Higher resources decrease fluctuating selection during host-parasite coevolution

This is the final version of the article. Available from the publisher via the DOI in this record.We still know very little about how the environment influences coevolutionary dynamics. Here, we investigated both theoretically and empirically how nutrient availability affects the relative extent of escalation of resistance and infectivity (arms race dynamic; ARD) and fluctuating selection (fluctuating selection dynamic; FSD) in experimentally coevolving populations of bacteria and viruses. By comparing interactions between clones of bacteria and viruses both within- and between-time points, we show that increasing nutrient availability resulted in coevolution shifting from FSD, with fluctuations in average infectivity and resistance ranges over time, to ARD. Our model shows that range fluctuations with lower nutrient availability can be explained both by elevated costs of resistance (a direct effect of nutrient availability), and reduced benefits of resistance when population sizes of hosts and parasites are lower (an indirect effect). Nutrient availability can therefore predictably and generally affect qualitative coevolutionary dynamics by both direct and indirect (mediated through ecological feedbacks) effects on costs of resistance.This work was funded by NERC (UK). ABu was supported by the Royal Society and ABe by a the Leverhulme Trust Early Career Fellowship

Crafting Partnerships: Exploring Student-Led Feminist Strategies for Community Literacy Projects

Relationships have served as a cornerstone to feminist research in community-based research and service learning sites, as feminist scholars have argued for co-constructing knowledges in these sites, while being attentive to the reciprocal nature of these relationships within any context of and for learning (Bayer, Grossman, & Dubois, 2015; Parks & Goldblatt, 2000; Novek, 1999). These relationships are especially crucial when feminists attempt to create real and sustained partnerships through mentoring in their community-based literacy site (DuBois & Karcher, 2005). We stress the value of cultivating sustained relationships, as oftentimes discourses surrounding service learning exhibit a level of engagement that is not sustained and/or does not adequately expose the workings of power and privilege in a systematic way (Deans, 2002). In light of our feminist motivations, we need to continuously create spaces to foreground the value of experience and take seriously the process of cultivating relationships with students in ways that are both ethical and accountable.https://nsuworks.nova.edu/shss_facbooks/1122/thumbnail.jp

Differential impact of simultaneous migration on coevolving hosts and parasites

BACKGROUND: The dynamics of antagonistic host-parasite coevolution are believed to be crucially dependent on the rate of migration between populations. We addressed how the rate of simultaneous migration of host and parasite affected resistance and infectivity evolution of coevolving meta-populations of the bacterium Pseudomonas fluorescens and a viral parasite (bacteriophage). The increase in genetic variation resulting from small amounts of migration is expected to increase rates of adaptation of both host and parasite. However, previous studies suggest phages should benefit more from migration than bacteria; because in the absence of migration, phages are more genetically limited and have a lower evolutionary potential compared to the bacteria. RESULTS: The results supported the hypothesis: migration increased the resistance of bacteria to their local (sympatric) hosts. Moreover, migration benefited phages more than hosts with respect to 'global' (measured with respect to the whole range of migration regimes) patterns of resistance and infectivity, because of the differential evolutionary responses of bacteria and phage to different migration regimes. Specifically, we found bacterial global resistance peaked at intermediate rates of migration, whereas phage global infectivity plateaued when migration rates were greater than zero. CONCLUSION: These results suggest that simultaneous migration of hosts and parasites can dramatically affect the interaction of host and parasite. More specifically, the organism with the lower evolutionary potential may gain the greater evolutionary advantage from migration

Background Rejection in the DMTPC Dark Matter Search Using Charge Signals

The Dark Matter Time Projection Chamber (DMTPC) collaboration is developing low-pressure gas TPC detectors for measuring WIMP-nucleon interactions. Optical readout with CCD cameras allows for the detection for the daily modulation in the direction of the dark matter wind, while several charge readout channels allow for the measurement of additional recoil properties. In this article, we show that the addition of the charge readout analysis to the CCD allows us too obtain a statistics-limited 90% C.L. upper limit on the $e^-$ rejection factor of $5.6\times10^{-6}$ for recoils with energies between 40 and 200 keV$_{\mathrm{ee}}$. In addition, requiring coincidence between charge signals and light in the CCD reduces CCD-specific backgrounds by more than two orders of magnitude.Comment: 8 pages, 6 figures. For proceedings of DPF 2011 conferenc

