Characterisation of the transmissivity field of a fractured and karstic aquifer, Southern France

International audienceGeological and hydrological data collected at the Terrieu experimental site north of Montpellier, in a confined carbonate aquifer indicates that both fracture clusters and a major bedding plane form the main flow paths of this highly heterogeneous karst aquifer. However, characterising the geometry and spatial location of the main flow channels and estimating their flow properties remain difficult. These challenges can be addressed by solving an inverse problem using the available hydraulic head data recorded during a set of interference pumping tests.We first constructed a 2D equivalent porous medium model to represent the test site domain and then employed regular zoning parameterisation, on which the inverse modelling was performed. Because we aim to resolve the fine-scale characteristics of the transmissivity field, the problem undertaken is essentially a large-scale inverse model, i.e. the dimension of the unknown parameters is high. In order to deal with the high computational demands in such a large-scale inverse problem, a gradient-based, non-linear algorithm (SNOPT) was used to estimate the transmissivity field on the experimental site scale through the inversion of steady-state, hydraulic head measurements recorded at 22 boreholes during 8 sequential cross-hole pumping tests. We used the data from outcrops, borehole fracture measurements and interpretations of inter-well connectivities from interference test responses as initial models to trigger the inversion. Constraints for hydraulic conductivities, based on analytical interpretations of pumping tests, were also added to the inversion models. In addition, the efficiency of the adopted inverse algorithm enables us to increase dramatically the number of unknown parameters to investigate the influence of elementary discretisation on the reconstruction of the transmissivity fields in both synthetic and field studies.By following the above approach, transmissivity fields that produce similar hydrodynamic behaviours to the real head measurements were obtained. The inverted transmissivity fields show complex, spatial heterogeneities with highly conductive channels embedded in a low transmissivity matrix region. The spatial trend of the main flow channels is in a good agreement with that of the main fracture sets mapped on outcrops in the vicinity of the Terrieu site suggesting that the hydraulic anisotropy is consistent with the structural anisotropy. These results from the inverse modelling enable the main flow paths to be located and their hydrodynamic properties to be estimated

Neutron spectroscopy with the Spherical Proportional Counter

A novel large volume spherical proportional counter, recently developed, is used for neutron measurements. Gas mixtures of $N_{2}$ with $C_{2}H_{6}$ and pure $N_{2}$ are studied for thermal and fast neutron detection, providing a new way for the neutron spectroscopy. The neutrons are detected via the ${}^{14}N(n, p)C^{14}$ and ${}^{14}N(n, \alpha)B^{11}$ reactions. Here we provide studies of the optimum gas mixture, the gas pressure and the most appropriate high voltage supply on the sensor of the detector in order to achieve the maximum amplification and better resolution. The detector is tested for thermal and fast neutrons detection with a ${}^{252}Cf$ and a ${}^{241}Am-{}^{9}Be$ neutron source. The atmospheric neutrons are successfully measured from thermal up to several MeV, well separated from the cosmic ray background. A comparison of the spherical proportional counter with the current available neutron counters is also given.Comment: 7 pages, 10 figure

Lowering the background level and the energy threshold of Micromegas x-ray detectors for axion searches

Axion helioscopes search for solar axions by their conversion in x-rays in the presence of high magnetic fields. The use of low background x-ray detectors is an essential component contributing to the sensitivity of these searches. In this work, we review the recent advances on Micromegas detectors used in the CERN Axion Solar Telescope (CAST) and proposed for the future International Axion Observatory (IAXO). The actual setup in CAST has achieved background levels below 10$^{-6}$ keV$^{-1}$ cm$^{-2}$ s$^{-1}$, a factor 100 lower than the first generation of Micromegas detectors. This reduction is based on active and passive shielding techniques, the selection of radiopure materials, offline discrimination techniques and the high granularity of the readout. We describe in detail the background model of the detector, based on its operation at CAST site and at the Canfranc Underground Laboratory (LSC), as well as on Geant4 simulations. The best levels currently achieved at LSC are low than 10$^{-7}$ keV$^{-1}$ cm$^{-2}$ s$^{-1}$ and show good prospects for the application of this technology in IAXO. Finally, we present some ideas and results for reducing the energy threshold of these detectors below 1 keV, using high-transparent windows, autotrigger electronics and studying the cluster shape at different energies. As a high flux of axion-like-particles is expected in this energy range, a sub-keV threshold detector could enlarge the physics case of axion helioscopes.Comment: Proceedings of 3rd International Conference on Technology and Instrumentation in Particle Physics (TIPP 2014

