Current issues relating to artificial reefs in European seas

European artificial reef research has now been active for about three decades. For much of that time research has been conducted within national programmes, focussing on national or local issues, and has taken place predominately in the Mediterranean Sea. Over the past ten years or so interest in artificial reef technology and science has spread into the NE Atlantic and Baltic Sea with an associated variation in aims and ideas. Reef scientists working in European seas have run projects to assess artificial reefs as tools to protect habitat from destruction from trawling (Spain, Italy and France), promote nature conservation (Monaco, Italy and France), aid fisheries (Italy, Spain, Portugal and France), assess novel materials for reef construction (Italy and UK), investigate habitat use for lobsters (UK, Italy and Israel), for aquaculture (Italy), as experimental sites where habitat parameters are known (UK, Holland and Italy) and as biofiltration structures (Finland, Russia, Poland and Romania). This variety of investigation is one of the strengths of artificial reef research in Europe, the community is diverse and there is great scientific value in establishing collaboration and dialogue with colleagues. The majority of artificial reef investigations have been, and still are, experimental with Italy dominating the research effort and Spain currently leading the way in the tonnage of reef material deployed, primarily for seagrass habitat protection. Problems associated with old descriptive, qualitative research have led to developments in quantification and comparative studies which have allowed a scientific perspective to be put on artificial reef deployments across Europe. Currently, as part of the EARRN (European Artificial Reef Research Network) initiative, there is an acceptance of the need to standardise some of the ecological methods used. If this is not practicable in some cases then at least the reporting of results will be done in such a way to allow comparison with data gathered elsewhere

Indirect determination of the Kugo-Ojima function from lattice data

We study the structure and non-perturbative properties of a special Green's function, u(q), whose infrared behavior has traditionally served as the standard criterion for the realization of the Kugo-Ojima confinement mechanism. It turns out that, in the Landau gauge, u(q) can be determined from a dynamical equation, whose main ingredients are the gluon propagator and the ghost dressing function, integrated over all physical momenta. Using as input for these two (infrared finite) quantities recent lattice data, we obtain an indirect determination of u(q). The results of this mixed procedure are in excellent agreement with those found previously on the lattice, through a direct simulation of this function. Most importantly, in the deep infrared the function deviates considerably from the value associated with the realization of the aforementioned confinement scenario. In addition, the dependence of u(q), and especially of its value at the origin, on the renormalization point is clearly established. Some of the possible implications of these results are briefly discussed.Comment: 25 pages, 10 figures; v2: typos corrected, expanded version that matches the published articl

Bivariate analysis of basal serum anti-Müllerian hormone measurements and human blastocyst development after IVF

Background To report on relationships among baseline serum anti-Müllerian hormone (AMH) measurements, blastocyst development and other selected embryology parameters observed in non-donor oocyte IVF cycles. Methods Pre-treatment AMH was measured in patients undergoing IVF (n = 79) and retrospectively correlated to in vitro embryo development noted during culture. Results Mean (+/- SD) age for study patients in this study group was 36.3 ± 4.0 (range = 28-45) yrs, and mean (+/- SD) terminal serum estradiol during IVF was 5929 +/- 4056 pmol/l. A moderate positive correlation (0.49; 95% CI 0.31 to 0.65) was noted between basal serum AMH and number of MII oocytes retrieved. Similarly, a moderate positive correlation (0.44) was observed between serum AMH and number of early cleavage-stage embryos (95% CI 0.24 to 0.61), suggesting a relationship between serum AMH and embryo development in IVF. Of note, serum AMH levels at baseline were significantly different for patients who did and did not undergo blastocyst transfer (15.6 vs. 10.9 pmol/l; p = 0.029). Conclusions While serum AMH has found increasing application as a predictor of ovarian reserve for patients prior to IVF, its roles to estimate in vitro embryo morphology and potential to advance to blastocyst stage have not been extensively investigated. These data suggest that baseline serum AMH determinations can help forecast blastocyst developmental during IVF. Serum AMH measured before treatment may assist patients, clinicians and embryologists as scheduling of embryo transfer is outlined. Additional studies are needed to confirm these correlations and to better define the role of baseline serum AMH level in the prediction of blastocyst formation

Balancing selected medication costs with total number of daily injections: a preference analysis of GnRH-agonist and antagonist protocols by IVF patients

BACKGROUND: During in vitro fertilization (IVF), fertility patients are expected to self-administer many injections as part of this treatment. While newer medications have been developed to substantially reduce the number of these injections, such agents are typically much more expensive. Considering these differences in both cost and number of injections, this study compared patient preferences between GnRH-agonist and GnRH-antagonist based protocols in IVF. METHODS: Data were collected by voluntary, anonymous questionnaire at first consultation appointment. Patient opinion concerning total number of s.c. injections as a function of non-reimbursed patient cost associated with GnRH-agonist [A] and GnRH-antagonist [B] protocols in IVF was studied. RESULTS: Completed questionnaires (n = 71) revealed a mean +/- SD patient age of 34 +/- 4.1 yrs. Most (83.1%) had no prior IVF experience; 2.8% reported another medical condition requiring self-administration of subcutaneous medication(s). When out-of-pocket cost for [A] and [B] were identical, preference for [B] was registered by 50.7% patients. The tendency to favor protocol [B] was weaker among patients with a health occupation. Estimated patient costs for [A] and [B] were $259.82 +/- 11.75 and$654.55 +/- 106.34, respectively (p < 0.005). Measured patient preference for [B] diminished as the cost difference increased. CONCLUSIONS: This investigation found consistently higher non-reimbursed direct medication costs for GnRH-antagonist IVF vs. GnRH-agonist IVF protocols. A conditional preference to minimize downregulation (using GnRH-antagonist) was noted among some, but not all, IVF patient sub-groups. Compared to IVF patients with a health occupation, the preference for GnRH-antagonist was weaker than for other patients. While reducing total number of injections by using GnRH-antagonist is a desirable goal, it appears this advantage is not perceived equally by all IVF patients and its utility is likely discounted heavily by patients when nonreimbursed medication costs reach a critical level

