Phytochemicals as Potential Epidrugs in Type 2 Diabetes Mellitus

Type 2 diabetes Mellitus (T2DM) prevalence has significantly increased worldwide in recent years due to population age, obesity, and modern sedentary lifestyles. The projections estimate that 439 million people will be diabetic in 2030. T2DM is characterized by an impaired ß-pancreatic cell function and insulin secretion, hyperglycemia and insulin resistance, and recently the epigenetic regulation of ß-pancreatic cells differentiation has been underlined as being involved. It is currently known that several bioactive molecules, widely abundant in plants used as food or infusions, have a key role in histone modification and DNA methylation, and constituted potential epidrugs candidates against T2DM. In this sense, in this review the epigenetic mechanisms involved in T2DM and protein targets are reviewed, with special focus in studies addressing the potential use of phytochemicals as epidrugs that prevent and/or control T2DM in vivo and in vitro. As main findings, and although some controversial results have been found, bioactive molecules with epigenetic regulatory function, appear to be a potential replacement/complementary therapy of pharmacological hypoglycemic drugs, with minimal side effects. Indeed, natural epidrugs have shown to prevent or delay the T2DM development and the morbidity associated to dysfunction of blood vessels, eyes and kidneys due to sustained hyperglycemia in T2DM patients.This work was supported by CONICYT PIA/APOYO CCTE AFB170007. NC-M acknowledges the Portuguese Foundation for Science and Technology under the Horizon 2020 Program (PTDC/PSI-GER/ 28076/2017)

Cut-off low systems over Iraq: Contribution to annual precipitation and synoptic analysis of extreme events

We combine daily in situ precipitation data with meteorological reanalysis data in order to explore the contribution of cut-off low systems to the seasonal and interannual rainfall variations over Baghdad from 2005 to 2016. During these 12 years (average rainfall of 131 ± 67 mm/year), 38 rainy cut-off lows brought 43% of the total precipitation, with extreme inter-annual variations. Indeed, precipitation associated with autumn cut-off lows was the principal factor that turned an arid into a wet year: during the three most arid years cut-off lows contributed about 25% of the average rainfall (10 out of 40 mm/year) while during the three wettest years they contributed near 67% (171 out of 254 mm/year). The extreme-rain cut-off low systems displayed analogous synoptic characteristics: upper-atmosphere divergence, upwards vertical motions in the middle atmosphere, and lower-atmosphere winds into central Iraq at times when the surface Red Sea and Persian Gulf waters were warmer than the surface air. During those days previous to an extreme event, the surface waters cooled substantially and the amount of precipitable water increased largely, suggesting high latent heat transfer. In order to characterize those conditions that favour rainfall, we focus on the November 18–20, 2013 cut-off low system, which led to the largest flooding and wettest year in Baghdad between 2005 and 2016. The distribution of properties in the middle (500 hPa) and upper (250 hPa) troposphere shows that the region was affected by intense horizontal divergence and upwards motions, coinciding with a surface low over the Arabian Peninsula that caused intense northwards winds over the Persian Gulf and brought substantial moisture to central Iraq. The analysis of several stability indexes indicates that convective instability played a secondary role during the episode.Peer ReviewedPostprint (author's final draft

Prognostic value of neutrophil-to-lymphocyte ratio in COVID-19 patients: A systematic review and meta-analysis

Background: Neutrophil-to-lymphocyte ratio (NLR) is an accessible and widely used biomarker. NLR may be used as an early marker of poor prognosis in patients with COVID-19. Objective: To evaluate the prognostic value of the NLR in patients diagnosed with COVID-19. Methods: We conducted a systematic review and meta-analysis. Observational studies that reported the association between baseline NLR values (ie, at hospital admission) and severity or all-cause mortality in COVID-19 patients were included. The quality of the studies was assessed using the Newcastle-Ottawa Scale (NOS). Random effects models and inverse variance method were used for meta-analyses. The effects were expressed as odds ratios (ORs) and their 95% confidence intervals (CIs). Small study effects were assessed with the Egger's test. Results: We analysed 61 studies (n = 15 522 patients), 58 cohorts, and 3 case-control studies. An increase of one unit of NLR was associated with higher odds of severity (OR 6.22; 95%CI 4.93 to 7.84; P <.001) and higher odds of all-cause mortality (OR 12.6; 95%CI 6.88 to 23.06; P <.001). In our sensitivity analysis, we found that 41 studies with low risk of bias and moderate heterogeneity (I2 = 53% and 58%) maintained strong association between NLR values and both outcomes (severity: OR 5.36; 95% CI 4.45 to 6.45; P <.001; mortality: OR 10.42 95% CI 7.73 to 14.06; P =.005). Conclusions: Higher values of NLR were associated with severity and all-cause mortality in hospitalised COVID-19 patients.Revisión por pare

