Habituation is not neutral or equal: Individual differences in tolerance suggest an overlooked personality trait

In behavioral studies, observer effects can be substantial, even for habituated animals, but few studies account for potential observer-related phenomenon empirically. We used wild, habituated chacma baboons to explore two key assumptions of behavioral ecology (i) that observers become a “neutral” stimulus and (ii) that habituation is “equal” across group members. Using flight initiation distance (FID) methods within a personality paradigm, the behavioral responses of baboons suggested that observers were not perceived as neutral but instead viewed as a high-ranking social threat. Habituation was also not equal across group members, with repeatable individual differences more important than contextual factors (e.g., habitat) in determining the distance at which baboons visually oriented or displaced from observers. A strong correlation between individual visual tolerance and displacement tolerance (i.e., convergent validity) indicated a personality trait. We offer several suggestions for how to account for these factors and minimize potential bias in future studies

Monkey-based Research on Human Disease: The Implications of Genetic Differences

Assertions that the use of monkeys to investigate human diseases is valid scientifically are frequently based on a reported 90–93% genetic similarity between the species. Critical analyses of the relevance of monkey studies to human biology, however, indicate that this genetic similarity does not result in sufficient physiological similarity for monkeys to constitute good models for research, and that monkey data do not translate well to progress in clinical practice for humans. Salient examples include the failure of new drugs in clinical trials, the highly different infectivity and pathology of SIV/HIV, and poor extrapolation of research on Alzheimer’s disease, Parkinson’s disease and stroke. The major molecular differences underlying these inter-species phenotypic disparities have been revealed by comparative genomics and molecular biology — there are key differences in all aspects of gene expression and protein function, from chromosome and chromatin structure to post-translational modification. The collective effects of these differences are striking, extensive and widespread, and they show that the superficial similarity between human and monkey genetic sequences is of little benefit for biomedical research. The extrapolation of biomedical data from monkeys to humans is therefore highly unreliable, and the use of monkeys must be considered of questionable value, particularly given the breadth and potential of alternative methods of enquiry that are currently available to scientists

Fitness declines toward range limits and local adaptation to climate affect dispersal evolution during climate-induced range shifts

Sherpa Romeo yellow journal (pre-print only, accepted for publication)Dispersal ability will largely determine whether species track their climatic niches during climate change, a process especially important for populations at contracting (low-­latitude/low-­elevation) range limits that otherwise risk extinction. We investigate whether dispersal evolution at contracting range limits is facilitated by two processes that potentially enable edge populations to experience and adjust to the effects of climate deterioration before they cause extinction: a) climate-­‐induced fitness declines toward range limits, and b) local adaptation to a shifting climate gradient. We simulate a species distributed continuously along a temperature gradient using a spatially explicit, individual-­‐ based model. We compare range-­‐wide dispersal evolution during climate stability vs. directional climate change, with uniform fitness vs. fitness that declines toward range limits (RLs), and for a single climate genotype vs. multiple genotypes locally adapted to temperature. Dispersal decreased toward stable RLs when range-­‐wide fitness was uniform, but increased when fitness declined toward RLs, due to highly dispersive genotypes maintaining sink populations at RLs, increased kin selection in smaller populations, and an emergent fitness asymmetry that favoured dispersal in low-­‐quality habitat. However, this initial dispersal advantage at low-­‐fitness RLs did not facilitate climate tracking, as it was outweighed by an increased probability of extinction. Locally-­‐adapted genotypes benefited from staying close to their climate optima; this selected against dispersal under stable climates but for increased dispersal throughout shifting ranges, compared to cases without local adaptation. Dispersal increased at expanding RLs in most scenarios, but only increased at the range centre and contracting RLs given local adaptation to climate

Are ultracompact minihalos really ultracompact?

Ultracompact minihalos (UCMHs) have emerged as a valuable probe of the primordial power spectrum of density fluctuations at small scales. UCMHs are expected to form at early times in regions with δρ/ρ≳10-3, and they are theorized to possess an extremely compact ρ∞r-9/4 radial density profile, which enhances their observable signatures. Nonobservation of UCMHs can thus constrain the primordial power spectrum. Using N-body simulations to study the collapse of extreme density peaks at z≃1000, we show that UCMHs forming under realistic conditions do not develop the ρ∞r-9/4 profile and instead develop either ρ∞r-3/2 or ρ∞r-1 inner density profiles depending on the shape of the power spectrum. We also demonstrate via idealized simulations that self-similarity - the absence of a scale length - is necessary to produce a halo with the ρ∞r-9/4 profile, and we argue that this implies such halos cannot form from a Gaussian primordial density field. Prior constraints derived from UCMH nonobservation must be reworked in light of this discovery. Although the shallower density profile reduces UCMH visibility, our findings reduce their signal by as little as O(10-2) while allowing later-forming halos to be considered, which suggests that new constraints could be significantly stronger

Density profiles of ultracompact minihalos: Implications for constraining the primordial power spectrum

