470 research outputs found
From Jerusalem to Athens: a model of contemporary evangelistic preaching
https://place.asburyseminary.edu/ecommonsatsdissertations/1140/thumbnail.jp
Invasive versus non-invasive management of elderly patients with non-ST elevation myocardial infarction:cohort study based on routine clinical data (NIHR Health Informatics Collaborative SENIOR-NSTEMI Study)
The Bright and Dark Side of Altruism: Demographic, Personality Traits, and Disorders Associated with Altruism
This study looked at personality trait and personality disorder correlates of self-rated altruism. In two studies over 4,000 adult British managers completed a battery of tests including a âbright sideâ personality trait measure (HPI); a âdark sideâ/disorders measure (HDS), and a measure of their Motives and Values which included Altruism. The two studies showed similar results revealing that those who were low on Adjustment (Neuroticism) but high on Interpersonal Sensitivity (Agreeableness), Prudence (Conscientiousness) and Inquisitiveness (Openness) were more likely to value Altruism and be motivated to commit altruistic acts which concerns helping others and creating an environment that places emphasis on customer service. Those more interested in âGetting Alongâ with others were more Altruistic than those more interested in âGetting Aheadâ of others. Implications for the selection and management of altruistic people in a business are considered. Limitations and future directions of this research are also noted
Intravenous lidocaine as a non-opioid adjunct analgesic for traumatic rib fractures.
INTRODUCTION: Pain management is the pillar of caring for patients with traumatic rib fractures. Intravenous lidocaine (IVL) is a well-established non-opioid analgesic for post-operative pain, yet its efficacy has yet to be investigated in trauma patients. We hypothesized that IVL is associated with decreased inpatient opioid requirements among patients with rib fractures.
METHODS: We retrospectively evaluated adult patients presenting to our Level 1 trauma center with isolated chest wall injuries. After 1:1 propensity score matching patients who received vs did not receive IVL, we compared the two groups\u27 average daily opioid use, opioid use in the last 24 hours of admission, and pain scores during admissions hours 24-48. We performed multivariable linear regression for these outcomes (with sensitivity analysis for the opioid use outcomes), adjusting for age as a moderating factor and controlling for hospital length of stay and injury severity.
RESULTS: We identified 534 patients, among whom 226 received IVL. Those who received IVL were older and had more serious injury. Compared to propensity-score matched patients who did not receive IVL, patients who received IVL had similar average daily opioid use and pain scores, but 40% lower opioid use during the last 24 hours of admission (p = 0.002). Multivariable regression-with and without sensitivity analysis-did not show an effect of IVL on any outcomes.
CONCLUSION: IVL was crudely associated with decreased opioid requirements in the last 24 hours of admission, the time period associated with opioid use at 90 days post-discharge. However, we did not observe beneficial effects of IVL on multivariable adjusted analyses; we are conducting a randomized control trial to further evaluate IVL\u27s opioid-sparing effects for patients with rib fractures
Constraint-based, Single-point Approximate Kinetic Energy Functionals
We present a substantial extension of our constraint-based approach for
development of orbital-free (OF) kinetic-energy (KE) density functionals
intended for the calculation of quantum-mechanical forces in multi-scale
molecular dynamics simulations. Suitability for realistic system simulations
requires that the OF-KE functional yield accurate forces on the nuclei yet be
relatively simple. We therefore require that the functionals be based on DFT
constraints, local, dependent upon a small number of parameters fitted to a
training set of limited size, and applicable beyond the scope of the training
set. Our previous "modified conjoint" generalized-gradient-type functionals
were constrained to producing a positive-definite Pauli potential. Though
distinctly better than several published GGA-type functionals in that they gave
semi-quantitative agreement with Born-Oppenheimer forces from full Kohn-Sham
results, those modified conjoint functionals suffer from unphysical
singularities at the nuclei. Here we show how to remove such singularities by
introducing higher-order density derivatives. We give a simple illustration of
such a functional used for the dissociation energy as a function of bond length
for selected molecules.Comment: 16 pages, 9 figures, 2 tables, submitted to Phys. Rev.
Unconventional quantum Hall effect and Berryâs phase 2pi in bilayer graphene.
There are known two distinct types of the integer quantum Hall effect. One is the conventional quantum Hall effect, characteristic of two-dimensional semiconductor systems, and the other is its relativistic counterpart recently observed in graphene, where charge carriers mimic Dirac fermions characterized by Berryâs phase pi, which results in a shifted positions of Hall plateaus. Here we report a third type of the integer quantum Hall effect. Charge carriers in bilayer graphene have a parabolic energy spectrum but are chiral and exhibit Berryâs phase 2pi affecting their quantum dynamics. The Landau quantization of these fermions results in plateaus in Hall conductivity at standard integer positions but the last (zero-level) plateau is missing. The zero-level anomaly is accompanied by metallic conductivity in the limit of low concentrations and high magnetic fields, in stark contrast to the conventional, insulating behavior in this regime. The revealed chiral fermions have no known analogues and present an intriguing case for quantum-mechanical studies
The role of Schizosaccharomyces pombe SUMO ligases in genome stability
SUMOylation is a post-translational modification that affects a large number of proteins, many of which are nuclear. While the role of SUMOylation is beginning to be elucidated, it is clear that understanding the mechanisms that regulate the process is likely to be important. Control of the levels of SUMOylation is brought about through a balance of conjugating and deconjugating activities, i.e. of SUMO (small ubiquitin-related modifier) conjugators and ligases versus SUMO proteases. Although conjugation of SUMO to proteins can occur in the absence of a SUMO ligase, it is apparent that SUMO ligases facilitate the SUMOylation of specific subsets of proteins. Two SUMO ligases in Schizosaccharomyces pombe, Pli1 and Nse2, have been identified, both of which have roles in genome stability. We report here on a comparison between the properties of the two proteins and discuss potential roles for the proteins
The interlayer cohesive energy of graphite from thermal desorption of polyaromatic hydrocarbons
We have studied the interaction of polyaromatic hydrocarbons (PAHs) with the
basal plane of graphite using thermal desorption spectroscopy. Desorption
kinetics of benzene, naphthalene, coronene and ovalene at sub-monolayer
coverages yield activation energies of 0.50 eV, 0.85 eV, 1.40 eV and 2.1 eV,
respectively. Benzene and naphthalene follow simple first order desorption
kinetics while coronene and ovalene exhibit fractional order kinetics owing to
the stability of 2-D adsorbate islands up to the desorption temperature.
Pre-exponential frequency factors are found to be in the range
- as obtained from both Falconer--Madix (isothermal
desorption) analysis and Antoine's fit to vapour pressure data. The resulting
binding energy per carbon atom of the PAH is 5 meV and can be identified
with the interlayer cohesive energy of graphite. The resulting cleavage energy
of graphite is ~meV/atom which is considerably larger than previously
reported experimental values.Comment: 8 pages, 4 figures, 2 table
- âŠ