51 research outputs found
Rationale and design of a multicenter randomized controlled trial on a 'minimal intervention' in Dutch army personnel with nonspecific low back pain [ISRCTN19334317]
- Author
- AF Mannion
- AJ Beurskens
- AJ Beurskens
- BW Nelson
- C Manniche
- DM Carpenter
- DP Goldberg
- FR Hansen
- G Bronfort
- GC Wendel-Vos
- I Cohen
- IH Gommans
- J. E. Jr. Ware
- JH Brussaard
- JH Brussaard
- JT Tucci
- JW Vlaeyen
- L Goubert
- M Cardol
- M Kankaanpaa
- M Koeter
- M Roland
- M van Tulder
- O Miltner
- PH Helmhout
- PW Stratford
- R Karasek
- RP Miller
- RW Ostelo
- S Leggett
- S Mior
- SV Risch
- V Mooney
- V Mooney
- VH Hildebrandt
- Publication venue
- BioMed Central
- Publication date
- 01/01/2004
- Field of study
BACKGROUND: Researchers from the Royal Netherlands Army are studying the potential of isolated lumbar extensor training in low back pain in their working population. Currently, a randomized controlled trial is carried out in five military health centers in The Netherlands and Germany, in which a 10-week program of not more than 2 training sessions (10–15 minutes) per week is studied in soldiers with nonspecific low back pain for more than 4 weeks. The purpose of the study is to investigate the efficacy of this 'minimal intervention program', compared to usual care. Moreover, attempts are made to identify subgroups of different responders to the intervention. METHODS: Besides a baseline measurement, follow-up data are gathered at two short-term intervals (5 and 10 weeks after randomization) and two long-term intervals (6 months and one year after the end of the intervention), respectively. At every test moment, participants fill out a compound questionnaire on a stand-alone PC, and they undergo an isometric back strength measurement on a lower back machine. Primary outcome measures in this study are: self-assessed degree of complaints and degree of handicap in daily activities due to back pain. In addition, our secondary measurements focus on: fear of movement/(re-) injury, mental and social health perception, individual back extension strength, and satisfaction of the patient with the treatment perceived. Finally, we assess a number of potential prognostic factors: demographic and job characteristics, overall health, the degree of physical activity, and the attitudes and beliefs of the physiotherapist towards chronic low back pain. DISCUSSION: Although a substantial number of trials have been conducted that included lumbar extension training in low back pain patients, hardly any study has emphasized a minimal intervention approach comparable to ours. For reasons of time efficiency and patient preferences, this minimal sports medicine approach of low back pain management is interesting for the population under study, and possibly for comparable working populations with physical demanding job activities
Lysine harvesting is an antioxidant strategy and triggers underground polyamine metabolism
- Author
- A Feller
- A Krüger
- A Kuehne
- A Stincone
- AF Tucci
- AK Tyagi
- B Andi
- B Szappanos
- C Godon
- C Ludwig
- C Taxis
- CB Brachmann
- Clara Correia-Melo
- CS Ough
- D Shenton
- D Toroser
- David Alejandro Peña Navarro
- F Bianchi
- H Mi
- I Nogae
- J Peter
- J Zhang
- Jakob Vowinckel
- Jason Shu Lim Yu
- JO Park
- Joanna Segal
- K Campbell
- K Campbell
- K Igarashi
- K Sasidharan
- KA Morano
- KH Slekar
- L Heirendt
- Leonor Miller-Fleming
- Lucia Herrera-Dominguez
- M Albertsen
- M Kahm
- M Mülleder
- M Mülleder
- M Ralser
- M Ralser
- M Reyes-Becerril
- Markus Ralser
- Michael Mülleder
- ML Mo
- Mohammad Tauqeer Alam
- N-M Grüning
- Oscar Méndez-Lucio
- PA Whitney
- PC Tomar
- Robert Haas
- S Mima
- Stephan Kamrad
- T Uemura
- TE Dever
- Viridiana Olin-Sandoval
- VT Dufe
- Y Yamamoto
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 08/08/2019
- Field of study
Both single and multicellular organisms depend on anti-stress mechanisms that enable them to deal with sudden changes in the environment, including exposure to heat and oxidants. Central to the stress response are dynamic changes in metabolism, such as the transition from the glycolysis to the pentose phosphate pathway—a conserved first-line response to oxidative insults1,2. Here we report a second metabolic adaptation that protects microbial cells in stress situations. The role of the yeast polyamine transporter Tpo1p3,4,5 in maintaining oxidant resistance is unknown6. However, a proteomic time-course experiment suggests a link to lysine metabolism. We reveal a connection between polyamine and lysine metabolism during stress situations, in the form of a promiscuous enzymatic reaction in which the first enzyme of the polyamine pathway, Spe1p, decarboxylates lysine and forms an alternative polyamine, cadaverine. The reaction proceeds in the presence of extracellular lysine, which is taken up by cells to reach concentrations up to one hundred times higher than those required for growth. Such extensive harvest is not observed for the other amino acids, is dependent on the polyamine pathway and triggers a reprogramming of redox metabolism. As a result, NADPH—which would otherwise be required for lysine biosynthesis—is channelled into glutathione metabolism, leading to a large increase in glutathione concentrations, lower levels of reactive oxygen species and increased oxidant tolerance. Our results show that nutrient uptake occurs not only to enable cell growth, but when the nutrient availability is favourable it also enables cells to reconfigure their metabolism to preventatively mount stress protection
