709 research outputs found
Transverse Spin Structure of the Nucleon through Target Single Spin Asymmetry in Semi-Inclusive Deep-Inelastic Reaction at Jefferson Lab
Jefferson Lab (JLab) 12 GeV energy upgrade provides a golden opportunity to
perform precision studies of the transverse spin and
transverse-momentum-dependent structure in the valence quark region for both
the proton and the neutron. In this paper, we focus our discussion on a
recently approved experiment on the neutron as an example of the precision
studies planned at JLab. The new experiment will perform precision measurements
of target Single Spin Asymmetries (SSA) from semi-inclusive electro-production
of charged pions from a 40-cm long transversely polarized He target in
Deep-Inelastic-Scattering kinematics using 11 and 8.8 GeV electron beams. This
new coincidence experiment in Hall A will employ a newly proposed solenoid
spectrometer (SoLID). The large acceptance spectrometer and the high polarized
luminosity will provide precise 4-D (, , and ) data on the
Collins, Sivers, and pretzelocity asymmetries for the neutron through the
azimuthal angular dependence. The full 2 azimuthal angular coverage in the
lab is essential in controlling the systematic uncertainties. The results from
this experiment, when combined with the proton Collins asymmetry measurement
and the Collins fragmentation function determined from the ee collision
data, will allow for a quark flavor separation in order to achieve a
determination of the tensor charge of the d quark to a 10% accuracy. The
extracted Sivers and pretzelocity asymmetries will provide important
information to understand the correlations between the quark orbital angular
momentum and the nucleon spin and between the quark spin and nucleon spin.Comment: 23 pages, 13 figures, minor corrections, matches published versio
Effectiveness of offloading interventions to heal foot ulcers in persons with diabetes: a systematic review
Background Offloading interventions are commonly used in clinical practice to heal foot ulcers. The aim of this updated systematic review is to investigate the effectiveness of offloading interventions to heal diabetic foot ulcers. Methods We updated our previous systematic review search of PubMed, EMBASE, and Cochrane databases to also include original studies published between July 29, 2014 and August 13, 2018 relating to four offloading intervention categories in populations with diabetic foot ulcers: (a) offloading devices, (b) footwear, (c) other offloading techniques, and (d) surgical offloading techniques. Outcomes included ulcer healing, plantar pressure, ambulatory activity, adherence, adverse events, patient‐reported measures, and cost‐effectiveness. Included controlled studies were assessed for methodological quality and had key data extracted into evidence and risk of bias tables. Included non‐controlled studies were summarised on a narrative basis. Results We identified 41 studies from our updated search for a total of 165 included studies. Six included studies were meta‐analyses, 26 randomised controlled trials (RCTs), 13 other controlled studies, and 120 non‐controlled studies. Five meta‐analyses and 12 RCTs provided high‐quality evidence for non‐removable knee‐high offloading devices being more effective than removable offloading devices and therapeutic footwear for healing plantar forefoot and midfoot ulcers. Total contact casts (TCCs) and non‐removable knee‐high walkers were shown to be equally effective. Moderate‐quality evidence exists for removable knee‐high and ankle‐high offloading devices being equally effective in healing, but knee‐high devices have a larger effect on reducing plantar pressure and ambulatory activity. Low‐quality evidence exists for the use of felted foam and surgical offloading to promote healing of plantar forefoot and midfoot ulcers. Very limited evidence exists for the efficacy of any offloading intervention for healing plantar heel ulcers, non‐plantar ulcers, and neuropathic ulcers with infection or ischemia. Conclusion Strong evidence supports the use of non‐removable knee‐high offloading devices (either TCC or non‐removable walker) as the first‐choice offloading intervention for healing plantar neuropathic forefoot and midfoot ulcers. Removable offloading devices, either knee‐high or ankle‐high, are preferred as second choice over other offloading interventions. The evidence bases to support any other offloading intervention is still weak and more high‐quality controlled studies are needed in these areas
Two-loop Corrections to the B to pi Form Factor from QCD Sum Rules on the Light-Cone and |V(ub)|
We calculate the leading-twist O(alphas^2 beta0) corrections to the B to pi
transition form factor f+(0) in light-cone sum rules. We find that, as
expected, there is a cancellation between the O(alphas^2 beta0) corrections to
fB f+(0) and the large corresponding corrections to fB, calculated in QCD sum
rules. This suggests the insensitivity of the form factors calculated in the
light-cone sum rules approach to this source of radiative corrections. We
further obtain an improved determination of the CKM matrix element |V(ub)|,
using latest results from BaBar and Belle for f+(0)|V(ub)|.Comment: 18 pages, 3 figure
Electromagnetic form factors of charged and neutral kaons in an extended vector-meson-dominance model
A model is developed for electromagnetic form factors of the charged and
neutral K-mesons. The formalism is based on ChPT Lagrangians with vector
mesons. The form factors, calculated without fitting parameters, are in a good
agreement with experiment for space-like and time-like photon momenta.
