Probe-configuration dependent dephasing in a mesoscopic interferometer

Dephasing in a ballistic four-terminal Aharonov-Bohm geometry due to charge and voltage fluctuations is investigated. Treating two terminals as voltage probes, we find a strong dependence of the dephasing rate on the probe configuration in agreement with a recent experiment by Kobayashi et al. (J. Phys. Soc. Jpn. 71, 2094 (2002)). Voltage fluctuations in the measurement circuit are shown to be the source of the configuration dependence.Comment: 4 pages, 3 figure

Sedimentary ancient DNA from Lake Skartjorna, Svalbard: assessing the resilience of arctic flora to Holocene climate change

Reconstructing past vegetation and species diversity from arctic lake sediments can be challenging because of low pollen and plant macrofossil concentrations. Information may be enhanced by metabarcoding of sedimentary ancient DNA (sedaDNA). We developed a Holocene record from Lake Skartjørna, Svalbard, using sedaDNA, plant macrofossils and sediment properties, and compared it with published records. All but two genera of vascular plants identified as macrofossils in this or a previous study were identified with sedaDNA. Six additional vascular taxa were found, plus two algal and 12 bryophyte taxa, by sedaDNA analysis, which also detected more species per sample than macrofossil analysis. A shift from Salix polaris-dominated vegetation, with Koenigia islandica, Ranunculaceae and the relatively thermophilic species Arabis alpina and Betula, to Dryas octopetala-dominated vegetation ~6600–5500 cal. BP suggests a transition from moist conditions 1–2°C warmer than today to colder/drier conditions. This coincides with a decrease in runoff, inferred from core lithology, and an independent record of declining lacustrine productivity. This mid-Holocene change in terrestrial vegetation is broadly coincident with changes in records from marine sediments off the west coast of Svalbard. Over the Holocene sedaDNA records little floristic change, and it clearly shows species persisted near the lake during time intervals when they are not detected as macrofossils. The flora has shown resilience in the presence of a changing climate, and, if future warming is limited to 2°C or less, we might expect only minor floristic changes in this region. However, the Holocene record provides no analogues for greater warming

Perfluorooctane sulfonate concentrations in amniotic fluid, biomarkers of fetal Leydig cell function, and cryptorchidism and hypospadias in Danish boys (1980–1996)

Background: Exposure to perfluorooctane sulfonate (PFOS) may potentially disturb fetal Leydig cell hormone production and male genital development. Objectives: We aimed to study the associations between levels of amniotic fluid PFOS, fetal steroid hormone, and insulin-like factor 3 (INSL3) and the prevalence of cryptorchidism and hypospadias. Methods: Using the Danish National Patient Registry, we selected 270 cryptorchidism cases,75 hypospadias cases, and 300 controls with stored maternal amniotic fluid samples available in a Danish pregnancy-screening biobank (1980–1996). We used mass spectrometry to measure PFOS in amniotic fluid from 645 persons and steroid hormones in samples from 545 persons. INSL3 was measured by immunoassay from 475 persons. Associations between PFOS concentration in amniotic fluid, hormone levels, and genital malformations were assessed by confounder-adjusted linear and logistic regression. Results: The highest tertile of PFOS exposure (> 1.4 ng/mL) in amniotic fluid was associated with a 40% (95% CI: –69, –11%) lower INSL3 level and an 18% (95% CI: 7, 29%) higher testosterone level compared with the lowest tertile (< 0.8 ng/mL). Amniotic fluid PFOS concentration was not associated with cryptorchidism or hypospadias. Conclusions: Environmental PFOS exposure was associated with steroid hormone and INSL3 concentrations in amniotic fluid, but was not associated with cryptorchidism or hypospadias in our study population. Additional studies are needed to determine whether associations with fetal hormone levels may have long-term implications for reproductive health

Phthalates and Perfluorooctanesulfonic Acid in Human Amniotic Fluid: Temporal Trends and Timing of Amniocentesis in Pregnancy

Background: Measures of prenatal environmental exposures are important, and amniotic fluid levels may directly reflect fetal exposures during hypothesized windows of vulnerability

Shallow structure beneath the Central Volcanic Complex of Tenerife from new gravity data: implications for its evolution and recent reactivation

We present a new local Bouguer anomaly map of the Central Volcanic Complex (CVC) of Tenerife, Spain, constructed from the amalgamation of 323 new high precision gravity measurements with existing gravity data from 361 observations. The new anomaly map images the high-density core of the CVC and the pronounced gravity low centred in the Las Cañadas caldera in greater detail than previously available. Mathematical construction of a sub-surface model from the local anomaly data, employing a 3D inversion based on 'growing' the sub-surface density distribution via the aggregation of cells, enables mapping of the shallow structure beneath the complex, giving unprecedented insights into the sub-surface architecture. We find the resultant density distribution in agreement with geological and other geophysical data. The modelled sub-surface structure supports a vertical collapse origin of the caldera, and maps the headwall of the ca. 180 ka Icod landslide, which appears to lie buried beneath the Pico Viejo–Pico Teide stratovolcanic complex. The results allow us to put into context the recorded ground deformation and gravity changes at the CVC during its reactivation in spring 2004 in relation to its dominant structural building blocks. For example, the areas undergoing the most significant changes at depth in recent years are underlain by low-density material and are aligned along long-standing structural entities, which have shaped this volcanic ocean island over the past few million years

