706 research outputs found
Decoherentie in een neutron interferentie experiment : een onderzoek met behulp van positieve operator waardige maten
Radiation-induced oscillatory magnetoresistance as a sensitive probe of the zero-field spin splitting in high mobility GaAs/AlGaAs devices
We suggest an approach for characterizing the zero-field spin splitting of
high mobility two-dimensional electron systems, when beats are not readily
observable in the Shubnikov-de Haas effect. The zero-field spin splitting and
the effective magnetic field seen in the reference frame of the electron is
evaluated from a quantitative study of beats observed in radiation-induced
magnetoresistance oscillations.Comment: 4 pages, 4 color figure
Helioseismology of Sunspots: A Case Study of NOAA Region 9787
Various methods of helioseismology are used to study the subsurface
properties of the sunspot in NOAA Active Region 9787. This sunspot was chosen
because it is axisymmetric, shows little evolution during 20-28 January 2002,
and was observed continuously by the MDI/SOHO instrument. (...) Wave travel
times and mode frequencies are affected by the sunspot. In most cases, wave
packets that propagate through the sunspot have reduced travel times. At short
travel distances, however, the sign of the travel-time shifts appears to depend
sensitively on how the data are processed and, in particular, on filtering in
frequency-wavenumber space. We carry out two linear inversions for wave speed:
one using travel-times and phase-speed filters and the other one using mode
frequencies from ring analysis. These two inversions give subsurface wave-speed
profiles with opposite signs and different amplitudes. (...) From this study of
AR9787, we conclude that we are currently unable to provide a unified
description of the subsurface structure and dynamics of the sunspot.Comment: 28 pages, 18 figure
Electron spin as a spectrometer of nuclear spin noise and other fluctuations
This chapter describes the relationship between low frequency noise and
coherence decay of localized spins in semiconductors. Section 2 establishes a
direct relationship between an arbitrary noise spectral function and spin
coherence as measured by a number of pulse spin resonance sequences. Section 3
describes the electron-nuclear spin Hamiltonian, including isotropic and
anisotropic hyperfine interactions, inter-nuclear dipolar interactions, and the
effective Hamiltonian for nuclear-nuclear coupling mediated by the electron
spin hyperfine interaction. Section 4 describes a microscopic calculation of
the nuclear spin noise spectrum arising due to nuclear spin dipolar flip-flops
with quasiparticle broadening included. Section 5 compares our explicit
numerical results to electron spin echo decay experiments for phosphorus doped
silicon in natural and nuclear spin enriched samples.Comment: Book chapter in "Electron spin resonance and related phenomena in low
dimensional structures", edited by Marco Fanciulli. To be published by
Springer-Verlag in the TAP series. 35 pages, 9 figure
TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome
G-protein-coupled receptors (GPCRs) remain major drug targets, despite our incomplete understanding of how they signal through 16 non-visual G-protein signal transducers (collectively named the transducerome) to exert their actions. To address this gap, we have developed an open-source suite of 14 optimized bioluminescence resonance energy transfer (BRET) Gαβγ biosensors (named TRUPATH) to interrogate the transducerome with single pathway resolution in cells. Generated through exhaustive protein engineering and empirical testing, the TRUPATH suite of Gαβγ biosensors includes the first Gα15 and GαGustducin probes. In head-to-head studies, TRUPATH biosensors outperformed first-generation sensors at multiple GPCRs and in different cell lines. Benchmarking studies with TRUPATH biosensors recapitulated previously documented signaling bias and revealed new coupling preferences for prototypic and understudied GPCRs with potential in vivo relevance. To enable a greater understanding of GPCR molecular pharmacology by the scientific community, we have made TRUPATH biosensors easily accessible as a kit through Addgene
Dual action antifungal small molecule modulates multidrug efflux and TOR signaling.
There is an urgent need for new strategies to treat invasive fungal infections, which are a leading cause of human mortality. Here, we establish two activities of the natural product beauvericin, which potentiates the activity of the most widely deployed class of antifungal against the leading human fungal pathogens, blocks the emergence of drug resistance, and renders antifungal-resistant pathogens responsive to treatment in mammalian infection models. Harnessing genome sequencing of beauvericin-resistant mutants, affinity purification of a biotinylated beauvericin analog, and biochemical and genetic assays reveals that beauvericin blocks multidrug efflux and inhibits the global regulator TORC1 kinase, thereby activating the protein kinase CK2 and inhibiting the molecular chaperone Hsp90. Substitutions in the multidrug transporter Pdr5 that enable beauvericin efflux impair antifungal efflux, thereby impeding resistance to the drug combination. Thus, dual targeting of multidrug efflux and TOR signaling provides a powerful, broadly effective therapeutic strategy for treating fungal infectious disease that evades resistance
Fermentation and nutritive value of silage and hay made from the aerial part of cassava (Manihot esculenta Crantz)
Modeling the Subsurface Structure of Sunspots
While sunspots are easily observed at the solar surface, determining their
subsurface structure is not trivial. There are two main hypotheses for the
subsurface structure of sunspots: the monolithic model and the cluster model.
Local helioseismology is the only means by which we can investigate
subphotospheric structure. However, as current linear inversion techniques do
not yet allow helioseismology to probe the internal structure with sufficient
confidence to distinguish between the monolith and cluster models, the
development of physically realistic sunspot models are a priority for
helioseismologists. This is because they are not only important indicators of
the variety of physical effects that may influence helioseismic inferences in
active regions, but they also enable detailed assessments of the validity of
helioseismic interpretations through numerical forward modeling. In this paper,
we provide a critical review of the existing sunspot models and an overview of
numerical methods employed to model wave propagation through model sunspots. We
then carry out an helioseismic analysis of the sunspot in Active Region 9787
and address the serious inconsistencies uncovered by
\citeauthor{gizonetal2009}~(\citeyear{gizonetal2009,gizonetal2009a}). We find
that this sunspot is most probably associated with a shallow, positive
wave-speed perturbation (unlike the traditional two-layer model) and that
travel-time measurements are consistent with a horizontal outflow in the
surrounding moat.Comment: 73 pages, 19 figures, accepted by Solar Physic
Measurement of and charged current inclusive cross sections and their ratio with the T2K off-axis near detector
We report a measurement of cross section and the first measurements of the cross section
and their ratio
at (anti-)neutrino energies below 1.5
GeV. We determine the single momentum bin cross section measurements, averaged
over the T2K -flux, for the detector target material (mainly
Carbon, Oxygen, Hydrogen and Copper) with phase space restricted laboratory
frame kinematics of 500 MeV/c. The
results are and $\sigma(\nu)=\left( 2.41\
\pm0.022{\rm{(stat.)}}\pm0.231{\rm (syst.)}\ \right)\times10^{-39}^{2}R\left(\frac{\sigma(\bar{\nu})}{\sigma(\nu)}\right)=
0.373\pm0.012{\rm (stat.)}\pm0.015{\rm (syst.)}$.Comment: 18 pages, 8 figure
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