p73: A Multifunctional Protein in Neurobiology
- Author
- A Bagchi
- A Caricasole
- A Ferreira
- A Mudher
- A Yang
- A Yang
- AF Lee
- Alessandro Rufini
- AR Alvarez
- AV Molofsky
- B Strooper De
- BA Yankner
- Berna S. Sayan
- C Culmsee
- C Hooper
- C Hooper
- C Wilson
- CB Dugani
- CD Pozniak
- CD Pozniak
- CH Reynolds
- D Harold
- Daniele Bano
- DP Hanger
- Ewen Gallagher
- F Checler
- F Mantovani
- F Murray-Zmijewski
- F Talos
- F Tissir
- FH Gage
- FM LaFerla
- Francesca Grespi
- Franco Conforti
- G Melino
- Gerry Melino
- GS Walsh
- H Okazawa
- J Hardy
- J Wang
- J Wang
- JC Lambert
- JR Burke
- K Meletis
- KH Vousden
- L González-Cano
- M Agostini
- M Fujitani
- M Kaghad
- M Muller
- M Shoji
- Maria Niklison-Chirou
- Massimiliano Agostini
- MC Vazquez
- MK Wetzel
- MT Corasaniti
- MT Wilhelm
- N Billon
- N Sahara
- Paola Tucci
- Pierluigi Nicotera
- PM Campeau
- R Tomasini
- Richard A Knight
- Richard Killick
- Richard Tomasini
- S Ramadan
- SP Braithwaite
- Tak W. Mak
- Tania Velletri
- TJ Grob
- V Dötsch
- V Laurenzi De
- V Laurenzi De
- VD Laurenzi De
- Y Kitamura
- YC Liou
- Publication venue
- Humana Press Inc
- Publication date
- 01/01/2011
- Field of study
p73, a transcription factor of the p53 family, plays a key role in many biological processes including neuronal development. Indeed, mice deficient for both TAp73 and ΔNp73 isoforms display neuronal pathologies, including hydrocephalus and hippocampal dysgenesis, with defects in the CA1-CA3 pyramidal cell layers and the dentate gyrus. TAp73 expression increases in parallel with neuronal differentiation and its ectopic expression induces neurite outgrowth and expression of neuronal markers in neuroblastoma cell lines and neural stem cells, suggesting that it has a pro-differentiation role. In contrast, ΔNp73 shows a survival function in mature cortical neurons as selective ΔNp73 null mice have reduced cortical thickness. Recent evidence has also suggested that p73 isoforms are deregulated in neurodegenerative pathologies such as Alzheimer’s disease, with abnormal tau phosphorylation. Thus, in addition to its increasingly accepted contribution to tumorigenesis, the p73 subfamily also plays a role in neuronal development and neurodegeneration
Clinimetric evaluation of active range of motion measures in patients with non-specific neck pain: a systematic review
- Author
- A Bruton
- A Peollson
- AB Solinger
- AF Mannion
- AL Morphett
- Bouwien C. M. Smits-Engelsman
- C Eechaute
- C Veenhof
- C Vos
- CA Lantz
- CA Lantz
- CB Terwee
- Chantal H. P. de Koning
- CL Koerhuis
- CM Petersen
- CY Hsieh
- D Capuano-Pucci
- DE Hole
- E Trijffel van
- E Viikari-Juntura
- EM Malmstrom
- Erik J. M. Hendriks
- F Antonaci
- FR Genderen Van
- GJ Bergman
- GL Pellechia
- H Alantara
- HC Vet de
- HW Christensen
- HW Christensen
- J Dvorak
- J Dvorak
- J. Bart Staal
- JA Balogun
- JA Cleland
- JAK Moffett
- JL Hoving
- JR Landis
- JV Viitanen
- JW Youdas
- JW Youdas
- K Jordan
- K Jordan
- K Jordan
- KN Lohr
- KW Bush
- M Alund
- M Amiri
- M Haas
- M Hoppenbrouwers
- M Tousignant
- M Tousignant
- M Tousignant
- M Tousignant
- MA Seffinger
- MJ Haynes
- MJ Stochkendahl
- MV Bulgheroni
- N Assink
- N Bogduk
- N Kadir
- N Strimpakos
- NR Ordway
- PH Trott
- R Fejer
- R Fitzpatrick
- RA Swinkels
- RK Pringle
- RS Wainner
- S Agarwal
- S Agarwal
- S Love
- SD Bot
- SD Bot
- SF Wang
- SK Wu
- SL Olson
- SL O’Driscoll
- SM Tucci
- SR Piva
- Sylvia P. van den Heuvel
- TR Jenkinson
- TT Chiu
- VA Wolfenberger
- VF Ferrario
- W Frobin
- W Rheault
- WP C Maksymowich Mallon
- Z Dvir
- Z Dvir
- ZJ Zachman
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2008
- Field of study
The study is to provide a critical analysis of the research literature on clinimetric properties of instruments that can be used in daily practice to measure active cervical range of motion (ACROM) in patients with non-specific neck pain. A computerized literature search was performed in Medline, Cinahl and Embase from 1982 to January 2007. Two reviewers independently assessed the clinimetric properties of identified instruments using a criteria list. The search identified a total of 33 studies, investigating three different types of measurement instruments to determine ACROM. These instruments were: (1) different types of goniometers/inclinometers, (2) visual estimation, and (3) tape measurements. Intra- and inter-observer reliability was demonstrated for the cervical range of motion instrument (CROM), Cybex electronic digital instrument (EDI-320) and a single inclinometer. The presence of agreement was assessed for the EDI-320 and a single inclinometer. The CROM received a positive rating for construct validity. When clinical acceptability is taken into account both the CROM and the single inclinometer can be considered appropriate instruments for measuring the active range of motion in patients with non-specific neck pain in daily practice. Reliability is the aspect most frequently evaluated. Agreement, validity and responsiveness are documented less frequently
EFFECT OF PHOSPHATE FERTILIZATION AND BASE SATURATION OF SUBSTRATE ON THE SEEDLINGS GROWTH AND QUALITY OF Plathymenia foliolosa Benth.
