115 research outputs found
GlcNAcstatin:a picomolar, selective O-GlcNAcase inhibitor that modulates intracellular O-glcNAcylation levels
A self-consistent treatment of non-equilibrium spin torques in magnetic multilayers
It is known that the transfer of spin angular momenta between current
carriers and local moments occurs near the interface of magnetic layers when
their moments are non-collinear. However, to determine the magnitude of the
transfer, one should calculate the spin transport properties far beyond the
interface regions. Based on the spin diffusion equation, we present a
self-consistent approach to evaluate the spin torque for a number of layered
structures. One of the salient features is that the longitudinal and transverse
components of spin accumulations are inter-twined from one layer to the next,
and thus, the spin torque could be significantly amplified with respect to
treatments which concentrate solely on the transport at the interface due to
the presence of the much longer longitudinal spin diffusion length. We conclude
that bare spin currents do not properly estimate the spin angular momentum
transferred between to the magnetic background; the spin transfer that occurs
at interfaces should be self-consistently determined by embedding it in our
globally diffuse transport calculations.Comment: 21 pages, 6 figure
Magnetization reversal by injection and transfer of spin: experiments and theory
Reversing the magnetization of a ferromagnet by spin transfer from a current,
rather than by applying a magnetic field, is the central idea of an extensive
current research. After a review of our experiments of current-induced
magnetization reversal in Co/Cu/Co trilayered pillars, we present the model we
have worked out for the calculation of the current-induced torque and the
interpretation of the experiments
Theory of Current-Induced Magnetization Precession
We solve appropriate drift-diffusion and Landau-Lifshitz-Gilbert equations to
demonstrate that unpolarized current flow from a non-magnet into a ferromagnet
can produce a precession-type instability of the magnetization. The fundamental
origin of the instability is the difference in conductivity between majority
spins and minority spins in the ferromagnet. This leads to spin accumulation
and spin currents that carry angular momentum across the interface. The
component of this angular momentum perpendicular to the magnetization drives
precessional motion that is opposed by Gilbert damping. Neglecting magnetic
anisotropy and magnetostatics, our approximate analytic and exact numerical
solutions using realistic values for the material parameters show (for both
semi-infinite and thin film geometries) that a linear instability occurs when
both the current density and the excitation wave vector parallel to the
interface are neither too small nor too large. For many aspects of the problem,
the variation of the magnetization in the direction of the current flows makes
an important contribution.Comment: Submitted to Physical Review
The hVPS34-SGK3 pathway counteracts inhibition of the PI3K-Akt to maintain mTORC1 and tumour growth
We explore mechanisms that enable cancer cells to tolerate PI3K or Akt inhibitors. Prolonged treatment of breast cancer cells with PI3K or Akt inhibitors leads to increased expression and activation of a kinase termed SGK3 that is related to Akt. Under these conditions, SGK3 is controlled by hVps34 that generates PtdIns(3)P, which binds to the PX domain of SGK3 promoting phosphorylation and activation by its upstream PDK1 activator. Furthermore, under conditions of prolonged PI3K/Akt pathway inhibition, SGK3 substitutes for Akt by phosphorylating TSC2 to activate mTORC1. We characterise 14h, a compound that inhibits both SGK3 activity and activation in vivo, and show that a combination of Akt and SGK inhibitors induced marked regression of BT‐474 breast cancer cell‐derived tumours in a xenograft model. Finally, we present the kinome‐wide analysis of mRNA expression dynamics induced by PI3K/Akt inhibition. Our findings highlight the importance of the hVps34‐SGK3 pathway and suggest it represents a mechanism to counteract inhibition of PI3K/Akt signalling. The data support the potential of targeting both Akt and SGK as a cancer therapeutic
Layer thickness dependence of the current induced effective field vector in Ta|CoFeB|MgO
The role of current induced effective magnetic field in ultrathin magnetic
heterostructures is increasingly gaining interest since it can provide
efficient ways of manipulating magnetization electrically. Two effects, known
as the Rashba spin orbit field and the spin Hall spin torque, have been
reported to be responsible for the generation of the effective field. However,
quantitative understanding of the effective field, including its direction with
respect to the current flow, is lacking. Here we show vector measurements of
the current induced effective field in Ta|CoFeB|MgO heterostructrures. The
effective field shows significant dependence on the Ta and CoFeB layers'
thickness. In particular, 1 nm thickness variation of the Ta layer can result
in nearly two orders of magnitude difference in the effective field. Moreover,
its sign changes when the Ta layer thickness is reduced, indicating that there
are two competing effects that contribute to the effective field. The relative
size of the effective field vector components, directed transverse and parallel
to the current flow, varies as the Ta thickness is changed. Our results
illustrate the profound characteristics of just a few atomic layer thick metals
and their influence on magnetization dynamics
Influence of a Uniform Current on Collective Magnetization Dynamics in a Ferromagnetic Metal
We discuss the influence of a uniform current, , on the
magnetization dynamics of a ferromagnetic metal. We find that the magnon energy
has a current-induced contribution proportional to
, where is the spin-current, and
predict that collective dynamics will be more strongly damped at finite . We obtain similar results for models with and without local moment
participation in the magnetic order. For transition metal ferromagnets, we
estimate that the uniform magnetic state will be destabilized for . We discuss the relationship of this effect to
the spin-torque effects that alter magnetization dynamics in inhomogeneous
magnetic systems.Comment: 12 pages, 2 figure
Current-Driven Magnetization Dynamics in Magnetic Multilayers
We develop a quantum analog of the classical spin-torque model for
current-driven magnetic dynamics. The current-driven magnetic excitation at
finite field becomes significantly incoherent. This excitation is described by
an effective magnetic temperature rather than a coherent precession as in the
spin-torque model. However, both the spin-torque and effective temperature
approximations give qualitatively similar switching diagrams in the
current-field coordinates, showing the need for detailed experiments to
establish the proper physical model for current-driven dynamics.Comment: 5 pages, 2 figure
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