Mesosphere-Lower-Thermosphere Neutral Density Measurements from Low-cost COTS Accelerometers and Ionization Gauge

Measurements of aerodynamic drag on objects can be used to determine the density of the medium provided other variables are known. The Space and Atmospheric Instrumentation Laboratory launched a midlatitude sounding rocket named SpEED Demon from Wallops Flight Facility in August 2022. Among the instruments onboard were sensitive low-cost MEMS accelerometers allowing for neutral density measurements through the drag technique up to 100km in altitude. In addition to sensitive accelerometers on the main payload, four ejectable subpayloads also carry an accelerometer providing simultaneous multi-point neutral density measurements, akin to a ‘falling cylinder’ experiment. We present the flight performance and results of this drag-based density measurement technique from the SpEED Demon launch. Drag-derived density results are compared with density measurements from an ionization gauge instrument and the MSIS atmospheric model to provide validation of the technique, showing agreement within 10% in the 80-100km altitude range

On the Short-Term Variability of Turbulence and Temperature in the Winter Mesosphere

Four mesosphere–lower thermosphere temperature and turbulence profiles were obtained in situ within ∼30 min and over an area of about 100 by 100 km during a sounding rocket experiment conducted on 26 January 2015 at Poker Flat Research Range in Alaska. In this paper we examine the spatial and temporal variability of mesospheric turbulence in relationship to the static stability of the background atmosphere. Using active payload attitude control, neutral density fluctuations, a tracer for turbulence, were observed with very little interference from the payload spin motion, and with high precision (%) at sub-meter resolution. The large-scale vertical temperature structure was very consistent between the four soundings. The mesosphere was almost isothermal, which means more stratified, between 60 and 80 km, and again between 88 and 95 km. The stratified regions adjoined quasi-adiabatic regions assumed to be well mixed. Additional evidence of vertical transport and convective activity comes from sodium densities and trimethyl aluminum trail development, respectively, which were both observed simultaneously with the in situ measurements. We found considerable kilometer-scale temperature variability with amplitudes of 20 K in the stratified region below 80 km. Several thin turbulent layers were embedded in this region, differing in width and altitude for each profile. Energy dissipation rates varied between 0.1 and 10 mW kg−1, which is typical for the winter mesosphere. Very little turbulence was observed above 82 km, consistent with very weak small-scale gravity wave activity in the upper mesosphere during the launch night. On the other hand, above the cold and prominent mesopause at 102 km, large temperature excursions of +40 to +70 K were observed. Simultaneous wind measurements revealed extreme wind shears near 108 km, and combined with the observed temperature gradient, isolated regions of unstable Richardson numbers (0Kp∼5)

Treatment of signs and symptoms of the common cold using EPs 7630 - results of a meta-analysis

© 2019 The Author(s) The efficacy of Pelargonium sidoides preparation EPs 7630 in the common cold (CC) was assessed by performing meta-analyses of randomized, double-blind, placebo-controlled trials. Mean differences (MD) and risk ratios (RR) with their 95% confidence intervals (CI) were computed. Five trials with a total of 833 patients were included. All trials had a treatment period of ten days with visits at days 3, 5, and 10 after baseline and used a ten-symptom Cold Intensity Score (CIS) as the primary outcome. Significant differences favoring EPs 7630 were observed for total CIS reduction (day 5: MD = -2·30; 95%CI = -4·12,-0·49; day 10: MD = -1·16; 95%CI = -2·22,-0·10), proportion of patients with substantial improvement (day 5: RR = 1·73; day 10: RR = 1·06) and complete remission (day 5: RR = 2·52; day 10: RR = 2·13). Subjects treated with EPs 7630 missed fewer days at work, used less paracetamol and had an improved sleep quality. No serious adverse reactions to EPs 7630 were reported. The results support the efficacy of EPs 7630 in adults with CC

Gravity Wave Ducting Observed in the Mesosphere Over Jicamarca, Peru

Short-period gravity waves are ubiquitous in the mesosphere, but the vertical structures of their perturbations are difficult to observe. The Jicamarca 50-MHz very high frequency radar allows observations of winds and turbulent scatter with high temporal and vertical resolution. We present a case of a quasi-monochromatic gravity wave with period 520 (±40) s that is likely ducted below a southward wind jet between 68 and 74 km. Above this layer of evanescence, a northward wind enables it to emerge into a more stable layer, where it is refracted to a short vertical wavelength of 2.2 (±0.2) km; data show evidence of weak nonlinearity, and possible overturning or partial reflection from higher altitudes, above the observable region, in the form of a standing wave structure in vertical velocity at approximately 75 km. Based on the dispersion relation, and with help of a two-dimensional model, we determine that most likely the wave is propagating northward and is being ducted below and tunneling through the regions of evanescence created by the wind flow and typical mesospheric thermal structure. This is the first time that such an event has been identified in the Jicamarca mesospheric echoes, and it is distinct from Kelvin-Helmholtz billows also commonly seen with this sensitive radar—instead apparently revealing tunneling of the gravity wave through ambient winds