Vitamin B12 levels in thyroid disorders: A systematic review and meta-analysis

Background and aims: Numerous studies have found an association between vitamin deficiency and thyroid disorders (TD). The presence of anti-parietal cell antibodies is indicative of reduced ability to absorb vitamin B12. Thus, this study reviewed the existing studies with the objective of assessing differences in the serum levels of vitamin B12 among patients with and without TD, the frequency of vitamin B12 deficiency in patients with TD, and the presence of anti-parietal cell antibodies in patients with TD. Methods: A meta-analysis of random-effects model was conducted to calculate pooled frequencies, mean differences (MD), and their respective 95% confidence intervals (CI). We identified 64 studies that met our inclusion criteria (n = 28597). Results: We found that patients with hypothyroidism had lower vitamin B12 levels than healthy participants (MD: −60.67 pg/mL; 95% CI: −107.31 to −14.03 pg/mL; p = 0.01). No significant differences in vitamin B12 levels were observed between healthy participants and patients with hyperthyroidism (p = 0.78), autoimmune thyroid disease (AITD) (p = 0.22), or subclinical hypothyroidism (SH) (p = 0.79). The frequencies of vitamin B12 deficiency among patients with hypothyroidism, hyperthyroidism, SH, and AITD were 27%, 6%, 27%, and 18%, respectively. Conclusions: Patients with hypothyroidism had lower levels of vitamin B12 than healthy participants. No significant differences were observed between vitamin B12 levels and hyperthyroidism, AITD, or SH. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=324422, identifier (CRD42022324422)

Vitamin B12 levels in thyroid disorders: A systematic review and meta-analysis

Background and aims: Numerous studies have found an association between vitamin deficiency and thyroid disorders (TD). The presence of anti-parietal cell antibodies is indicative of reduced ability to absorb vitamin B12. Thus, this study reviewed the existing studies with the objective of assessing differences in the serum levels of vitamin B12 among patients with and without TD, the frequency of vitamin B12 deficiency in patients with TD, and the presence of anti-parietal cell antibodies in patients with TD. Methods: A meta-analysis of random-effects model was conducted to calculate pooled frequencies, mean differences (MD), and their respective 95% confidence intervals (CI). We identified 64 studies that met our inclusion criteria (n = 28597). Results: We found that patients with hypothyroidism had lower vitamin B12 levels than healthy participants (MD: −60.67 pg/mL; 95% CI: −107.31 to −14.03 pg/mL; p = 0.01). No significant differences in vitamin B12 levels were observed between healthy participants and patients with hyperthyroidism (p = 0.78), autoimmune thyroid disease (AITD) (p = 0.22), or subclinical hypothyroidism (SH) (p = 0.79). The frequencies of vitamin B12 deficiency among patients with hypothyroidism, hyperthyroidism, SH, and AITD were 27%, 6%, 27%, and 18%, respectively. Conclusions: Patients with hypothyroidism had lower levels of vitamin B12 than healthy participants. No significant differences were observed between vitamin B12 levels and hyperthyroidism, AITD, or SH. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=324422, identifier (CRD42022324422). Copyright © 2023 Benites-Zapata, Ignacio-Cconchoy, Ulloque-Badaracco, Hernandez-Bustamante, Alarcón-Braga, Al-kassab-Córdova and Herrera-Añazco.Revisión por pare

