MRSA eradication of newly acquired lower respiratory tract infection in cystic fibrosis

UK cystic fibrosis (CF) guidelines recommend eradication of methicillin-resistant Staphylococcus aureus (MRSA) when cultured from respiratory samples. As there is no clear consensus as to which eradication regimen is most effective, we determined the efficacy of eradication regimens used in our CF centre and long-term clinical outcome. All new MRSA positive sputum cultures (n=37) that occurred between 2000 and 2014 were reviewed. Eradication regimen characteristics and clinical, microbiological and long-term outcome data were collected. Rifampicin plus fusidic acid was the most frequently used regimen (24 (65%) out of 37 patients), with an overall success rate of 79% (19 out of 24 patients). Eradication failure was more likely in patients with an additional MRSA-positive peripheral screening swab (p=0.03) and was associated with worse survival (p=0.04). Our results demonstrate the feasibility and clinical benefits of MRSA eradication. As peripheral colonisation was associated with lower eradication success, strategies combining systemic and topical treatments should be considered to optimise outcomes in CF patients

Taking Back the Work: A Cooperative Inquiry into Leaders of Color in Movement-Building Organizations

Through the Leadership for a Changing World Research and Documentation program, a group of leaders of color committed to social justice came together to reflect on the specific obstacles leaders of color face as they engage in movement building and to find ways to overcome these barriers. Together they asked: How do we build, strengthen and sustain movement-building organizations led by people of color? In the report, the group has identified four strategies to help community-based leaders of color engage in "taking back the work," with examples of each based on their successful work in communities

Letter to Andrew Inglis Clark, Tasmania from John B. Moore, New York, 16 Mar 1907

Hopes Clark has recovered from his late illness. Sees Clark's son Conway quite often. Mr Strauss left New York for Washington when he was appointed to the Cabinet so haven't been able to take Conway to meet him. Strauss and his three brothers are all strong Democrats, although Oscar is now a Republican due to his relations with Mr Roosevelt. Talks about the process of electing judges in America and how it impairs the independence of the bench. C4/C237.....Letter transcribed by Jeffrey Gilbert, University of Tasmania

Pain relief for women with cervical intraepithelial neoplasia undergoing colposcopy treatment

Treatment for CIN is usually undertaken in an outpatient colposcopy clinic to remove the pre-cancerous cells from the cervix. It commonly involves lifting the cells off the cervix with electrically heated wire (diathermy) or laser, or destroying the abnormal cells with freezing methods (cryotherapy). This is potentially a painful procedure. The purpose of this review is to determine which, if any, pain relief should be used during cervical colposcopy treatment. We identified 17 trials and these reported different forms of pain relief before, during and after colposcopy. Evidence from two small trials showed that women having a colposcopy treatment had less pain and blood loss if the cervix was injected with a combination of a local anaesthetic drug and a drug that causes blood vessels to constrict (narrow), compared with placebo. Although taking oral pain-relieving drugs (e.g. ibuprofen) before treatment on the cervix in the colposcopy clinic is recommended by most guidelines, evidence from two small trials did not show that this practice reduced pain during the procedure. Most of the evidence in this field is of a low to moderate quality and further research may change these findings. Additionally, we were unable to obtain evidence with regards to dosage of the local anaesthetic drug or method of administering local anaesthetic into the cervix. There is need for high-quality trials with sufficient numbers of participants in order to provide the data necessary to estimate these effects

1,2-Bis(1,3-dithiol-2-yl­idene)hydrazine

The title mol­ecule, C6H4N2S4, has a crystallographically imposed centre of symmetry located at the mid-point of the N—N single bond. The mol­ecule is essentially planar: the two five-membered rings form a dihedral angle of 0.17 (6)°. The crystal packing exhibits short inter­molecular S⋯S contacts of 3.549 (2) Å

Patterns of Change in Prayer Activity, Expectancies, and Contents During Older Adulthood

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/96747/1/jssr12014.pd

Sphalerons and the Electroweak Phase Transition in Models with Higher Scalar Representations

