Statistical M-Estimation and Consistency in Large Deformable Models for Image Warping

The problem of defining appropriate distances between shapes or images and modeling the variability of natural images by group transformations is at the heart of modern image analysis. A current trend is the study of probabilistic and statistical aspects of deformation models, and the development of consistent statistical procedure for the estimation of template images. In this paper, we consider a set of images randomly warped from a mean template which has to be recovered. For this, we define an appropriate statistical parametric model to generate random diffeomorphic deformations in two-dimensions. Then, we focus on the problem of estimating the mean pattern when the images are observed with noise. This problem is challenging both from a theoretical and a practical point of view. M-estimation theory enables us to build an estimator defined as a minimizer of a well-tailored empirical criterion. We prove the convergence of this estimator and propose a gradient descent algorithm to compute this M-estimator in practice. Simulations of template extraction and an application to image clustering and classification are also provided

First measurement of Ωc0 production in pp collisions at s=13 TeV

The inclusive production of the charm–strange baryon 0 c is measured for the first time via its hadronic √ decay into −π+ at midrapidity (|y| <0.5) in proton–proton (pp) collisions at the centre-of-mass energy s =13 TeV with the ALICE detector at the LHC. The transverse momentum (pT) differential cross section multiplied by the branching ratio is presented in the interval 2 < pT < 12 GeV/c. The pT dependence of the 0 c-baryon production relative to the prompt D0-meson and to the prompt 0 c-baryon production is compared to various models that take different hadronisation mechanisms into consideration. In the measured pT interval, the ratio of the pT-integrated cross sections of 0 c and prompt + c baryons multiplied by the −π+ branching ratio is found to be larger by a factor of about 20 with a significance of about 4σ when compared to e+e− collisions

Resolved versus confirmed ARDS after 24 h: insights from the LUNG SAFE study

Purpose: To evaluate patients with resolved versus confirmed ARDS, identify subgroups with substantial mortality risk, and to determine the utility of day 2 ARDS reclassification. Methods: Our primary objective, in this secondary LUNG SAFE analysis, was to compare outcome in patients with resolved versus confirmed ARDS after 24\ua0h. Secondary objectives included identifying factors associated with ARDS persistence and mortality, and the utility of day 2 ARDS reclassification. Results: Of 2377 patients fulfilling the ARDS definition on the first day of ARDS (day 1) and receiving invasive mechanical ventilation, 503 (24%) no longer fulfilled the ARDS definition the next day, 52% of whom initially had moderate or severe ARDS. Higher tidal volume on day 1 of ARDS was associated with confirmed ARDS [OR 1.07 (CI 1.01\u20131.13), P = 0.035]. Hospital mortality was 38% overall, ranging from 31% in resolved ARDS to 41% in confirmed ARDS, and 57% in confirmed severe ARDS at day 2. In both\ua0resolved and confirmed\ua0ARDS, age, non-respiratory SOFA score, lower PEEP and P/F ratio, higher peak pressure and respiratory rate were each\ua0associated with mortality. In confirmed ARDS, pH and the presence of immunosuppression or neoplasm were also associated\ua0with mortality. The increase in area under the receiver operating curve for ARDS reclassification on day 2 was marginal. Conclusions: ARDS, whether resolved or confirmed at day 2, has a high mortality rate. ARDS reclassification at day 2 has limited predictive value for mortality. The substantial mortality risk in severe confirmed ARDS suggests that complex interventions might best be tested in this population. Trial Registration: ClinicalTrials.gov NCT02010073. \ua9 2018, Springer-Verlag GmbH Germany, part of Springer Nature and ESICM

Correction to: Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study

Correction to: Intensive Care Med (2016) 42:1865\u20131876 DOI 10.1007/s00134-016-4571-

<math display="inline"><mrow><mi>ψ</mi><mo stretchy="false">(</mo><mn>2</mn><mi>S</mi><mo stretchy="false">)</mo></mrow></math> Suppression in Pb-Pb Collisions at the LHC

International audienceThe production of the ψ(2S) charmonium state was measured with ALICE in Pb-Pb collisions at sNN=5.02  TeV, in the dimuon decay channel. A significant signal was observed for the first time at LHC energies down to zero transverse momentum, at forward rapidity (2.5&lt;y&lt;4). The measurement of the ratio of the inclusive production cross sections of the ψ(2S) and J/ψ resonances is reported as a function of the centrality of the collisions and of transverse momentum, in the region pT&lt;12  GeV/c. The results are compared with the corresponding measurements in pp collisions, by forming the double ratio [σψ(2S)/σJ/ψ]Pb-Pb/[σψ(2S)/σJ/ψ]pp. It is found that in Pb-Pb collisions the ψ(2S) is suppressed by a factor of ∼2 with respect to the J/ψ. The ψ(2S) nuclear modification factor RAA was also obtained as a function of both centrality and pT. The results show that the ψ(2S) resonance yield is strongly suppressed in Pb-Pb collisions, by a factor of up to ∼3 with respect to pp. Comparisons of cross section ratios with previous Super Proton Synchrotron findings by the NA50 experiment and of RAA with higher-pT results at LHC energy are also reported. These results and the corresponding comparisons with calculations of transport and statistical models address questions on the presence and properties of charmonium states in the quark-gluon plasma formed in nuclear collisions at the LHC

Accessing the strong interaction between Λ baryons and charged kaons with the femtoscopy technique at the LHC