- Author
- Alvarez V VH
- Bernardino DCS
- Brondani GE
- Caione G
- Carneiro JGA
- Ceconi DE
- Costa GS
- Cruz CAF
- Cruz CAF
- Dechen AR
- Eliane Cristina Sampaio de Freitas
- Fernandes LA
- Fonseca EP
- Gomes JM
- Gonçalves EO
- Gonçalves EO
- Gonçalves JLM
- Haroldo Nogueira de Paiva
- Helio Garcia Leite
- Lorenzi H
- Malavolta E
- Novais RF
- Passos MAA
- Schumacher MV
- Silva AF
- Soares I
- Sílvio Nolasco de Oliveira Neto
- Tucci CAF
- Vale FR
- Valeri SV
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Medium-chain acyl-CoA dehydrogenase deficiency associated with a novel splice mutation in the ACADM gene missed by newborn screening
- Author
- A. Wehrle
- AF Dessein
- AK Iafolla
- B Blois
- B Wilcken
- B Wilcken
- B Wilcken
- B. Vetter
- BS Andresen
- DC Lehotay
- DS Millington
- E. Lausch
- EH Smith
- EH Touma
- EM Maier
- EM Maier
- F Gemignani
- GL Arnold
- GW Wilhelm
- I Yokota
- J Zschocke
- K Raymond
- K. O. Schwab
- L Waddell
- M Sturm
- P Bross
- P. Villavicencio-Lorini
- RJ Pollitt
- S. Tucci
- Sarah C. Grünert
- SD Grosse
- U Nennstiel-Ratzel
- U. Spiekerkoetter
- Y Wu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Comportamento da diarréia infantil antes e após consumo de água pluvial em município do semi-árido Brasileiro
- Author
- Amaral LA
- Benyus JM
- Bittencourt SA
- Blackburn DM
- Bloch D
- Borges CVD
- Cezar-Vaz MR
- Emanuella Silva Joventino
- Escolástica Rejane Ferreira Moura
- Fernandes FBP
- Freitas CM
- Garcia JGD
- Gazin P
- Giselle Lima de Freitas
- Heller L
- Hurtado-Guerrero AF
- Lorena Barbosa Ximenes
- Mandú ENT
- Matos MIS
- Mello DA
- Ministério da Saúde (BR)
- Ministério da Saúde (BR)
- Moreira JC
- Raul Feitoza Rogerio
- Ribeiro EM
- Rocha CMBM
- Sabrina Ferreira da Silva
- Shimizu Helena Eri
- Smeltzer SC
- Teixeira JC
- Tucci CEM
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
- Abdo WF
- Abellan AN
- Abellán AN
- Abellán AN
- Abellán AN
- Abrams ST
- Ackerley C
- Acuña M
- Adda M
- Adhikari NK
- Adriano G
- Adrie C
- Affatato R
- Affatato R
- Afonso-Rivero D
- Agarossi A
- Agarwal LK
- Ageeva T
- Agrawal R
- Aguayo-DeHoyos E
- Aguilar AL
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguirregabyria M
- Ahmadnia E
- Ahn C
- Ahn JY
- Ahn JY
- Ahn MY
- Ahn MY
- Aitken LM
- Akalaev R
- Akbarzadeh A
- Akcan-Arikan A
- Akhlagh SH
- Akhtar N
- AKI Research Group
- Akiduki N
- Akin S
- Akizuki N
- Akkoc T
- Ala-Kokko T
- Alanio A
- Albaiceta GM
- Albaladejo P
- Alberto F
- Albuisson E
- Alcala MA
- Alcázar L
- Aldabo-Pallas T
- Aldana NN
- Aldecoa C
- Alegría L
- Alejandro R
- Alejo GC
- Alejos RM
- Alexandrova E
- Algarte R
- Algarte R
- Algieri I
- Algora-Weber A
- Alhamdi Y
- Aliaga FA
- Aliberti S
- Alkan A
- Almudena PM
- Almudevar PM
- Almudevar PM
- Almudévar PM
- Altıntas ND
- Alvarez J
- Alves SC
- Alzola LM
- Amargianitakis V
- Amaro R
- Amato MB
- Ambler M
- Amerongen MP
- Amininejad T
- Amor LL
- Amorim V
- Anand RK
- Andersen LW
- Andersson S
- Andoh K
- Andrade AH
- Andrade AH
- Andrade AH
- Andrade G
- Andreis DT
- Andreis DT
- Annane D
- Antonelli M
- Antoniadou A
- Antonio C
- Antonucci E
- Antón DG
- Anzueto A
- Appiani F
- Aquevedo A
- Aragon C
- Araujo NJ
- Araujo VF
- ARIAM registry of adult cardiac surgery
- ARIAM-ANDALUCIA
- Arias CC
- Arias N
- Arias-Verdu MD
- Arias-Verdu MD
- Arias-Verdu MD
- Armaganidis A
- Arora MK
- Arora N
- Arrigo M
- Arslantas MK
- Artiguenave M
- Aslanian P
- Aspide R
- Asyralyyeva G
- Ataman S
- Ataman S
- Atchade E
- Atchade E
- Atchasiri S
- Athapattu P
- Atkins G
- Aublanc M
- Aublanc M
- Augustin P
- Augustin P
- Auquier P
- Avilés-Jurado FX
- Avramidis V
- Ayala LY
- Aydin M
- Azevedo JC
- Azevedo JR
- Aznar GP
- Babalis D
- Babini G
- Bachli EB
- Bader A
- Bader A
- Baena J
- Baidya DK
- Baikova VN
- Bakker J
- Balcázar LC
- Balcázar LC
- Baldassarri R
- Baldwin CE
- Balik M
- Ball I
- Ballin A
- Balsera B
- Banderas-Bravo ME
- Banderas-Bravo ME
- Bandert A
- Bangstad IL
- Baptista N
- Baquero JD
- Barbadillo S
- Barberet G
- Barberet G
- Barberet G
- Barbier J
- Barcenilla F
- Barea-Mendoza JA
- Barinas OD
- Baron AV
- Barrachina LG
- Barral M
- Basile-Filho A
- Bassi GL
- Bates D
- Battistini M
- Bauer M
- Bauer PR
- Baumstarck K
- Baumstarck K
- Bawin M
- Bazan N
- Bañeras J
- Beane A
- Beduneau G
- Beduneau G
- Beduneau G
- Beeharry SD
- Beerepoot M
- Begzjav T
- Beishuizen A
- Bell C
- Belletti A
- Bellissimo-Rodrigues F
- Belloli A
- Bellomo R
- Bellver BQ
- Belmonte R
- Ben-Hamouda N
- Bendel S
- Bendel S
- Benyamina M
- Beretta S
- Berg R
- Bergantino B
- Berghmans J
- Bernal FF
- Berric A
- Berrutti D
- Berthelsen RE
- Bertini P
- Bertini P
- Berto MB
- Besevli SG
- Bestle MH
- Bettex D
- Bettex DA
- Beunders R
- Bhasin D
- Bhattal MK
- Bhide S
- Bianchi I
- Bianchi I
- Bianzina S
- Bianzina S
- Bianzina S
- Bishop J
- Bissenova N
- Bisso MC
- Blans MJ
- Blobner M
- Bloomer MJ
- Blot K
- Blot S
- Blot S
- Boa F
- Bobi Q
- Bodingbauer M
- Bodí M
- Boer C
- Bogossian E
- Bonet S
- Bonn M
- Bonnet M
- Borges FK
- Bouadma L
- Boucekine M
- Bougouin W
- Bourenne J
- Boyd JG
- Boyd JG
- Bozbay S
- Bozza F
- Bradac O
- Brandon RA
- Brandon RB
- Braschi A
- Braschi A
- Braschi A
- Brasseur A
- Brasseur A
- Brasseur A
- Braune S
- Brazzi L
- Breitkreutz R
- Brianti R
- Brioni M
- Brochard L
- Brochard L
- Brochard L
- Brock N
- Brody DL
- Brook R
- Brousseau C
- Brown K
- Brugger SC
- Brugger SC
- Bruno F
- Bruno K
- Brusasco C
- Brusasco C
- Brusasco C
- Bruyere O
- Bucknall T
- Buddi S
- Buise M
- Buitinck SH
- Buranavanich P
- Bureau C
- Burle JF
- Burtin P
- Busico M
- Butler MB
- Butrov AV
- Caballero CH
- Caballero J
- Cabello JT
- Cabello JT
- Cabrera AR
- Cabrera JL
- Cabrera JL
- Cabrini L
- Cairus C
- Cakin O
- Caliskan K
- Calpe P
- Calvo CP
- Calvo SA
- Camargo M
- Cambronero JA
- Cameron C
- Campbell R
- Campelo FA
- Campelo FA
- Campos LM
- Cannesson M
- CAPCRI Study
- Capellier G
- Carbonara M
- Cardellino S
- Cardenas CL
- Cariou A
- Cariou A
- Carlesso E
- Carmona AF
- Carmona SA
- Carmona SA
- Carmona SA
- Carmona SA
- Carone M
- Carpio D
- Carratalá A
- Carreira MM
- Carrero-Gómez F
- Carreño ER
- Carreño R
- Carvalho JP
- Carvalho KV
- Casals XN
- Casals XN
- Cassina T
- Castañeda DP
- Castellana D
- Castellanos A
- Castellanos A
