Un nuevo condylocardiido en el Tortiense marino de la provincia de Valencia

Se describe Carditopsis villaltai nov. sp. en el Tortoniense de La Cañada (Valencia) y se discuten sus relaciones con las restantes formas miocenas del género en Europa

Un nuevo condylocardiido en el Tortiense marino de la provincia de Valencia

Se describe Carditopsis villaltai nov. sp. en el Tortoniense de La Cañada (Valencia) y se discuten sus relaciones con las restantes formas miocenas del género en Europa

Asociaciones malacológicas vivas y muertas de tres unidades bionómicas de la cala Portichol (Alicante, España)

Se estudia una parte del componente malacológico (gasterópodos provistos de concha y bivalvos) de tres unidades bionómicas de la cala Portichol (Alicante, España): los fondos de algas fotófilas infralitorales, de Caulerpa prolifera y de Posidonia oceanica. Las correspondientes asociaciones vivas permiten globalmente una distinción faunística bastante clara; pese a ello, la heterogeneidad encontrada en los fondos con Caulerpa prolifera parece aconsejar su reconsideración como caracterizador bionómico. La comparación entre las asociaciones vivas y muertas de estos tres tipos de fondo parece confirmar algunas opiniones expresadas en la bibliografía tafonómica. Probablemente la mayor parte de las asociaciones malacológicas inframareales que maneja el paleontólogo quedan muy alejadas de un fiel reflejo de la biocenosis original. Sin embargo, parece existir cierta regularidad en la importancia de los elementos alóctonos presentes en las mismas que se traduce en una mayor probabilidad de autoctonía en las formas más representadas.Shelly gastropods and bivalves from three bionomic units of Portichol Bay: bottoms with photophilous algae, Caulerpa prolifera and Posidonia oceanica, respectively, have been studied. The correspondent live assemblages allows globally a good faunistic distinction; neverthelees the heterogeneity founded in bottoms with Caulerpa prolifera seems to advise its reconsideration as a bionomic characterizer. The comparison between death and live assemblages from these three kinds of bottoms seems to prove some opinions expressed in the taphonomic bibliography. Likely the most of the subtidal malacological assemblages usually handled by the paleontologist are so far to be a good reflection of the original biocenose. Nonetheless a certain regularity in the importance of the present allochthonous elements world indicate a higher probability of autochthony of the more represented forms

A Point Mutation in the Transcriptional Repressor PerR Results in a Constitutive Oxidative Stress Response in Clostridioides difficile 630(delta)Derm

The human pathogen Clostridioides difficile has evolved into the leading cause of nosocomial diarrhea. The bacterium is capable of spore formation, which even allows survival of antibiotic treatment. Although C. difficile features an anaerobic lifestyle, we determined a remarkably high oxygen tolerance of the laboratory reference strain 630Δerm. A mutation of a single nucleotide (single nucleotide polymorphism [SNP]) in the DNA sequence (A to G) of the gene encoding the regulatory protein PerR results in an amino acid substitution (Thr to Ala) in one of the helices of the helix-turn-helix DNA binding domain of this transcriptional repressor in C. difficile 630Δerm. PerR is a sensor protein for hydrogen peroxide and controls the expression of genes involved in the oxidative stress response. We show that PerR of C. difficile 630Δerm has lost its ability to bind the promoter region of PerR-controlled genes. This results in a constitutive derepression of genes encoding oxidative stress proteins such as a rubrerythrin (rbr1) whose mRNA abundance under anaerobic conditions was increased by a factor of about 7 compared to its parental strain C. difficile 630. Rubrerythrin repression in strain 630Δerm could be restored by the introduction of PerR from strain 630. The permanent oxidative stress response of C. difficile 630Δerm observed here should be considered in physiological and pathophysiological investigations based on this widely used model strain

Modelling of Impact Falling Ball Test Response on Solid and EngineeredWood Flooring of Two Eucalyptus Species

