Monte Carlo Simulation of Ising Models with Dipole Interaction

Recently, a new memory effect was found in the metamagnetic domain structure of the diluted Ising antiferromagnet $Fe_x Mg_{1-x} Cl_2$ by domain imaging with Faraday contrast. Essential for this effect is the dipole interaction. We simulate the low temperature behavior of diluted Ising-antiferromagnets by a Monte Carlo simulation considering long range interaction. The metamagnetic domain structure occurring due to the dipole interaction is investigated by graphical representation. In the model considered the antiferromagnetic state is stable for an external magnetic field smaller than a lower boundary $B_{c1}$ while for fields larger than an upper boundary $B_{c2}$ the system is in the saturated paramagnetic phase, where the spins are ferromagnetically polarized. For magnetic fields in between these two boundaries a mixed phase occurs consisting of ferromagnetic domains in an antiferromagnetic background. The position of these ferromagnetic domains is stored in the system: after a cycle in which the field is first removed and afterwards applied again the domains reappear at their original positions. The reason for this effect can be found in the frozen antiferromagnetic domain state which occurs after removing the field.Comment: Latex, 10 pages; 3 postsript-figures, compressed tar-file, uuencoded, report 10109

The impact of acid deposition and forest harvesting on lakes and their forested catchments in south central Ontario: a critical loads approach

International audienceThe impact of acid deposition and tree harvesting on three lakes and their representative sub-catchments in the Muskoka-Haliburton region of south-central Ontario was assessed using a critical loads approach. As nitrogen dynamics in forest soils are complex and poorly understood, for simplicity and to allow comparison among lakes and their catchments, CLs (A) for both lakes and forest soils were calculated assuming that nitrate leaching from catchments will not change over time (i.e. a best case scenario). In addition, because soils in the region are shallow, base cation weathering rates for the representative sub-catchments were calculated for the entire soil profile and these estimates were also used to calculate critical loads for the lakes. These results were compared with critical loads obtained by the Steady State Water Chemistry (SSWC) model. Using the SSWC model, critical loads for lakes were between 7 and 19 meq m-2yr-1 higher than those obtained from soil measurements. Lakes and forests are much more sensitive to acid deposition if forests are harvested, but two acid-sensitive lakes had much lower critical loads than their respective forested sub-catchments implying that acceptable acid deposition levels should be dictated by the most acid-sensitive lakes in the region. Under conditions that assume harvesting, the CL (A) is exceeded at two of the three lakes and five of the six sub-catchments assessed in this study. However, sulphate export from catchments greatly exceeds input in bulk deposition and, to prevent lakes from falling below the critical chemical limit, sulphate inputs to lakes must be reduced by between 37% and 92% if forests are harvested. Similarly, sulphate leaching from forested catchments that are harvested must be reduced by between 16 and 79% to prevent the ANC of water draining the rooting zone from falling below 0 ?eq l-1. These calculations assume that extremely low calcium leaching losses (9?27 ?eq l-1) from forest soils can be maintained without any decrease in forest productivity. Calcium concentrations in the three lakes have decreased by between ?10 and 25% over the past 20 years and calculations assume that calcium concentrations in lakes can fall to around 30% of their current values without any harmful effects on biota. Both these assumptions require urgent investigation. Keywords: acid deposition, calcium, critical loads, forests, harvesting, lakes</p

Shape-dependent Depinning of a Domain Wall by a Magnetic Field and a Spin-Polarized Current

The effect of sample shape on the depinning of the domain wall (DW) driven by an applied magnetic field or a spin-polarized current is studied theoretically. The shape effect resulting from the modulation of the sample width (geometric pinning) can essentially affect the DW depinning. We found a good agreement between the ratios of the critical values of the magnetic field and the spin-polarized current predicted by the theory and measured in the experiment.Comment: 9 pages, 5 figure

Patterns of gene expression in schistosomes: localization by whole mount in situ hybridization

rom the identification of genes to the characterization of their functions and interactions. Developmental biologists have long used whole mount in situ hybridization (WISH) to determine gene expression patterns, as a vital tool for formulating and testing hypotheses about function. This paper describes the application of WISH to the study of gene expression in larval and adult schistosomes. Fixed worms were permeablized by proteinase K treatment for hybridization with digoxygenin-labelled RNA probes, with binding being detected by alkaline phosphatase-coupled anti-digoxygenin antibodies, and BM Purple substrate. Discrete staining patterns for the transcripts of the molecules Sm29, cathepsin L, antigen 10.3 and chorion were observed in the tegument cell bodies, gut epithelium, oesophageal gland and vitelline lobules, respectively, of adult worms. Transcripts of the molecules SGTP4, GP18-22 and cathepsin L were localized to tegument cell bodies and embryonic gut, respectively, of lung schistosomula. We also showed that Fast Red TR fluorescent substrate can refine the pattern of localization permitting use of confocal microscopy. We believe that method of WISH will find broad application, in synergy with other emerging post-genomic techniques, such as RNA interference, to studies focused at increasing our molecular understanding of schistosomes

The impact of broadband in schools

The report reviews evidence for the impact of broadband in English schools, exploring; Variations in provision in level of broadband connectivity; Links between the level of broadband activity and nationally accessible performance data; Aspects of broadband connectivity and the school environment that contribute to better outcomes for pupils and teachers; Academic and motivational benefits associated with educational uses of this technology