The Stability of Perceived Pubertal Timing Across Adolescence

It is unknown whether perceived pubertal timing changes as puberty progresses or whether it is an important component of adolescent identity formation that is fixed early in pubertal development. The purpose of this study is to examine the stability of perceived pubertal timing among a school-based sample of rural adolescents aged 11 to 17 (N=6,425; 50% female; 53% White). Two measures of pubertal timing were used, stage-normative, based on the Pubertal Development Scale, a self-report scale of secondary sexual characteristics, and peer-normative, a one-item measure of perceived pubertal timing. Two longitudinal methods were used: one-way random effects ANOVA models and latent class analysis. When calculating intraclass correlation coefficients using the one-way random effects ANOVA models, which is based on the average reliability from one time point to the next, both measures had similar, but poor, stability. In contrast, latent class analysis, which looks at the longitudinal response pattern of each individual and treats deviation from that pattern as measurement error, showed three stable and distinct response patterns for both measures: always early, always on-time, and always late. Study results suggest instability in perceived pubertal timing from one age to the next, but this instability is likely due to measurement error. Thus, it may be necessary to take into account the longitudinal pattern of perceived pubertal timing across adolescence rather than measuring perceived pubertal timing at one point in time

Estimating statistical power for open-enrollment group treatment trials

Modeling turnover in group membership has been identified as a key barrier contributing to a disconnect between the manner in which behavioral treatment is conducted (open enrollment groups) and the designs of substance abuse treatment trials (closed enrollment groups, individual therapy). Latent class pattern mixture models (LCPMM) are an emerging tool for modeling data from open enrollment groups with membership turnover in recently proposed treatment trials. The current article illustrates an approach to conducting power analyses for open enrollment designs based on Monte Carlo simulation of LCPMM models using parameters derived from published data from an RCT comparing Seeking Safety to a Community Care condition for women presenting with comorbid PTSD and substance use disorders. The example addresses discrepancies between the analysis framework assumed in power analyses of many recently-proposed open enrollment trials and the proposed use of LCPMM for data analysis

Chapter 4: Water

This chapter assesses observed and projected climate-induced changes in the water cycle, their current impacts and future risks on human and natural systems and the benefits and effectiveness of water-related adaptation efforts now and in the future

Opportunities to improve goat production and food security in Botswana through forage nutrition and the use of supplemental feeds

Goats fulfil a central role in food and nutritional security across Africa with over half of households owning or rearing goats in rural areas. However, goat performance is poor and mortality high. This study assessed the nutritional quality of commonly used feeds and proposes feed-baskets to enhance goat nutrition and health. Feeds were collected from 11 areas within the Central District of Botswana, and macronutrient analyses were conducted, including crude protein, fibre fractions, ash, and metabolizable energy (ME). Forage nutrition was compared across seasons and soil types. Additionally, seasonal supplementation trials were conducted to evaluate consumption rates of various supplements, including crop residues, pellets, Lablab purpureus, and Dichrostachys cinerea. Each supplement was provided ad libitum for a 24-h period, and consumption rates determined. Findings revealed significant differences in nutrition among various feed sources, across seasons, and in relation to soil types (p < 0.001). Consumption rates of supplements were higher during the dry season, possibly due to reduced forage availability. Supplement consumption rates varied across supplement type, with crop residues accounting for approximately 1% of dry matter intake, compared to up to 45% for pellets, 13% for L. purpureus, and 15% for D. cinerea. While wet season feed baskets exhibited higher ME values compared to dry-season feed-baskets, the relative impact of supplementation was more pronounced during the dry season. These results highlight the potential for optimizing goat diets through improved grazing and browsing management, especially during the reduced nutritional availability in the dry season in Botswana. Such diet optimisation may improve goat health and productivity, which may positively impact the food and financial security of smallholders by providing both increased yields and increased resilience. Importantly, rural communities can experience some of the lowest food security levels in the region. The interventions explored in this study utilise natural capital, often freely available, which can be deployed through existing husbandry systems, potentially making them accessible and practical to smallholders

Investigating MgII Absorption in Paired Quasar Sight-Lines

We test whether the Tinker & Chen model of MgII absorption due to the gaseous halo around a galaxy can reproduce absorption in quasar pairs (both lensed and physical) and lensed triples and quads from the literature. These quasars exhibit absorption from a total of 38 MgII systems spanning z=0.043 - 2.066 with mean redshift =1.099 and weighted mean rest-frame equivalent width of 0.87 Ang. Using the Tinker & Chen model to generate simulated sight-lines, we marginalize the unknown parameters of the absorbing galaxies: dark matter halo mass, impact parameter, and azimuthal angle on the sky. We determine the ability of the model to statistically reproduce the observed variation in MgII absorption strength between paired sight-lines for different values of the gas covering fraction f_c and the characteristic length scale ell_c, within which the variation in absorption equivalent widths between sight-lines exponentially decreases. We find a best-fit f_c=0.60 \pm 0.15 and ell_c<8/h_70 kpc (1\sigma confidence limits), with smaller f_c allowed at larger ell_c. At 99.7% confidence, we are able to rule out f_c>0.87 for all values of ell_c and the region where ell_c<1.0/h_70 kpc and f_c<0.3.Comment: 24 pages, 11 figures, 2 tables, accepted for publication in MNRAS, 1 Dec 201

Perceived pubertal timing and recent substance use among adolescents: a longitudinal perspective: Perceived pubertal timing and substance use

To determine the longitudinal associations between perceived pubertal timing and recent substance use between the ages of 11 and 17