19 research outputs found
Variation and Association among Postpartum Reproduction and Production Characteristics in Holstein-Friesian Cattle
Some Factors Affecting Age at Puberty and the First 90 Days of Lactation in Holstein Heifers
Antinociceptive activity of furan-containing congeners of improgan and ranitidine
Furan-containing congeners of the histamine H(2) receptor antagonist ranitidine were synthesized and tested for improgan-like antinociceptive activity. The most potent ligand of the series, VUF5498, is the most potent improgan-like agent described to date (ED(50)= 25 nmol, icv). This compound is approximately equal in potency with morphine. These non-imidazole, improgan-like pain relievers further define the structural requirements for analgesics of this class and are important tools for ongoing mechanism-based studies