Contribution of the two-kaon channels to the muon anomalous magnetic moment
a_\mu is calculated.Comment: 23 pages, 11 figures, accepted for publication in Eur. Phys. J.
Detection of group A Streptococcus in tonsils from pediatric patients reveals high rate of asymptomatic streptococcal carriage
<p>Abstract</p> <p>Background</p> <p>Group A <it>Streptococcus </it>(GAS) causes acute tonsillopharyngitis in children, and approximately 20% of this population are chronic carriers of GAS. Antibacterial therapy has previously been shown to be insufficient at clearing GAS carriage. Bacterial biofilms are a surface-attached bacterial community that is encased in a matrix of extracellular polymeric substances. Biofilms have been shown to provide a protective niche against the immune response and antibiotic treatments, and are often associated with recurrent or chronic bacterial infections. The objective of this study was to test the hypothesis that GAS is present within tonsil tissue at the time of tonsillectomy.</p> <p>Methods</p> <p>Blinded immunofluorescent and histological methods were employed to evaluate palatine tonsils from children undergoing routine tonsillectomy for adenotonsillar hypertrophy or recurrent GAS tonsillopharyngitis.</p> <p>Results</p> <p>Immunofluorescence analysis using anti-GAS antibody was positive in 11/30 (37%) children who had tonsillectomy for adenotonsillar hypertrophy and in 10/30 (33%) children who had tonsillectomy for recurrent GAS pharyngitis. Fluorescent microscopy with anti-GAS and anti-cytokeratin 8 & 18 antibodies revealed GAS was localized to the tonsillar reticulated crypts. Scanning electron microscopy identified 3-dimensional communities of cocci similar in size and morphology to GAS. The characteristics of these communities are similar to GAS biofilms from <it>in vivo </it>animal models.</p> <p>Conclusion</p> <p>Our study revealed the presence of GAS within the tonsillar reticulated crypts of approximately one-third of children who underwent tonsillectomy for either adenotonsillar hypertrophy or recurrent GAS tonsillopharyngitis at the Wake Forest School of Medicine.</p> <p>Trial Registration</p> <p>The tissue collected was normally discarded tissue and no patient identifiers were collected. Thus, no subjects were formally enrolled.</p
Evidence for Factorization in Three-body B --> D(*) K- K0 Decays
Motivated by recent experimental results, we use a factorization approach to
study the three-body B --> D(*) K- K0 decay modes. Two mechanisms are proposed
for kaon pair production: current-produced (from vacuum) and transition (from B
meson). The Bbar0 --> D(*)+ K- K0 decay is governed solely by the
current-produced mechanism. As the kaon pair can be produced only by the vector
current, the matrix element can be extracted from e+ e- --> K Kbar processes
via isospin relations. The decay rates obtained this way are in good agreement
with experiment. Both current-produced and transition processes contribute to
B- --> D(*)0 K- K0 decays. By using QCD counting rules and the measured B- -->
D(*)0 K- K0 decay rates, the measured decay spectra can be understood.Comment: 17 pages, 6 figure
Constructing RNA dynamical ensembles by combining MD and motionally decoupled NMR RDCs: new insights into RNA dynamics and adaptive ligand recognition
We describe a strategy for constructing atomic resolution dynamical ensembles of RNA molecules, spanning up to millisecond timescales, that combines molecular dynamics (MD) simulations with NMR residual dipolar couplings (RDC) measured in elongated RNA. The ensembles are generated via a Monte Carlo procedure by selecting snap-shot from an MD trajectory that reproduce experimentally measured RDCs. Using this approach, we construct ensembles for two variants of the transactivation response element (TAR) containing three (HIV-1) and two (HIV-2) nucleotide bulges. The HIV-1 TAR ensemble reveals significant mobility in bulge residues C24 and U25 and to a lesser extent U23 and neighboring helical residue A22 that give rise to large amplitude spatially correlated twisting and bending helical motions. Omission of bulge residue C24 in HIV-2 TAR leads to a significant reduction in both the local mobility in and around the bulge and amplitude of inter-helical bending motions. In contrast, twisting motions of the helices remain comparable in amplitude to HIV-1 TAR and spatial correlations between them increase significantly. Comparison of the HIV-1 TAR dynamical ensemble and ligand bound TAR conformations reveals that several features of the binding pocket and global conformation are dynamically preformed, providing support for adaptive recognition via a ‘conformational selection’ type mechanism