Acceptance towards Monkeypox Vaccination: A Systematic Review and Meta-Analysis

Vaccination it is considered a vital strategy in order to mitigate monkeypox by protecting from severe disease and helping in reduction of hospitalisations. In this sense, this study aims to estimate the global prevalence of vaccination acceptance against monkeypox. We conducted a systematic review with a comprehensive search strategy for the following databases: PubMed, Scopus and Web of Science. A random-effect model meta-analysis was carried out using observational studies assessing the intention of vaccines against monkeypox from multiple continents. The quality assessment was developed using the Newcastle-Ottawa Scale adapted for cross-sectional studies. In addition, a subgroup analysis by study location and population and a sensitivity analysis was developed.Eleven cross-sectional studies were included. A total of 8045 participants were included. The pooled prevalence of monkeypox vaccination acceptance in all participants was 56.0% (95%CI: 42.0–70.0%). In the subgroup analysis of monkeypox vaccine acceptance according to continents, the prevalence of vaccine acceptance was 50.0% (95%CI: 24.0–76.0%) in Asian countries and 70.0% (95%CI: 55.0–84.0%) in European countries. The prevalence of vaccine acceptance was 43.0% (95%CI: 35.0–50.0%) in the general population, 63.0% (95%CI: 42.0–70.0%) in healthcare workers, and 84.0% (95%CI: 83.0–86.0%) in the LGBTI community. Despite the high prevalence of monkeypox vaccination acceptance in the LGBTI community found in our study, vaccination acceptance from healthcare workers and the general population are lower. Governments could use these results for planning, developing or promoting vaccination strategies and public health policies focused on these populations.Revisión por pare

Association between Lipid Profile and Apolipoproteins with Risk of Diabetic Foot Ulcer: A Systematic Review and Meta-Analysis

Background and Aims. Biomarkers are necessary to stratify the risk of diabetic foot ulcers (DFUs). This systematic review and meta-analysis aimed to evaluate the association between the lipid profile and apolipoproteins with the risk of DFU. Methods. A systematic search was conducted in PubMed, Scopus, Cochrane Library, and Web of Science among adult patients. Cohort and case-control studies were included. Random-effects models were used for meta-analyses, and the effects were expressed as odds ratio (OR) and their 95% confidence intervals (CIs). We evaluated publication bias through Egger's test and funnel plot. Results. A total of 12 cohort studies and 26 case-control studies were included, with 17076 patients. We found that the higher values of total cholesterol (TC), low-density lipoprotein (LDL), triglycerides, and lipoprotein(a) (Lp(a)) were associated with a higher risk of developing DFU (OR: 1.47, OR: 1.47, OR: 1.5, OR: 1.85, respectively). Otherwise, the lower values of HDL were associated with a higher risk of developing DFU (OR: 0.49). Publication bias was not found for associations between TC, HDL, LDL, or TG and the risk of DFU. Conclusions. The high values of LDL, TC, TG, and Lp(a) and low values of HDL are associated with a higher risk of developing DFU. Furthermore, we did not find a significant association for VLDL, ApoA1, ApoB, and ApoB/ApoA1 ratio.Revisión por pare

Dialogic literacy: Talking, reading and writing among primary school children

This study investigates the interplay between talk, reading and writing as 6th grade Mexican primary school children worked together, in small groups, on a psycholinguistic task that required them to read three related texts and then write an integrative summary. The study was conducted in the context of an educational program called ‘Learning Together’ (LT), which uses collaborative learning to enhance the development of children's oracy and literacy. Analyses of children's dialogues using the Ethnography of Communication in combination with a novel ‘Scheme for Educational Dialogue Analysis (SEDA)’ (Hennessy et al., 2016), revealed important improvements in effective oral communication - and specifically a shift towards the use of dialogic styles of interaction - between the children who participated in the LT program (as compared to those who did not). These improvements were accompanied by significantly higher quality integrative summaries, not only when children worked in small groups but also individually. The latter results indicate appropriation of sophisticated literacy abilities by the children. Further analyses of the relations among talk, reading and writing suggest that these processes are interwoven through subtle intertextual relations and support each other in a dynamic and iterative manner. We discuss the theoretical, methodological and practical relevance of the study.The work reported in this paper was supported by the Dirección General de Asuntos del Personal Académico of the National Autonomous University of Mexico (UNAM) (DGAPA-UNAM) (PAPIIT Project Number: IN303716). Professor Rojas-Drummond would like to thank the Faculty of Education at the University of Cambridge, UK for hosting her as Visiting Scholar while part of this manuscript was being prepared. Her visiting Scholarship was funded by the National Council of Science and Technology in Mexico (CONACYT Project Number: 160873). In addition, some of the methodological tools used in the study reported derived from a collaborative work carried out for a project entitled ‘A Tool for Analysing Dialogic Interactions in Classrooms’ (http://tinyurl.com/BAdialogue) funded through the British Academy International Partnership and Mobility Scheme (ref. RG66509), between January 2013–December 2015

Prevalence of Toxocara eggs in Latin American parks: a systematic review and meta-analysis

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