Transforming Cities, Negotiating Centrality: Markets and Civic Buildings in Comparative Perspective (XVth c. - XXth c.); An Introduction

This HSR forum on central urban places in history discusses the spatial interactions between political and commercial centres. The narrative of western modernity we challenge here explains the increasing distance between prestigious political monuments and daily markets with the breakthroughs in hygiene of the last two centuries in western urbanism. On the one hand, the example of Venice shows that the hygiene politics of the 19th century were not that new and that they could also be used for a kind of social segregation. On the other hand, the model of the occidental city as political community and municipal institution must be questioned. For instance, Ottoman towns had developed institutions that represented local groups and which were linked with the markets and their actors. Western influence and colonisation destroyed those institutions, which also had consequences for the city centre. We propose the concept of vertical and horizontal centrality for use in discussions of the multiple dimensions of centrality

Políticas de seguridad y salud y el desempeño laboral en los trabajadores de la Municipalidad Provincial del Santa, 2021

La presente investigación tuvo por objetivo determinar la relación que existe entre la política de seguridad y salud con el desempeño laboral en los trabajadores de la Municipalidad Provincial del Santa, 2021. La investigación fue del tipo básica, de corte cuantitativa, de diseño no experimental, correlacional y corte transversal. La población de estudio estuvo conformada por 183 trabajadores presenciales del régimen laboral 276, los mismos que fueron considerados como muestra. Para el recojo de datos se aplicó dos cuestionarios, Política de Seguridad y Salud y Desempeño Laboral. Entre los resultados, se obtuvo que, existe relación directa entre la integración de la prevención y el desempeño laboral, existe una relación directa entre la dimensión ambiente de trabajo y desempeño laboral, existe relación directa entre los accidentes y enfermedades ocupacionales y el desempeño laboral, existe relación directa entre la formación en seguridad y salud ocupacional y el desempeño laboral, existe relación directa entre la seguridad y salud ocupacional y el desempeño laboral. Se concluyó que existió una correlación directa de nivel alto (Rho=0,716) y significativa (p-valor 0,000 < 0,05) entre las políticas de seguridad y salud y el desempeño laboral en el personal de la Municipalidad Provincial del Santa, 2021

Motivación laboral y satisfacción laboral del personal docente de la I.E.P. Jesús Maestro Nuevo Chimbote – 2018

La presente tesis buscó determinar la relación entre la motivación laboral y la satisfacción laboral del personal docente de la I.E.P Jesús Maestro, Nuevo Chimbote 2018. Este estudio fue correlacional, el diseño fue no experimental, de corte transversal. Se aplicó una encuesta de 40 preguntas, 20 orientadas a determinar la motivación laboral y otras 20 para medir la satisfacción laboral, aplicada a todo el personal docente que son 61. Ambos instrumentos buscaron responder las dimensiones, motivación interna, motivación externa, remuneraciones y beneficios, condiciones físicas y materiales, relaciones interpersonales, políticas y reglas para posteriormente generar información a partir de tablas de frecuencia y tablas cruzadas. La prueba chi cuadrado arrojó una significancia de 0.00 que al ser menor que 0.05, permitió aceptar la hipótesis alterna confirmando que si existe relación significativa entre las variables motivación laboral y satisfacción laboral del personal docente de la I.E.P Jesús Maestro según lo indica la Tabla N° 3, la motivación laboral del personal docente se encuentra en un nivel regular con un 39.30% (24), la satisfacción laboral del personal docente se encuentra en un nivel malo con un 36.10% (22). La dimensión motivación interna evidencia relación con las dimensiones, remuneraciones y beneficios, políticas y reglas. Por el contrario la dimensión motivación interna no guarda relación con la dimensión relaciones interpersonales, del mismo modo no guarda relación con las condiciones físicas y materiales. La dimensión motivación externa guarda relación con relaciones interpersonales, remuneraciones y beneficios, condiciones físicas y materiales y políticas y reglas

