102 research outputs found
Can new generations explain neutrino masses?
In this talk we explore the possibility that the smallness of the observed
neutrino masses is naturally understood in a modified version of the standard
model with N extra generations of fermions and N right-handed neutrinos, in
which light neutrino masses are generated at two loops. We find that with N = 1
it is not possible to fit the observed spectrum of masses and mixings while
with N = 2 it is. Within this extension, we analyse the parameters which are
allowed and the possible phenomenological signals of the model in future
experiments. Contribution to the proceedings of Les Rencontres de Moriond EW
2011, Young Scientist Forum
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Evaluación y descripción del desarrollo del discurso narrativo en español/Evaluation and description of narrative development in Spanish
Background and objectives: The skills involved in narrative production are a good indicator of children's current language competence and predict future linguistic performance. It is important in speech and language therapy and education research to have specific assessments of developing narrative abilities. To date, however, there are few tests that assess the development of narratives in Spanish. This research has a double objective: first, to adapt the Test of Narrative Production to Spanish; and second, to describe the development of narrative skills using the adapted test. Method: A total of 146 children aged 4-11 years with Spanish as their mother tongue were evaluated by the Test of Narrative Production adapted to Spanish, and were assessed for their narrative skills at the level of both macrostructure and microstructure. Results: A strong significant correlation between age and narrative performance was observed at the macrostructural and microstructural levels. However, although both levels showed a stabilization at age 9 years, at the microstructural level cohesive devices continued developing until age 11 years. Conclusions: The test can be considered a valid evaluation of narrative development in Spanish. The results are consistent with research in English-speaking children, where it has been shown that they acquire a similar level of narrative performance to that of adults at 9 years of age at the macrostructural level, but they continue to develop and refine the microstructural level until adolescence
A model for right-handed neutrino magnetic moments
A simple extension of the Standard Model providing Majorana magnetic moments
to right-handed neutrinos is presented. The model contains, in addition to the
Standard Model particles and right-handed neutrinos, just a singly charged
scalar and a vector-like charged fermion. The phenomenology of the model is
analysed and its implications in cosmology, astrophysics and lepton flavour
violating processes are extracted. If light enough, the charged particles
responsible for the right-handed neutrino magnetic moments could copiously be
produced at the LHC.Comment: 16 pages, 5 figure
On the nature of the fourth generation neutrino and its implications
We consider the neutrino sector of a Standard Model with four generations.
While the three light neutrinos can obtain their masses from a variety of
mechanisms with or without new neutral fermions, fourth-generation neutrinos
need at least one new relatively light right-handed neutrino. If lepton number
is not conserved this neutrino must have a Majorana mass term whose size
depends on the underlying mechanism for lepton number violation. Majorana
masses for the fourth generation neutrinos induce relative large two-loop
contributions to the light neutrino masses which could be even larger than the
cosmological bounds. This sets strong limits on the mass parameters and mixings
of the fourth generation neutrinos.Comment: To be published. Few typos corrected, references update
Glioblastoma: Vascular Habitats Detected at Preoperative Dynamic Susceptibility-weighted Contrast-enhanced Perfusion MR Imaging Predict Survival
[EN] Purpose: To determine if preoperative vascular heterogeneity of glioblastoma is predictive of overall survival of patients undergoing standard-of-care treatment by using an unsupervised multiparametric perfusion-based habitat-discovery algorithm.
Materials and Methods: Preoperative magnetic resonance (MR) imaging including dynamic susceptibility-weighted contrast material-enhanced perfusion studies in 50 consecutive patients with glioblastoma were retrieved. Perfusion parameters of glioblastoma were analyzed and used to automatically draw four reproducible habitats that describe the tumor vascular heterogeneity: high-angiogenic and low-angiogenic regions of the enhancing tumor, potentially tumor-infiltrated peripheral edema, and vasogenic edema. Kaplan-Meier and Cox proportional hazard analyses were conducted to assess the prognostic potential of the hemodynamic tissue signature to predict patient survival.
Results: Cox regression analysis yielded a significant correlation between patients' survival and maximum relative cerebral blood volume (rCBV(max)) and maximum relative cerebral blood flow (rCBF(max)) in high-angiogenic and low-angiogenic habitats (P < .01, false discovery rate-corrected P < .05). Moreover, rCBF(max) in the potentially tumor-infiltrated peripheral edema habitat was also significantly correlated (P < .05, false discovery rate-corrected P < .05). Kaplan-Meier analysis demonstrated significant differences between the observed survival of populations divided according to the median of the rCBV(max) or rCBF(max) at the high-angiogenic and low-angiogenic habitats (log-rank test P < .05, false discovery rate-corrected P < .05), with an average survival increase of 230 days.
Conclusion: Preoperative perfusion heterogeneity contains relevant information about overall survival in patients who undergo standard-of-care treatment. The hemodynamic tissue signature method automatically describes this heterogeneity, providing a set of vascular habitats with high prognostic capabilities.Study supported by H2020 European Institute of Innovation and Technology (POC-2016.SPAIN-07) and Universitat Politecnica de Valencia (PAID-10-14). J.J.A., E.F.G., and J.M.G.G. supported by Secretaria de Estado de Investigacion, Desarrollo e Innovacion (DPI2016-80054-R, TIN2013-43457-R). E.F.G. supported by CaixaImpulse program from Fundacio Bancaria "la Caixa" (LCF/TR/CI16/10010016). E.F.G and A.A.B. supported by the Universitat Politecnica de Valencia Instituto Investigacion Sanitaria de La Fe (C05).Juan -Albarracín, J.; Fuster García, E.; Pérez-Girbés, A.; Aparici-Robles, F.; Alberich Bayarri, A.; Revert Ventura, AJ.; Martí Bonmatí, L.... (2018). Glioblastoma: Vascular Habitats Detected at Preoperative Dynamic Susceptibility-weighted Contrast-enhanced Perfusion MR Imaging Predict Survival. Radiology. 287(3):944-954. https://doi.org/10.1148/radiol.2017170845S944954287
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