Estimates of vertical eddy diffusivity in the upper mesosphere in the presence of a mesospheric inversion layer

Rayleigh and resonance lidar observations were made during the Turbopause experiment at Poker Flat Research Range, Chatanika Alaska (65° N, 147° W) over a 10 h period on the night of 17–18 February 2009. The lidar observations revealed the presence of a strong mesospheric inversion layer (MIL) at 74 km that formed during the observations and was present for over 6 h. The MIL had a maximum temperature of 251 K, amplitude of 27 ± 7 K, a depth of 3.0 km, and overlying lapse rate of 9.4 ± 0.3 K km−1. The MIL was located at the lower edge of the mesospheric sodium layer. During this coincidence the lower edge of the sodium layer was lowered by 2 km to 74 km and the bottomside scale height of the sodium increased from 1 km to 15 km. The structure of the MIL and sodium are analyzed in terms of vertical diffusive transport. The analysis yields a lower bound for the eddy diffusion coefficient of 430 m2 s−1 and the energy dissipation rate of 2.2 mW kg−1 at 76–77 km. This value of the eddy diffusion coefficient, determined from naturally occurring variations in mesospheric temperatures and the sodium layer, is significantly larger than those reported for mean winter values in the Arctic but similar to individual values reported in regions of convective instability by other techniques

On the short-term variability of turbulence and temperature in the winter mesosphere

Four mesosphere–lower thermosphere temperature and turbulence profiles were obtained in situ within  ∼ 30&thinsp;min and over an area of about 100 by 100&thinsp;km during a sounding rocket experiment conducted on 26 January 2015 at Poker Flat Research Range in Alaska. In this paper we examine the spatial and temporal variability of mesospheric turbulence in relationship to the static stability of the background atmosphere. Using active payload attitude control, neutral density fluctuations, a tracer for turbulence, were observed with very little interference from the payload spin motion, and with high precision ( &lt; 0.01 %) at sub-meter resolution. The large-scale vertical temperature structure was very consistent between the four soundings. The mesosphere was almost isothermal, which means more stratified, between 60 and 80&thinsp;km, and again between 88 and 95&thinsp;km. The stratified regions adjoined quasi-adiabatic regions assumed to be well mixed. Additional evidence of vertical transport and convective activity comes from sodium densities and trimethyl aluminum trail development, respectively, which were both observed simultaneously with the in situ measurements. We found considerable kilometer-scale temperature variability with amplitudes of 20&thinsp;K in the stratified region below 80&thinsp;km. Several thin turbulent layers were embedded in this region, differing in width and altitude for each profile. Energy dissipation rates varied between 0.1 and 10&thinsp;mW&thinsp;kg−1, which is typical for the winter mesosphere. Very little turbulence was observed above 82&thinsp;km, consistent with very weak small-scale gravity wave activity in the upper mesosphere during the launch night. On the other hand, above the cold and prominent mesopause at 102&thinsp;km, large temperature excursions of +40 to +70&thinsp;K were observed. Simultaneous wind measurements revealed extreme wind shears near 108&thinsp;km, and combined with the observed temperature gradient, isolated regions of unstable Richardson numbers (0 &lt; Ri &lt; 0.25) were detected in the lower thermosphere. The experiment was launched into a bright auroral arc under moderately disturbed conditions (Kp ∼ 5).</p

Observations of Reduced Turbulence and Wave Activity in the Arctic Middle Atmosphere Following the January 2015 Sudden Stratospheric Warming

