Winter Shrouds Her Resting Place With Snow

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Pretreatment with beta-blockers and the frequency of hypokalemia in patients with acute chest pain

Plasma potassium concentration was measured at admission in 1234 patients who presented with acute chest pain. One hundred and ninety five patients were on P blockers before admission. The potassium concentrations of patients admitted early (within four hours of onsetof symptoms) were compared with those admitted later (4-18 hours after onset of symptoms). There was a transient fall in plasma potassium concentrations in patients not pre-treated with , B blockers. This was not seen in patients who had been on P blockers before admission. Nonselective, B blockers were more effective than cardioselective agents in maintaining concentrationsof plasma potassium. These findings suggest a mechanism for the beneficial effects of ,B blockers on morbidity and mortality in acute myocardial infarction

The non-forward BFKL amplitude and rapidity gap physics

We discuss the BFKL approach to processes with large momentum transferred through a rapidity gap. The Mueller and Tang scheme to the BFKL non-forward parton-parton elastic scattering amplitude at large $t$, is extended to include higher conformal spins. The new contributions are found to decrease with increasing energy, as follows from the gluon reggeisation phenomenon, and to vanish for asymptotically high energies. However, at moderate energies and high $|t|$, the higher conformal spins dominate the amplitude. We illustrate the effects by studying the production of two high $E_T$ jets separated by a rapidity gap at HERA energies. In a simplified framework, we find excellent agreement with the HERA photoproduction data once we incorporate the rapidity gap survival probability against soft rescattering effects. We emphasize that measurements of the analogous process in electroproduction may probe different summations over conformal spins.Comment: Latex, 14 pages, 3 figures; the final version to appear in Phys. Lett. B; a short discussion of the Tevatron data added; a previously missing factor of i^n introduced in eq. (13

The small-scale manufacture of compound animal feed (ODNRI Bulletin No. 9)

This bulletin supersedes TDRI report G67 The small-scale manufacture of compound animal feed, which was first published in 1971. lt retains a similar format to G67, but the text has been extensively revised and expanded in the light of numerous enquiries dealt with by ODNRI on all aspects of feed production in the intervening years. lt is hoped that it will act as a technical and investment guide for those interested in initiating the production of compound animal feeds, as well as acting as a useful reference report for those already actively operating in this field. Chapter 1 describes the economic background to the industry; theoretical aspects of animal nutrition are dealt with in Chapter 2; these are related to the properties of the various raw materials used in feed production in Chapter 3. Chapter 4 describes the manufacturing process and examines the physical requirements for setting up plants at various scales of output, and Chapter 5 develops cost and return models for the plants described

Picturing classical and quantum Bayesian inference

We introduce a graphical framework for Bayesian inference that is sufficiently general to accommodate not just the standard case but also recent proposals for a theory of quantum Bayesian inference wherein one considers density operators rather than probability distributions as representative of degrees of belief. The diagrammatic framework is stated in the graphical language of symmetric monoidal categories and of compact structures and Frobenius structures therein, in which Bayesian inversion boils down to transposition with respect to an appropriate compact structure. We characterize classical Bayesian inference in terms of a graphical property and demonstrate that our approach eliminates some purely conventional elements that appear in common representations thereof, such as whether degrees of belief are represented by probabilities or entropic quantities. We also introduce a quantum-like calculus wherein the Frobenius structure is noncommutative and show that it can accommodate Leifer's calculus of `conditional density operators'. The notion of conditional independence is also generalized to our graphical setting and we make some preliminary connections to the theory of Bayesian networks. Finally, we demonstrate how to construct a graphical Bayesian calculus within any dagger compact category.Comment: 38 pages, lots of picture

