What Makes Decentralised Energy Storage Schemes Successful? An Assessment Incorporating Stakeholder Perspectives

Decentralised energy storage is increasingly seen as being important for decarbonising local energy systems and the global market for such systems is expected to grow significantly. Several studies have looked into the technical development of decentralised energy storage systems, as well as examining how different business models can enable them to capture a variety of value streams. Recent work has also explored public perceptions of energy storage, yet so far there has been little focus on how the different dimensions affecting deployment interact together. Here, we present the result of a deliberative workshop which gathers stakeholders’ views and addresses how the interplay between these three dimensions affects successful deployment. Our approach is holistic and integrative and utilises a participatory decision-making methodology. The findings of the research add substantially to the understanding of how decentralised energy storage schemes should be implemented. The research reveals that there are many aspects that can help to either facilitate or impede a storage scheme, and stakeholders perceive multiple ways to engage with the deployment of the technology. We show that the following four principles could contribute to achieving success: maximizing simplicity and clarity; managing expectations, uncertainty and risk; generating benefits for the community; and the involvement of trusted actors

Tumor Necrosis Factor Alpha-Induced Recruitment of Inflammatory Mononuclear Cells Leads to Inflammation and Altered Brain Development in Murine Cytomegalovirus-Infected Newborn Mice

Congenital human cytomegalovirus (HCMV) infection is a significant cause of abnormal neurodevelopment and long-term neurological sequelae in infants and children. Resident cell populations of the developing brain have been suggested to be more susceptible to virus-induced cytopathology, a pathway thought to contribute to the clinical outcomes following intrauterine HCMV infection. However, recent findings in a newborn mouse model of the infection in the developing brain have indicated that elevated levels of proinflammatory mediators leading to mononuclear cell activation and recruitment could underlie the abnormal neurodevelopment. In this study, we demonstrate that treatment with tumor necrosis factor alpha (TNF-α)-neutralizing antibodies decreased the frequency of CD45+ Ly6Chi CD11b+ CCR2+ activated myeloid mononuclear cells (MMCs) and the levels of proinflammatory cytokines in the blood and the brains of murine CMV-infected mice. This treatment also normalized neurodevelopment in infected mice without significantly impacting the level of virus replication. These results indicate that TNF-α is a major component of the inflammatory response associated with altered neurodevelopment that follows murine CMV infection of the developing brain and that a subset of peripheral blood myeloid mononuclear cells represent a key effector cell population in this model of virus-induced inflammatory disease of the developing brain

The angular-momentum flux in the solar wind observed during Solar Orbiter's first orbit

Aims: We present the first measurements of the angular-momentum flux in the solar wind recorded by the Solar Orbiter spacecraft. Our aim is to validate these measurements to support future studies of the Sun’s angular-momentum loss. Methods: We combined 60-min averages of the proton bulk moments and the magnetic field measured by the Solar Wind Analyser (SWA) and the magnetometer (MAG) onboard Solar Orbiter. We calculated the angular-momentum flux per solid-angle element using data from the first orbit of the mission’s cruise phase in 2020. We separated the contributions from protons and from magnetic stresses to the total angular-momentum flux. Results: The angular-momentum flux varies significantly over time. The particle contribution typically dominates over the magneticfield contribution during our measurement interval. The total angular-momentum flux shows the largest variation and is typically anticorrelated with the radial solar-wind speed. We identify a compression region, potentially associated with a co-rotating interaction region or a coronal mass ejection, which leads to a significant localised increase in the angular-momentum flux, albeit without a significant increase in the angular momentum per unit mass. We repeated our analysis using the density estimate from the Radio and Plasma Waves (RPW) instrument. Using this independent method, we find a decrease in the peaks of positive angular-momentum flux, but otherwise, our results remain consistent. Conclusions: Our results largely agree with previous measurements of the solar wind’s angular-momentum flux in terms of amplitude, variability, and dependence on radial solar-wind bulk speed. Our analysis highlights the potential for more detailed future studies of the solar wind’s angular momentum and its other large-scale properties with data from Solar Orbiter. We emphasise the need for studying the radial evolution and latitudinal dependence of the angular-momentum flux in combination with data from Parker Solar Probe and other assets at heliocentric distances of 1 au and beyond

Garden and landscape-scale correlates of moths of differing conservation status: significant effects of urbanization and habitat diversity

Moths are abundant and ubiquitous in vegetated terrestrial environments and are pollinators, important herbivores of wild plants, and food for birds, bats and rodents. In recent years, many once abundant and widespread species have shown sharp declines that have been cited by some as indicative of a widespread insect biodiversity crisis. Likely causes of these declines include agricultural intensification, light pollution, climate change, and urbanization; however, the real underlying cause(s) is still open to conjecture. We used data collected from the citizen science Garden Moth Scheme (GMS) to explore the spatial association between the abundance of 195 widespread British species of moth, and garden habitat and landscape features, to see if spatial habitat and landscape associations varied for species of differing conservation status. We found that associations with habitat and landscape composition were species-specific, but that there were consistent trends in species richness and total moth abundance. Gardens with more diverse and extensive microhabitats were associated with higher species richness and moth abundance; gardens near to the coast were associated with higher richness and moth abundance; and gardens in more urbanized locations were associated with lower species richness and moth abundance. The same trends were also found for species classified as increasing, declining and vulnerable under IUCN (World Conservation Union) criteria

Severe stress switches CRF action in the nucleus accumbens from appetitive to aversive.