Modelling acidification, recovery and target loads for headwater catchments in Nova Scotia, Canada

The response of twenty acid-sensitive headwater catchments in Nova Scotia to acidic deposition was investigated for the period 1850&ndash;2100 using a dynamic hydrochemical model (MAGIC: Model of Acidification of Groundwater in Catchments). To ensure robust model simulation, MAGIC was calibrated to the long-term chemical trend in annual lake observations (13&ndash;20 years). Model simulations indicated that the surface waters of all twenty catchments acidified to the 1970s but showed subsequent recovery (increases in acid neutralising capacity (ANC) and pH) as sulphate deposition decreased. However, under proposed future emissions reductions (approximately 50% of current deposition) simulated ANC and pH will not return to estimated pre-industrial levels by 2100. An ANC of 20 &mu;mol_c L^&minus;1 and pH of 5.4 were defined as acceptable chemical thresholds (or critical chemical limits) for aquatic organisms in the current study. Under the proposed emissions reductions only one catchment is predicted to remain below the critical limit for ANC by 2100; three additional catchments are predicted to remain below the critical limit for pH. Dynamic models may be used to estimate target loads, i.e., the required deposition reductions to achieve recovery within a given time. Setting target loads at approximately 30% of current depositions would allow three of the four lakes to reach the chemical criteria by 2030. In contrast to the generally good prognosis for surface waters, soils lost an average of 32% of estimated initial base saturation and recovery is estimated to be very slow, averaging 23% lower than pre-acidification levels in 2100

Tablet PCs in schools: Case study report: A report for Becta by the Open University

The publication provides an analysis of twelve case studies involving schools in England that were using Tablet PCs. The analysis is complemented by brief individual reports describing aspects of how each of these schools was using Tablet PCs

Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction

The MEK inhibitors cobimetinib and trametinib are used in combination with BRAF inhibitors to treat metastatic melanoma but increase rates of hemorrhage relative to BRAF inhibitors alone. Platelets express several members of the MAPK signalling cascade including MEK1 and MEK2 and ERK1 and ERK2 but their role in platelet function and haemostasis is ambiguous as previous reports have been contradictory. It is therefore unclear if MEK inhibitors might be causing platelet dysfunction and contributing to increased hemorrhage. In the present study we performed pharmacological characterisation of cobimetinib and trametinib in vitro to investigate potential for MEK inhibitors to cause platelet dysfunction. We report that whilst both cobimetinib and trametinib are potent inhibitors of platelet MEK activity, treatment with trametinib did not alter platelet function. Treatment with cobimetinib results in inhibition of platelet aggregation, integrin activation, alpha-granule secretion and adhesion but only at suprapharmacological concentrations. We identified that the inhibitory effects of high concentrations of cobimetinib are associated with off-target inhibition on Akt and PKC. Neither inhibitor caused any alteration in thrombus formation on collagen under flow conditions in vitro. Our findings demonstrate that platelets are able to function normally when MEK activity is fully inhibited, indicating MEK activity is dispensable for normal platelet function. We conclude that the MEK inhibitors cobimetinib and trametinib do not induce platelet dysfunction and are therefore unlikely to contribute to increased incidence of bleeding reported during MEK inhibitor therapy

Origin of adiabatic and non-adiabatic spin transfer torques in current-driven magnetic domain wall motion

A consistent theory to describe the correlated dynamics of quantum mechanical itinerant spins and semiclassical local magnetization is given. We consider the itinerant spins as quantum mechanical operators, whereas local moments are considered within classical Lagrangian formalism. By appropriately treating fluctuation space spanned by basis functions, including a zero-mode wave function, we construct coupled equations of motion for the collective coordinate of the center-of-mass motion and the localized zero-mode coordinate perpendicular to the domain wall plane. By solving them, we demonstrate that the correlated dynamics is understood through a hierarchy of two time scales: Boltzmann relaxation time when a non-adiabatic part of the spin-transfer torque appears, and Gilbert damping time when adiabatic part comes up.Comment: 4 pages, 2 figure

Domain-wall profile in the presence of anisotropic exchange interactions: Effective on-site anisotropy

Starting from a D-dimensional XXZ ferromagnetic Heisenberg model in an hypercubic lattice, it is demonstrated that the anisotropy in the exchange coupling constant leads to a D-dependent effective on-site anisotropy interaction often ignored for D>1. As a result the effective width of the wall depends on the dimensionality of the system. It is shown that the effective one-dimensional Hamiltonian is not the one-dimensional XXZ version as assumed in previous theoretical work. We derive a new expression for the wall profile that generalizes the standard Landau-Lifshitz form. Our results are found to be in very good agreement with earlier numerical work using the Monte Carlo method. Preceding theories concerning the domain wall contribution to magnetoresistance have considered the role of D only through the modification of the density of states in the electronic band structure. This Brief Report reveals that the wall profile itself contains an additional D dependence for the case of anisotropic exchange interactions.Comment: 4 pages; new title and abstract; 1 figure comparing our results with earlier numerical work; a more general model containing the usual on-site anisotropy; new remarks and references on the following two topics: (a) experimental evidence for the existence of spin exchange anisotropy, and (b) preceding theories concerning the domain wall contribution to magnetoresistance; to appear in Phys. Rev.