A novel method of silicon synthesis by CVD

Silicon fibers were synthesized by a novel CVD method including in the interaction of aluminum monofluoride with silicon oxide, the final product containing nanofibers in an amount of 15 wt. %. The possibility of selective reduction of silicon oxide from the chamotte refractory plate was also demonstrated. Si was characterized by SEM and XRD. Thermodynamics and mechanism of silicon fiber formation were also considered. © 2019 Author(s)

Novel method of silicon synthesis by CVD

Silicon fibers were synthesized by a novel CVD method including in the interaction of aluminum monofluoride with silicon oxide, the final product containing nanofibers in an amount of 15 wt. %. The possibility of selective reduction of silicon oxide from the chamotte refractory plate was also demonstrated. Si was characterized by SEM and XRD. Thermodynamics and mechanism of silicon fiber formation were also considered. © 2019 Author(s)

The study of TIM polymer composite materials thermal conductivity

A recent trend in electronic technology deals with a sharp performance increase within decrease dimensions and mass of devices. High-performance thermal interface materials (TIM) primarily thermal pastes are indispensable to application. A number of filler materials: ceramics (aluminum nitride, silicon carbide, alumina) metals (aluminum, copper) and graphite were considered to apply. The data containing average particles size, specific surface area, and maximal volume and mass fraction for various materials was obtained. The thermal conductivity of samples with aluminum and graphite dramatically exceed values obtained within mathematical models' calculation. The highest thermal conductivity values were obtained for SiC (1.37 W/(m·K)), AlN (1.09 W/(m·K)), C (2.85 W/(m·K)) and Al (1.20 W/(m·K)), that mad the mentioned above materials the most promising for high-performance thermal pastes. © 2019 Author(s)

Differential Regulation of the Period Genes in Striatal Regions following Cocaine Exposure

Several studies have suggested that disruptions in circadian rhythms contribute to the pathophysiology of multiple psychiatric diseases, including drug addiction. In fact, a number of the genes involved in the regulation of circadian rhythms are also involved in modulating the reward value for drugs of abuse, like cocaine. Thus, we wanted to determine the effects of chronic cocaine on the expression of several circadian genes in the Nucleus Accumbens (NAc) and Caudate Putamen (CP), regions of the brain known to be involved in the behavioral responses to drugs of abuse. Moreover, we wanted to explore the mechanism by which these genes are regulated following cocaine exposure. Here we find that after repeated cocaine exposure, expression of the Period (Per) genes and Neuronal PAS Domain Protein 2 (Npas2) are elevated, in a somewhat regionally selective fashion. Moreover, NPAS2 (but not CLOCK (Circadian Locomotor Output Cycles Kaput)) protein binding at Per gene promoters was enhanced following cocaine treatment. Mice lacking a functional Npas2 gene failed to exhibit any induction of Per gene expression after cocaine, suggesting that NPAS2 is necessary for this cocaine-induced regulation. Examination of Per gene and Npas2 expression over twenty-four hours identified changes in diurnal rhythmicity of these genes following chronic cocaine, which were regionally specific. Taken together, these studies point to selective disruptions in Per gene rhythmicity in striatial regions following chronic cocaine treatment, which are mediated primarily by NPAS2. © 2013 Falcon et al

The study of TIM polymer composite materials thermal conductivity

Support by the Ministry of Education and Science of the Russian Federation is gratefully acknowledged: calculation results (chapter 3.1) were obtained under research project # 3.6064.2017/8.9 and experimental results (chapter 3.2) - under project # 3.10704.2018/11.12

Insertion of silica into nanoporous alumina by chemical deposition technique

This paper presents an experimental consideration of the deposition of silicon dioxide in a nanoporous material. The matrix was filled in organic media containing tetraethoxysilane. The analysis of the obtained product on XRD, silica, was carried out using scanning electron microscopy in combination with EDX analysis. The characteristics of the filling of nanopo-rous materials by chemical precipitation from organic liquid media are considered. Electro-physical characteristics of the obtained composite were studied

Technology development for obtaining a multilayer nanoporous aluminum oxide

Experimental preparation of multilayer nanoporous alumina was carried out. The oxide was obtained from aluminum, purity 99.7%. Obtaining aluminum oxide was carried out in a complex electrolyte containing a mixture of acids. The method of mixed multipulse anodizing was applied, using constant current and constant voltage modes. SEM investigated the obtained nanoporous oxide. The geometrical characteristics were determined. A method for controlling the thickness is proposed based on the analysis of changes in the growth rates of anodic alumina

Contribution of Cytochrome P450 and ABCB1 Genetic Variability on Methadone Pharmacokinetics, Dose Requirements, and Response

Although the efficacy of methadone maintenance treatment (MMT) in opioid dependence disorder has been well established, the influence of methadone pharmacokinetics in dose requirement and clinical outcome remains controversial. The aim of this study is to analyze methadone dosage in responder and nonresponder patients considering pharmacogenetic and pharmacokinetic factors that may contribute to dosage adequacy. Opioid dependence patients (meeting Diagnostic and Statistical Manual of Mental Disorders, [4th Edition] criteria) from a MMT community program were recruited. Patients were clinically assessed and blood samples were obtained to determine plasma concentrations of (R,S)-, (R) and (S)- methadone and to study allelic variants of genes encoding CYP3A5, CYP2D6, CYP2B6, CYP2C9, CYP2C19, and P-glycoprotein. Responders and nonresponders were defined by illicit opioid consumption detected in random urinalysis. The final sample consisted in 105 opioid dependent patients of Caucasian origin. Responder patients received higher doses of methadone and have been included into treatment for a longer period. No differences were found in terms of genotype frequencies between groups. Only CYP2D6 metabolizing phenotype differences were found in outcome status, methadone dose requirements, and plasma concentrations, being higher in the ultrarapid metabolizers. No other differences were found between phenotype and responder status, methadone dose requirements, neither in methadone plasma concentrations. Pharmacokinetic factors could explain some but not all differences in MMT outcome and methadone dose requirements

Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts

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