HAZARD ANALYSIS AND CCP DETERMINATION IN THE SMOKED CHICKEN LEG PRODUCTION PROCESS

Hazard analysis, the first principle within the HACCP system has been identified as one of the most demanding tasks for a HACCP team. The second principle of HACCP is determination of Critical Control Points, at which control can be applied and is essential to prevent or eliminate a food safety hazard or to reduce it to an acceptable level. In this study hazard analysis and CCP determination for the smoked chicken leg production was made. Using UGent method 5 production processes/steps were determined as CCPs

DETERMINATION THE QUALITY OF DRINKING WATER BY INDIRECT METHOD ON SCALE TEST

Investigation of the composition of elements in drinking water, from water network of Belgrade city, with indirect method. This method is based on the scale that is made with precipitation from the water during heating, indicated presence of alkali and alkaline earth elements to a greater extent and heavy metals which is quite expected. Somewhat unexpectedly the presence of some elements, whose presence leads to a greater amount isn’t desirable, because they have the cumulative effect (Hg, Pb, Ni, As ), which indicates that these are areas of developed industrial production. The water from which was formed scale found a greater presence of Fe, Cu, and Mn. Scale testing determined the presence of radioactive elements U and Sr in drinking water. Based on X-ray diffraction analysis of the composition of the sample is composed of a mixture Mg calcite and aragonite. Multidisciplinary approach to the analysis of the scale is defining the new original indirect method of determining the quality of drinking water, so far not recorded in the literature

3D-QSAR study of pyrazolo[3,4-d]pyrimidines and 1,3,4-thiadiazoles as BCR-ABL1 inhibitors

The treatment of chronic myeloid leukemia (CML) was revolutionized by introducing Bcr-Abl1 inhibitors to the extent that today it could be considered as manageable chronic disease. Although, ATP-competitive Bcr-Abl1 inhibitors set the milestone for treatment of CML, resistance on therapy in significant number of patients still remains major challenge. 3D quantitative structure-activity relationship (3D-QSAR) model of selected Bcr-Abl1 inhibitors was built in order to gain insight into structural requirements for inhibitory activity. The 3D-QSAR model with best validation parameters was selected for further study and design of novel inhibitors.14th International Conference on Fundamental and Applied Aspects of Physical Chemistry, September 24–28, 2018, Belgrad

Mixing Bandt-Pompe and Lempel-Ziv approaches: another way to analyze the complexity of continuous-states sequences

In this paper, we propose to mix the approach underlying Bandt-Pompe permutation entropy with Lempel-Ziv complexity, to design what we call Lempel-Ziv permutation complexity. The principle consists of two steps: (i) transformation of a continuous-state series that is intrinsically multivariate or arises from embedding into a sequence of permutation vectors, where the components are the positions of the components of the initial vector when re-arranged; (ii) performing the Lempel-Ziv complexity for this series of `symbols', as part of a discrete finite-size alphabet. On the one hand, the permutation entropy of Bandt-Pompe aims at the study of the entropy of such a sequence; i.e., the entropy of patterns in a sequence (e.g., local increases or decreases). On the other hand, the Lempel-Ziv complexity of a discrete-state sequence aims at the study of the temporal organization of the symbols (i.e., the rate of compressibility of the sequence). Thus, the Lempel-Ziv permutation complexity aims to take advantage of both of these methods. The potential from such a combined approach - of a permutation procedure and a complexity analysis - is evaluated through the illustration of some simulated data and some real data. In both cases, we compare the individual approaches and the combined approach.Comment: 30 pages, 4 figure

DETERMINATION THE QUALITY OF DRINKING WATER BY INDIRECT METHOD ON SCALE TEST

Investigation of the composition of elements in drinking water, from water network of Belgrade city, with indirect method. This method is based on the scale that is made with precipitation from the water during heating, indicated presence of alkali and alkaline earth elements to a greater extent and heavy metals which is quite expected. Somewhat unexpectedly the presence of some elements, whose presence leads to a greater amount isn’t desirable, because they have the cumulative effect (Hg, Pb, Ni, As ), which indicates that these are areas of developed industrial production. The water from which was formed scale found a greater presence of Fe, Cu, and Mn. Scale testing determined the presence of radioactive elements U and Sr in drinking water. Based on X-ray diffraction analysis of the composition of the sample is composed of a mixture Mg calcite and aragonite. Multidisciplinary approach to the analysis of the scale is defining the new original indirect method of determining the quality of drinking water, so far not recorded in the literatur

