Sprachenpolitik als Sicherheitsproblem in der Ukraine

This paper presents the design, implementation, and measurements of a complete electronic frontend intended for high-resolution spatial detection of ion beams at counting rates higher than 106 particles per second (p/s). The readout system is made up of three main multichannel building blocks, namely, a transimpedance preamplifier, a signal-conditioning line receiver, and a charge-to-digital converter, as well as some off-the-shelf components. The preamplifier and the line receiver have been specifically designed and optimized to minimize the overlapping probability of ion beams tracking, at high counting rates, in low-pressure gaseous secondary electron detectors. Experimental results are shown, considering α particles sources and particles beams, featuring an adaptive shaping time frame of 170-230 ns with a peak signal-to-noise ratio of up to 25 dB. These performance metrics are competitive with the state of the art, demonstrating the suitability of the reported data acquisition and instrumentation system for precise and fast particle tracking detection

DROM: Enabling Efficient and Effortless Malleability for Resource Managers

In the design of future HPC systems, research in resource management is showing an increasing interest in a more dynamic control of the available resources. It has been proven that enabling the jobs to change the number of computing resources at run time, i.e. their malleability, can significantly improve HPC system performance. However, job schedulers and applications typically do not support malleability due to the common belief that it introduces additional programming complexity and performance impact. This paper presents DROM, an interface that provides efficient malleability with no effort for program developers. The running application is enabled to adapt the number of threads to the number of assigned computing resources in a completely transparent way to the user through the integration of DROM with standard programming models, such as OpenMP/OmpSs, and MPI. We designed the APIs to be easily used by any programming model, application and job scheduler or resource manager. Our experimental results from two realistic use cases analysis, based on malleability by reducing the number of cores a job is using per node and jobs co-allocation, show the potential of DROM for improving the performance of HPC systems. In particular, the workload of two MPI+OpenMP neuro-simulators are tested, reporting improvement in system metrics, such as total run time and average response time, up to 8% and 48%, respectively.This work is partially supported by the Span- ish Government through Programa Severo Ochoa (SEV-2015-0493), by the Spanish Ministry of Science and Technology through TIN2015-65316-P project, by the Generalitat de Catalunya (contract 2017-SGR-1414) and from the European Union’s Horizon 2020 under grant agreement No 785907 (HBP SGA2)Peer ReviewedPostprint (author's final draft

Genetic analysis of carcass traits of steers adjusted to age, weight, or fat thickness slaughter endpoints

Carcass measurements from 1,664 steers from the Germ Plasm Utilization project at U.S. Meat Animal Research Center were used to estimate heritabilities (h2) of, and genetic correlations (rg) among, 14 carcass traits adjusted to different endpoints (age, carcass weight, and fat thickness): HCW (kg), dressing percent (DP), adjusted fat thickness (AFT, cm), LM area (LMA, cm2), KPH (%), marbling score (MS), yield grade (YG), predicted percentage of retail product (PRP), retail product weight (RPW, kg), fat weight (FW, kg), bone weight (BNW, kg), actual percentage retail product (RPP), fat percent (FP), and bone percent. Fixed effects in the model included breed group, feed energy level, dam age, birth year, significant (P \u3c 0.05) interactions, covariate for days on feed, and the appropriate covariate for endpoint nested (except age) within breed group. Random effects in the model were additive genetic effect of animal and total maternal effect of dam. Parameters were estimated by REML. For some traits, estimates of h2 and phenotypic variance changed with different endpoints. Estimates of h2 for HCW,DP, RPW, and BNW at constant age, weight, or fat thickness were 0.27, —, and 0.41; 0.19, 0.26, and 0.18; 0.42, 0.32, and 0.50; and 0.43, 0.32, and 0.48, respectively. Magnitude and/or sign of rg also changed across endpoints for 54 of the 91 trait pairs. Estimates for HCW-LMA, AFTRPW, LMA-YG, LMA-PRP, LMA-FW, LMA-RPP, and LMA-FP at constant age, weight, or fat thickness were 0.32, —, and 0.51; −0.26, −0.77, and —; −0.71, −0.89, and −0.66; 0.68, 0.85, and 0.63; −0.16, −0.51, and 0.22; 0.47, 0.57, and 0.27; and −0.44, −0.43, and −0.18, respectively. Fat thickness was highly correlated with YG (0.86 and 0.85 for common age and weight) and PRP (−0.85 and −0.82 for common age and weight), indicating that selection for decreased fat thickness would improve YG and PRP. Carcass quality, however, would be affected negatively because of moderate rg (0.34 and 0.35 for common age and weight) between MS and AFT. Estimates of h2 and phenotypic variance indicate that enough genetic variation exists to change measures of carcass merit by direct selection. For some carcass traits, however, magnitude of change would depend on effect of endpoint on h2 and phenotypic variance. Correlated responses to selection would differ depending on endpoint