Stressors motivate an array of adaptive responses ranging from \u27fight or flight\u27 to an internal urgency signal facilitating long-term goals. However, traumatic or chronic uncontrollable stress promotes the onset of major depressive disorder, in which acute stressors lose their motivational properties and are perceived as insurmountable impediments. Consequently, stress-induced depression is a debilitating human condition characterized by an affective shift from engagement of the environment to withdrawal. An emerging neurobiological substrate of depression and associated pathology is the nucleus accumbens, a region with the capacity to mediate a diverse range of stress responses by interfacing limbic, cognitive and motor circuitry. Here we report that corticotropin-releasing factor (CRF), a neuropeptide released in response to acute stressors and other arousing environmental stimuli, acts in the nucleus accumbens of naive mice to increase dopamine release through coactivation of the receptors CRFR1 and CRFR2. Remarkably, severe-stress exposure completely abolished this effect without recovery for at least 90 days. This loss of CRF\u27s capacity to regulate dopamine release in the nucleus accumbens is accompanied by a switch in the reaction to CRF from appetitive to aversive, indicating a diametric change in the emotional response to acute stressors. Thus, the current findings offer a biological substrate for the switch in affect which is central to stress-induced depressive disorders

Multiple Local and Recent Founder Effects of TGM1 in Spanish Families

<div><h3>Background</h3><p>Mutations in the <em>TGM1</em> gene encoding transglutaminase 1 are a major cause of autosomal recessive congenital ichthyosis. In the Galician (NW Spain) population, three mutations, c.2278C>T, c.1223_1227delACAC and c.984+1G>A, were observed at high frequency, representing ∼46%, ∼21% and ∼13% of all <em>TGM1</em> gene mutations, respectively. Moreover, these mutations were reported only once outside of Galicia, pointing to the existence of historical episodes of local severe genetic drift in this region.</p> <h3>Methodology/Principal Findings</h3><p>In order to determine whether these mutations were inherited from a common ancestor in the Galician population, and to estimate the number of generations since their initial appearance, we carried out a haplotype-based analysis by way of genotyping 21 SNPs within and flanking the <em>TGM1</em> gene and 10 flanking polymorphic microsatellite markers spanning a region of 12 Mb. Two linkage disequilibrium based methods were used to estimate the time to the most recent common ancestor (TMRCA), while a Bayesian-based procedure was used to estimate the age of the two mutations. Haplotype reconstruction from unphased genotypes of all members of the affected pedigrees indicated that all carriers for each of the two mutations harbored the same haplotypes, indicating common ancestry.</p> <h3>Conclusions/Significance</h3><p>In good agreement with the documentation record and the census, both mutations arose between 2,800–2,900 years ago (y.a.), but their TMRCA was in the range 600–1,290 y.a., pointing to the existence of historical bottlenecks in the region followed by population growth. This demographic scenario finds further support on a Bayesian Coalescent Analysis based on <em>TGM1</em> haplotypes that allowed estimating the occurrence of a dramatic reduction of effective population size around 900–4,500 y.a. (95% highest posterior density) followed by exponential growth.</p> </div

The contribution of alpha particles to the solar wind angular momentum flux in the inner heliosphere

This is the final version. Available from EDP Sciences via the DOI in this recordContext. An accurate assessment of the Sun’s angular momentum (AM) loss rate is an independent constraint for models that describe the rotation evolution of Sun-like stars. Aims. In-situ measurements of the solar wind taken by Parker Solar Probe (PSP), at radial distances of ∼ 28−55R , are used to constrain the solar wind AM-loss rate. For the first time with PSP, this includes a measurement of the alpha particle contribution. Methods. The mechanical AM flux in the solar wind protons (core and beam), and alpha particles, is determined as well as the transport of AM through stresses in the interplanetary magnetic field. The solar wind AM flux is averaged over three hour increments, so that our findings more accurately represent the bulk flow. Results. During the third and fourth perihelion passes of PSP, the alpha particles contain around a fifth of the mechanical AM flux in the solar wind (the rest is carried by the protons). The proton beam is found to contain ∼ 10−50% of the proton AM flux. The sign of the alpha particle AM flux is observed to correlate with the proton core. The slow wind has a positive AM flux (removing AM from the Sun as expected), and the fast wind has a negative AM flux. As with previous works, the differential velocity between the alpha particles and the proton core tends to be aligned with the interplanetary magnetic field. Conclusions. In future, by utilising the trends in the alpha-proton differential velocity, it may be possible to estimate the alpha particle contribution when only measurements of the proton core are available. Based on the observations from this work, the alpha particles contribute an additional 10 − 20% to estimates of the solar wind AM-loss rate which consider only the proton and magnetic field contributions. Additionally, the AM flux of the proton beam can be just as significant as the alpha particles, and so should not be neglected in future studies.European Union Horizon 202