Continuous use of fitness apps and shaping factors among college students: a mixed-method investigation

Objective: This current study pursued an exploration of the psychological mechanism that determines college students’ continuance intention to use fitness apps. Methods: This current study adopted a mixed methods research that composed two distinct phases. Study 1 was quantitative research that helped to identify determinants of Chinese college students’ continuance intention to use. A self-reported questionnaire was completed by 379 college students to ascertain their user experience. Study 2 was qualitative research. A semi-structured interview was conducted with a sample of 10 college students. Study 2 can be seen as a follow-up study and it pursued an in-depth understanding on how college students use fitness apps in the everyday life and their views towards study 1’s major findings. Results: The results revealed that five factors (confirmed usefulness, confirmed ease of use, satisfaction, fitness achievement and social connection) were found to significantly and positively affect college students’ continuous intention to use fitness apps. Entertainment did not show obvious impact. In the interview, college students reported that even if they don't obtain entertainment from fitness apps, they will still push themselves to use them, because they have a very specific goal when using fitness apps, which is to achieve health and fitness. Conclusion: These findings indicated that successful fitness apps should make users feel convenient to use and indeed improves the fitness user's efficiency. Besides, people are more eager to get the information with strong credibility with the negligible effort. This implies more efforts should be made to design apps that can provide high-quality services. Moreover, if apps designers can pay more attention to protecting the personal information and data, it will inspire more people to use social connection functions

Cyclic Vomiting Syndrome in 41 adults: the illness, the patients, and problems of management

BACKGROUND: Cyclic Vomiting Syndrome (CVS) is a disorder characterized by recurrent, stereotypic episodes of incapacitating nausea, vomiting and other symptoms, separated by intervals of comparative wellness. This report describes the clinical features, co-morbidities and problems encountered in management of 41 adult patients who met the diagnostic criteria for CVS. METHODS: This is a retrospective study of adults with CVS seen between 1994 and 2003. Follow-up data were obtained by mailed questionnaires. RESULTS: Age of onset ranged from 2 to 49 years. The duration of CVS at the time of consultation ranged from less than 1 year to 49 years. CVS episodes were stereotypic in respect of their hours of onset, symptomatology and length. Ninety-three percent of patients had recognizable prodromes. Half of the patients experienced a constellation of symptoms consisting of CVS episodes, migraine diathesis, inter-episodic dyspeptic nausea and a history of panic attacks. Deterioration in the course of CVS is indicated by coalescence of episodes in time. The prognosis of CVS is favorable in the majority of patients. CONCLUSION: CVS is a disabling disorder affecting adults as well as children. Because its occurrence in adults is little known, patients experience delayed or mis-diagnosis and ineffectual, sometimes inappropriately invasive management

Mutations in CTNNA1 cause butterfly-shaped pigment dystrophy and perturbed retinal pigment epithelium integrity

Butterfly-shaped pigment dystrophy is an eye disease characterized by lesions in the macula that can resemble the wings of a butterfly. Here we report the identification of heterozygous missense mutations in the CTNNA1 gene (encoding alpha-catenin 1) in three families with butterfly-shaped pigment dystrophy. In addition, we identified a Ctnna1 missense mutation in a chemically induced mouse mutant, tvrm5. Parallel clinical phenotypes were observed in the retinal pigment epithelium (RPE) of individuals with butterfly-shaped pigment dystrophy and in tvrm5 mice, including pigmentary abnormalities, focal thickening and elevated lesions, and decreased light-activated responses. Morphological studies in tvrm5 mice demonstrated increased cell shedding and the presence of large multinucleated RPE cells, suggesting defects in intercellular adhesion and cytokinesis. This study identifies CTNNA1 gene variants as a cause of macular dystrophy, indicates that CTNNA1 is involved in maintaining RPE integrity and suggests that other components that participate in intercellular adhesion may be implicated in macular disease