Frecuencia de anticuerpos séricos contra los virus de la rinotraqueitis infecciosa bovina y diarrea viral bovina en toros, y su relación con la presencia de los virus en semen

The objective was to estimate the frequency of serum antibodies against infectious bovine rhinotracheitis (IBRV) and bovine viral diarrhea (BVDV) viruses in unvaccinated bulls, as well as the relationship between the presence of antibodies in serum and the presence of these viruses in semen. Antibodies were detected by ELISA, while the presence of the viruses in semen by PCR. Logistic regression analyses were performed with the PROC GENMOD of SAS. The factors were: state, herd nested in state, and genotype of the bull (except for the presence of the viruses in semen). The degree of association between the presence of serum antibodies and the presence of the viruses in semen was measured by the phi (r) correlation. None of the three factors were significant (P>0.05). For IBRV, the frequency of serum antibodies by state ranged from 66 to 86 %, while by herd, it ranged from 28 to 90 %. For BVDV, the frequency of serum antibodies by state ranged from 58 to 76 %, while by herd, it ranged from 43 to 86 %. The presence of IBRV in semen, by state, ranged from 50 to 55 %, while by herd, it ranged from 33 to 80 %. No association (P>0.05) was found between the presence of antibodies in serum and the presence of IBRV (r=0.07) and BVDV in semen (r=0.16). The presence of serum antibodies suggests infection of bulls, but the presence of the viruses in semen suggests their transmission by sexual contact.El objetivo fue estimar la frecuencia de anticuerpos séricos contra los virus de la rinotraqueitis infecciosa bovina (VRIB) y diarrea viral bovina (VDVB) en toros no vacunados, así como la relación entre la presencia de anticuerpos en suero y la presencia de dichos virus en semen. Los anticuerpos se detectaron mediante ELISA, mientras que la presencia de los virus en semen mediante PCR. Se realizaron análisis de regresión logística con PROC GENMOD de SAS. Los factores fueron: estado, hato anidado en estado, y genotipo del toro (excepto para la presencia de los virus en semen). El grado de asociación entre la presencia de anticuerpos séricos y la presencia de los virus en semen se midió mediante la correlación phi (r). Ninguno de los tres factores fue significativo (P>0.05). Para el VRIB, la frecuencia de anticuerpos séricos por estado varió de 66 a 86 %, mientras que por hato varió de 28 a 90 %. Para el VDVB, la frecuencia de anticuerpos séricos por estado osciló de 58 a 76 %, mientras que por hato osciló de 43 a 86 %. La presencia del VRIB en semen, por estado, varió de 50 a 55 %, mientras que por hato varió de 33 a 80 %. No se encontró asociación (P>0.05) entre la presencia de anticuerpos en suero y la presencia del VRIB (r=0.07) y VDVB en semen (r=0.16). La presencia de anticuerpos séricos sugiere la infección de los toros, pero la presencia de los virus en semen sugiere su transmisión por contacto sexual

Methodology to improve the model of series inductance in CMOS integrated inductors