In this study, dynamic hardness tests on solid and engineered wood flooring specimens of Eucalyptus globulus Labill. and Eucalyptus grandis W. Hill ex Maiden hardwoods were performed because nowadays, these fast-growing hardwoods are still scarcely employed for this use. Furthermore, another two examples of hardwood commonly applied on wood flooring, Quercus robur L. and Hymenaea courbaril L., were also tested. To compare their properties, a dynamic impact hardness test based on the impact of steel balls, with several diameters, and drop heights was developed. Accordingly, 120 solid wood flooring specimens and 120 engineering wood flooring specimens were producing with these four hardwood species. Dynamic impact tests were made with three steel balls of different diameters (30–40–50 mm), and they were carried out from five different drop heights (0.60–0.75–0.90–1.05–1.20 m). The impact of the steel ball drew the size of the footprint on the surface and this mark was measured with a digital caliper for both dimensions, diameter and depth, as footprint diameter (FD) and indentation depth (ID). Data from 3000 samples, corresponding to 120 different individual groups (4 species × 3 ball diameters × 5 drop height × 2 floor type) were analyzed. Results indicated that the variability of ID (CV between 19.25–25.61%) is much greater than the values achieved for FD (CV between 6.72–7.91%). Regarding the fast-growing hardwood species tested, E. globulus showed a similar behavior to traditional hardwood applied on wood flooring in Europe, Q. robur, and it could be a promising growth in the flooring industry. However, E. grandis showed the worst values compared to traditional hardwood in all test configurations.Laboratorio de Investigaciones en Mader

Eficacia de la terapia de ondas de choque como alternativa de tratamiento en lesiones del manguito rotador

Rotator cuff injuries are reason for consultation frequent in elderly patients. Most of the time there are no background traumatic acute generating progressive limitations in activities of daily living (ADLS). The objective of this study is to show results in tendonitis of the rotator cuff, in patients treated with extracorporeal shock wave therapy (ESWT). It is a prospective descriptive observational study which presents clinical and functional outcomes in patients with described lesion, treated with ESWT with poor response to conventional treatments and clinical pictures of longstanding through implementing visual analog scale (VAS) of pain and evaluation of range of motion. The greater presence of lesion is present in women 63.6%. Mostly affected shoulder was right in a 63.6%. Found significant changes in VAS pre and post treatment with averages of 7.9 and 0.5 respectively and different statistical p < 0.001. We were conclude that the ESWT is an effective method in the treatment of the tendonitis of the rotator cuff with relief from pain and return to functional levels.Las lesiones del manguito rotador resultan motivo de consulta frecuente en pacientes mayores. La mayoría de las veces no existen antecedentes traumáticos agudos generando limitación progresiva en actividades la vida diaria (AVD). El objetivo de este estudio es mostrar resultados en tendinosis del manguito rotador, en pacientes tratados con terapia de ondas de choque extracorpóreas (TOCE). Se realiza un estudio observacional descriptivo prospectivo en el cual presentan resultados clínicos y funcionales en pacientes con lesión descrita, tratados con TOCE con pobre respuesta a tratamientos convencionales y cuadros clínicos de larga data mediante la aplicación de Escala Visual Análoga (EVA) del dolor y valoración del rango de movilidad. La mayor presencia de lesión se presentó en mujeres 63.6%. El hombro mayormente afectado fue derecho en un 63.6%. Se encontró cambios significativos en EVA pre y post tratamiento con medias de 7.9 y 0.5 respectivamente y diferencia estadística p<0.001. Igualmente se evidenció diferencia estadísticamente significativa de los diferentes rangos de movimiento pre y post tratamiento p<0.001. Se concluye que la TOCE es un método eficaz en el tratamiento de las tendinosis del manguito rotador con alivio del dolor y retorno a niveles funcionales

Estudio de herramientas de simulación en redes definidas por software

A medida que aumentan los servicios y el software, las exigencias de usuarios para contar con disponibilidad, garantía, calidad y seguridad de la información son mayores. Las arquitecturas de redes existentes no fueron diseñadas para satisfacer dichas necesidades, provocando que las organizaciones de hoy en día, se vean limitadas en posibilidades. Por este motivo, se impulsa a reexaminar las arquitecturas actuales, buscando responder con nuevas técnicas y tecnologías. La llegada de la virtualización ha flexibilizado la definición y el uso de sus recursos, permitiendo definir y modificar en tiempo real, a nivel software, una infraestructura completa basada en perfiles de aplicaciones, en necesidades de rendimiento, etc. El análisis de infraestructura de redes y DataCenters orientados a servicios se vuelve un elemento crítico en las empresas de telecomunicaciones. En este contexto, se desarrolla un proyecto de investigación que estudia nuevas tendencias de redes de información como las Redes Definidas por Software y propone un modelo basado en esta tecnología, a fin de cubrir nuevas demandas de usuarios y organizaciones.Eje: Arquitectura, Redes y Sistemas Operativos.Red de Universidades con Carreras en Informática (RedUNCI

