<p>Abstract</p> <p>Background</p> <p>Accurately measuring <it>in-vivo</it> motion of the knee's patellofemoral (PF) joint is challenging. Conventional measurement techniques have largely been unable to accurately measure three-dimensional, <it>in-vivo</it> motion of the patella during dynamic activities. The purpose of this study was to assess the accuracy of a new model-based technique for measuring PF joint motion.</p> <p>Methods</p> <p>To assess the accuracy of this technique, we implanted tantalum beads into the femur and patella of three cadaveric knee specimens and then recorded dynamic biplane radiographic images while manually flexing and extending the specimen. The position of the femur and patella were measured from the biplane images using both the model-based tracking system and a validated dynamic radiostereometric analysis (RSA) technique. Model-based tracking was compared to dynamic RSA by computing measures of bias, precision, and overall dynamic accuracy of four clinically-relevant kinematic parameters (patellar shift, flexion, tilt, and rotation).</p> <p>Results</p> <p>The model-based tracking technique results were in excellent agreement with the RSA technique. Overall dynamic accuracy indicated errors of less than 0.395 mm for patellar shift, 0.875° for flexion, 0.863° for tilt, and 0.877° for rotation.</p> <p>Conclusion</p> <p>This model-based tracking technique is a non-invasive method for accurately measuring dynamic PF joint motion under <it>in-vivo</it> conditions. The technique is sufficiently accurate in measuring clinically relevant changes in PF joint motion following conservative or surgical treatment.</p

Evolving Indications for Tricuspid Valve Surgery

More attention has been paid to the mitral valve (MV) than the tricuspid valve (TV), and this relative paucity of data has led to confusion regarding the timing of TV surgery. We review the American College of Cardiology/American Heart Association and European Society of Cardiology guidelines to identify areas of concordance (severe tricuspid regurgitation [TR] in a patient undergoing mitral valve surgery); discordance (less than severe TR but with markers for late TR recurrence such as pulmonary hypertension, a dilated TV annulus, atrial fibrillation, permanent transtricuspid pacing wires and others); and disagreement (surgery for primary TR). We provide our perspective from Northwestern University on these issues and where the guidelines are silent (TR in patients undergoing non-mitral valve operations). Finally, we review recent publications on the results of TV repair and replacement. Although there have been scant publications in the past, there have been more useful publications in recent years to guide our decision making

Proteasome Inhibitors Block DNA Repair and Radiosensitize Non-Small Cell Lung Cancer

Despite optimal radiation therapy (RT), chemotherapy and/or surgery, a majority of patients with locally advanced non-small cell lung cancer (NSCLC) fail treatment. To identify novel gene targets for improved tumor control, we performed whole genome RNAi screens to identify knockdowns that most reproducibly increase NSCLC cytotoxicity. These screens identified several proteasome subunits among top hits, including the topmost hit PSMA1, a component of the core 20 S proteasome. Radiation and proteasome inhibition showed synergistic effects. Proteasome inhibition resulted in an 80–90% decrease in homologous recombination (HR), a 50% decrease in expression of NF-κB-inducible HR genes BRCA1 and FANCD2, and a reduction of BRCA1, FANCD2 and RAD51 ionizing radiation-induced foci. IκBα RNAi knockdown rescued NSCLC radioresistance. Irradiation of mice with NCI-H460 xenografts after inducible PSMA1 shRNA knockdown markedly increased murine survival compared to either treatment alone. Proteasome inhibition is a promising strategy for NSCLC radiosensitization via inhibition of NF-κB-mediated expression of Fanconi Anemia/HR DNA repair genes.American Society for Radiation Oncology (Junior Faculty Career Research Training Award)Harvard University. Joint Center for Radiation Therapy (Foundation Grant)Dana-Farber/Harvard Cancer Center (SPORE Developmental Research Project Award in Lung Cancer Research)National Cancer Institute (U.S.) (Award K08CA172354