2,660 research outputs found
Generalised Space-time and Gauge Transformations
We consider the generalised space-time introduced by the author in 2003 in
the context of the non-linear realisation of the semi-direct product of E11 and
its first fundamental representation. For all the fields we propose gauge
transformations which are compatible with the underlying E11 structure. A
crucial role is played by the generalised vielbein that the generalised
space-time possess. We work out the explicit form of the gauge transformations,
at low levels, in four, five and eleven dimensions.Comment: 33 page
Hybrid fruits for Improving health—A comprehensive review.
Several species of hybrid fruits, such as citrus, grapes, blueberries, apples, tomatoes, and lingonberries among others, have attracted scientific attention in recent years, especially due to their reported antioxidant and anti-inflammatory properties. The bagasse, leaves, bark, and seeds of these hybrid fruits have large amounts of polyphenols, such as flavonoids, which act as potent antioxidants. Several studies have been carried out in cellular models of neurotoxicity of the extract of these fruits, to document the beneficial effects for human health, as well as to prove its antiproliferative effect in cancer cells. In the present review, through a synthesis of existing information in the scientific literature, we demonstrate that hybrid fruits are a source of antioxidant and bioactive compounds, which act in the inhibition of diseases such as cancer, diabetes, and inflammatory and neurodegenerative diseases, and consequently improving human health.artigo n. 219
Identification of cell-surface mannans in a virulent Helicobacter pylori strain
With the intent of contributing to a carbohydrate-based vaccine against the gastroduodenal pathogen, Helicobacter pylori, we report here the structure of cell-surface mannans obtained from a virulent strain. Unlike other wild-type strains, this strain was found to express in good quantities this polysaccharide in vitro. Structural analysis revealed a branched mannan formed by a backbone of α-(1→6)-linked mannopyranosyl residues with approximately 80% branching at the O-2 position. The branches were composed of O-2-linked Man residues in both α- and β-configurations: (image)
In addition, this strain also expressed cell-surface emblematic H. pylori lipopolysaccharides (LPS) containing partially fucosylated polyLacNAc O-chains. Affinity assays with polymyxin-B and concanavalin A revealed no association between the mannan and the LPS. The described mannans may be implicated in the mediation of host–microbial interactions and immunological modulation.This work was supported by Fundacao para a Ciencia e Tecnologia (FCT) through project Pylori E&LPS POCI/QUI/56393/2004, PhD grant SFRH/BD/19929/2004, by the Natural Sciences and Engineering Research Council of Canada (NSERC), and by the European Network of Research Infrastructures within the 6th Framework Programme of the EC (Contract # RII3-026145, EU-NMR). The authors further thank Dr. Adrien Favier (RALF-NMR facility, Grenoble - France) for conducting NMR experiments
He II 4686 emission from the massive binary system in Car: constraints to the orbital elements and the nature of the periodic minima
{\eta} Carinae is an extremely massive binary system in which rapid spectrum
variations occur near periastron. Most notably, near periastron the He II
line increases rapidly in strength, drops to a minimum value,
then increases briefly before fading away. To understand this behavior, we
conducted an intense spectroscopic monitoring of the He II
emission line across the 2014.6 periastron passage using ground- and
space-based telescopes. Comparison with previous data confirmed the overall
repeatability of EW(He II ), the line radial velocities, and the
timing of the minimum, though the strongest peak was systematically larger in
2014 than in 2009 by 26%. The EW(He II ) variations, combined
with other measurements, yield an orbital period d. The observed
variability of the EW(He II ) was reproduced by a model in which
the line flux primarily arises at the apex of the wind-wind collision and
scales inversely with the square of the stellar separation, if we account for
the excess emission as the companion star plunges into the hot inner layers of
the primary's atmosphere, and including absorption from the disturbed primary
wind between the source and the observer. This model constrains the orbital
inclination to -, and the longitude of periastron to
-. It also suggests that periastron passage occurred on
d. Our model also reproduced EW(He II )
variations from a polar view of the primary star as determined from the
observed He II emission scattered off the Homunculus nebula.Comment: The article contains 23 pages and 17 figures. It has been accepted
for publication in Ap
Generalised geometry, eleven dimensions and E11
We construct the non-linear realisation of E11 and its first fundamental
representation in eleven dimensions at low levels. The fields depend on the
usual coordinates of space-time as well as two form and five form coordinates.