Stratospheric water vapour and high climate sensitivity in a version of the HadSM3 climate model

It has been shown previously that one member of the Met Office Hadley Centre single-parameter perturbed physics ensemble – the so-called "low entrainment parameter" member – has a much higher climate sensitivity than other individual parameter perturbations. Here we show that the concentration of stratospheric water vapour in this member is over three times higher than observations, and, more importantly for climate sensitivity, increases significantly when climate warms. The large surface temperature response of this ensemble member is more consistent with stratospheric humidity change, rather than upper tropospheric clouds as has been previously suggested. The direct relationship between the bias in the control state (elevated stratospheric humidity) and the cause of the high climate sensitivity (a further increase in stratospheric humidity) lends further doubt as to the realism of this particular integration. This, together with other evidence, lowers the likelihood that the climate system's physical sensitivity is significantly higher than the likely upper range quoted in the Intergovernmental Panel on Climate Change's Fourth Assessment Report

Non-perturbative momentum dependence of the coupling constant and hadronic models

Models of hadron structure are associated with a hadronic scale which allows by perturbative evolution to calculate observables in the deep inelastic region. The resolution of Dyson-Schwinger equations leads to the freezing of the QCD running coupling (effective charge) in the infrared, which is best understood as a dynamical generation of a gluon mass function, giving rise to a momentum dependence which is free from infrared divergences. We use this new development to understand why perturbative treatments are working reasonably well despite the smallness of the hadronic scale.Comment: Changes in Acknowledgments and PACS number

Selection of single blastocysts for fresh transfer via standard morphology assessment alone and with array CGH for good prognosis IVF patients: results from a randomized pilot study

Background Single embryo transfer (SET) remains underutilized as a strategy to reduce multiple gestation risk in IVF, and its overall lower pregnancy rate underscores the need for improved techniques to select one embryo for fresh transfer. This study explored use of comprehensive chromosomal screening by array CGH (aCGH) to provide this advantage and improve pregnancy rate from SET. Methods First-time IVF patients with a good prognosis (age <35, no prior miscarriage) and normal karyotype seeking elective SET were prospectively randomized into two groups: In Group A, embryos were selected on the basis of morphology and comprehensive chromosomal screening via aCGH (from d5 trophectoderm biopsy) while Group B embryos were assessed by morphology only. All patients had a single fresh blastocyst transferred on d6. Laboratory parameters and clinical pregnancy rates were compared between the two groups. Results For patients in Group A (n=55), 425 blastocysts were biopsied and analyzed via aCGH (7.7 blastocysts/patient). Aneuploidy was detected in 191/425 (44.9%) of blastocysts in this group. For patients in Group B (n=48), 389 blastocysts were microscopically examined (8.1 blastocysts/patient). Clinical pregnancy rate was significantly higher in the morphology+aCGH group compared to the morphology-only group (70.9 and 45.8%, respectively; p=0.017); ongoing pregnancy rate for Groups A and B were 69.1 vs. 41.7%, respectively (p=0.009). There were no twin pregnancies. Conclusion Although aCGH followed by frozen embryo transfer has been used to screen at risk embryos (e.g., known parental chromosomal translocation or history of recurrent pregnancy loss), this is the first description of aCGH fully integrated with a clinical IVF program to select single blastocysts for fresh SET in good prognosis patients. The observed aneuploidy rate (44.9%) among biopsied blastocysts highlights the inherent imprecision of SET when conventional morphology is used alone. Embryos randomized to the aCGH group implanted with greater efficiency, resulted in clinical pregnancy more often, and yielded a lower miscarriage rate than those selected without aCGH. Additional studies are needed to verify our pilot data and confirm a role for on-site, rapid aCGH for IVF patients contemplating fresh SET

The myth of agency and the misattribution of blame in collective imaginaries of the future

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149565/1/bjos12662_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149565/2/bjos12662.pd

Suppression factors in diffractive photoproduction of dijets

After new publications of H1 data for the diffractive photoproduction of dijets, which overlap with the earlier published H1 data and the recently published data of the ZEUS collaboration, have appeared, we have recalculated the cross sections for this process in next-to-leading order (NLO) of perturbative QCD to see whether they can be interpreted consistently. The results of these calculations are compared to the data of both collaborations. We find that the NLO cross sections disagree with the data, showing that factorization breaking occurs at that order. If direct and resolved contributions are both suppressed by the same amount, the global suppression factor depends on the transverse-energy cut. However, by suppressing only the resolved contribution, also reasonably good agreement with all the data is found with a suppression factor independent of the transverse-energy cut.Comment: 28 pages, 11 figures, 3 table