Promoter Sequences Prediction Using Relational Association Rule Mining

In this paper we are approaching, from a computational perspective, the problem of promoter sequences prediction, an important problem within the field of bioinformatics. As the conditions for a DNA sequence to function as a promoter are not known, machine learning based classification models are still developed to approach the problem of promoter identification in the DNA. We are proposing a classification model based on relational association rules mining. Relational association rules are a particular type of association rules and describe numerical orderings between attributes that commonly occur over a data set. Our classifier is based on the discovery of relational association rules for predicting if a DNA sequence contains or not a promoter region. An experimental evaluation of the proposed model and comparison with similar existing approaches is provided. The obtained results show that our classifier overperforms the existing techniques for identifying promoter sequences, confirming the potential of our proposal

Limits of the dynamical approach to non-linear response of mesoscopic systems

We have considered the nonlinear response of mesoscopic systems of non-interacting electrons to the time-dependent external field. In this consideration the inelastic processes have been neglected and the electron thermalization occurs due to the electron exchange with the reservoirs. We have demonstrated that the diagrammatic technique based on the method of analytical continuation or on the Keldysh formalism is capable to describe the heating automatically. The corresponding diagrams contain a novel element, {\it the loose diffuson}. We have shown the equivalence of such a diagrammatic technique to the solution to the kinetic equation for the electron energy distribution function. We have identified two classes of problems with different behavior under ac pumping. In one class of problems (persistent current fluctuations, Kubo conductance) the observable depends on the electron energy distribution renormalized by heating. In another class of problems (Landauer conductance) the observable is insensitive to heating and depends on the temperature of electron reservoirs. As examples of such problems we have considered in detail the persistent current fluctuations under ac pumping and two types of conductance measurements (Landauer conductance and Kubo conductance) that behave differently under ac pumping.Comment: 21 pages, RevTex, 10 eps.figures; final version to appear in Phys.Rev.

Continuous Spectrum of Automorphism Groups and the Infraparticle Problem

This paper presents a general framework for a refined spectral analysis of a group of isometries acting on a Banach space, which extends the spectral theory of Arveson. The concept of continuous Arveson spectrum is introduced and the corresponding spectral subspace is defined. The absolutely continuous and singular-continuous parts of this spectrum are specified. Conditions are given, in terms of the transposed action of the group of isometries, which guarantee that the pure-point and continuous subspaces span the entire Banach space. In the case of a unitarily implemented group of automorphisms, acting on a $C^*$-algebra, relations between the continuous spectrum of the automorphisms and the spectrum of the implementing group of unitaries are found. The group of spacetime translation automorphisms in quantum field theory is analyzed in detail. In particular, it is shown that the structure of its continuous spectrum is relevant to the problem of existence of (infra-)particles in a given theory.Comment: 31 pages, LaTeX. As appeared in Communications in Mathematical Physic

Xenoandrogenic Activity in Serum Differs across European and Inuit Populations

Background: Animal and in vitro studies have indicated that human male reproductive disorders can arise as a result of disrupted androgen receptor (AR) signalling by persistent organic pollutants (POPs) . Our aim in the present study was to compare serum xenoandrogenic activity between study groups with different POP exposures and to evaluate correlations to the POP proxy markers 2,2\ub4,4,4\ub4,5,5\ub4-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl) -ethylene (p,p\ub4-DDE) .Methods: We determined xenoandrogenic activity in the serum fraction containing the lipophilic POPs but free of endogenous hormones. Adult male serum (n = 261) from Greenland, Sweden, Warsaw (Poland) , and Kharkiv (Ukraine) was analyzed. Xenoandrogenic activity was determined as the effect of serum extract alone (XAR) and in the presence of the synthetic AR agonist R1881 (XARcomp) on AR transactivated luciferase activity.Results: The study groups differed significantly with respect to XARcomp activity, which was increased in the Inuits and decreased in the European study groups ; we observed no difference for XAR activity. We found the highest level of the AR antagonist p,p\ub4-DDE in Kharkiv, and accordingly, this study group showed the highest percent of serum samples with decreased XARcomp activities. Furthermore, the percentage of serum samples with decreased XARcomp activities followed the p,p\ub4-DDE serum level for the European study groups. No correlations between serum XAR or XARcomp activities and the two POP markers were revealed.Conclusions: The differences in XARcomp serum activity between the study groups suggest differences in chemical exposure profiles, genetics, and/or lifestyle factors

Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene

Previously, we have shown that a mutation in the mitochondrial DNA-encoded tRNA(Leu(UUR)) gene is associated with type 2 diabetes. One of the consequences of this mutation is a reduced aminoacylation of tRNA(Leu(UUR)). In this study, we have examined whether variants in the leucyl tRNA synthetase gene (LARS2), involved in aminoacylation of tRNA(Leu(UUR)), associate with type 2 diabetes. Direct sequencing of LARS2 cDNA from 25 type 2 diabetic subjects revealed eight single nucleotide polymorphisms. Two of the variants were examined in 7,836 subjects from four independent populations in the Netherlands and Denmark. A -109 g/a variant was not associated with type 2 diabetes. Allele frequencies for the other variant, H324Q, were 3.5% in type 2 diabetic and 2.7% in control subjects, respectively. The common odds ratio across all four studies was 1.40 (95% CI 1.12-1.76), P = 0.004. There were no significant differences in clinical variables between carriers and noncarriers. In this study, we provide evidence that the LARS2 gene may represent a novel type 2 diabetes susceptibility gene. The mechanism by which the H324Q variant enhances type 2 diabetes risk needs to be further established. This is the first report of association between an aminoacyl tRNA synthetase gene and disease. Our results further highlight the important role of mitochondria in glucose homeostasis