183 research outputs found
The role of Background Independence for Asymptotic Safety in Quantum Einstein Gravity
We discuss various basic conceptual issues related to coarse graining flows
in quantum gravity. In particular the requirement of background independence is
shown to lead to renormalization group (RG) flows which are significantly
different from their analogs on a rigid background spacetime. The importance of
these findings for the asymptotic safety approach to Quantum Einstein Gravity
(QEG) is demonstrated in a simplified setting where only the conformal factor
is quantized. We identify background independence as a (the ?) key prerequisite
for the existence of a non-Gaussian RG fixed point and the renormalizability of
QEG.Comment: 2 figures. Talk given by M.R. at the WE-Heraeus-Seminar "Quantum
Gravity: Challenges and Perspectives", Bad Honnef, April 14-16, 2008; to
appear in General Relativity and Gravitatio
Casimir Effect on the Worldline
We develop a method to compute the Casimir effect for arbitrary geometries.
The method is based on the string-inspired worldline approach to quantum field
theory and its numerical realization with Monte-Carlo techniques. Concentrating
on Casimir forces between rigid bodies induced by a fluctuating scalar field,
we test our method with the parallel-plate configuration. For the
experimentally relevant sphere-plate configuration, we study curvature effects
quantitatively and perform a comparison with the ``proximity force
approximation'', which is the standard approximation technique. Sizable
curvature effects are found for a distance-to-curvature-radius ratio of a/R >~
0.02. Our method is embedded in renormalizable quantum field theory with a
controlled treatment of the UV divergencies. As a technical by-product, we
develop various efficient algorithms for generating closed-loop ensembles with
Gaussian distribution.Comment: 27 pages, 10 figures, Sect. 2.1 more self-contained, improved data
for Fig. 6, minor corrections, new Refs, version to be published in JHE
Perturbative Computation of the Gluonic Effective Action via Polyaokov's World-Line Path Integral
The Polyakov world-line path integral describing the propagation of gluon
field quanta is constructed by employing the background gauge fixing method and
is subsequently applied to analytically compute the divergent terms of the one
(gluonic) loop effective action to fourth order in perturbation theory. The
merits of the proposed approach is that, to a given order, it reduces to
performing two integrations, one over a set of Grassmann and one over a set of
Feynman-type parameters through which one manages to accomodate all Feynman
diagrams entering the computation at once.Comment: 21 page
On the Nature of the Phase Transition in SU(N), Sp(2) and E(7) Yang-Mills theory
We study the nature of the confinement phase transition in d=3+1 dimensions
in various non-abelian gauge theories with the approach put forward in [1]. We
compute an order-parameter potential associated with the Polyakov loop from the
knowledge of full 2-point correlation functions. For SU(N) with N=3,...,12 and
Sp(2) we find a first-order phase transition in agreement with general
expectations. Moreover our study suggests that the phase transition in E(7)
Yang-Mills theory also is of first order. We find that it is weaker than for
SU(N). We show that this can be understood in terms of the eigenvalue
distribution of the order parameter potential close to the phase transition.Comment: 15 page
Categorizing Different Approaches to the Cosmological Constant Problem
We have found that proposals addressing the old cosmological constant problem
come in various categories. The aim of this paper is to identify as many
different, credible mechanisms as possible and to provide them with a code for
future reference. We find that they all can be classified into five different
schemes of which we indicate the advantages and drawbacks.
Besides, we add a new approach based on a symmetry principle mapping real to
imaginary spacetime.Comment: updated version, accepted for publicatio
Effect of a selective nonsteroidal anti-inflammatory inhibitor of cyclooxygenase-2 on the small bowel of rats
An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types
The geology and geophysics of Kuiper Belt object (486958) Arrokoth
The Cold Classical Kuiper Belt, a class of small bodies in undisturbed orbits beyond Neptune, are primitive objects preserving information about Solar System formation. The New Horizons spacecraft flew past one of these objects, the 36 km long contact binary (486958) Arrokoth (2014 MU69), in January 2019. Images from the flyby show that Arrokoth has no detectable rings, and no satellites (larger than 180 meters diameter) within a radius of 8000 km, and has a lightly-cratered smooth surface with complex geological features, unlike those on previously visited Solar System bodies. The density of impact craters indicates the surface dates from the formation of the Solar System. The two lobes of the contact binary have closely aligned poles and equators, constraining their accretion mechanism
Effect of age, sex and gender on pain sensitivity: A narrative review
© 2017 Eltumi And Tashani. Introduction: An increasing body of literature on sex and gender differences in pain sensitivity has been accumulated in recent years. There is also evidence from epidemiological research that painful conditions are more prevalent in older people. The aim of this narrative review is to critically appraise the relevant literature investigating the presence of age and sex differences in clinical and experimental pain conditions. Methods: A scoping search of the literature identifying relevant peer reviewed articles was conducted on May 2016. Information and evidence from the key articles were narratively described and data was quantitatively synthesised to identify gaps of knowledge in the research literature concerning age and sex differences in pain responses. Results: This critical appraisal of the literature suggests that the results of the experimental and clinical studies regarding age and sex differences in pain contain some contradictions as far as age differences in pain are concerned. While data from the clinical studies are more consistent and seem to point towards the fact that chronic pain prevalence increases in the elderly findings from the experimental studies on the other hand were inconsistent, with pain threshold increasing with age in some studies and decreasing with age in others. Conclusion: There is a need for further research using the latest advanced quantitative sensory testing protocols to measure the function of small nerve fibres that are involved in nociception and pain sensitivity across the human life span. Implications: Findings from these studies should feed into and inform evidence emerging from other types of studies (e.g. brain imaging technique and psychometrics) suggesting that pain in the older humans may have unique characteristics that affect how old patients respond to intervention
Non-minimal coupling of the scalar field and inflation
We study the prescriptions for the coupling constant of a scalar field to the
Ricci curvature of spacetime in specific gravity and scalar field theories. The
results are applied to the most popular inflationary scenarios of the universe;
their theoretical consistency and certain observational constraints are
discussed.Comment: 23 pages, LaTex, no figures, to appear in Physical Review
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