- Castillo-Lorente E
- Castillo-Lorente E
- Catalan M
- Catalán RM
- Catena E
- Catena E
- Cauwenberghs H
- Cavalcanti D
- Cavalheiro AM
- Cavalier E
- Cavicchi FZ
- Cavicchi FZ
- Cengiz M
- Ceriani R
- Cermelli S
- Cerović O
- Cha YS
- Chabanne R
- Chacon-Alves S
- Champigneulle B
- Champigneulle B
- Chan KC
- Chan KK
- Chan WS
- Chang CH
- Chang WY
- Chao A
- Chao A
- Chao AS
- Chao HC
- Chaouat M
- Charitidou E
- Charpentier C
- Charpentier J
- Charron C
- Chatelon J
- Chaudhari HK
- Chaussard M
- Chavanon O
- Chaves S
- Chelly J
- Chemam S
- Chen CM
- Chen CM
- Chen CW
- Chen CW
- Chen GQ
- Chen L
- Chen YS
- Chen YS
- Chen YS
- Cheng CC
- Cheng CC
- Cheng CC
- Cheng CC
- Cheng KC
- Cheng YJ
- Chernyshuk S
- Chevret S
- Chhor V
- Chiang CC
- Chiang CH
- Chiang CH
- Chiang CH
- Chiappa C
- Chiou KR
- Chiou KR
- Chiou KR
- Chiu LC
- Chiumello D
- Chiurazzi C
- Chiurazzi C
- Cho Y
- Cho YJ
- Cho YJ
- Choi JY
- Choi JY
- Choi KS
- Choi S
- Choi YJ
- Choi YY
- Chok L
- Cholkraisuwat J
- Cholley B
- Chondropoulos S
- Chou W
- Chouris I
- Chouvarda I
- Christopher KB
- Chrétien JM
- Chrétien JM
- Chrétien JM
- Chumaev A
- Chung CR
- Churchill K
- Chytas A
- Cinel I
- Cinnella G
- Citerio G
- Citerio G
- Clavel M
- Clemente EA
- Clermont G
- Cleyet M
- Cohen Y
- Colaprico A
- Colino L
- Collange O
- Colombo A
- Colombo A
- Colson P
- Combes A
- Concha P
- Connolly B
- Constan A
- Constan A
- Constan A
- Conte V
- Conti G
- Conti G
- Contreras KM
- Contreras MR
- Cook DJ
- Coombs M
- Cordeiro CP
- Cordero M
- Cordolcini V
- Cordovilla-Guardia S
- Cordón J
- Corona A
- Corona A
- Corradi F
- Corradi F
- Corradi F
- Correa-Chamorro E
- Corte FD
- Cortes ML
- Corzo L
- Coss-Bu JA
- Coss-Bu JA
- Costa MI
- Costa RC
- Costa RC
- Costa RC
- Costanzo E
- Cotoia A
- Cottini SR
- Cottle D
- Cotton H
- Cotton H
- Courant P
- Cowan R
- Creagh-Brown B
- Cressoni M
- Creteur J
- Creteur J
- Creteur J
- Creteur J
- Creteur J
- Creteur J
- Creteur J
- Creteur J
- Crimella F
- Cron N
- Cuellar AI
- Cui N
- Cunha MM
- Curiel-Balsera E
- Curiel-Balsera E
- Curinga M
- Curtis A
- Cuthbertson BH
- Cutuli SL
- Câmara M
- D'Arsigny C
- da Silva SL
- da Silva VZ
- Daga-Ruiz D
- Dalhuisen A
- Dalorzo M
- Damas P
- Dambrosio M
- Damås JK
- Das Neves A
- David H
- Davis C
- Davis P
- Day A
- de Abreu MG
- De Backer A
- De Brito-Ashurst I
- De Cassai A
- De Freitas FF
- De Gasperi A
- de Hoyos EA
- De la Calle-Pedrosa N
- de la Fuente MV
- De La Fuente-Martos C
- De La Fuente-Martos C
- De La Rica AS
- De la Torre MA
- De Maglie M
- De Maglie M
- de Molina FJ
- De Morton N
- de Oca Sandoval MA
- De Pascale G
- De Rosa S
- De Sanctis F
- De Silva AP
- De Sousa I
- de Vera AP
- de Wilde W
- De Zani D
- Deblier I
- DeBrunnar R
- Del Arco A
- Del Moral OL
- Del Olmo R
- Del Rosario CG
- Del Sorbo L
- Delgado CP
- Delgado MJ
- Delgado-Amaya M
- Demirkiran O
- Demoule A
- Denehy L
- Der Kinderen EP
- Descotte E
- Deshpande K
- Desmard M
- Desmard M
- Deveugele M
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- Di Giancamillo M
- Di Gravio V
- Di Gregorio A
- Di Mussi R
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- Dimopoulou IK
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- Engelberts D
- ENVIN-HELICS Study Group
- Erb J
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- Escalada SH
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- Escórcio S
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- Espinasse F
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- Fernández IF
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- FINNRESUSCI Study Group
- Fischer G
- Fleischmann E
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- Frontera PR
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- García-Martínez MV
- García-Olivares P
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- GETGAG/SEMICYUC
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- Gonçalves B
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- Gordon M
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- Grangé S
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- Hernández AA
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- Hernández AA
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- Hernández-Tejedor A
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- Hualde JB
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- Huang WC
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- Huber W
- Huddart S
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- Hung CY
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- Hutchings S
- Hutchison R
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- Hwang GS
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- Ibsen M
- Idei M
- Idei M
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- Iglesias-Santiago A
- Ignacio ML
- Iida A
- Iijima H
- Ilan R
- Ilyina V
- Imanaka H
- Inaloo S
- Ince C
- Iotti GA
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- IPREA Study Group
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- Jang BH
- Janotka M
- Janotka M
- Janotka M
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- Jansen N
- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
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- Jardim M
- Jareño A
- Javadpour S
- Jayasinghe S
- Jean-Baptiste S
- Jean-Baptiste S
- Jensen AE
- Jensen JU
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- Jeong WY
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- Jimenez-Herrera MF
- Jiménez GJ
- Jo YH
- Joachim J
- Jochmans S
- John G
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- Jonas M
- Jonas M
- Jones C
- Joshi R
- Joshi V
- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
- Juan WC
- Juanas CA
- Judickas S
- Juez A
- Juliarena A
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- Jun IG
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- Jung KW
- Junior JM
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- Kaminsky GE
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- Kim JM
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- Kolnikova I
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- Kouatchet A
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- Krishna B