Enhanced density fluctuations on small scales would lead to the formation of numerous dark matter minihalos, so limits on the minihalo abundance can place upper bounds on the small-scale primordial power spectrum. In particular, the ultracompact minihalo (UCMH), a dark matter structure hypothesized to possess a r-9/4 density profile due to its formation at z≥1000, has been used to establish an upper bound on the primordial power spectrum at scales smaller than 2 Mpc. The extreme slope of this density profile amplifies the observational signals of UCMHs. However, we recently showed via N-body simulations that the r-9/4 density profile does not develop in realistic formation scenarios, throwing UCMH-derived power spectrum constraints into question. Instead, minihalos develop shallower inner profiles with power-law indices between -3/2 and -1. In this paper, we expand on that result and discuss its implications. Using a model that is calibrated to simulation results and predicts halo structures in spiked power spectra based on their formation times, we calculate new upper bounds on the primordial power spectrum based on limits on the dark matter annihilation rate within the Galaxy. We find that despite assuming shallower profiles, this minihalo model actually yields stronger constraints than the previous UCMH picture owing to its inclusion of all minihalos instead of only the earliest-forming ones

First integrals of Ginzburg-Landau equations and stability criteria for vortex-free state in unconventional superconductors

The first integrals of the Ginzburg-Landau equations for a vortex-free state of superconductors with different mixed symmetries of the order parameter are found. The general boundary conditions for the order parameter at the ideal interface between the superconductor and vacuum are derived. Based on these integrals and boundary conditions, we analyze the stability criteria for vortex-free state in unconventional superconductors. The threshold field above which the Abrikosov vortices can enter the superconductor is found to be higher or equal to the thermodynamic critical field for all states under study.Comment: 8 pages, pdf file, no figure

An Anglo-Saxon execution cemetery at Walkington Wold, Yorkshire

This paper presents a re-evaluation of a cemetery excavated over 30 years ago at Walkington Wold in east Yorkshire. The cemetery is characterized by careless burial on diverse alignments, and by the fact that most of the skeletons did not have associated crania. The cemetery has been variously described as being the result of an early post-Roman massacre, as providing evidence for a ‘Celtic’ head cult or as an Anglo-Saxon execution cemetery. In order to resolve the matter, radiocarbon dates were acquired and a re-examination of the skeletal remains was undertaken. It was confirmed that the cemetery was an Anglo-Saxon execution cemetery, the only known example from northern England, and the site is set into its wider context in the paper

T-bet controls intestinal mucosa immune responses via repression of type 2 innate lymphoid cell function

Innate lymphoid cells (ILCs) play an important role in regulating immune responses at mucosal surfaces. The transcription factor T-bet is crucial for the function of ILC1s and NCR+ ILC3s and constitutive deletion of T-bet prevents the development of these subsets. Lack of T-bet in the absence of an adaptive immune system causes microbiota-dependent colitis to occur due to aberrant ILC3 responses. Thus, T-bet expression in the innate immune system has been considered to dampen pathogenic immune responses. Here, we show that T-bet plays an unexpected role in negatively regulating innate type 2 responses, in the context of an otherwise intact immune system. Selective loss of T-bet in ILCs leads to the expansion and increased activity of ILC2s, which has a functionally important impact on mucosal immunity, including enhanced protection from Trichinella spiralis infection and inflammatory colitis. Mechanistically, we show that T-bet controls the intestinal ILC pool through regulation of IL-7 receptor signalling. These data demonstrate that T-bet expression in ILCs acts as the key transcriptional checkpoint in regulating pathogenic vs. protective mucosal immune responses, which has significant implications for the understanding of the pathogenesis of inflammatory bowel diseases and intestinal infections

Low-diffusion Xe-He gas mixtures for rare-event detection: electroluminescence yield

High pressure xenon Time Projection Chambers (TPC) based on secondary scintillation (electroluminescence) signal amplification are being proposed for rare event detection such as directional dark matter, double electron capture and double beta decay detection. The discrimination of the rare event through the topological signature of primary ionisation trails is a major asset for this type of TPC when compared to single liquid or double-phase TPCs, limited mainly by the high electron diffusion in pure xenon. Helium admixtures with xenon can be an attractive solution to reduce the electron diffu- sion significantly, improving the discrimination efficiency of these optical TPCs. We have measured the electroluminescence (EL) yield of Xe–He mixtures, in the range of 0 to 30% He and demonstrated the small impact on the EL yield of the addition of helium to pure xenon. For a typical reduced electric field of 2.5 kV/cm/bar in the EL region, the EL yield is lowered by ∼ 2%, 3%, 6% and 10% for 10%, 15%, 20% and 30% of helium concentration, respectively. This decrease is less than what has been obtained from the most recent simulation framework in the literature. The impact of the addition of helium on EL statistical fluctuations is negligible, within the experimental uncertainties. The present results are an important benchmark for the simulation tools to be applied to future optical TPCs based on Xe-He mixtures. [Figure not available: see fulltext.]