The interaction between Λ baryons and kaons/antikaons is a crucial ingredient for the strangeness S=0 and S=−2 sector of the meson–baryon interaction at low energies. In particular, the ΛK‾ might help in understanding the origin of states such as the Ξ(1620), whose nature and properties are still under debate. Experimental data on Λ–K and Λ–K‾ systems are scarce, leading to large uncertainties and tension between the available theoretical predictions constrained by such data. In this Letter we present the measurements of Λ–K⊕+Λ‾–K− and Λ–K⊕−Λ‾–K+ correlations obtained in the high-multiplicity triggered data sample in pp collisions at s=13 TeV recorded by ALICE at the LHC. The correlation function for both pairs is modeled using the Lednický–Lyuboshits analytical formula and the corresponding scattering parameters are extracted. The Λ–K⊕−Λ‾–K+ correlations show the presence of several structures at relative momenta k⁎ above 200 MeV/c, compatible with the Ω baryon, the Ξ(1690), and Ξ(1820) resonances decaying into Λ–K− pairs. The low k⁎ region in the Λ–K⊕−Λ‾–K+ also exhibits the presence of the Ξ(1620) state, expected to strongly couple to the measured pair. The presented data allow to access the ΛK+ and ΛK− strong interaction with an unprecedented precision and deliver the first experimental observation of the Ξ(1620) decaying into ΛK−

Production of pions, kaons, and protons as a function of the relative transverse activity classifier in pp collisions at s \sqrt{s} = 13 TeV

International audienceThe production of π$^{±}$, K$^{±}$, and $\left(\overline{\textrm{p}}\right)\textrm{p}$ is measured in pp collisions at $\sqrt{s}$ = 13 TeV in different topological regions of the events. Particle transverse momentum (p$_{T}$) spectra are measured in the “toward”, “transverse”, and “away” angular regions defined with respect to the direction of the leading particle in the event. While the toward and away regions contain the fragmentation products of the near-side and away-side jets, respectively, the transverse region is dominated by particles from the Underlying Event (UE). The relative transverse activity classifier, R$_{T}$ = N$_{T}$/〈N$_{T}$〉, is used to group events according to their UE activity, where N$_{T}$ is the measured charged-particle multiplicity per event in the transverse region and 〈N$_{T}$〉 is the mean value over all the analysed events. The first measurements of identified particle p$_{T}$ spectra as a function of R$_{T}$ in the three topological regions are reported. It is found that the yield of high transverse momentum particles relative to the R$_{T}$-integrated measurement decreases with increasing R$_{T}$ in both the toward and the away regions, indicating that the softer UE dominates particle production as R$_{T}$ increases and validating that R$_{T}$ can be used to control the magnitude of the UE. Conversely, the spectral shapes in the transverse region harden significantly with increasing R$_{T}$. This hardening follows a mass ordering, being more significant for heavier particles. Finally, it is observed that the p$_{T}$-differential particle ratios \left(\textrm{p}+\overline{\textrm{p}}\right)/\left({\uppi}^{+}+{\uppi}^{-}\right) and (K$^{+}$ + K$^{−}$)/(π$^{+}$ + π$^{−}$) in the low UE limit (R$_{T}$ → 0) approach expectations from Monte Carlo generators such as PYTHIA 8 with Monash 2013 tune and EPOS LHC, where the jet-fragmentation models have been tuned to reproduce e$^{+}$e$^{−}$ results.[graphic not available: see fulltext

Anisotropic flow and flow fluctuations of identified hadrons in Pb–Pb collisions at sNN \sqrt{s_{\textrm{NN}}} = 5.02 TeV

International audienceThe first measurements of elliptic flow of π$^{±}$, K$^{±}$, $\textrm{p}+\overline{\textrm{p}}$, ${\textrm{K}}_{\textrm{S}}^0$, $\Lambda +\overline{\Lambda}$, ϕ, ${\Xi}^{-}+{\overline{\Xi}}^{+}$, and ${\varOmega}^{-}+{\overline{\varOmega}}^{+}$ using multiparticle cumulants in Pb–Pb collisions at $\sqrt{s_{\textrm{NN}}}$ = 5.02 TeV are resented. Results obtained with two- (v$_{2}${2}) and four-particle cumulants (v$_{2}${4}) are shown as a function of transverse momentum, p$_{T}$, for various collision centrality intervals. Combining the data for both v$_{2}${2} and v$_{2}${4} also allows us to report the first measurements of the mean elliptic flow, elliptic flow fluctuations, and relative elliptic flow fluctuations for various hadron species. These observables probe the event-by-event eccentricity fluctuations in the initial state and the contributions from the dynamic evolution of the expanding quark–gluon plasma. The characteristic features observed in previous p$_{T}$-differential anisotropic flow measurements for identified hadrons with two-particle correlations, namely the mass ordering at low p$_{T}$ and the approximate scaling with the number of constituent quarks at intermediate p$_{T}$, are similarly present in the four-particle correlations and the combinations of v$_{2}${2} and v$_{2}${4}. In addition, a particle species dependence of flow fluctuations is observed that could indicate a significant contribution from final state hadronic interactions. The comparison between experimental measurements and CoLBT model calculations, which combine the various physics processes of hydrodynamics, quark coalescence, and jet fragmentation, illustrates their importance over a wide p$_{T}$ range.[graphic not available: see fulltext