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- Ku NS
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- Kulkarni AP
- Kumari BK
- Kumbamu A
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- Kurmukov IA
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- Kwon HM
- Kwon WY
- Kwon WY
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- Labra C
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- Lafuente E
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- Lake K
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- Lapteva K
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- Latini R
- Latini R
- Latini R
- Latorre J
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- Lattuada M
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- Legrand M
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- Lichtenstein D
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- Lischinsky A
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- Lombardo MD
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- Lopez-Gude MJ
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- Loudet CI
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- MacKay A
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- Maekawa K
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- Maghsoudi B
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- Marcos-Zambrano LJ
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- Martín-Loeches I
- Martínez F
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- Martínez L
- Martínez M
- Martínez MP
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- Martínez-Carmona JF
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- Mejías CR
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- Menendez R
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- Mercat A
- Mercat A
- Mergulhão PJ
- Merino-Vega D
- Messenger D
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- Midwinter MJ
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- Miguelena PR
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- Mora-Ordóñez JM
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- Morán I
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- Okayama Research Investigation Organizing Network (ORION)investigators
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- Perez-Borrero L
- Perez-Vela JL
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- Perinel S
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- Pertuz ED
- Pertuz ED
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- Petrova MV
- Petsikas D
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- Pickkers P
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- PICS- HCPA: Programa Intrahospitalar de Combate à Sepse do Hospital de Clínicas de Porto Alegre
- Pienovi R
- Pierce C
- Pifferi S
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- Pinto JL
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- Pirracchio R
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- Plug Working Group
- PLUG working group
- PLUG Working Group
- PLUG Working Group
- PLUG Working Group
- Plug working group
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- Podlepich V
- Pognuz ER
- Poissy J
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- PS-ICU Group
- Psarologakis C
- Puerto-Morlán A
- Pugliese F
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- Pulham RA
- Pulitano' SM
- Pusapati R
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- Puthucheary ZA
- Putzu A
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- Quintana S
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- Rapid Diagnosis of Infections in the Critically Ill Team
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- ReVA Research Network and the PROVE Network Investigators
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- Rodríguez FG
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- Romero JC
- Romero JC
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- Romeu JD
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- Ros Martínez J
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- Rosario LE
- Rosario LE
- Rosario LE
- Rosario LE
- Rosario LE
- Rossetti AO
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- Rota L
- Roth GA
- Rottoli MR
- Rotzel HB
- Rousseau AF
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- Rouzé A
- Rowlerson A
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- Rubio RJ
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- Ruiz FC
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- Ruiz-Ramos J
- Ruiz-Rodriguez JC
- Ruiz-Rodríguez JC
- Ruiz-Ruano RDEL
- Runge I
- Runge I
- Runge I
- Rutherford WB
- Rutten AM
- Rydingsward JE
- Saadat F
- Sabetian G
- Sabeļņikovs O
- Sabirov D
- Sadamoto Y
- Sadamoto Y
- Sadamoto Y
- Saeed S
- Saha T
- Saigal S
- Saito M
- Saito N
- Saitou N
- Sakai Y
- Sakieva FI
- Sakuma M
- Sakuraya M
- Sales G
- Salgado DR
- Salluh J
- Sampath S
- Sampath S
- Sampley S
- Sampson D
- Samuels T
- Samy W
- Sanchez A
- Sanchez JA
- Sanchez-Orézzoli MG
- Sandiumenge A
- Sandiumenge A
- Sandroni C
- Sani D
- Santacruz C
- Santana JD
- Santana JD
- Santana MC
- Santana MC
- Santana PS
- Santana PS
- Santana SR
- Santana SR
- Santiago AI
- Santiago AI
- Santos F
- Sanui M
- Sanz ER
- Sanz ER
- Sanz ER
- Sanz ER
- Sanz ER
- Sanz ER
- Sanz NM
- Sanz NM
- Sanz NM
- Sato K
- Savi C
- Savin I
- Savvidou S
- Sawamura A
- Sawamura A
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- Sawamura A
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- Scales DC
- Scanziani E
- Scanziani E
- Schaller SJ
- Schlaepfer P
- Schleifer J
- Schmid RM
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- Schneider AG
- Schoenenberger JA
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- Shekerdemian LS
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- Shimony JS
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- Skrifvars MB
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- Snelson C
- Snyder AZ
- Sobhanian S
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- Soilemezi E
- Sokolova E
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- Solligård E
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- Somhorst P