Measurements of turbulence and waves were made as part of the Mesosphere-Lower Thermosphere Turbulence Experiment (MTeX) on the night of 25–26 January 2015 at Poker Flat Research Range, Chatanika, Alaska (65°N, 147°W). Rocket-borne ionization gauge measurements revealed turbulence in the 70- to 88-km altitude region with energy dissipation rates between 0.1 and 24 mW/kg with an average value of 2.6 mW/kg. The eddy diffusion coefficient varied between 0.3 and 134 m2/s with an average value of 10 m2/s. Turbulence was detected around mesospheric inversion layers (MILs) in both the topside and bottomside of the MILs. These low levels of turbulence were measured after a minor sudden stratospheric warming when the circulation continued to be disturbed by planetary waves and winds remained weak in the stratosphere and mesosphere. Ground-based lidar measurements characterized the ensemble of inertia-gravity waves and monochromatic gravity waves. The ensemble of inertia-gravity waves had a specific potential energy of 0.8 J/kg over the 40- to 50-km altitude region, one of the lowest values recorded at Chatanika. The turbulence measurements coincided with the overturning of a 2.5-hr monochromatic gravity wave in a depth of 3 km at 85 km. The energy dissipation rates were estimated to be 3 mW/kg for the ensemble of waves and 18 mW/kg for the monochromatic wave. The MTeX observations reveal low levels of turbulence associated with low levels of gravity wave activity. In the light of other Arctic observations and model studies, these observations suggest that there may be reduced turbulence during disturbed winters

Observations of Reduced Turbulence and Wave Activity in the Arctic Middle Atmosphere Following the January 2015 Sudden Stratospheric Warming

Measurements of turbulence and waves were made as part of the Mesosphere-Lower Thermosphere Turbulence Experiment (MTeX) on the night of 25–26 January 2015 at Poker Flat Research Range, Chatanika, Alaska (65°N, 147°W). Rocket-borne ionization gauge measurements revealed turbulence in the 70- to 88-km altitude region with energy dissipation rates between 0.1 and 24 mW/kg with an average value of 2.6 mW/kg. The eddy diffusion coefficient varied between 0.3 and 134 m2/s with an average value of 10 m2/s. Turbulence was detected around mesospheric inversion layers (MILs) in both the topside and bottomside of the MILs. These low levels of turbulence were measured after a minor sudden stratospheric warming when the circulation continued to be disturbed by planetary waves and winds remained weak in the stratosphere and mesosphere. Ground-based lidar measurements characterized the ensemble of inertia-gravity waves and monochromatic gravity waves. The ensemble of inertia-gravity waves had a specific potential energy of 0.8 J/kg over the 40- to 50-km altitude region, one of the lowest values recorded at Chatanika. The turbulence measurements coincided with the overturning of a 2.5-hr monochromatic gravity wave in a depth of 3 km at 85 km. The energy dissipation rates were estimated to be 3 mW/kg for the ensemble of waves and 18 mW/kg for the monochromatic wave. The MTeX observations reveal low levels of turbulence associated with low levels of gravity wave activity. In the light of other Arctic observations and model studies, these observations suggest that there may be reduced turbulence during disturbed winters

Home parenteral nutrition with an omega-3-fatty-acid-enriched MCT/LCT lipid emulsion in patients with chronic intestinal failure (the HOME study):study protocol for a randomized, controlled, multicenter, international clinical trial

BACKGROUND: Home parenteral nutrition (HPN) is a life-preserving therapy for patients with chronic intestinal failure (CIF) indicated for patients who cannot achieve their nutritional requirements by enteral intake. Intravenously administered lipid emulsions (ILEs) are an essential component of HPN, providing energy and essential fatty acids, but can become a risk factor for intestinal-failure-associated liver disease (IFALD). In HPN patients, major effort is taken in the prevention of IFALD. Novel ILEs containing a proportion of omega-3 polyunsaturated fatty acids (n-3 PUFA) could be of benefit, but the data on the use of n-3 PUFA in HPN patients are still limited. METHODS/DESIGN: The HOME study is a prospective, randomized, controlled, double-blind, multicenter, international clinical trial conducted in European hospitals that treat HPN patients. A total of 160 patients (80 per group) will be randomly assigned to receive the n-3 PUFA-enriched medium/long-chain triglyceride (MCT/LCT) ILE (Lipidem/Lipoplus® 200 mg/ml, B. Braun Melsungen AG) or the MCT/LCT ILE (Lipofundin® MCT/LCT/Medialipide® 20%, B. Braun Melsungen AG) for a projected period of 8 weeks. The primary endpoint is the combined change of liver function parameters (total bilirubin, aspartate transaminase and alanine transaminase) from baseline to final visit. Secondary objectives are the further evaluation of the safety and tolerability as well as the efficacy of the ILEs. DISCUSSION: Currently, there are only very few randomized controlled trials (RCTs) investigating the use of ILEs in HPN, and there are very few data at all on the use of n-3 PUFAs. The working hypothesis is that n-3 PUFA-enriched ILE is safe and well-tolerated especially with regard to liver function in patients requiring HPN. The expected outcome is to provide reliable data to support this thesis thanks to a considerable number of CIF patients, consequently to broaden the present evidence on the use of ILEs in HPN. TRIAL REGISTRATION: ClinicalTrials.gov, ID: NCT03282955. Registered on 14 September 2017