Resonant tunneling through a small quantum dot coupled to superconducting leads

We address the problem of non-linear transport through discrete electronic levels in a small quantum dot coupled to superconducting electrodes. In our approach the low temperature I-V characteristics can be calculated including all multiple quasi-particle and Andreev processes. The limit of very weak coupling to the leads and large charging energies is briefly analyzed comparing the calculated lineshapes of the I-V curves with recent experimental results. When the coupling to the leads increases and Coulomb blockade effects can be neglected, the combination of multiple Andreev processes and resonant transmission gives rise to a rich subgap structure which largely differs from the one found in the more studied S-N-S systems. We show how multiple processes can be included within a simple sequential tunneling picture qualitatively explaining the subgap structure. We suggest an experimental set-up where the predicted effects could be observed.Comment: 11 pages, 4 postscript figures, to be published in Phys. Rev. B (rapid communications

Low-temperature oxidation effects on the morphological and structural properties of hexagonal Zn nanodisks

Ambient-atmosphere oxidation in the temperature range of 90-450 C was performed over Zn films composed by well-faceted hexagonal nanodisks, which were deposited by thermal evaporation. Morphological and structural properties of oxidized Zn nanodisks were studied by scanning electron microscopy, transmission electron microscopy, energy dispersive spectroscopy, X-ray diffraction, and Raman scattering measurements. It was found that Zn nanodisks keep its original shape only when they are annealed at 90 or 150 C. Smooth oxidation ocurred only on the rectangular faces of Zn nandodisks heated at 150 C. Thermal oxidation at 250 C favored growth of ZnO nanoneedles over the surface of the Zn nanodisks. Hexagonal-shape of Zn nanodisks was transformed completely into a complex morphology composed by different shaped particles, with further increase in oxidation temperature to 450 C

ANALYSIS OF THE UV SOLAR IRRADIANCE FOR THE SYNTHESIS OF PRE-VITAMIN D3 ON THE SKIN, IN ROSARIO, ARGENTINA

In the last years, the study of vitamin D has raised due to the increase in the incidence of people who have deficient levels of this vitamin. Few foods contain vitamin D3 naturally, the main source of obtaining the ultraviolet (UV)solar radiation, which triggers the synthesis on the skin’s surface. In this study, the effective UV solar irradiance for the synthesis of pre-vitamin D3 was determined in Rosario city, Argentina, using three methods: a) ProportionalityCoefficient, b) Herman’s equation and c) TUV model. The values were compared in clear sky conditions at solar noon.The Solar Exposure Times (TES) that reach the minimum doses of solar UV radiation for the synthesis of pre-vitamin D3 and erythema were calculated, along the period june 2019 - may 2020. The variation of the TES to accumulate the minimum dose of pre-vitamin D3 and erythema with a photoexposure of 25 % of the body (face, neck and arms) is discusse

Circadian rhythms in the efficacy of intravenous alteplase in patients with acute ischemic stroke and middle cerebral artery occlusion

Peer ReviewedPostprint (author's final draft

The effectiveness of virtual environments in developing collaborative strategies between industrial robots and humans

Testing and implementation of Human-Robot Collaboration (HRC) could be dangerous due to the high-speed movements and massive forces generated by industrial robots. Wherever humans and industrial robots share a common workplace, accidents are likely to happen and always unpredictable. This has hindered the development of human robot collaborative strategies as well as the ability of authorities to pass regulations on how humans and robots should work together in close proximities. This paper presents the use of a Virtual Reality digital twin of a physical layout as a mechanism to understand human reactions to both predictable and unpredictable robot motions. A set of established metrics as well as a newly developed Kinetic Energy Ratio metric are used to analyse human reactions and validate the effectiveness of the Virtual Reality environment. It is the aim that Virtual Reality digital twins could inform the safe implementation of Human-Robot Collaborative strategies in factories of the future

Pulsed electric field increases the extraction yield of extra virgin olive oil without loss of its biological properties

Introduction: Pulsed electric field (PEF) has been used for improving extraction of extra virgin olive oil (EVOO). However, the biological changes induced by the consumption of pulsed electric field-obtained extra virgin olive oil (PEFEVOO) have not been studied yet. Materials and methods: EVOO oils from Empeltre variety were prepared by standard (STD) cold pressure method involving crushing of the olives, malaxation and decanting and by this procedure including an additional step of PEF treatment. Chemical analyses of EVOO oils were done. Male and female Apoe-deficient mice received diets differing in both EVOOs for 12 weeks, and their plasma, aortas and livers were analyzed. Results: PEF application resulted in a 17% increase in the oil yield and minimal changes in chemical composition regarding phytosterols, phenolic compounds and microRNA. Only in females mice consuming PEF EVOO, a decreased plasma total cholesterol was observed, without significant changes in atherosclerosis and liver steatosis. Conclusion: PEF technology applied to EVOO extraction maintains the EVOO quality and improves the oil yield. The equivalent biological effects in atherosclerosis and fatty liver disease of PEF-obtained EVOO further support its safe use as a food

Blood Biomarker Panels for the Early Prediction of Stroke‐Associated Complications

Background Acute decompensated heart failure (ADHF) and respiratory tract infections (RTIs) are potentially life-threatening complications in patients experiencing stroke during hospitalization. We aimed to test whether blood biomarker panels might predict these complications early after admission. Methods and Results Nine hundred thirty-eight patients experiencing ischemic stroke were prospectively recruited in the Stroke-Chip study. Post-stroke complications during hospitalization were retrospectively evaluated. Blood samples were drawn within 6 hours after stroke onset, and 14 biomarkers were analyzed by immunoassays. Biomarker values were normalized using log-transformation and Z score. PanelomiX algorithm was used to select panels with the best accuracy for predicting ADHF and RTI. Logistic regression models were constructed with the clinical variables and the biomarker panels. The additional predictive value of the panels compared with the clinical model alone was evaluated by receiver operating characteristic curves. An internal validation through a 10-fold cross-validation with 3 repeats was performed. ADHF and RTI occurred in 19 (2%) and 86 (9.1%) cases, respectively. Three-biomarker panels were developed as predictors: vascular adhesion protein-1 >5.67, NT-proBNP (N-terminal pro-B-type natriuretic peptide) >4.98 and d-dimer >5.38 (sensitivity, 89.5%; specificity, 71.7%) for ADHF; and interleukin-6 >3.97, von Willebrand factor >3.67, and d-dimer >4.58 (sensitivity, 82.6%; specificity, 59.8%) for RTI. Both panels independently predicted stroke complications (panel for ADHF: odds ratio [OR] [95% CI], 10.1 [3-52.2]; panel for RTI: OR, 3.73 [1.95-7.14]) after adjustment by clinical confounders. The addition of the panel to clinical predictors significantly improved areas under the curve of the receiver operating characteristic curves in both cases. Conclusions Blood biomarkers could be useful for the early prediction of ADHF and RTI. Future studies should assess the usefulness of these panels in front of patients experiencing stroke with respiratory symptoms such as dyspnea

Thrombectomy within 8 hours after symptom onset in ischemic stroke

BACKGROUND: We aimed to assess the safety and efficacy of thrombectomy for the treatment of stroke in a trial embedded within a population-based stroke reperfusion registry. METHODS: During a 2-year period at four centers in Catalonia, Spain, we randomly assigned 206 patients who could be treated within 8 hours after the onset of symptoms of acute ischemic stroke to receive either medical therapy (including intravenous alteplase when eligible) and endovascular therapy with the Solitaire stent retriever (thrombectomy group) or medical therapy alone (control group). All patients had confirmed proximal anterior circulation occlusion and the absence of a large infarct on neuroimaging. In all study patients, the use of alteplase either did not achieve revascularization or was contraindicated. The primary outcome was the severity of global disability at 90 days, as measured on the modified Rankin scale (ranging from 0 [no symptoms] to 6 [death]). Although the maximum planned sample size was 690, enrollment was halted early because of loss of equipoise after positive results for thrombectomy were reported from other similar trials. RESULTS Thrombectomy reduced the severity of disability over the range of the modified Rankin scale (adjusted odds ratio for improvement of 1 point, 1.7; 95% confidence interval [CI], 1.05 to 2.8) and led to higher rates of functional independence (a score of 0 to 2) at 90 days (43.7% vs. 28.2%; adjusted odds ratio, 2.1; 95% CI, 1.1 to 4.0). At 90 days, the rates of symptomatic intracranial hemorrhage were 1.9% in both the thrombectomy group and the control group (P = 1.00), and rates of death were 18.4% and 15.5%, respectively (P = 0.60). Registry data indicated that only eight patients who met the eligibility criteria were treated outside the trial at participating hospitals. CONCLUSIONS: Among patients with anterior circulation stroke who could be treated within 8 hours after symptom onset, stent retriever thrombectomy reduced the severity of post-stroke disability and increased the rate of functional independence

Economía y finanzas sociales: avances en la investigación

Esta obra colectiva propone un cambio de paradigma en la investigación científica, financiera y económica, cuyo centro de atención es reducir las desigualdades sociales y económicas, mejorar la sostenibilidad ambiental y la creación eficiente de valor económico. Desde un punto de vista crítico y mediante diversos enfoques teóricos, metodológicos y disciplinares, los autores analizan el esquema financiero predominante en las economías de mercado, al tiempo que abordan temas como la inclusión financiera, la banca ética o las experiencias e intervenciones en y sobre la economía social.ITESO, A.C

Global data on earthworm abundance, biomass, diversity and corresponding environmental properties

14 p.Earthworms are an important soil taxon as ecosystem engineers, providing a variety of crucial ecosystem functions and services. Little is known about their diversity and distribution at large spatial scales, despite the availability of considerable amounts of local-scale data. Earthworm diversity data, obtained from the primary literature or provided directly by authors, were collated with information on site locations, including coordinates, habitat cover, and soil properties. Datasets were required, at a minimum, to include abundance or biomass of earthworms at a site. Where possible, site-level species lists were included, as well as the abundance and biomass of individual species and ecological groups. This global dataset contains 10,840 sites, with 184 species, from 60 countries and all continents except Antarctica. The data were obtained from 182 published articles, published between 1973 and 2017, and 17 unpublished datasets. Amalgamating data into a single global database will assist researchers in investigating and answering a wide variety of pressing questions, for example, jointly assessing aboveground and belowground biodiversity distributions and drivers of biodiversity change