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- Song I
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- Spadaro S
- Spadaro S
- Spahn DR
- Spatenkova V
- Spazzadeschi A
- Spijkstra JJ
- Spronk PE
- Spronk PE
- Sprung CL
- St George’s University of London
- Stamm J
- Stamouli M
- Stanić R
- Starczewska M
- Staszewsky L
- Stauffert N
- Stella A
- Stephens T
- Stiphout C
- Stocchetti N
- Stocchetti N
- Stougianni M
- Street H
- Stretti F
- Struijs A
- Stubbs C
- Stubbs C
- Student Research Committee - Shiraz University of Medical Sciences
- Stümpfle R
- Stümpfle R
- Su F
- Su L
- Su PL
- Su PL
- Suchomel P
- Suh GJ
- Suh GJ
- Suh GJ
- Suh GY
- Suh JW
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- Sun WZ
- Sun XM
- Sung D
- Suwanpasu S
- Suzuki S
- Suzuki T
- Swart M
- Sy O
- Sydow K
- Sylla P
- Sáez VC
- Sánchez B
- Sánchez B
- Sánchez EC
- Sánchez MJ
- Sánchez MJ
- Sánchez MJ
- Sánchez MJ
- Sánchez MJ
- Sánchez MJ
- Sánchez PC
- Sánchez PC
- Sánchez-Elvira LA
- Tabatabaei HR
- Tabei SH
- Taccone F
- Taccone FS
- Taccone FS
- Taccone FS
- Taccone FS
- Taccone FS
- Taccone FS
- Taccone FS
- Taggu A
- Taggu A
- Takahashi H
- Takaki S
- Takaki S
- Takeda M
- Takeda M
- Takei T
- Takei T
- Talan L
- Tamura T
- Tanaka H
- Tanaka S
- Tanaka S
- Tane N
- Tang KB
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- Tapia A
- Tapponnier R
- Tapponnier R
- Tapponnier R
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- Thabut G
- Theodorakopoulou M
- Thies P
- Thilakasiri MC
- Thomas B
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- Thévenin D
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- Tirumala S
- Tjepkema-Cloostermans MC
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- Tofiño AL
- Toh CH
- Tokyo Womens Medical University
- Tomas E
- Tomas E
- Tomic I
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- Tomás MA
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- Tonetti T
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- Torner MM
- Torrance HD
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- Tsukahara K
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- Tsunoda M
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- Tucci MR
- Tudor BA
- Tuinman PR
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- Uriona S
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- Valbuena BL
- Valeiras-Valero A
- Vallecoccia MS
- Vallejo-Báez J
- Vallverdu M
- Vallverdu M
- Vallverdú I
- Vallés J
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- van der Heiden ES
- van der Hoeven JG
- van der Hoeven JG
- van der Voort PH
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- van Ieperen SN
- Van Logten T
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- van Putten MJ
- van Thiel RJ
- van Wijk A
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- Vaneker I
- Vanhuyse F
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- Vaquerizo C
- Varas GM
- Varas JL
- Varea MM
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- Varma A
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- Vatsik MV
- Vazquez D
- Vedage D
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- Vezzani A
- Vezzani A
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- Viciana R
- Vidal A
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- Vidal MV
- Viegas E
- Vieillard-Baron A
- Vieira JE
- Viera MA
- Viera MA
- Vigne C
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- Villa P
- Villalba D
- Villamizar PR
- Villamizar PR
- Villanova M
- Villard I
- Villarreal E
- Villarreal E
- Vincent B
- Vincent JL
- Vincent JL
- Vincent JL
- Vincent JL
- Vincent JL
- Vincent JL
- Vincent JL
- Vinje LJ
- Vinsonneau C
- Vitaller S
- Vittone F
- Vogelaers D
- Voiriot G
- Volker T
- Volta CA
- Volta CA
- Vondrakova D
- Vondrakova D
- Vondrakova D
- Vong LV
- Vourli S
- Vrettou C
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- Vázquez CF
- Vázquez CF
- Wada T
- Wada T
- Wada T
- Wada T
- Waldauf P
- Wand S
- Wang CH
- Wang H
- Wann SR
- Wann SR
- Wann SR
- Wann SR
- Wathanawatthu T
- Wee S
- Welte T
- Welters I
- Wetz A
- Weyer CM
- White C
- Wiesner O
- Wijayatilake DS
- Wildenberg L
- Wilks M
- Wilson ME
- WIND study group
- WIND study group
- WIND study group
- Winder-Rhodes S
- Witter T
- Wolf M
- Wolff M
- Wong Y
- Wood B
- Wood CA
- Wood D
- Wood M
- Wray J
- Xie Z
- Xini A
- Xini A
- Xiol EA
- Xu M
- Yager T
- Yaguchi A
- Yaguchi A
- Yamaguchi O
- Yamaguchi O
- Yamaguchi Y
- Yamaguchi Y
- Yamamoto H
- Yamamoto N
- Yaman G
- Yamashita K
- Yamazaki A
- Yan WW
- Yan WW
- Yang JH
- Yang JS
- Yang YL
- Yasuda H
- Yatabe T
- Yebenes JC
- Yeh YC
- Yemets H
- Yergaliyeva A
- Yılmaz G
- Yilmazer F
- Yodice P
- Yokoyama M
- Yonis H
- Yonis H
- Yonis H
- Yoon SZ
- Yoruk F
- Yoshida K
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshihiro S
- Yoshitake E
- You KM
- Youn AM
- Young A
- Yu KM
- Yumoto T
- Yuzawa J
- Yuzawa J
- Zabaletta WJ
- Zabini D
- Zahorec M
- Zaien I
- Zakynthinos S
- Zanello M
- Zani D
- Zarantonello F
- Zayas B
- Zepeda EM
- Zeroual N
- Zerva L
- Zhang J
- Zhou JC
- Zhou JC
- Zhou JX
- Zhovnir V
- Zibandah N
- Zijlstra F
- Zimmerman J
- Zogheib E
- Zogheib E
- Zogheib E
- Zullino V
- Zwaag J
- Zýková I
- Álvarez JT
- Álvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine
- Author
- A Boing
- A Gaspari
- A Kübler
- A Marudi
- A Matheson
- A Tridente
- A. A. Amelia
- A. Abbas
- A. Adams
- A. Agnoli
- A. Al Khulaifi
- A. Al Khulaifi
- A. Aldawood
- A. AlHussain
- A. Ali
- A. Almenyar
- A. Alrashid
- A. Alsheikhly
- A. Alves
- A. Ankuli
- A. Arbouti
- A. Armaganidis
- A. Artigas
- A. Asimakos
- A. B. Belli
- A. B. Cayci Sivri
- A. Bandyopadhyay
- A. Basu
- A. Bedova
- A. Belli
- A. Ben Souissi
- A. Ben Souissi
- A. Ben Souissi
- A. Ben Souissi
- A. Bond
- A. Borgman
- A. Borowska
- A. Boutin
- A. Boutin
- A. Boyce
- A. Braschi
- A. Budnyuk
- A. C. Rodrigues
- A. Cariou
- A. Casazza
- A. Chakraborty
- A. Cirodde
- A. Crizaldo Toledo
- A. Cudia
- A. Cuoghi
- A. D. Dubrawski
- A. Dardashti
- A. Dean
- A. Dean
- A. Delfosse
- A. Dhaliwal
- A. Dhaliwal
- A. Dobru
- A. Docherty
- A. Doronzio
- A. Douvdevani
- A. Dukoff-Gordon
- A. Durward
- A. E Van den Berg
- A. Eden
- A. Eissa
- A. Enguix-Armada
- A. Escalante