This paper presents a systematic optimization methodology to achieve an accurate estimation of series inductance of inductors implemented in standard CMOS technologies. Proposed method is based on an optimization procedure which aims to obtain adjustment factors associated to main physical inductor characteristics, allowing to estimate more accurate series inductance values that can be used in design stage. Experimental measurements of diverse square inductor geometries are shown and compared with previous approaches in order to demonstrate and validate presented approach.National Council of Science and Technology of México (CONACYT) TEC2013-45638-C3-3-RSpanish Ministry of Economy and Competitiveness TEC2013-45638-C3-3-REuropean Regional Development Fund TEC2013-45638-C3-3-RConsejería de Economía, Innovación, Ciencia y Empleo de la Junta de Andalucía P12-TIC-148

Prevalencia de diversos serovares de Leptospira interrogans en vacas no vacunadas en los estados de Puebla, Tabasco y Veracruz, México

The objective was to compare the prevalences of antibodies against different serovars of Leptospira interrogans among the states of Puebla, Tabasco and Veracruz, as well as among some of their municipalities, and to determine if the health status of the cows influences their fertility. Blood samples were taken from 423 cows (Bos taurus x Bos indicus and Bos indicus) from 24 ranches in 11 municipalities in the aforementioned states. The prevalences of the Hardjo and Inifap serovars were higher (P0.05). The number of serovars in the state of Veracruz was higher (P0.05); however, vaccination of cattle against Leptospira interrogans is recommended in order to decrease the risks associated with this bacterium in cattle and humans.El objetivo fue comparar las prevalencias de anticuerpos contra diferentes serovares de Leptospira interrogans entre los estados de Puebla, Tabasco y Veracruz, así como entre algunos de sus municipios, y determinar si el estatus sanitario de las vacas influye en su fertilidad. Se tomaron muestras de sangre de 423 vacas (Bos taurus x Bos indicus y Bos indicus) de 24 ranchos de 11 municipios de los estados mencionados. Las prevalencias de los serovares Hardjo e Inifap fueron mayores (P0.05). El número de serovares en el estado de Veracruz fue mayor (P0.05); sin embargo, se recomienda la vacunación del ganado contra Leptospira interrogans, con el fin de disminuir los riesgos asociados con esta bacteria en bovinos y humanos

Extractos de neem en el comportamiento de Aphis nerii y la transmisión del virus de la mancha anular del papayo

The effect of neem extracts on feeding behavior of Aphis nerii, as well as Papaya Ringspot Virus (PRSV-p) transmission, was determined. We evaluated papaya seedlings sprayed under laboratory conditions with a 10% aqueous extract of unpeeled neem seed and with a water control. Two time periods, exploratory (0 to 3 min) and feeding (>3 to 20 min), were used to evaluate aphid feeding behavior. Aphid mortality was determined 24 h after spraying. Viral transmission was measured by ELISA tests. No significant differences (p > 0.05) were obtained in the exploratory feeding behavior. However, significantly more aphids (p < 0.05) stopped feeding on neemsprayed plants from the >3 to 20 min period. Also, higher (p < 0.05) aphid mortality (37% vs. 10%) was found in neem-sprayed plants. However, no significant differences (p > 0.05) were found in PRSV-p transmission, thus indicating that neem seed aqueous extracts did not prevent viral transmission.Se determinó el efecto de extractos de neem en el comportamiento de alimentación y la transmisión del Virus de la Mancha Anular del Papayo (PRSV-p) por Aphis nerii. Se evaluó un extracto acuoso al 10% de semillas de neem sin escarificar, y un testigo con agua, asperjados en plantas de papayo en el laboratorio. El comportamiento de alimentación del áfido se estudió en dos fases: exploratoria (0 hasta 3 min) y de alimentación (>3 hasta 20 min). Se determinó la mortalidad de áfidos a las 24 h. El análisis de la transmisión del virus se realizó con base en pruebas de ELISA. No se detectaron diferencias significativas (p > 0.05) en cuanto al comportamiento de alimentación para la fase exploratoria, lo que indica que el neem no afecta la búsqueda y el probado inicial del áfido sobre la planta. En cambio, un número significativamente mayor de áfidos (p < 0.05) dejó de alimentarse en la fase >3 hasta 20 min. Además, la mortalidad de áfidos es mayor (p < 0.05) en el tratamiento con plantas asperjadas con neem (37% vs. 10%). No se encontraron diferencias significativas (p > 0.05) en la transmisión del PRSV-p por Aphis nerii, lo que indica que los extractos acuosos de semillas de neem no impiden la transmisión del virus

