Extraction, Refining and Characterization of the Fixed Oil of Basil (Ocimumbasilicum L.) Seeds

Basil is considered one of the important medicinal and aromatic plants in Sudan and worldwide. It is very rich sources of phytochemicals which have vital properties affecting human health in reduce risks and diseases. The present study aimed to evaluate the physicochemical characteristics of basil seeds and the oil extracted from them. This included four accessions of basil grown in National Oil Seed Processing Research Institute (NOPRI) farm- University of Gezira- Sudan: (two local accessions of NOPRI and Umteraibat, and two accessions (Egyptian and Maldivian) obtained from Institute for Plant Genetics and Crop Plant Research (IPK), Gatersleben, Germany. Themethods used the American Oil Chemists Society (AOCS) official methods. The percentage of moisture content (4-5), oil content (19-28%), crude protein (15-20%), crude fiber (30-36%)and ash (5-8%)for basil seeds. The physical properties of crude oil were specific gravity at room temperature (0.92-0.93) and refractive index (1.4809-1.4823) at 20°C. The Lovibond readings for crude oil color were in the range (0.6-2.5) for the red color and (18-70) for the yellow color, while for the refined oil the red color was (0.2-0.5) and yellow was (2.5-6.2). Chemical properties were: free fatty acids for crude oil (0.2-0.76%) and (0.04-0.06%) for refined oil; peroxide and saponification values and the unsaponifiable matter were (5.7-24.9) ml.eqv.\kg, (195-198) mg KOH/g and (1.6-2.2%) respectively. The fatty acid composition was analyzed using GC-MS, and the percentage of the unsaturated fatty acids oleic, linoleic and linolenic were (0.78-2.13), (22.91-40.39%)and (22.83-39.32%)respectively; the most abundant saturated fatty acids were palmitic and stearic at (14.7-16.67%) and (9.18-11.57%) respectively

Carcinome adénoïde kystique de la fosse nasale: à propos d'un cas et revue de littérature

Parmi les tumeurs de la tête et du cou,  le carcinome adénoïde kystique ne représente que 1%. C’est la tumeur maligne la plus fréquente des glandes salivaires accessoires. Sa localisation dans la fosse nasale est exceptionnelle. Nous rapportons un cas de carcinome adénoïde kystique de la fosse nasale chez une patiente de 42 ans qui se présente pour une symptomatologie  nasale. La  tomodensitométrie objective un processus tissulaire de la fosse nasale droite, l’endoscopie montre une tumeur s’étendant au vestibule avec à la biopsie un carcinome adénoïde kystique. La prise en charge chirurgicale a consisté en une exérèse de la tumeur avec maxillectomie totale suivie d'une radiothérapie

Research Output on Strategy Formulation and Implementation: Global Picture, Development and Key Bibliometric Indicators

Effective strategic management serves as the bedrock for an organization's vision, goal attainment, and stakeholder expectations. Consequently, the research focus on strategy formulation and implementation has garnered substantial attention in recent decades. This study aims to evaluate bibliometric indicators of research productivity related to strategy formulation and implementation through meticulous bibliometric analysis. The analysis leverages the R Bibliometrix library on scientific publications indexed in the Web of Science database. The dataset comprises 672 publications on strategy formulation and implementation, spanning the years 1971 to 2022. Authored by 1,280 contributors from 69 countries, these publications are dispersed across 374 diverse sources, including journals and books. Impressively, this body of work has garnered a cumulative total of 24,635 citations, averaging 36.66 citations per document. The top-ranking article, "The Resource-Based Theory of Competitive Advantage: Implications for Strategy Formulation" by Robert M. Grant, stands out with 3,649 citations. Examining global scientific production, the United States emerges as the primary contributor with 154 publications (22.91%), followed by China with 56 (8.33%) and the United Kingdom with 54 (8.03%). The study's findings offer valuable insights for researchers and organizations alike, shedding light on significant research contributions. This comprehensive assessment enables a nuanced understanding of the historical progression and growth within this domain. Additionally, it identifies current focal points of research and highlights areas that warrant attention in future studies

Masse des glandes salivaires : Quel est votre diagnostic ?

A travers cet article, les auteurs mettent en relief deux observations à propos d’un syndrome tumoral des glandes salivaires principales évoluant progressivement, dont les investigations ont concluent à une pathologie infectieuse de localisation inhabituelle et évoquée en dernier après une pathologie tumorale bénigne ou maligne.

Adénome pléomorphe et carcinome à cellules myoépithéliales : association rare au sein d’une tumeur du palais.