- A. Escalante
- A. Ezzamouri
- A. F. Francke
- A. F. Turgeon
- A. F. Turgeon
- A. F. Van Rootselaar
- A. F. Van Rootselaar
- A. Fayed
- A. Fernandez
- A. Fischer
- A. Fogagnolo
- A. Fuller
- A. Fuller
- A. G. Murchison
- A. G. Proudfoot
- A. Garcia
- A. Garcia-Alcantara
- A. Garcia-De la Torre
- A. Garland
- A. Garland
- A. Gaspari
- A. Ghuysen
- A. Giannini
- A. Gobatto
- A. Goloubev
- A. Grubb
- A. Gruber
- A. Gultekin
- A. H. Zwinderman
- A. Hagiwara
- A. Hana
- A. Hana
- A. Harts
- A. Hejazi
- A. Hernández-Lozano
- A. Hernández-Lozano
- A. Hovingh
- A. Huber
- A. Itani
- A. J. Groeneveld
- A. J. Hoogendijk
- A. K. Kink
- A. K. Kuzovlev
- A. K. Tashima
- A. Kapuagasi
- A. Kar
- A. Kaskovagheorgescu
- A. Kaushal
- A. Khaghani
- A. Kindawi
- A. Kleinsasser
- A. Kodaira
- A. Kutz
- A. Kuzovlev
- A. Körner
- A. L Luciani
- A. L. Lange
- A. Lepape
- A. Lesmes
- A. Lima
- A. Lima
- A. Linder
- A. Loza
- A. López Lago
- A. M. Magnuson
- A. M. Tuip-de Boer
- A. Maaoui
- A. Machado
- A. Mahrous
- A. Malamas
- A. Marinho
- A. Marinho
- A. Marinho
- A. Marinho
- A. Marinho
- A. Marinho
- A. Marinho
- A. Martins
- A. Marudi
- A. Marudi
- A. Matroud
- A. Mebazaa
- A. Mignon
- A. Min
- A. Molokhia
- A. Molokhia
- A. Molokhia
- A. Molokhia
- A. Molokhia
- A. Morelli
- A. Morris
- A. Motos
- A. N. Ahmad
- A. Nadeem
- A. Nau
- A. Neill
- A. Nyman
- A. Núñez
- A. Oglinda
- A. Omar
- A. Omar
- A. Omar
- A. Omar
- A. Orlando
- A. Osipov
- A. Ozcan
- A. O’Loughlin
- A. O’Sullivan
- A. O’Sullivan
- A. O’Sullivan
- A. P. Pagano
- A. P. Torelly
- A. Pagano
- A. Patarchi
- A. Pautova
- A. Pavli
- A. Pesenti
- A. Prekates
- A. Psirides
- A. Puerto-Morlan
- A. Puxty
- A. Pérez-Calatayud
- A. R. Robles Caballero
- A. Radford
- A. Raithatha
- A. Raithatha
- A. Raithatha
- A. Reiter
- A. Rhodes
- A. Rhodes
- A. Rhodes
- A. Riahi
- A. Riahi
- A. Riahi
- A. Riahi
- A. Riviere
- A. Riviere
- A. Riviere
- A. Robles
- A. Rogers
- A. Rousseau
- A. Roze des Ordons
- A. Ruijter
- A. Rutten
- A. S. Alsaawi
- A. S. Stieglitz
- A. Salgueiro
- A. Salgueiro
- A. Salgueiro
- A. Sarmento
- A. Sarmento
- A. Savitsky
- A. Scheirer
- A. Schiavi
- A. Seldon
- A. Sell
- A. Sen
- A. Sergeev
- A. Shabanov
- A. Shafie
- A. Shafquat
- A. Shiraishi
- A. Silva-Pinto
- A. Silva-Pinto
- A. Spassov
- A. Stella
- A. Steuber
- A. Stieglitz
- A. Stilwell
- A. Sánchez-López
- A. Sánchez-López
- A. Taha
- A. Taha
- A. Taskin
- A. Temple
- A. Tinmouth
- A. Tinmouth
- A. Torres
- A. Torres
- A. Torres
- A. Touborg Lassen
- A. Tridente
- A. Tridente
- A. Tridente
- A. Tridente
- A. Trifi
- A. Trifi
- A. Tsimogianni
- A. Turgeon
- A. Turgeon
- A. Vakalos
- A. Vakalos
- A. Vakalos
- A. Vakalos
- A. Van Assche
- A. Van Assche
- A. Varma
- A. Vassi
- A. Vercueil
- A. Vieillard-Baron
- A. Violaki
- A. Violaki
- A. Vuylsteke
- A. W. Waldmann
- A. Wald
- A. Waldmann
- A. Waldmann
- A. Webber
- A. Wheeler
- A. Yalcin
- A. Zepeda-Mendoza
- A. Zerman
- AF Donneau
- AK Güler
- AT Tesnieres
- B Adamik
- B Avard
- B. Al Raiy
- B. AlGhamdi
- B. Alhamadi
- B. Alotaibi
- B. Avard
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- B. Balicco
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- B. Borgatta
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- B. Civantos
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- E. Arch-Tirado
- E. Arita
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- E. Chochliourou
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- E. Colombaroli
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- E. D. Arul
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- E. Der Kinderen
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- E. Doumaki
- E. Dubief
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- E. Gómez-Sánchez
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- E. Helme
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- E. Herrera-Ramos
- E. Hoste
- E. Ischaki
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- E. Kompanje
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- E. Kotzapanagiotou
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- E. Mancini
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- E. Michael
- E. Moltchanova
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- E. Mukeria
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- E. Nakstad
- E. Nieuwkoop
- E. Nsutebu
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- E. Oloktsidou
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- E. Orenbuch-Harroch
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- E. Peters
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- E. R. Ruggiero
- E. Rodríguez Ruíz
- E. Samkinidou
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- E. Scarlatescu
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- E. Senturk
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- E. Tamayo
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- E. Tamberg
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- E. Tina
- E. Toth-martin
- E. Tuzun
- E. Tuzun
- E. Varo Pérez
- E. Vasilarou
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- E. Vicaut
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- F. A. Rocha
- F. AlEid
- F. Alenezi
- F. Ampatzidou
- F. Ampatzidou
- F. Ampatzidou
- F. Asota
- F. B. Borrelli
- F. B. Jatene
- F. Bloos
- F. Boutouta
- F. Brazier
- F. Brazier
- F. Brazier
- F. Brazier
- F. Breckenridge
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- F. Candidi
- F. Cardoso
- F. Ceia
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- F. Dalla Corte
- F. Daly
- F. Daly
- F. Elkmann
- F. Esen
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- F. Faria
- F. Frame
- F. Gaioto
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- F. Galas
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- F. Güiza
- F. Haddad
- F. Idone
- F. Jans
- F. Kelly
- F. Kunimoto
- F. Lagiou
- F. Lauzier
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- F. Lauzier
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- F. Lemos
- F. Lucena
- F. Mojoli
- F. Mounajergi
- F. Numis
- F. Numis
- F. Ortolano
- F. Paladino
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- F. Q. Reis
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- F. R. Machado
