New possibilities and tools for corporate strategic management for supporting its high competitiveness and economic effectiveness

The purpose of the article is to determine new possibilities and tools for corporate strategic management and to substantiate the necessity for their usage for supporting a company’s competitiveness and economic effectiveness in modern Russia. The information and analytical basis of the research consists of the materials of the Report on global competitiveness for 2016-2017, prepared within the World economic forum. For verification of the offered hypothesis, the methods of deduction, induction, synthesis, systemic, problem, and structural & functional analysis, as well as analysis of causal connections, and the methods of modeling and formalization were used. Because of the research, a conclusion is made that imperfection of the process of strategic management is a reason for low competitiveness and economic effectiveness of modern Russian companies. To solve this problem, the authors substantiate the necessity for applying the principle of interactivity, which supposes consideration of new possibilities and usage of leading tools in the process of corporate strategic management and develop the recommendations and offer an interactive model for strategic management of a modern company in modern Russia for the purpose of supporting high competitiveness and economic effectiveness of domestic entrepreneurship.peer-reviewe

Недифференцированная дисплазия соединительной ткани и остеоартрит коленных суставов: особенности клинических проявлений и состояния углеводного обмена

Objective: to evaluate the impact of undifferentiated connective tissue dysplasia (CTD) on the clinical manifestations of primary osteoarthritis (OA) in postmenopausal women.Patients and methods. The case-control study included 38 postmenopausal women with primary knee OA, radiological stage II. The main group included 19 patients who met the criteria for CTD, the control group included 19 patients without CTD.Results and discussion. Patients in the control group had significantly higher values of body mass index, hip circumference and more pronounced clinical manifestations of menopausal syndrome. Patients in the control group had all clinical components and laboratory criteria of the metabolic syndrome, they also had greater limitations of joint function compared to patients of the main group. In patients with CTD pathogenetic mechanisms of development and progression of OA differ from the metabolic phenotype of OA.Conclusion. The dysplastic phenotype of OA develops in the absence of metabolic syndrome and with less functional impairment than the metabolic phenotype. The metabolic phenotype of OA is associated with insulin resistance, more pronounced functional and psycho-emotional disturbances.Цель исследования – оценить влияние недифференцированной дисплазии соединительной ткани (ДСТ) на клиническую картину первичного остеоартрита (ОА) у женщин в постменопаузе.Пациенты и методы. В исследование «случай-контроль» включено 38 женщин в постменопаузе с первичным ОА коленных суставов II рентгенологической стадии. Основную группу составили 19 больных, соответствовавших критериям ДСТ, группу контроля – 19 пациенток без ДСТ.Результаты и обсуждение. Больные контрольной группы имели значимо более высокие показатели индекса массы тела, окружности бедер и более выраженные клинические проявления менопаузального синдрома. У пациенток контрольной группы выявлены все клинические компоненты и лабораторные критерии метаболического синдрома и большие ограничения функции суставов, чем у больных основной группы. У пациенток с ДСТ ОА имеет отличные от метаболического фенотипа патогенетические механизмы развития и прогрессирования.Заключение. Диспластический фенотип ОА развивается при отсутствии метаболического синдрома и протекает с меньшими функциональными нарушениями, чем метаболический фенотип. Метаболический фенотип ОА ассоциирован с инсулинорезистентностью, более выраженными функциональными и психоэмоциональными ограничениями

