The role of answer fluency and perceptual fluency in the monitoring and control of reasoning: Reply to Alter, Oppenheimer, and Epley

In this reply, we provide an analysis of Alter et al. (2013) response to our earlier paper (Thompson et al., 2013). In that paper, we reported difficulty in replicating Alter, Oppenheimer, Epley, and Eyre’s (2007) main finding, namely that a sense of disfluency produced by making stimuli difficult to perceive, increased accuracy on a variety of reasoning tasks. Alter, Oppenheimer, and Epley (2013) argue that we misunderstood the meaning of accuracy on these tasks, a claim that we reject. We argue and provide evidence that the tasks were not too difficult for our populations (such that no amount of “metacognitive unease” would promote correct responding) and point out that in many cases performance on our tasks was well above chance or on a par with Alter et al.’s (2007) participants. Finally, we reiterate our claim that the distinction between answer fluency (the ease with which an answer comes to mind) and perceptual fluency (the ease with which a problem can be read) is genuine, and argue that Thompson et al. (2013) provided evidence that these are distinct factors that have different downstream effects on cognitive processe

International study into the use of intermittent hormone therapy in the treatment of carcinoma of the prostate : A meta-analysis of 1446 patients

OBJECTIVE: To review pooled phase II data to identify features of different regimens of intermittent hormone therapy (IHT), developed to reduce the morbidity of treating metastatic prostate cancer, and which carries a theoretical advantage of delaying the onset of androgen-independent prostate cancer, (AIPC) that are associated with success, highlighting features which require exploration with prospective trials to establish the best strategies for using this treatment. METHODS: Individual data were collated on 1446 patients with adequate information, from 10 phase II studies with >50 cases, identified through Pubmed. RESULTS: Univariate and multivariate Cox proportional hazard models were developed to predict treatment success with a high degree of statistical success. The prostate-specific antigen (PSA) nadir, the PSA threshold to restart treatment, and medication type and duration, were important predictors of outcome. CONCLUSIONS: The duration of biochemical remission after a period of HT is a durable early indicator of how rapidly AIPC and death will occur, and will make a useful endpoint in future trials to investigate the best ways to use IHT based on the important treatment cycling variables described above. Patients spent a mean of 39% of the time off treatment. The initial PSA level and PSA nadir allow the identification of patients with prostate cancer in whom it might be possible to avoid radical therapy.Peer reviewe

Hematopoietic cytokines as therapeutic players in early stages Parkinson’s disease

Parkinson's disease (PD) is a devastating age related neurodegenerative disease that is believed to have a lengthy prodromal state. It is critical to find methods of interfering with the progression of this early degenerative stage by inducing compensatory recovery processes to slow or prevent the eventual clinical symptoms. The current perspective article argues that immune system signalling molecules represent such a promising therapeutic approach. Two cytokines of interest are granulocyte macrophage-colony stimulating factor (GM-CSF) and erythropoietin (EPO). These hematopoietic cytokines have been protective in models of stroke, neuronal injury, and more recently PD. It is our belief that these trophic cytokines can be used not only for cell protection but also regeneration. However, success is likely dependent on early intervention. This paper will outline our perspective on the development of novel trophic recovery treatments for PD. In particular, we present new data from our lab suggesting that EPO and GM-CSF can foster neural re-innervation in a mild or partial lesion PD model that could be envisioned as reflecting the early stages of the disease

The longitudinal impact of bars with rounded ends

Not availabl

"I can't be arsed": A small-scale exploration of students' self-reported motivation on entering a course of study and eventual "success"

Purpose: The purpose of this paper is to explore the university course trajectories of students from entry to a 3-year full-time undergraduate programme, to graduation with an honours degree, in the light of their self-reported motivations to study. This small-scale investigation took place at a UK Higher Education Institution (HEI). Design/methodology/approach: A small-scale survey using the Academic Motivation (to study) Scale was administered to 102 students on entry to a full-time undergraduate degree course in an interdisciplinary information-based department in a UK HEI. The students' motivation profiles were assessed in relation to their trajectory through the degree course and selected students were interviewed just prior to graduation. Findings: The report focuses on the pattern of student motivations - in general students who achieved "good" degrees were likely to have lower motivation and students achieving "not so good" degrees were likely to self-report higher levels of both autonomous and controlled motivations. Whilst the small sample size and individual variation may partly explain these results, interviews with a small number of participants allowed some further explication of these patterns. Research limitations/implications: Because of the complexity of variables potentially involved in studies relating to motivation, the focus of this study was practitioner reflection. Thus, it examines self-reported motivations measured on a established scale and 'success' in terms of progression and attainment. The research findings were from a small cohort study in a convenience sample of 102 students in a particular context, so there are necessarily limits on the generalisability of the study. Practical implications: Elements around student achievement and progression related to their motivation are identified, and may contribute to effective design of learning experiences that students "can be arsed" to engage in. Originality/value: New empirical data are reported which provide an insight into student attitudes to study and the applicability of teacher responses, which are briefly discussed in relation to socio-cognitive and socio-cultural perspectives. © Emerald Group Publishing Limited