- F. Ragusa
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- F. Ravat
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- F. Righetti
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- F. Rodríguez de Castro
- F. Schaap
- F. Seabra Pereira
- F. T. Tagliazucchi
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- F. Tubach
- F. Turani
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- F. V. De Marco
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- F. Verga
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- G Miccinesi
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- G. Davies
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- G. Droc
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- G. Micha
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- G. Pagliarello
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- H. Aya
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- H. Castro
- H. Castro
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- H. Hines
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- H. Ishikura
- H. Ishikura
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- H. Takahashi
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- H. Venkatesh
- H. Wulf
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- H. Yasuda
- H. Yoshida
- I Gonzalez
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- I. A. Murdoch
- I. Alamanos
- I. Aragão
- I. Aragão
- I. Aramendi
- I. Budnik
- I. Cinel
- I. Cinel
- I. D. Douglas
- I. D. Welters
- I. D. Welters
- I. D. Weltes
- I. Elsayed
- I. Guerreiro
- I. Herrmann
- I. Hussain
- I. Klein
- I. Korobko
- I. Kozhevnikova
- I. Kuchyn
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- I. Linsberger
- I. Mandel
- I. Meex
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- I. Moreira
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- I. Patanwala
- I. Patanwala
- I. Piper
- I. Pneumatikos
- I. R. Rätsep
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- I. Suhodolo
- I. Tsangaris
- I. Vanhorebeek
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- V. Karsegard
- V. Kiselev
- V. Koulouras
- V. Lopez
- V. Lopez
- V. Lopez
- V. Lostarakos
- V. Lupu
- V. Maraj
- V. MArtinez
- V. Medo
- V. Moroz
- V. Moroz
- V. Moroz
- V. Naushad
- V. Navapurkar
- V. Negi
- V. P. Dan
- V. Panagiotidou
- V. Panagiotidou
- V. Perez-Valero
- V. Rudnov
- V. Spatenkova
- V. Tangsujaritvijit
- V. Theodorou
- V. Vein
- V. Vicka
- V. Weber
- V. Weber
- W. Almutairi
- W. Bernal
- W. C. De Jongh
- W. C. Ngu
- W. Dersch
- W. Eertmans
- W. Huber
- W. J. Federspiel
- W. J. Wiersinga
- W. J. Wiersinga
- W. Manzanares
- W. Manzanares
- W. Manzanares
- W. N. Van Mook
- W. W. Windisch
- W. Windisch
- W. Windisch
- W. Y. Sim
- W. Z. Linde-Zwirble
- X. Capdevila
- X. Gee
- X. L. Lin
- Y. Akeda
- Y. Akeda
- Y. Alhamdi
- Y. Arabi
- Y. Arabi
- Y. Arabi
- Y. Arabi
- Y. Arabi
- Y. Arunan
- Y. Ben Aicha
- Y. Boussarsar
- Y. Boussarsar
- Y. Cohen
- Y. Dupertuis
- Y. Haraguchi
- Y. Himmel
- Y. Hoydonckx
- Y. Izutani
- Y. Izutani
- Y. Izutani
- Y. Kawano
- Y. Koide
- Y. Kokhanovsky
- Y. Masson
- Y. Nakamura
- Y. Nassar
- Y. Podoksenov
- Y. Que
- Y. S. Chiew
- Y. S. Chiew
- Y. Sakr
- Y. Sarshor
- Y. Schriel
- Y. Shouman
- Y. Su
- Y. Su
- Y. Svirko
- Y. Tekdos
- Y. Wong
- Z. Aidoni
- Z. Ali
- Z. Douira
- Z. Ghiorghiu
- Z. Ghiorghiu
- Z. Ghiorghiu
- Z. Ghiorghiu
- Z. Güllü
- Z. Güllü
- Z. Isýkdogan
- Z. Molnár
- Z. Ramsheva
- Z. Stanga
- Z. Stathi
- Z. Uzundurukan
- Z. Ülger
- Ó. Martínez González
- Ö. Özdedeoglu
- Ü. Gaygýsýz
- Ý. Kara
- Publication venue
- Springer Nature
- Publication date
- 01/01/2016
- Field of study
[This corrects the article DOI: 10.1186/s13054-016-1208-6.]
The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study
- Author
- Abadia M
- Abassy J
- Abate E
- Abbott Tom EF
- Abdelaal Samir A
- Abdeldayem H
- Abdelkabir M
- Abdelsamed A
- Abdulwahed E
- Abiyere H
- Abou Chaar MK
- Abukhalaf SA
- Abukhalaf Sadi
- Adamina Michel
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O
- Adeyeye A
- Adisa Adewale
- Afzal MF
- Agarwal Arnav
- Aggarwal M
- Agnes A
- Agostini C
- Agrawal A
- Agrawal N
- Agresta F
- Aguiar Junior S
- Ahmed A
- Ahmed K
- Ahmed Nafees R
- Ahmed Z
- Ahn JH
- Aime A
- Akhtar N
- Akkulak Murat
- Akrivou D
- Al Abdallah M
- Al Riyami S
- Al Sayed M
- Al-Masri M
- Al-Najjar H
- Al-Slaibi I
- Alaa S
- Alakaloko Felix
- Alameer Ehab
- Alamri Alex
- Alawneh F
- Albertsmeier M
- Albertsmeier Markus
- Alderson Derek
- Aldokali N
- Alemanno G
- Alfieri S
- Algallai M
- Ali AA
- Alkadiki Ghadah Z
- Almaadany Faraj S
- Almeida AC
- Almeida-Reis R
- Almezghwi H
- Almond Max
- Alrahawy M
- Alser Osaid
- Alshaar Muhammad
- Alshareea E
- Alshareef K
- Alshryda Sattar
- Alsoufi A
- Altamirano Riquoir C
- Altomare DF
- Altomi I
- Alurralde C
- Alvarez MR
- Alvi A
- Alwarfly S
- AlZAEDE S
- Alzeerelhouseini IAH
- Amaral MJ
- Amira G
- Amorim E
- Amrani L
- Anania G
- Anastasi A
- Andrade Kam da Silva A
- Andrade R
- Annessi V
- Annicchiarico A
- Antonakis P
- Antonopoulou M
- Aprile A
- Aremu M
- Arias-Amezquita F
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- Arnaud Alexis P
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- Athanasakis E
- Attia D
- Augestad Knut Magne
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- Bromage Steve
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- De Simone V
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- Devezas V
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- Publication venue
- 'Royal College of Obstetricians & Gynaecologists (RCOG)'
- Publication date
- 01/06/2022
- Field of study
AIM: The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery. METHODS: This was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin. RESULTS: Overall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P < 0.001). After adjustment, delay was not associated with a lower rate of complete resection (OR 1.18, 95% CI 0.90-1.55, P = 0.224), which was consistent in elective patients only (OR 0.94, 95% CI 0.69-1.27, P = 0.672). Longer delays were not associated with poorer outcomes. CONCLUSION: One in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease
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