Formação da motivação para boa disposição do futuro especialista

The main theories of motivation have been divided into two directions: substantial theories that consider motivation from structural positions, and procedural theories that consider motivation as a dynamic formation. These areas are united by the understanding of motivation as secondary formation to the motive. In this study the concept of “readiness” for activity is considered as an active-effective state of the individual. In the structure of professional readiness of the individual, researchers identify different components, among which the most important is the motivational – attitude to the profession, the need to complete the task successfully and interest in the activity. Of the main goal of this study is considering psychological readiness as a complex functional, psychological and personal formation. As follows in this study, psychological study includes: a positive attitude to a particular type of activity; adequate to the requirements of the character and temperament; the necessary knowledge, skills, habits; stable professionally important features of cognitive and emotional-volitional processes. The study persues a model of formation of positive motivation through a professional activity of subjects of education in terms of reinforcement on the basis of the following principles: taking into account all kinds of needs of the individual; taking into account the real contribution of each employee to the final result.Las principales teorías de motivación se han dividido en dos direcciones: teorías sustanciales que consideran la motivación desde posiciones estructurales y teorías de procedimiento que consideran la motivación como una formación dinámica. Estas áreas están unidas por la comprensión de la motivación como formación secundaria al motivo. En este estudio, el concepto de “preparación” para la actividad se considera como un estado activo-efectivo del individuo. En la estructura de preparación profesional del individuo, los investigadores identifican diferentes componentes, entre los cuales el más importante es la actitud motivadora hacia la profesión, la necesidad de completar la tarea con éxito y el interés en la actividad. El objetivo principal de este estudio es considerar la preparación psicológica como una formación funcional, psicológica y personal compleja. Como se explica a continuación en este estudio, el estudio psicológico incluye: una actitud positiva hacia un tipo particular de actividad; Adecuado a los requerimientos del carácter y temperamento; Los conocimientos, habilidades, hábitos necesarios; Características estables profesionalmente importantes de los procesos cognitivos y emocional-volitivos. El estudio persigue un modelo de formación de motivación positiva a través de una actividad profesional de sujetos de educación en términos de refuerzo.As principais teorias da motivação foram divididas em duas direções: teorias substanciais que consideram a motivação a partir de posições estruturais e teorias processuais que consideram a motivação como uma formação dinâmica. Essas áreas estão ligadas pela compreensão da motivação como formação secundária ao motivo. Neste estudo, o conceito de "preparação" para a atividade é considerado como um estado ativo-efetivo do indivíduo. Na estrutura de preparação profissional do indivíduo, os pesquisadores identificam diferentes componentes, dentre os quais o mais importante é a atitude motivadora em relação à profissão, a necessidade de completar a tarefa com sucesso e o interesse pela atividade. O principal objetivo deste estudo é considerar a preparação psicológica como uma complexa formação funcional, psicológica e pessoal. Como explicado abaixo neste estudo, o estudo psicológico inclui: uma atitude positiva em relação a um tipo particular de atividade; Adequado às exigências de caráter e temperamento; O conhecimento, habilidades, hábitos necessários; Características profissionalmente importantes estáveis de processos cognitivos e emocionais volitivos. O estudo persegue um modelo de treinamento de motivação positiva através de uma atividade profissional de sujeitos de educação em termos de reforço

The results of telecommunication technologies in case of promoting the «open door day» of the medical-preventive faculty of USMU

The results of telecommunication technologies integration in case of conduct an open day of the medical-preventive faculty (MPF) of the Ural State Medical University are presented. It is shown that the integration of modern demonstration equipment FLIPBOX (interactive display) for web conferencing has allowed to expand the geography of distance communication with applicants wishing to enter USMU at the MPF.Представлены результаты применения телекоммуникационных технологий в проведении дня открытых дверей лечебно-профилактического факультета (ЛПФ) Уральского государственного медицинского университета. Показано, что внедрение современного демонстративного оборудования FLIPBOX (интерактивный дисплей) для проведения веб-конференций позволило расширить географию дистанционной связи с абитуриентами, желающими поступать в УГМУ на ЛПФ

Assessment of employers ' satisfaction with graduates of medical and preventive faculty of USMU

The article is devoted to the analysis of monitoring of the employers views about the quality of medical and preventive faculty USMU graduates training. We presents the results of the survey of medical institutions heads about satisfaction with the level of practical training of graduates.Статья посвящена анализу результатов мониторинга удовлетворенности руководителей медицинских учреждений качеством подготовки выпускников лечебно-профилактического факультета УГМУ. Приводятся результаты изучения мнения работодателей в отношении уровня теоретической и практической подготовки выпускников, которые начали самостоятельную трудовую деятельност

Assessment of employers ‘satisfaction with graduates of medical and preventive faculty of USMU