Analysis of the geometrical influence of ring-opening samples on arterial circumferential residual stress reconstruction

This work consists of analyzing the impact of geometrical features (thickness and curvature) on the estimation of circumferential residual stresses in arteries. For this purpose, a specific sample of lamb abdominal artery is chosen for analysis and, through computational tools based on Python libraries, the stress-free geometry is captured after the ring opening test. Numerical simulations are then used to reconstruct the sample in order to estimate the circumferential residual stresses. Then, four stress-free geometry models are analyzed: an ideal geometry, i.e., constant curvature and thickness; a constant curvature and variable thickness geometry; a variable curvature and constant thickness geometry; and a variable curvature and thickness geometry. The numerical results show that models perform well from a geometric point of view, where the most different feature was the closed outer perimeter that differs about 14% from the closed real sample. As far as residual stress is concerned, differences up to 198% were found in more realistic models taking a constant curvature and thickness model as reference. Thus, the analysis of a realistic geometry with highly variable curvature and thickness can introduce, compared to an idealized geometry, significant differences in the estimation of residual stresses. This could indicate that the characterization of arterial residual stresses is not sufficient when considering only the opening angle and, therefore, it is also necessary to incorporate more geometrical variables

Cytokine Production but Lack of Proliferation in Peripheral Blood Mononuclear Cells from Chronic Chagas' Disease Cardiomyopathy Patients in Response to T. cruzi Ribosomal P Proteins

Background:Trypanosoma cruzi ribosomal P proteins, P2β and P0, induce high levels of antibodies in patients with chronic Chagas' disease Cardiomyopathy (CCC). It is well known that these antibodies alter the beating rate of cardiomyocytes and provoke apoptosis by their interaction with β1-adrenergic and M2-muscarinic cardiac receptors. Based on these findings, we decided to study the cellular immune response to these proteins in CCC patients compared to non-infected individuals.Methodology/Principal findings:We evaluated proliferation, presence of surface activation markers and cytokine production in peripheral blood mononuclear cells (PBMC) stimulated with P2β, the C-terminal portion of P0 (CP0) proteins and T. cruzi lysate from CCC patients predominantly infected with TcVI lineage. PBMC from CCC patients cultured with P2β or CP0 proteins, failed to proliferate and express CD25 and HLA-DR on T cell populations. However, multiplex cytokine assays showed that these antigens triggered higher secretion of IL-10, TNF-α and GM-CSF by PBMC as well as both CD4+ and CD8+ T cells subsets of CCC subjects. Upon T. cruzi lysate stimulation, PBMC from CCC patients not only proliferated but also became activated within the context of Th1 response. Interestingly, T. cruzi lysate was also able to induce the secretion of GM-CSF by CD4+ or CD8+ T cells.Conclusions/Significance:Our results showed that although the lack of PBMC proliferation in CCC patients in response to ribosomal P proteins, the detection of IL-10, TNF-α and GM-CSF suggests that specific T cells could have both immunoregulatory and pro-inflammatory potential, which might modulate the immune response in Chagas' disease. Furthermore, it was possible to demonstrate for the first time that GM-CSF was produced by PBMC of CCC patients in response not only to recombinant ribosomal P proteins but also to parasite lysate, suggesting the value of this cytokine to evaluate T cells responses in T. cruzi infection.Fil: Longhi, Silvia Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Atienza, Augusto. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaFil: Perez Prados, Graciela. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; ArgentinaFil: Buying, Alcinette. Torrey Pines Institute for Molecular Studies; Estados UnidosFil: Balouz, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Buscaglia, Carlos Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Santos, Radleigh. Torrey Pines Institute for Molecular Studies; Estados UnidosFil: Tasso, Laura Mónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Bonato, Ricardo. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaFil: Chiale, Pablo. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaFil: Pinilla, Clemencia. Torrey Pines Institute for Molecular Studies; Estados UnidosFil: Judkowski, Valeria A.. Torrey Pines Institute for Molecular Studies; Estados UnidosFil: Gomez, Karina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentin