Properties of Umbral Dots as Measured from the New Solar Telescope Data and MHD Simulations

We studied bright umbral dots (UDs) detected in a moderate size sunspot and compared their statistical properties to recent MHD models. The study is based on high resolution data recorded by the New Solar Telescope at the Big Bear Solar Observatory and 3D MHD simulations of sunspots. Observed UDs, living longer than 150 s, were detected and tracked in a 46 min long data set, using an automatic detection code. Total 1553 (620) UDs were detected in the photospheric (low chromospheric) data. Our main findings are: i) none of the analyzed UDs is precisely circular, ii) the diameter-intensity relationship only holds in bright umbral areas, and iii) UD velocities are inversely related to their lifetime. While nearly all photospheric UDs can be identified in the low chromospheric images, some small closely spaced UDs appear in the low chromosphere as a single cluster. Slow moving and long living UDs seem to exist in both the low chromosphere and photosphere, while fast moving and short living UDs are mainly detected in the photospheric images. Comparison to the 3D MHD simulations showed that both types of UDs display, on average, very similar statistical characteristics. However, i) the average number of observed UDs per unit area is smaller than that of the model UDs, and ii) on average, the diameter of model UDs is slightly larger than that of observed ones.Comment: Accepted by the AP

Utilization of complimentary and alternative medicine in primary care : what are the relations between it and conventional medicine?

Backgroud: Complementary and alternative medicine (CAM) utilization among various groups of patients in western countries is increasing. Objectives: To describe the utilization of various CAM methods in parallel with conventional pri- mary care medicine and the relations between it and conventional medicine. Study Design: Four hundred and eighty patients in two primary care clinics participated in the survey. The participants answered a structured questionnaire, which included socio-demographic information and details of CAM therapy utilization. Results: Eighty percent of those seeking CAM therapy received conventional medical treatment for the same complaint as well. When asked if CAM should be funded 69% agreed, 14% disagreed and 8.3% were undecided. The most frequent causes for using CAM therapy were insufficient improve- ment by conventional treatment (36%), a reluctance to take medications (19%) and willingness to try a new modality (13%). Most of those who received CAM therapy felt it was beneficial and claim they would return to use it in the future under similar circumstances. Conclusions: We found that the term complementary is more appropriate as most patients use CAM in parallel to conventional medicine. Patients using CAM are satisfied and intend to use CAM in the future.peer-reviewe

Brightness, distribution, and evolution of sunspot umbral dots

We present a 106-minute TiO (705.7nm) time series of high spatial and temporal resolution that contains thousands of umbral dots (UDs) in a mature sunspot in the active region NOAA 10667 at $\mu$=0.95. The data were acquired with the 1-m Swedish Solar Telescope on La Palma. With the help of a multilevel tracking (MLT) algorithm the sizes, brightnesses, and trajectories of 12836 umbral dots were found and analyzed. The MLT allows UDs with very low contrast to be reliably identified. Inside the umbra we determine a UD filling factor of 11%. The histogram of UD lifetimes is monotonic, i.e. a UD does not have a typical lifetime. Three quarters of the UDs lived for less than 150s and showed no or little motion. The histogram of the UD diameters exhibits a maximum at 225km, i.e. most of the UDs are spatially resolved. UDs display a typical horizontal velocity of 420m/s and a typical peak intensity of 51% of the mean intensity of the quiet photosphere, making them on average 20% brighter than the local umbral background. Almost all mobile UDs (large birth-death distance) were born close to the umbra-penumbra boundary, move towards the umbral center, and are brighter than average. Notably bright and mobile UDs were also observed along a prominent UD chain, both ends of which are located at the umbra-penumbra boundary. Their motion started primarily at either of the ends of the chain, continued along the chain, and ended near the chain's center. We observed the splitting and merging of UDs and the temporal succession of both. For the first time the evolution of brightness, size, and horizontal speed of a typical UD could be determined in a statistically significant way. Considerable differences between the evolution of central and peripheral UDs are found, which point to a difference in origin

An audit of discharge summaries

Background: In the continuum of patient care, admission to the department of medicine constitutes a brief yet critical period. Subsequent patient care depends on the discharge summary (DS) and its implementation. Aim: To evaluate the department of medicine -family physician interface by a discharge summaries audit. Method: A retrospective study analyzing all admissions and discharges between a department of medicine and a primary care clinic over a period of ten months. Results: 129 DS were evaluated and compared to 97 available primary care medical charts. Most admissions were due to a medical emergency (95%), the patients were often elderly and 23% lived alone. Hospital stay averaged 4.0±2.4 days, readmission rate was 15.8%. In 73% of the DS at least one new drug was prescribed. The family physician was the one expected to continue treatment in most of the cases, but in over a third of the patients, a referral to further consultation was deemed necessary. The DS was found in 82% of the primary care charts. Median time interval between discharge and consultation with the family physician was three days (range 1-30). Home visits by physicians were documented in eight cases only. Conclusion: Most discharged patients require further evaluation and newly prescribed medications, making a timely and coordinated continuous care in the community mandatory. A high quality, rapidly available DS is therefore important for the family physician. Whether improved communication will reduce readmissions and improve patient prognosis and quality of care should be clarified by further study.peer-reviewe

Comprehensive methylome map of lineage commitment from haematopoietic progenitors.

Epigenetic modifications must underlie lineage-specific differentiation as terminally differentiated cells express tissue-specific genes, but their DNA sequence is unchanged. Haematopoiesis provides a well-defined model to study epigenetic modifications during cell-fate decisions, as multipotent progenitors (MPPs) differentiate into progressively restricted myeloid or lymphoid progenitors. Although DNA methylation is critical for myeloid versus lymphoid differentiation, as demonstrated by the myeloerythroid bias in Dnmt1 hypomorphs, a comprehensive DNA methylation map of haematopoietic progenitors, or of any multipotent/oligopotent lineage, does not exist. Here we examined 4.6 million CpG sites throughout the genome for MPPs, common lymphoid progenitors (CLPs), common myeloid progenitors (CMPs), granulocyte/macrophage progenitors (GMPs), and thymocyte progenitors (DN1, DN2, DN3). Marked epigenetic plasticity accompanied both lymphoid and myeloid restriction. Myeloid commitment involved less global DNA methylation than lymphoid commitment, supported functionally by myeloid skewing of progenitors following treatment with a DNA methyltransferase inhibitor. Differential DNA methylation correlated with gene expression more strongly at CpG island shores than CpG islands. Many examples of genes and pathways not previously known to be involved in choice between lymphoid/myeloid differentiation have been identified, such as Arl4c and Jdp2. Several transcription factors, including Meis1, were methylated and silenced during differentiation, indicating a role in maintaining an undifferentiated state. Additionally, epigenetic modification of modifiers of the epigenome seems to be important in haematopoietic differentiation. Our results directly demonstrate that modulation of DNA methylation occurs during lineage-specific differentiation and defines a comprehensive map of the methylation and transcriptional changes that accompany myeloid versus lymphoid fate decisions

Chromospheric Anemone Jets as Evidence of Ubiquitous Reconnection

The heating of the solar chromosphere and corona is a long-standing puzzle in solar physics. Hinode observations show the ubiquitous presence of chromospheric anemone jets outside sunspots in active regions. They are typically 3 to 7 arc seconds = 2000 to 5000 kilometers long and 0.2 to 0.4 arc second = 150 to 300 kilometers wide, and their velocity is 10 to 20 kilometers per second. These small jets have an inverted Y-shape, similar to the shape of x-ray anemone jets in the corona. These features imply that magnetic reconnection similar to that in the corona is occurring at a much smaller spatial scale throughout the chromosphere and suggest that the heating of the solar chromosphere and corona may be related to small-scale ubiquitous reconnection.Comment: 10 pages, 5 figure

The Epithelial-Mesenchymal Transition Factor SNAIL Paradoxically Enhances Reprogramming

Summary Reprogramming of fibroblasts to induced pluripotent stem cells (iPSCs) entails a mesenchymal to epithelial transition (MET). While attempting to dissect the mechanism of MET during reprogramming, we observed that knockdown (KD) of the epithelial-to-mesenchymal transition (EMT) factor SNAI1 (SNAIL) paradoxically reduced, while overexpression enhanced, reprogramming efficiency in human cells and in mouse cells, depending on strain. We observed nuclear localization of SNAI1 at an early stage of fibroblast reprogramming and using mouse fibroblasts expressing a knockin SNAI1-YFP reporter found cells expressing SNAI1 reprogrammed at higher efficiency. We further demonstrated that SNAI1 binds the let-7 promoter, which may play a role in reduced expression of let-7 microRNAs, enforced expression of which, early in the reprogramming process, compromises efficiency. Our data reveal an unexpected role for the EMT factor SNAI1 in reprogramming somatic cells to pluripotency

Chemotherapeutic Treatment of Priapism in Metastatic Rectal Cancer

A 65-year-old man was admitted with penile tenderness and dysuria due to priapism. Enhanced computed tomography revealed metastatic tumors in the liver, lung, sacrum and lymph nodes. Advanced rectal cancer, detected by colonoscopy as a primary tumor, was treated with chemotherapy (FOLFOX4). Although the rectal cancer showed no change, five months of chemotherapy improveid the priapism, suggesting that chemotherapy can improve rare symptoms of rectal cancer

Cholinergic modulation of striatal microcircuits

The purpose of this review is to bridge the gap between earlier literature on striatal cholinergic interneurons and mechanisms of microcircuit interaction demonstrated with the use of newly available tools. It is well known that the main source of the high level of acetylcholine in the striatum, compared to other brain regions, is the cholinergic interneurons. These interneurons provide an extensive local innervation that suggests they may be a key modulator of striatal microcircuits. Supporting this idea requires the consideration of functional properties of these interneurons, their influence on medium spiny neurons, other interneurons, and interactions with other synaptic regulators. Here, we underline the effects of intrastriatal and extrastriatal afferents onto cholinergic interneurons and discuss the activation of pre- and postsynaptic muscarinic and nicotinic receptors that participate in the modulation of intrastriatal neuronal interactions. We further address recent findings about corelease of other transmitters in cholinergic interneurons and actions of these interneurons in striosome and matrix compartments. In addition, we summarize recent evidence on acetylcholine-mediated striatal synaptic plasticity and propose roles for cholinergic interneurons in normal striatal physiology. A short examination of their role in neurological disorders such as Parkinson\u27s, Huntington\u27s, and Tourette\u27s pathologies and dystonia is also included