The article is devoted to the analysis of monitoring of the employers views about the quality of medical and preventive faculty USMU graduates training. We presents the results of the survey of medical institutions heads about satisfaction with the level of practical training of graduates.Статья посвящена анализу результатов мониторинга удовлетворенности работодателей качеством подготовки выпускников лечебно-профилактического факультета УГМУ. Приводятся результаты изучения мнения руководителей лечебно-профилактических учреждений в отношении уровня теоретической и практической подготовки выпускников, начавших самостоятельную трудовую деятельность

Dynamics of the results of the state final certification of students of the medical and preventiv faculty over the past 5 years

The article considers the results of three stages of the State final certification of students of the 6th year of the Faculty of Medicine and Prevention for the last 5 years from 2017 to 2021. A comparative analysis was carried out, problems and prospects were identified.В статье рассмотрены результаты трех этапов Государственной итоговой аттестации студентов 6 курса лечебно-профилактического факультета за последние 5 лет с 2017 по 2021 год. Проведен сравнительный анализ, выявлены проблемы и перспектив

The Adnectin CT-322 is a novel VEGF receptor 2 inhibitor that decreases tumor burden in an orthotopic mouse model of pancreatic cancer

<p>Abstract</p> <p>Background</p> <p>Pancreatic cancer continues to have a 5-year survival of less than 5%. Therefore, more effective therapies are necessary to improve prognosis in this disease. Angiogenesis is required for tumor growth, and subsequently, mediators of angiogenesis are attractive targets for therapy. Vascular endothelial growth factor (VEGF) is a well-characterized mediator of tumor angiogenesis that functions primarily by binding and activating VEGF receptor 2 (VEGFR2). In this study, we evaluate the use of CT-322, a novel biologic (Adnectin). This small protein is based on a human fibronectin domain and has beneficial properties in that it is fully human, stable, and is produced in bacteria. CT-322 binds to and inhibits activation of VEGFR2.</p> <p>Methods</p> <p>The efficacy of CT-322 was evaluated <it>in vivo </it>using two orthotopic pancreatic tumor models. The first model was a human tumor xenograft where MiaPaCa-2 cells were injected into the tail of the pancreas of nude mice. The second model was a syngeneic tumor using Pan02 cells injected into pancreas of C57BL/6J mice. In both models, therapy was initiated once primary tumors were established. Mice bearing MiaPaCa-2 tumors were treated with vehicle or CT-322 alone. Gemcitabine alone or in combination with CT-322 was added to the treatment regimen of mice bearing Pan02 tumors. Therapy was given twice a week for six weeks, after which the animals were sacrificed and evaluated (grossly and histologically) for primary and metastatic tumor burden. Primary tumors were also evaluated by immunohistochemistry for the level of apoptosis (TUNEL), microvessel density (MECA-32), and VEGF-activated blood vessels (Gv39M).</p> <p>Results</p> <p>Treatment with CT-322 was effective at preventing pancreatic tumor growth and metastasis in orthotopic xenograft and syngeneic models of pancreatic cancer. Additionally, CT-322 treatment increased apoptosis, reduced microvessel density and reduced the number of VEGF-activated blood vessels in tumors. Finally, CT-322, in combination with gemcitabine was safe and effective at controlling the growth of syngeneic pancreatic tumors in immunocompetent mice.</p> <p>Conclusion</p> <p>We conclude that CT-322 is an effective anti-VEGFR2 agent and that further investigation of CT-322 for the treatment of pancreatic cancer is warranted.</p

The most frequent errors in control tasks for “Medical care” direction of training

The most typical errors detected during test items for the current and final control of knowledge provided by the Federal Educational Standard for the direction of training 31.05.01 «Medical care». In a cross-sectional study more than 500 test items for the current and final control of knowledge have been reviewed. The obtained results are being implemented during preparation for the state final certification of 2019.Работа посвящена оценке наиболее типичных ошибок, выявляемых при рецензировании тестовых заданий для текущего и итогового контроля знаний, предусмотренных ФГОС ВО по направлению подготовки 31.05.01 «Лечебное дело». В одномоментном исследовании оценены более 500 вариантов представленных для рецензии тестовых заданий для текущего и итогового контроля знаний в рамках подготовки к государственной итоговой аттестации 2019 г. На основании полученных результатов разработаны и проводятся коррекционные мероприятия в рамках подготовки контрольно-измерительных средств для государственной итоговой аттестации 2019 г