Cold-regions river flow observed from space

Knowledge of water-surface velocities in rivers is useful for understanding a wide range of lotic processes and systems, such as water and ice fluxes and forces, mixing, solute and sediment transport, bed and bank stability, aquatic and riparian ecology, and extreme hydrologic events. In cold regions, river-ice break up and the associated downstream transport of ice debris is often the most important hydrological event of the year, producing flood levels that commonly exceed those for the open-water period and dramatic consequences for river infrastructure and ecology. Quantification of river surface velocity and currents has relied mostly on very scarce in situ measurements or particle tracking in laboratory models, with few attempts to cover entire river reaches. Accurate and complete surface-velocity fields on rivers have rarely been produced. Here, we use river-ice debris as an index of surface water velocity, and track it over a time period of about one minute, which is the typical time lapse between the two or more images that form a stereo data set in spaceborne, alongtrack optical-stereo mapping. In this way, we measure and visualize for the first time, the almost complete surface velocity field of a river. Examples are used from approximately 80 km and 40 km long reaches of the St. Lawrence and Mackenzie rivers, respectively. The methodology and results will be valuable to a number of disciplines requiring detailed information about river flow, such as hydraulics, hydrology, river ecology and natural-hazard management

Exposing the human nude phenotype [4]

Peer reviewedSubmitted Versio

Stochastic Variational Search for ΛΛ4^{4}_{\Lambda\Lambda}H

A four-body calculation of the $pn\Lambda\Lambda$ bound state, $^{\ 4}_{\Lambda\Lambda}$H, is performed using the stochastic variational method and phenomenological potentials. The$NN$,$\Lambda N$, and$\Lambda\Lambda$potentials are taken from a recent Letter by Filikhin and Gal, PRL{\bf 89}, 172502 (2002). Although their Faddeev-Yakubovsky calculation found no bound-state solution over a wide range of$\Lambda\Lambda$interaction strengths, the present variational calculation gives a bound-state energy, which is clearly lower than the$_\Lambda^3{H}+\Lambda$threshold, even for a weak$\Lambda\Lambda$interaction strength deduced from a recent experimental$B_{\Lambda\Lambda}(^{6}_{\Lambda\Lambda}{He})$value. The binding energies obtained are close to, and slightly larger than, the values obtained from the three-body$d\Lambda\Lambda$ model in the Letter.Comment: Corrected typos, added addtional calculations regarding a truncated to l=0 interaction model, 4 pages, 3 figure

Detection of TMPRSS2 : ERG fusion gene in circulating prostate cancer cells

Creative Commons Attribution-NonCommercial-Share Alike 3.0 license (CC BY-NC SA)Aim: To investigate the existence of TMPRSS2:ERG fusion gene in circulating tumor cells (CTC) from prostate cancer patients and its potential in monitoring tumor metastasis. Methods: We analyzed the frequency of TMPRSS2: ERG and TMPRSS2:ETV1 transcripts in 27 prostate cancer biopsies from prostatectomies, and TMPRSS2:ERG transcripts in CTC isolated from 15 patients with advanced androgen independent disease using reverse transcription polymerase chain reaction (RT-PCR). Fluorescence in situ hybridization (FISH) was applied to analyze the genomic truncation of ERG, which is the result of TMPRSS2:ERG fusion in 10 of the 15 CTC samples. Results: TMPRSS2: ERG transcripts were found in 44% of our samples, but we did not detect expression of TMPRSS2:ETV1. Using FISH analysis we detected chromosomal rearrangements affecting the ERG gene in 6 of 10 CTC samples, including 1 case with associated TMPRSS2:ERG fusion at the primary site. However, TMPRSS2:ERG transcripts were not detected in any of the 15 CTC samples, including the 10 cases analyzed by FISH. Conclusion: Although further study is required to address the association between TMPRSS2:ERG fusion and prostate cancer metastasis, detection of genomic truncation of the ERG gene by FISH analysis could be useful for monitoring the appearance of CTC and the potential for prostate cancer metastasis.Peer reviewedFinal Published versio

Novel Weak Decays in Doubly Strange Systems

The strangeness-changing ($\Delta S = 1$) weak baryon-baryon interaction is studied through the nonmesonic weak decay of double-$\Lambda$ hypernuclei. Besides the usual nucleon-induced decay $\Lambda N \to N N$ we discuss novel hyperon-induced decay modes $\Lambda \Lambda \to \Lambda N$ and $\Lambda \Lambda \to \Sigma N$. These reactions provide unique access to the exotic $\Lambda \Lambda$K and $\Lambda \Sigma$K vertices which place new constraints on Chiral Pertubation Theory ($\chi$PT) in the weak SU(3) sector. Within a meson-exchange framework, we use the pseudoscalar $\pi,\eta,K$ octet for the long-range part while parametrizing the short-range part through the vector mesons $\rho, \omega, K^*$. Realistic baryon-baryon forces for the $S=0,-1$ and -2 sectors account for the strong interaction in the initial and final states. For $^6_{\Lambda \Lambda}$He the new hyperon-induced decay modes account for up to 4% of the total nonmesonic decay rate. Predictions are made for all possible nonmesonic decay modes.Comment: 19 pages, 2 ps figures, 9 table