The cellular and synaptic architecture of the mechanosensory dorsal horn

The deep dorsal horn is a poorly characterized spinal cord region implicated in processing low-threshold mechanoreceptor (LTMR) information. We report an array of mouse genetic tools for defining neuronal components and functions of the dorsal horn LTMR-recipient zone (LTMR-RZ), a role for LTMR-RZ processing in tactile perception, and the basic logic of LTMR-RZ organization. We found an unexpectedly high degree of neuronal diversity in the LTMR-RZ: seven excitatory and four inhibitory subtypes of interneurons exhibiting unique morphological, physiological, and synaptic properties. Remarkably, LTMRs form synapses on between four and 11 LTMR-RZ interneuron subtypes, while each LTMR-RZ interneuron subtype samples inputs from at least one to three LTMR classes, as well as spinal cord interneurons and corticospinal neurons. Thus, the LTMR-RZ is a somatosensory processing region endowed with a neuronal complexity that rivals the retina and functions to pattern the activity of ascending touch pathways that underlie tactile perception

A new HPLC method for simultaneously measuring chloride, sugars, organic acids and alcohols in food samples

This paper introduces an original, rapid, efficient and reliable HPLC method for the accurate and simultaneous quantification (g/L) of chloride in samples containing sugars, organic acids and alcohols. Separation was achieved using a HI-Plex H column at 35oC, with H2SO4 (0.005 N) as the mobile phase at a flow rate of 0.4 mL/min. The column effluent was monitored by a Refractive Index (RI) detector. A linear response was achieved over NaCl concentrations of 0.25 – 2.5 g/L and 5 – 40 g/L. The analytical method inter- and intra-run accuracy and precision were better than ±10.0%. Investigating the mechanism of detection using different chloride and sodium s reviled that this method can be used for determining the total concentration of chloride salts when in suspension. This method was successfully applied to 15 samples of commercial food products and the salt content obtained from this method was compared with 3 other methods for salt determination. The (HI-Plex H) column was designed for determining the concentrations of sugars, organic acids and alcohols when in solution. Hence, application of our new methodology would allow the determination of sugars, alcohols and organic acids in samples derived from seawater-based fermentation media as well as samples from salty food and dairy products

Origins and genetic legacy of prehistoric dogs

Dogs were the first domestic animal, but little is known about their population history and to what extent it was linked to humans. We sequenced 27 ancient dog genomes and found that all dogs share a common ancestry distinct from present-day wolves, with limited gene flow from wolves since domestication but substantial dog-to-wolf gene flow. By 11,000 years ago, at least five major ancestry lineages had diversified, demonstrating a deep genetic history of dogs during the Paleolithic. Coanalysis with human genomes reveals aspects of dog population history that mirror humans, including Levant-related ancestry in Africa and early agricultural Europe. Other aspects differ, including the impacts of steppe pastoralist expansions in West and East Eurasia and a near-complete turnover of Neolithic European dog ancestry

Ecological barriers mediate spatiotemporal shifts of bird communities at a continental scale

This study was supported by the Swiss National Science Foundation (grant P2BEP3_195232) and by the Academy of Finland (project 323527 and project 329251).Species' range shifts and local extinctions caused by climate change lead to community composition changes. At large spatial scales, ecological barriers, such as biome boundaries, coastlines, and elevation, can influence a community's ability to shift in response to climate change. Yet, ecological barriers are rarely considered in climate change studies, potentially hindering predictions of biodiversity shifts. We used data from two consecutive European breeding bird atlases to calculate the geographic distance and direction between communities in the 1980s and their compositional best match in the 2010s and modeled their response to barriers. The ecological barriers affected both the distance and direction of bird community composition shifts, with coastlines and elevation having the strongest influence. Our results underscore the relevance of combining ecological barriers and community shift projections for identifying the forces hindering community adjustments under global change. Notably, due to (macro)ecological barriers, communities are not able to track their climatic niches, which may lead to drastic changes, and potential losses, in community compositions in the future.Publisher PDFPeer reviewe