KIR+ CD8+ T Lymphocytes in Cancer Immunosurveillance and Patient Survival: Gene Expression Profiling

Killer-cell immunoglobulin-like receptors (KIR) are molecules expressed by the most important cells of the immune system for cancer immune vigilance, natural killer (NK) and effector T cells. In this manuscript we study the role that cytotoxic CD8+ T cells expressing KIR receptors could play in cancer immune surveillance. With this objective, frequencies of different KIR+ CD8+ T cell subsets are correlated with the overall survival of patients with melanoma, ovarian and bladder carcinomas. In addition, the gene expression profile of KIR+ CD8+ T cell subsets related to the survival of patients is studied with the aim of discovering new therapeutic targets, so that the outcome of patients with cancer can be improved. Killer-cell immunoglobulin-like receptors (KIR) are expressed by natural killer (NK) and effector T cells. Although KIR+ T cells accumulate in oncologic patients, their role in cancer immune response remains elusive. This study explored the role of KIR+CD8+ T cells in cancer immunosurveillance by analyzing their frequency at diagnosis in the blood of 249 patients (80 melanomas, 80 bladder cancers, and 89 ovarian cancers), their relationship with overall survival (OS) of patients, and their gene expression profiles. KIR2DL1+ CD8+ T cells expanded in the presence of HLA-C2-ligands in patients who survived, but it did not in patients who died. In contrast, presence of HLA-C1-ligands was associated with dose-dependent expansions of KIR2DL2/S2+ CD8+ T cells and with shorter OS. KIR interactions with their specific ligands profoundly impacted CD8+ T cell expression profiles, involving multiple signaling pathways, effector functions, the secretome, and consequently, the cellular microenvironment, which could impact their cancer immunosurveillance capacities. KIR2DL1/S1+ CD8+ T cells showed a gene expression signature related to efficient tumor immunosurveillance, whereas KIR2DL2/L3/S2+CD8+ T cells showed transcriptomic profiles related to suppressive anti-tumor responses. These results could be the basis for the discovery of new therapeutic targets so that the outcome of patients with cancer can be improved

Short- and Long-Term Prognosis of Patients With Takotsubo Syndrome Based on Different Triggers: Importance of the Physical Nature

Background Takotsubo syndrome (TTS) is an acute reversible heart condition initially believed to represent a benign pathology attributable to its self-limiting clinical course; however, little is known about its prognosis based on different triggers. This study compared short- and long-term outcomes between TTS based on different triggers, focusing on various physical triggering events. Methods and Results We analyzed patients with a definitive TTS diagnosis recruited for the Spanish National Registry on TTS (RETAKO [Registry on Takotsubo Syndrome]). Short- and long-term outcomes were compared between different groups according to triggering factors. A total of 939 patients were included. An emotional trigger was detected in 340 patients (36.2%), a physical trigger in 293 patients (31.2%), and none could be identified in 306 patients (32.6%). The main physical triggers observed were infections (30.7%), followed by surgical procedures (22.5%), physical activities (18.4%), episodes of severe hypoxia (18.4%), and neurological events (9.9%). TTS triggered by physical factors showed higher mortality in the short and long term, and within this group, patients whose physical trigger was hypoxia were those who had a worse prognosis, in addition to being triggered by physical factors, including age >70 years, diabetes mellitus, left ventricular eyection fraction <30% and shock on admission, and increased long-term mortality risk. Conclusions TTS triggered by physical factors could present a worse prognosis in terms of mortality. Under the TTS label, there could be as yet undiscovered very different clinical profiles, whose differentiation could lead to individual better management, and therefore the perception of TTS as having a benign prognosis should be generally ruled out