New pixelized Micromegas detector with low discharge rate for the COMPASS experiment

New Micromegas (Micro-mesh gaseous detectors) are being developed in view of the future physics projects planned by the COMPASS collaboration at CERN. Several major upgrades compared to present detectors are being studied: detectors standing five times higher luminosity with hadron beams, detection of beam particles (flux up to a few hundred of kHz/mm^{2}, 10 times larger than for the present Micromegas detectors) with pixelized read-out in the central part, light and integrated electronics, and improved robustness. Two solutions of reduction of discharge impact have been studied, with Micromegas detectors using resistive layers and using an additional GEM foil. Performance of such detectors has also been measured. A large size prototypes with nominal active area and pixelized read-out has been produced and installed at COMPASS in 2010. In 2011 prototypes featuring an additional GEM foil, as well as an resistive prototype, are installed at COMPASS and preliminary results from those detectors presented very good performance. We present here the project and report on its status, in particular the performance of large size prototypes with an additional GEM foil.Comment: 11 pages, 5 figures, proceedings to the Micro-Pattern Gaseous Detectors conference (MPGD2011), 29-31 August 2011, Kobe, Japa

X-ray detection with Micromegas with background levels below 10−6^{-6} keV−1^{-1}cm−2^{-2}s−1^{-1}

Micromegas detectors are an optimum technological choice for the detection of low energy x-rays. The low background techniques applied to these detectors yielded remarkable background reductions over the years, being the CAST experiment beneficiary of these developments. In this document we report on the latest upgrades towards further background reductions and better understanding of the detectors' response. The upgrades encompass the readout electronics, a new detector design and the implementation of a more efficient cosmic muon veto system. Background levels below 10$^{-6}$keV$^{-1}$cm$^{-2}$s$^{-1}$ have been obtained at sea level for the first time, demonstrating the feasibility of the expectations posed by IAXO, the next generation axion helioscope. Some results obtained with a set of measurements conducted in the x-ray beam of the CAST Detector Laboratory will be also presented and discussed

Low Background Micromegas in CAST

Solar axions could be converted into x-rays inside the strong magnetic field of an axion helioscope, triggering the detection of this elusive particle. Low background x-ray detectors are an essential component for the sensitivity of these searches. We report on the latest developments of the Micromegas detectors for the CERN Axion Solar Telescope (CAST), including technological pathfinder activities for the future International Axion Observatory (IAXO). The use of low background techniques and the application of discrimination algorithms based on the high granularity of the readout have led to background levels below 10$^{-6}$ counts/keV/cm$^2$/s, more than a factor 100 lower than the first generation of Micromegas detectors. The best levels achieved at the Canfranc Underground Laboratory (LSC) are as low as 10$^{-7}$ counts/keV/cm$^2$/s, showing good prospects for the application of this technology in IAXO. The current background model, based on underground and surface measurements, is presented, as well as the strategies to further reduce the background level. Finally, we will describe the R&D paths to achieve sub-keV energy thresholds, which could broaden the physics case of axion helioscopes.Comment: 6 pages, 3 figures, Large TPC Conference 2014, Pari

Flash flood mitigation as a positive consequence of anthropogenic forcing on the groundwater resource in a karst catchment