We derive the terms in the dynamics that contain the three form and six form
fields and show that when we restricted their field dependence to be only on
the usual space-time we recover the correct self-duality relation. Should this
result generalise to the gravity fields then the non-linear realisation is an
extension of the maximal supergravity theory, as previously conjectured. We
also comment on the connections between the different approaches to generalised
geometry.Comment: 17 pages, Trivial typos corrected in version one and a substantial
note added which gives the equation of motion relating the gravity field to
its dua
Infant mortality: comparison between two birth cohorts from Southeast and Northeast, Brazil
OBJECTIVE: To obtain population estimates and profile risk factors for infant mortality in two birth cohorts and compare them among cities of different regions in Brazil. METHODS: In Ribeirão Preto, southeast Brazil, infant mortality was determined in a third of hospital live births (2,846 singleton deliveries) in 1994. In São LuÃs, northeast Brazil, data were obtained using systematic sampling of births stratified by maternity unit (2,443 singleton deliveries) in 1997-1998. Mothers answered standardized questionnaires shortly after delivery and information on infant deaths was retrieved from hospitals, registries and the States Health Secretarys' Office. The relative risk (RR) was estimated by Poisson regression. RESULTS: In São LuÃs, the infant mortality rate was 26.6/1,000 live births, the neonatal mortality rate was 18.4/1,000 and the post-neonatal mortality rate was 8.2/1,000, all higher than those observed in Ribeirão Preto (16.9, 10.9 and 6.0 per 1,000, respectively). Adjusted analysis revealed that previous stillbirths (RR=3.67 vs 4.13) and maternal ageOBJETIVO: Obter estimativas populacionais e fatores de risco de mortalidade infantil em coortes de nascimentos e comparar esses fatores entre cidades de diferentes regiões do PaÃs. MÉTODOS: Em Ribeirão Preto, SP, a mortalidade infantil foi avaliada em 1/3 dos nascidos vivos hospitalares (2.846 partos únicos) em 1994. Em São LuÃs, MA, foi feita amostragem sistemática de partos estratificada por maternidade (2.443 partos únicos) em 1997/98. As mães responderam a questionários padronizados logo após o parto e as informações sobre os óbitos foram coletadas nos hospitais, nos cartórios e nas secretarias estaduais de saúde. Risco relativo (RR) e intervalo de confiança de 95% foram estimados pela regressão de Poisson. RESULTADOS: O coeficiente de mortalidade infantil (CMI) em São LuÃs foi 26,6/1.000 nascidos vivos, o coeficiente de mortalidade neonata (CMN)l 18,4/1.000 e o coeficiente de mortalidade pós-neonatal (CMPN) 8,2/1.000, valores superiores aos de Ribeirão Preto, com CMI 16,9/1.000, CMN 10,9/1.000,CMPN 6,0/1.000. Na análise ajustada, nas duas cidades, natimorto prévio (RR=3,67 vs 4,13) e idade matern
Revisiting the chemistry of apple pomace polyphenols
Hot water is an easily implementable process for polyphenols extraction. To evaluate the effect of this process on apple pomace, the overall polyphenolic composition was assessed before and after hot water extraction, followed by extractions with aqueous/organic solutions. As determined by UHPLC-DAD, flavan-3-ols were the main apple native polyphenols. Their amount decreased 50% after hot water extraction, while the other classes remained unchanged. Dihydrochalcones and hydroxycinnamic acid oxidation products, were also observed, alongside with non-extractable oxidised procyanidins that represented more than 4-fold the amount of native apple polyphenols in the pomace. Microwave superheated-water extraction of the insoluble cell wall material in water/acetone solutions and the high amounts of polyphenols that were insoluble in water/ethanol solutions suggested that oxidised procyanidins could be covalently linked to polysaccharides. These complexes represented up to 40% of the available polyphenols from apple pomace, potentially relevant for agro-food waste valuation.publishe
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