Le carcinome ex-adénome pléomorphe est une tumeur mixte maligne et rare. Nous rapportons une observation d’une patiente, âgée de 50 ans, qui consulte pour une tuméfaction du palais évoluant depuis 8 ans et dont les investigations aboutissent à un carcinome ex-adénome pléomorphe. Le carcinome ex-adénome pléomorphe touche essentiellement la glande parotide ; la localisation palatine est exceptionnelle. La composante épithéliale dégénérée correspond le plus souvent à un adénocarcinome ou à un carcinome indifférencié, rarement à un carcinome épidermoïde. Le pronostic est excellent pour les formes non et peu invasives. L’exérèse chirurgicale est le traitement de choix

Dyspnée laryngée : à propos de 240 cas

La dyspnée laryngée est une difficulté respiratoire liée à la réduction du calibre de la filière laryngée. C’est une urgence diagnostique et thérapeutique. Les étiologies sont multiples mais à rechercher après la mise en condition du malade. Il s’agit d’une étude prospective portant sur 240 cas de dyspnée laryngée admis aux urgences oto-rhino-laryngologiques durant la période Mars 2014 et Février 2015 L’âge moyen des patients était de 50 ans, On notait une prédominance masculine. 75% de nos patients étaient tabagiques chroniques. 80 % des patients avaient une dyspnée inspiratoire avec des signes de luttes respiratoires.57 % avaient nécessité une trachéotomie sous anesthésie locale soit immédiate soit après échec du traitement médical. L’étiologie tumorale était prédominante avec un pourcentage de 43,33%. Notre série avait noté 5 décès. La prise en charge de la dyspnée laryngée comporte 3 volets; diagnostiquer la dyspnée laryngée, évaluer sa gravité et chercher son étiologie pour un traitement adaptée. Il ne faut en aucun moment s’acharner à chercher l’étiologie avant de mettre en condition le malade dyspnéique. Une fois stabilisé, le diagnostic est souvent fait grâce à une panoplie d’examen endoscopique et radiologique pour permettre une prise en charge adaptée.

Intérêt du lambeau frontal dans les pertes de substance de la face. A propos de cinq cas

Nous nous intéresserons surtout aux lambeaux à pédicules sus sourciliers à travers des observations cliniques de cinq patients ayant bénéficié, dans notre structure, d’un lambeau frontal dont on discutera la fiabilité et les indications. Le critère d’inclusion a été la présence d’une perte de substance du tiers moyen de la face quelle que soit son étiologie. Les résultats esthétiques ont été très bons dans tous les cas

Oxygen Levels Do Not Determine Radiation Survival of Breast Cancer Stem Cells

For more than a century oxygen has been known to be one of the most powerful radiosensitizers. However, despite decades of preclinical and clinical research aimed at overcoming tumor hypoxia, little clinical progress has been made so far. Ionizing radiation damages DNA through generation of free radicals. In the presence of oxygen these lesions are chemically modified, and thus harder to repair while hypoxia protects cells from radiation (Oxygen enhancement ratio (OER)). Breast cancer stem cells (BSCSs) are protected from radiation by high levels of free radical scavengers even in the presence of oxygen. This led us to hypothesize that BCSCs exhibit an OER of 1. Using four established breast cancer cell lines (MCF-7, T47D, MDA-MB-231, SUM159PT) and primary breast cancer samples, we determined the number of BCSCs using cancer stem cell markers (ALDH1, low proteasome activity), compared radiation clonogenic survival and mammosphere formation under normoxic and hypoxic conditions, and correlated these results to the expression levels of key members of the free radical scavenging systems. The number of BCSCs increased with increased aggressiveness of the cancer. This correlated with increased radioresistance (SF8Gy), and decreasing OERs. When cultured as mammospheres, breast cancer cell lines and primary samples were highly radioresistant and not further protected by hypoxia (OER∼1)

The impact of immediate breast reconstruction on the time to delivery of adjuvant therapy: the iBRA-2 study

Background: Immediate breast reconstruction (IBR) is routinely offered to improve quality-of-life for women requiring mastectomy, but there are concerns that more complex surgery may delay adjuvant oncological treatments and compromise long-term outcomes. High-quality evidence is lacking. The iBRA-2 study aimed to investigate the impact of IBR on time to adjuvant therapy. Methods: Consecutive women undergoing mastectomy ± IBR for breast cancer July–December, 2016 were included. Patient demographics, operative, oncological and complication data were collected. Time from last definitive cancer surgery to first adjuvant treatment for patients undergoing mastectomy ± IBR were compared and risk factors associated with delays explored. Results: A total of 2540 patients were recruited from 76 centres; 1008 (39.7%) underwent IBR (implant-only [n = 675, 26.6%]; pedicled flaps [n = 105,4.1%] and free-flaps [n = 228, 8.9%]). Complications requiring re-admission or re-operation were significantly more common in patients undergoing IBR than those receiving mastectomy. Adjuvant chemotherapy or radiotherapy was required by 1235 (48.6%) patients. No clinically significant differences were seen in time to adjuvant therapy between patient groups but major complications irrespective of surgery received were significantly associated with treatment delays. Conclusions: IBR does not result in clinically significant delays to adjuvant therapy, but post-operative complications are associated with treatment delays. Strategies to minimise complications, including careful patient selection, are required to improve outcomes for patients