How binding of small molecule and peptide ligands to HIV-1 TAR alters the RNA motional landscape
The HIV-1 TAR RNA represents a well-known paradigm to study the role of dynamics and conformational change in RNA function. This regulatory RNA changes conformation in response to binding of Tat protein and of a variety of peptidic and small molecule ligands, indicating that its conformational flexibility and intrinsic dynamics play important roles in molecular recognition. We have used 13C NMR relaxation experiments to examine changes in the motional landscape of HIV-1 TAR in the presence of three ligands of different affinity and specificity. The ligands are argininamide, a linear peptide mimic of the Tat basic domain and a cyclic peptide that potently inhibits Tat-dependent activation of transcription. All three molecules induce the same motional characteristics within the three nucleotides bulge that represents the Tat-binding site. However, the cyclic peptide has a unique motional signature in the apical loop, which represents a binding site for the essential host co-factor cyclin T1. These results suggest that all peptidic mimics of Tat induce the same dynamics in TAR within this protein binding site. However, the new cyclic peptide mimic of Tat represents a new class of ligands with a unique effect on the dynamics and the structure of the apical loop
Information management in the early stages of the COVID-19 pandemic
This paper reviews the information management aspects of the early months of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Coronavirus 19 outbreak. It shows that the transition from epidemic to pandemic was caused partly by poor management of information that was publicly available in January 2020.
The approach combines public domain epidemic data with economic, demographic, health, social and political data and investigates how information was managed by governments. It includes case studies of early-stage information management, from countries with high and low COVID-19 impacts (as measured by deaths per million).
The reasons why the information was not acted upon appropriately include “dark side” information behaviours Stone et al. (2019). Many errors and misjudgements could have been avoided by using learnings from previous epidemics, particularly the 1918-19 flu epidemic, when international travel (mainly of troops in World War 1) was a prime mode of spreading. It concludes that if similar outbreaks are not to turn into pandemics, much earlier action is needed, mainly closing borders and locking-down.
The research is based on what was known at the time of writing, when the pandemic’s exact origin was uncertain, when some statistics about actions and results were unavailable and when final results were unknown.
Governments faced with early warning signs or pandemics must act much faster.
This is one of the first analyses of information management practices relating to the pandemic’s early stages
Atmospheric Muon Flux at Sea Level, Underground, and Underwater
The vertical sea-level muon spectrum at energies above 1 GeV and the
underground/underwater muon intensities at depths up to 18 km w.e. are
calculated. The results are particularly collated with a great body of the
ground-level, underground, and underwater muon data. In the hadron-cascade
calculations, the growth with energy of inelastic cross sections and pion,
kaon, and nucleon generation in pion-nucleus collisions are taken into account.
For evaluating the prompt muon contribution to the muon flux, we apply two
phenomenological approaches to the charm production problem: the recombination
quark-parton model and the quark-gluon string model. To solve the muon
transport equation at large depths of homogeneous medium, a semi-analytical
method is used. The simple fitting formulas describing our numerical results
are given. Our analysis shows that, at depths up to 6-7 km w. e., essentially
all underground data on the muon intensity correlate with each other and with
predicted depth-intensity relation for conventional muons to within 10%.
However, the high-energy sea-level data as well as the data at large depths are
contradictory and cannot be quantitatively decribed by a single nuclear-cascade
model.Comment: 47 pages, REVTeX, 15 EPS figures included; recent experimental data
and references added, typos correcte
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