Multiple AGN in the crowded field of the compact group SDSSJ0959+1259

We present a multi-wavelength study of a newly discovered compact group (CG), SDSS J0959+1259, based data from XMM-Newton, SDSS and the Calar Alto optical imager BUSCA. With a maximum velocity offset of 500 km s$^{-1}$, a mean redshift of 0.035, and a mean spatial extension of 480 kpc, this CG is exceptional in having the highest concentration of nuclear activity in the local Universe, established with a sensitivity limit L$_{X}>4\times$10$^{40}$ erg s$^{-1}$ in 2--10 keV band and R-band magnitude $M_R < -19$. The group is composed of two type-2 Seyferts, one type-1 Seyfert, two LINERs and three star forming galaxies. Given the high X-ray luminosity of LINERs which reaches $\sim 10^{41}$ erg s$^{-1}$, it is likely that they are also accretion driven, bringing the number of active nuclei in this group to to 5 out of 8 (AGN fraction of 60\%). The distorted shape of one member of the CG suggests that strong interactions are taking place among its galaxies through tidal forces. Therefore, this system represents a case study for physical mechanisms that trigger nuclear activity and star formation in CGs.Comment: 8 pages, 4 figures and 4 tables. Accepted for publication in MNRA

Plan estratégico de comunicación de la empresa “Viaje Lindo Airlines”

Tras un accidente en el cual se presentó fallas en la estabilidad del avión y fallecieron 70 personas, se desató una crisis en la empresa Viaje Lindo Airlines que afectó directamente a su imagen y reputación. No solo hubo un problema externo, sino también interno debido a que los colaboradores presentaban quejas de mal clima laboral y hubo mala organización en las áreas de la empresa. Ahora, Viaje Lindo Airlines busca gestionar la crisis a través de la realización de un plan de comunicación interno y externo con un nuevo enfoque en cuanto a sus valores, identidad, promesa de marca y políticas de comunicación interna

SAÚDE SEXUAL E REPRODUTIVA NA ATENÇÃO PRIMÁRIA À SAÚDE: RELATOS DE MULHERES LÉSBICAS

Objetivo: analisar relatos de mulheres lésbicas acerca dos atendimentos à saúde sexual e reprodutiva em serviços de Atenção Primária à Saúde. Método: estudo qualitativo do tipo exploratório descritivo realizado em 2019. Dez mulheres lésbicas expuseram seus relatos em duas sessões de grupo focal, estratégia que gerou os dados da pesquisa. Estes foram submetidos à análise de conteúdo do tipo temática. Resultados: as participantes expressaram aspectos culturais desafiadores para a qualidade das abordagens, como preconceito, objetificação do corpo, aceitação da homossexualidade e desconhecimento de suas práticas afetivo-sexuais. Compreendiam que suas necessidades de saúde sexual e reprodutiva não eram atendidas, conforme elas mesmas as definiam, mas reconheceram empatia e acolhimento na interação com alguns profissionais de saúde. Considerações Finais: revelaram-se atendimentos influenciados por estereótipos de gênero e sexualidade, o que reduz o acesso a uma Atenção Primária à Saúde de qualidade, promotora do cuidado para com a saúde de mulheres lésbicas

Synthesis of benzylpiperazine derivatives containing the pyrazine moiety with potential activity against M. tuberculosis/Síntese de derivados da benzilpiperazina contendo a fracção pirazina com potencial actividade contra a M. tuberculosis

A tuberculose (TB) ainda é um problema de saúde pública global, apesar dos esforços e recentes avanços na medicina e farmacologia. A Organização Mundial da Saúde estima que em 2018, 1,5 milhões de pessoas morreram em todo o mundo devido à tuberculose. Nesse contexto, é urgente a busca por novas moléculas que possam oferecer mais eficácia, menor tempo de tratamento, com menores efeitos adversos conta TB. O presente trabalho descreve a síntese de oito novas benzilpiperazinas contendo o núcleo pirazina, com potencial atividade antituberculose. As moléculas foram planejadas de maneira racional, utilizando-se a técnica de hibridação molecular, a partir do fármaco pirazinamida e do núcleo benzilpiperazina. As substâncias propostas foram obtidas a partir de um processo sintético simples e reprodutivo, em rendimentos baixos

Multi-instrument analysis of 67P/Churyumov-Gerasimenko coma particles: COPS-GIADA data fusion

