Richness and Current Status of Gymnosperm Communities in Aguascalientes, Mexico

The gymnosperm diversity of Aguascalientes, Mexico, is presented. Fifteen species from five genera and three families are reported, two of Coniferales (Cupressaceae and Pinaceae) and one of Gnetales (Ephedraceae). Pinus is the most diverse and abundant genus with seven species. The most abundant species is P. teocote, while P. strobiformis is the scarcest. Juniperus is the next most diverse genus, represented by four species, with J. deppeana the most abundant and J. durangensis the scarcest. Cupressus lusitanica, Taxodium mucronatum and Ephedra compacta are each the sole representatives of their genera. Most conifers occupy the mountainous part of the state, forming temperate forest; exceptions are Taxodium, which is located on the margins of permanent streams, and J. coahuilensis, which is found in the low parts of the Aguascalientes Valley over calcareous soils in the northern part of the state. Ephedra is distributed in the northeast part of Aguascalientes in microphyll desert scrub. The current status of the gymnosperm communities in the state of Aguascalientes is discussed

Extracellular Vesicles Derived from Plasmodium-infected and Non-infected Red Blood Cells as Targeted Drug Delivery Vehicles

Among several factors behind drug resistance evolution in malaria is the challenge of administering overall doses that are not toxic for the patient but that, locally, are sufficiently high to rapidly kill the parasites. Thus, a crucial antimalarial strategy is the development of drug delivery systems capable of targeting antimalarial compounds to Plasmodium with high specificity. In the present study, extracellular vesicles (EVs) have been evaluated as a drug delivery system for the treatment of malaria. EVs derived from naive red blood cells (RBCs) and from Plasmodium falciparum-infected RBCs (pRBCs) were isolated by ultrafiltration followed by size exclusion chromatography. Lipidomic characterization showed that there were no significant qualitative differences between the lipidomic profiles of pRBC-derived EVs (pRBC-EVs) and RBC-derived EVs (RBC-EVs). Both EVs were taken up by RBCs and pRBCs, although pRBC-EVs were more efficiently internalized than RBC-EVs, which suggested their potential use as drug delivery vehicles for these cells. When loaded into pRBC-EVs, the antimalarial drugs atovaquone and tafenoquine inhibited in vitro P. falciparum growth more efficiently than their free drug counterparts, indicating that pRBC-EVs can potentially increase the efficacy of several small hydrophobic drugs used for the treatment of malaria

Antioxidant and Cytotoxicological Effects of Aloe vera

Currently, food industries use supplements from Aloe vera as highly concentrated powders (starting products), which are added to the final product at a concentration of 1x, meaning 10 g/L for decolourized and spray-dried whole leaf powder (WLP) or 5 g/L for decolourized and spray-dried inner leaf powder (ILG) and also for nondecolourized and belt-dried inner leaf powder (ILF). Flavonoids, tannins, or saponins could not be detected for any starting product at this concentration and their total phenol concentration of 68–112 μM gallate-eq. was much lower than in fresh extract; however, their antioxidant capacity of 90–123 μM ascorbate-eq. for DPPH was similar to the fresh extract. Starting products, dissolved at 1x, had an aloin concentration of 0.04 to 0.07 ppm, a concentration much lower than the industry standard of 10 ppm for foodstuff. While decolourized starting products (i.e., treated with activated carbon) exhibited low cytotoxicity on HeLa cells (CC50 = 15 g/L ILG or 50 g/L WLP), ILF at CC50 = 1–5 g/L exhibited cytotoxic effects, that is, at concentrations even below the recommended for human consumption. Probable causes for the cytotoxicity of ILF are the exposure to high temperatures (70–85°C) combined with a high fibre content

Modelo de seguridad para la prevención del lavado de dinero.

TESINA C7.142

Intracellular antigens released from Balb/c mice kidneys under chemically induced apoptosis and/or necrosis

Apoptosis is a physiologic process that makes certain the cellular exchange; after apoptosis cellular corpses are cleared by phagocytosis. In autoimmunity, some mechanisms of apoptosis are not succeeding and result in autoimmunity; for instance the failure in the Fas pathway in lymphoid ontogeny fosters the autoimmune clone survival. Additionally the insufficient clearance of apoptotic material represents a potential danger that may activate the pre-existent auto-reactive clones, and may trigger the autoantibody production (1). Is now accepted that antigens from apoptotic origin are better targeted by autoantibodies (2-4), and the source of apoptotic remains is broad spread, nevertheless the skin is very important because is an easy target of the UV light, and may induce antibody depositionesulting in skin lesions, this mechanism is important in SCLE (5)

Investigación, reflexión y acción de la realidad socio-educativa a principios del siglo XXI : vol. I

Consciente de la importancia de la investigación educativa para promover las transformaciones que permitan ofrecer a la sociedad nacional e internacional una educación pertinente y relevante que al mismo tiempo, contribuya con el desarrollo humano, en febrero del 2011 y en el marco de la celebración del 30 aniversario de su fundación, el Instituto de Investigación en Educación (INIE) organiza el II Congreso Internacional de Investigación Educativa: Su Incidencia en la Realidad Social. Los aportes presentados durante este II Congreso Internacional de Investigación Educativa, se han recopilado en la publicación del libro digital: Investigación, reflexión y acción de la realidad socio-educativa a principios del siglo XXI. Estos trabajos tienen por objetivo ofrecer propuestas para repensar la educación y los procesos educativos que se desarrollan en las aulas, así como valorar la importancia de realizar las transformaciones que se requieren a partir de los resultados de las investigaciones