In this work we investigate the sphaleron solution in a $SU(2)\times U(1)_X$ gauge theory, which also encompasses the Standard Model, with higher scalar representation(s) ($J^{(i)},X^{(i)}$). We show that the field profiles describing the sphaleron in higher scalar multiplet, have similar trends like the doublet case with respect to the radial distance. We compute the sphaleron energy and find that it scales linearly with the vacuum expectation value of the scalar field and its slope depends on the representation. We also investigate the effect of $U(1)$ gauge field and find that it is small for the physical value of the mixing angle, $\theta_{W}$ and resembles the case for the doublet. For higher representations, we show that the criterion for strong first order phase transition, $v_{c}/T_{c}>\eta$, is relaxed with respect to the doublet case, i.e. $\eta<1$.Comment: 20 pages, 5 figures & 1 table, published versio

A 1000-yr-old tsunami in the Indian Ocean points to greater risk for East Africa

© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Maselli, V., Oppo, D., Moore, A. L., Gusman, A. R., Mtelela, C., Iacopini, D., Taviani, M., Mjema, E., Mulaya, E., Che, M., Tomioka, A. L., Mshiu, E., & Ortiz, J. D. A 1000-yr-old tsunami in the Indian Ocean points to greater risk for East Africa. Geology, 48(8), (2020): 808-813, doi:10.1130/G47257.1.The December 2004 Sumatra-Andaman tsunami prompted an unprecedented research effort to find ancient precursors and quantify the recurrence time of such a deadly natural disaster. This effort, however, has focused primarily along the northern and eastern Indian Ocean coastlines, in proximal areas hardest hit by the tsunami. No studies have been made to quantify the recurrence of tsunamis along the coastlines of the western Indian Ocean, leading to an underestimation of the tsunami risk in East Africa. Here, we document a 1000-yr-old sand layer hosting archaeological remains of an ancient coastal Swahili settlement in Tanzania. The sedimentary facies, grain-size distribution, and faunal assemblages indicate a tsunami wave as the most likely cause for the deposition of this sand layer. The tsunami in Tanzania is coeval with analogous deposits discovered at eastern Indian Ocean coastal sites. Numerical simulations of tsunami wave propagation indicate a megathrust earthquake generated by a large rupture of the Sumatra-Andaman subduction zone as the likely tsunami source. Our findings provide evidence that teletsunamis represent a serious threat to coastal societies along the western Indian Ocean, with implications for future tsunami hazard and risk assessments in East Africa.This work was funded by the National Geographic Society (grant N. CP-R008–17). Maselli acknowledges support from the Canada First Research Excellence Fund through the Ocean Frontier Institute. We are extremely grateful to the editor, two anonymous reviewers, J. Bourgeois, G. Eberli, A. Prendergast, and C. Gouramanis for all the suggestions provided, which greatly improved the quality of the manuscript. We would like to thank the United Republic of Tanzania and the University of Dar es Salaam for allowing us to perform the field work activity. This is ISMAR Bologna scientific contribution number 2024

A 1000-yr-old tsunami in the Indian Ocean points to greater risk for East Africa: reply

© The Author(s), 2021. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Maselli, V., Oppo, D., Moore, A. L., Gusman, A. R., Mtelela, C., Iacopini, D., Taviani, M., Mjema, E., Mulaya, E., Che, M., Tomioka, A. L., Mshiu, E., & Ortiz, J. D. A 1000-yr-old tsunami in the Indian Ocean points to greater risk for East Africa: reply. Geology, 49(1), (2021): E516-E516, https://doi.org/10.1130/G48585Y.1.We appreciate Somerville’s (2020) interest in our work, and the opportunity to further expand the discussion about the occurrence of a trans-oceanic tsunami in the Indian Ocean generated by a megathrust earthquake ~1000 years ago. Somerville suggests a connection between the inferred tsunami deposit presented by us (Maselli et al., 2020) and a tsunami event reported to have occurred in Nagapattinam (India) in the year 900 CE and described in Kalaki Krishnamurty’s book (Rastogi and Jaiswal, 2006)