The European Space Agency's Rosetta mission to comet 67P/Churyumov-Gerasimenko has offered scientists the opportunity to study a comet in unprecedented detail. Four instruments of the Rosetta orbiter, namely, the Micro-Imaging Dust Analysis System (MIDAS), the Grain Impact Analyzer and Dust Accumulator (GIADA), the COmetary Secondary Ion Mass Analyser (COSIMA), and the Rosetta Orbiter Spectrometer for Ion and Neutral Analysis (ROSINA) have provided information on cometary dust particles. Cross-instrument comparisons are crucial to characterize cometary dust particles beyond the capabilities of individual sensors, as they are sensitive to different dust components. We present the first comparison between detections of the ROSINA COmet Pressure Sensor (COPS) and GIADA. These two instruments are complementary as the former is sensitive solely to volatiles of icy particles, while the latter measured the dust particle as a whole, including refractories and condensed (semi)volatiles. Our goal is to correlate the particles detected by COPS and GIADA and to assess whether they belong to a common group. We statistically analyzed the in situ data of COPS and GIADA by calculating Pearson correlation coefficients. Among the several types of particles detected by GIADA, we find that COPS particles are significantly correlated solely with GIADA fluffy agglomerates (Pearson correlation coefficient of 0.55 and p-value of $4.6\cdot 10^{-3}$). This suggests that fluffy particles are composed of both refractories and volatiles. COPS volatile volumes, which may be represented by equivalent spheres with a diameter in the range between 0.06 $\mu$m and 0.8 $\mu$m, are similar to the sizes of the fractal particle's subunits identified by MIDAS (i.e., 0.05-0.18 $\mu$m).Comment: 6 pages, 3 figures, accepted for publication in A&

Chromosomal plasticity and evolutionary potential in the malaria vector Anopheles gambiae sensu stricto: insights from three decades of rare paracentric inversions

Background: In the Anopheles gambiae complex, paracentric chromosomal inversions are nonrandomly distributed along the complement: 18/31 (58%) of common polymorphic inversions are on chromosome arm 2R, which represents only ~30% of the complement. Moreover, in An.gambiae sensu stricto, 6/7 common polymorphic inversions occur on 2R. Most of these inversions are considered markers of ecological adaptation that increase the fitness of the carriers of alternative karyotypes in contrasting habitats. However, little is known about the evolutionary forces responsible for their origin and subsequent establishment in field populations. Results: Here, we present data on 82 previously undescribed rare chromosomal inversions (RCIs) recorded during extensive field sampling in 16 African countries over a 30 year period, which may shed light on the dynamics of chromosomal plasticity in An. gambiae. We analyzed breakpoint distribution, length, and geographic distribution of RCIs, and compared these measures to those of the common inversions. We found that RCIs, like common inversions, are disproportionately clustered on 2R, which may indicate that this arm is especially prone to breakages. However, contrasting patterns were observed between the geographic distribution of common inversions and RCIs. RCIs were equally frequent across biomes and on both sides of the Great Rift Valley (GRV), whereas common inversions predominated in arid ecological settings and west of the GRV. Moreover, the distribution of RCI lengths followed a random pattern while common inversions were significantly less frequent at shorter lengths. Conclusion: Because 17/82 (21%) RCIs were found repeatedly at very low frequencies – at the same sampling location in different years and/or in different sampling locations – we suggest that BMC Evolutionary Biology 2008, 8:309 http://www.biomedcentral.com/1471-2148/8/309 RCIs are subject mainly to drift under unperturbed ecological conditions. Nevertheless, RCIs may represent an important reservoir of genetic variation for An. gambiae in response to environmental changes, further testifying to the considerable evolutionary potential hidden within this pan-African malaria vector

Selective hepatitis B and D virus entry inhibitors from the group of pentacyclic lupane-type betulin-derived triterpenoids

Current treatment options against hepatitis B and D virus (HBV/HDV) infections have only limited curative effects. Identification of Na+/taurocholate co-transporting polypeptide (NTCP) as the high-affinity hepatic receptor for both viruses in 2012 enables target-based development of HBV/HDV cell-entry inhibitors. Many studies already identified appropriate NTCP inhibitors. However, most of them interfere with NTCP's physiological function as a hepatic bile acid transporter. To overcome this drawback, the present study aimed to find compounds that specifically block HBV/HDV binding to NTCP without affecting its transporter function. A novel assay was conceptualized to screen for both in parallel; virus binding to NTCP (measured via binding of a preS1-derived peptide of the large HBV/HDV envelope protein) and bile acid transport via NTCP. Hits were subsequently validated by in vitro HDV infection studies using NTCP-HepG2 cells. Derivatives of the birch-derived pentacyclic lupane-type triterpenoid betulin revealed clear NTCP inhibitory potency and selectivity for the virus receptor function of NTCP. Best performing compounds in both aspects were 2, 6, 19, and 25. In conclusion, betulin derivatives show clear structure-activity relationships for potent and selective inhibition of the HBV/HDV virus receptor function of NTCP without tackling its physiological bile acid transport function and therefore are promising drug candidates.Peer reviewe