The Mediterranean coastal region is prone to high-intensity rainfall events that are frequently associated with devastating flash floods. This paper discusses the role of a karst aquifer system in the flash floods of a Mediterranean river, the Lez river. Most of the Lez river watershed is located on karst terrains where interactions between surface water and groundwater take place. During extreme rainfall events, the presence of fractures and well-developed karst features in carbonate terrains enhances the infiltration processes and involves the concentration of the recharge into highly organized and permeable flow paths. The groundwater, therefore, quickly moves towards the natural outlets of the karst system. The influence of the Lez karst aquifer system on the associated river floods dynamics is analysed while considering the spatially distributed rainfall, as well as the time series of the groundwater level within the aquifer and of the Lez river discharge measured at various gauging stations. Special attention is given to the relative importance of the surface and underground processes involved in flash flood genesis. It is shown that the karst groundwater contributes to flash floods under certain conditions, while high-rate pumping within the karst aquifer, which generates significant drawdown, may mitigate flash floods under other conditions

Spectrum of Kidney Involvement in Patients with Myelodysplastic Syndromes.

Myelodysplastic syndromes (MDS) are characterized by a high prevalence of associated autoimmune manifestations. Kidney involvement has been rarely reported in MDS patients. We report on the spectrum of kidney pathological findings in MDS patients. We retrospectively identified MDS patients who had undergone a kidney biopsy between 2001 and 2019 in nine Swiss and French nephrology centres. Nineteen patients (median age 74 years [63-83]) were included. At the time of kidney biopsy, eleven (58%) patients had extra-renal auto-immune manifestations and sixteen (84%) presented with acute kidney injury. Median serum creatinine at diagnosis was 2.8 mg/dL [0.6-8.3] and median urinary protein to creatinine ratio was 1.2 g/g [0.2-11]. Acute tubulo-interstitial nephritis (TIN) was present in seven (37%) patients. Immunofluorescence study in one patient with acute TIN disclosed intense IgG deposits along the tubular basement membrane and Bowman's capsule. Other kidney pathological features included ANCA-negative pauci-immune necrotizing and crescentic glomerulonephritis (n = 3), membranous nephropathy (n = 2), IgA nephropathy (n = 1), IgA vasculitis (n = 1), immunoglobulin-associated membrano-proliferative glomerulonephritis type I (n=1), crescentic C3 glomerulopathy (n = 1), fibrillary glomerulonephritis (n = 1) and minimal change disease (n = 1). Eleven (58%) patients received immunosuppressive treatments, among whom one developed a severe infectious complication. After a median follow-up of 7 month [1-96], nine (47%) patients had chronic kidney disease stage 3 (n = 6) or 4 (n = 3) and five (26%) progressed to end-stage kidney disease. Three patients died. MDS are associated to several autoimmune kidney manifestations, predominantly acute TIN. MDS are to be listed among the potential causes of autoimmune TIN

Acute tubulointerstitial nephritis complicating Legionnaires' disease: a case report

<p>Abstract</p> <p>Introduction</p> <p>Legionnaires' disease is recognized as a multi-systemic illness. Afflicted patients may have pulmonary, renal, gastrointestinal tract and central nervous system complications. However, renal insufficiency is uncommon. The spectrum of renal involvement may range from a mild and transient elevation of serum creatinine levels to anuric renal failure requiring dialysis and may be linked to several causes. In our present case report, we would like to draw attention to the importance of the pathological documentation of acute renal failure by reporting a case of a patient with acute tubulointerstitial nephritis complicating Legionnaires' disease.</p> <p>Case presentation</p> <p>A 55-year-old Caucasian man was admitted to our hospital for community-acquired pneumonia complicated by acute renal failure. <it>Legionella pneumophila </it>serogroup type 1 was diagnosed. Although the patient's respiratory illness responded to intravenous erythromycin and ofloxacin therapy, his renal failure worsened, he became anuric, and hemodialysis was started. A renal biopsy was performed, which revealed severe tubulointerstitial nephritis. After initiation of steroid therapy, his renal function improved dramatically.</p> <p>Conclusions</p> <p>This case highlights the importance of kidney biopsies in cases where acute renal failure is a complicating factor in Legionnaires' disease. If the presence of acute tubulointerstitial nephritis can be confirmed, it will likely respond favorably to steroidal treatment and thus irreversible renal damage and chronic renal failure will be avoided.</p