Local time and the pricing of time-dependent barrier options

A time-dependent double-barrier option is a derivative security that delivers the terminal value $\phi(S_T)$ at expiry $T$ if neither of the continuous time-dependent barriers b_\pm:[0,T]\to \RR_+ have been hit during the time interval $[0,T]$. Using a probabilistic approach we obtain a decomposition of the barrier option price into the corresponding European option price minus the barrier premium for a wide class of payoff functions $\phi$, barrier functions $b_\pm$ and linear diffusions $(S_t)_{t\in[0,T]}$. We show that the barrier premium can be expressed as a sum of integrals along the barriers $b_\pm$ of the option's deltas \Delta_\pm:[0,T]\to\RR at the barriers and that the pair of functions $(\Delta_+,\Delta_-)$ solves a system of Volterra integral equations of the first kind. We find a semi-analytic solution for this system in the case of constant double barriers and briefly discus a numerical algorithm for the time-dependent case.Comment: 32 pages, to appear in Finance and Stochastic

Engineering threshold-based selection systems

Using model organisms to identify novel therapeutic targets is frequently constrained by pre-existing genetic toolkits. To expedite positive selection for identification of novel downstream effectors, we engineered conditional expression of activated CED-10/Rac to disrupt Caenorhabditis elegans embryonic morphogenesis, titrated to 100% lethality. The strategy of engineering thresholds for positive selection using experimental animals was validated with pharmacological and genetic suppression and is generalizable to diverse molecular processes and experimental systems

Questions of fairness and anti-doping in US cycling: The contrasting experiences of professionals and amateurs

The focus of researchers, media and policy on doping in cycling is often limited to the professional level of the sport. However, anti-doping test results since 2001 demonstrate that banned substances are also used by US cyclists at lower levels of the sport, necessitating a broader view of the patterns and motivations of substance use within the sport. In this article, we describe and explain the doping culture that has emerged in domestic US cycling among amateur and semi-professionals. Through analysis of records from sports governing bodies and journalistic reports, we assess the range of violation types and discuss the detection and punishing of riders who were not proven to have intended to cheat but became "collateral damage" in the war on doping. We argue that the phenomenon of doping is more complex than what has been shown to occur in elite sport, as it includes a wider variety of behaviours, situations and motivations. We develop fresh insights by examining cases where doping has been accidental, intrinsically motivated, non-performance enhancing or the result of prescribed medical treatments banned by anti-doping authorities. Such trends call into question the fairness of anti-doping measures, and we discuss the possibility of developing localised solutions to testing and sanctioning amateur athletes

An ALMA survey of submillimetre galaxies in the Extended Chandra Deep Field-South: detection of [C II] at z = 4.4

We present Atacama Large Millimeter Array (ALMA) 870-μm (345-GHz) observations of two submillimetre galaxies (SMGs) drawn from an ALMA study of the 126 submillimetre sources from the LABOCA Extended Chandra Deep Field-South Survey (LESS). The ALMA data identify the counterparts to these previously unidentified submillimetre sources and serendipitously detect bright emission lines in their spectra which we show are most likely to be [CII] 157.74 μm emission yielding redshifts of z = 4.42 and 4.44. This blind detection rate within the 7.5-GHz bandpass of ALMA is consistent with the previously derived photometric redshift distribution of SMGs and suggests a modest, but not dominant (≲25 per cent), tail of 870-μm selected SMGs at z ≳ 4. We find that the ratio of L[C II]/LFIR in these SMGs is much higher than seen for similarly far-infrared-luminous galaxies at z ˜ 0, which is attributed to the more extended gas reservoirs in these high-redshift ultraluminous infrared galaxies (ULIRGs). Indeed, in one system we show that the [C II] emission shows hints of extended emission on ≳ 3 kpc scales. Finally, we use the volume probed by our ALMA survey to show that the bright end of the [C II] luminosity function evolves strongly between z = 0 and ˜4.4, reflecting the increased interstellar medium cooling in galaxies as a result of their higher star formation rates. These observations demonstrate that even with short integrations, ALMA is able to detect the dominant fine-structure cooling lines from high-redshift ULIRGs, measure their energetics and spatially resolved properties and trace their evolution with redshift