Measurements of Polyatomic Molecule Formation on an Icy Grain Analog Using Fast Atoms

Carbon dioxide has been produced from the impact of a monoenergetic O(P-3) beam upon a surface cooled to 4.8 K and covered with a CO ice. Using temperature-programmed desorption and mass spectrometer detection, we have detected increasing amounts of CO2 formation with O(P-3) energies of 2, 5, 10, and 14 eV. This is the first measurement of polyatomic molecule formation on a surface with superthermal atoms. The goal of this work is to detect other polyatomic species, such as CH3OH, which can be formed under conditions that simulate the grain temperature, surface coverage, and superthermal atoms present in shock-heated circumstellar and interstellar regions

Elasticity and viscosity of ice measured in the experiment on wave propagation below the ice in HSVA ice tank

An experiment on the propagation of flexural-gravity waves was performed in the HSVA ice tank in 2018. Physical characteristics of the water-ice system were measured in different locations in the tank during the tests, with several sensors deployed in the water, on the ice and in the air. Periodical waves with frequencies of 0.5-1.5 Hz were generated by HSVA wave maker during 10 min in each test. The phase speeds and wave damping associated with anelastic deformations of ice were analyzed in the paper. Elastic modulus of ice was calculated for each wave period from the dispersion equation of flexural gravity waves where measured values of wave frequencies and wave speeds were substituted. Viscous coefficient of ice was calculated after the analysis of wave damping. Obtained values have relatively big dispersion which can be explained by natural variability of ice properties

Laboratory Investigations of the Bending Rheology of Floating Saline Ice and Physical Mechanisms of Wave Damping In the HSVA Hamburg Ship Model Basin Ice Tank

An experimental investigation of flexural-gravity waves was performed in the Hamburg Ship Model Basin HSVA ice tank. Physical characteristics of the water-ice system were measured in several locations of the tank with a few sensors deployed in the water and on the ice during the tests. The three-dimensional motion of ice was measured with the optical system Qualisys; water pressure was measured by several pressure sensors mounted on the tank wall, in-plane deformations of the ice and the temperatures of the ice and water were measured by fiber optic sensors; and acoustic emissions were recorded with compressional crystal sensors. The experimental setup and selected results of the tests are discussed in this paper. Viscous-elastic model (Burgers material) is adopted to describe the dispersion and attenuation of waves propagating below the ice. The elastic modulus and the coefficient of viscosity are calculated using the experimental data. The results of the measurements demonstrated the dependence of wave characteristics from the variability of ice properties during the experiment caused by the brine drainage. We showed that the cyclic motion of the ice along the tank, imitating ice drift, and the generation of under ice turbulence cause an increase of wave damping. Recorded acoustic emissions demonstrated cyclic microcracking occurring with wave frequencies and accompanying bending deformations of the ice. This explains the viscous and anelastic rheology of the model ice

Evidence-based selection of environmental factors and datasets for measuring multiple environmental deprivation in epidemiological research

This Environment and Human Health project aims to develop a health-based summary measure of multiple physical environmental deprivation for the UK, akin to the measures of multiple socioeconomic deprivation that are widely used in epidemiology. Here we describe the first stage of the project, in which we aimed to identify health-relevant dimensions of physical environmental deprivation and acquire suitable environmental datasets to represent population exposure to these dimensions at the small-area level. We present the results of this process: an evidence-based list of environmental dimensions with population health relevance for the UK, and the spatial datasets we obtained and processed to represent these dimensions. This stage laid the foundations for the rest of the project, which will be reported elsewhere

Differences in the Activity of Endogenous Bone Morphogenetic Protein Signaling Impact on the Ability of Induced Pluripotent Stem Cells to Differentiate to Corneal Epithelial-Like Cells

Cornea is a clear outermost layer of the eye which enables transmission of light onto the retina. The transparent corneal epithelium is regenerated by limbal stem cells (LSCs), whose loss/dysfunction results in LSCs deficiency (LSCD). Ex vivo expansion of autologous LSCs obtained from patient's healthy eye followed by transplantation onto the LSCs damaged/deficient eye, has provided a successful treatment for unilateral LSCD. However, this is not applicable to patient with total bilateral LSCD, where LSCs are lost/damaged from both eyes. We investigated the potential of human induced pluripotent stem cell (hiPSC) to differentiate into corneal epithelial-like cells as a source of autologous stem cell treatment for patients with total bilateral LSCD. Our study showed that combined addition of bone morphogenetic protein 4 (BMP4), all trans-retinoic acid and epidermal growth factor for the first 9 days of differentiation followed by cell-replating on collagen-IV-coated surfaces with a corneal-specific-epithelial cell media for an additional 11 days, resulted in step wise differentiation of human embryonic stem cells (hESC) to corneal epithelial progenitors and mature corneal epithelial-like cells. We observed differences in the ability of hiPSC lines to undergo differentiation to corneal epithelial-like cells which were dependent on the level of endogenous BMP signaling and could be restored via the activation of this signaling pathway by a specific transforming growth factor β inhibitor (SB431542). Together our data reveal a differential ability of hiPSC lines to generate corneal epithelial cells which is underlined by the activity of endogenous BMP signaling pathway

Influence of vibrations on indentation and compression strength of sea ice

Indentation and compression strengths of floating sea ice subjected to vibrations is discussed. The experiments were performed on the land fast ice of the Van-Mijen Fjord in March of 2018 and 2019. The ice thickness was around 70 cm, and the ice salinity was 4-5 ppt. Vibrations were introduced in the ice by the vibration plate with weight of 400 kg before the tests during 10-15 min. The vibration plate was standing and vibrating on the ice surface. The spectrum of vibrations was recorded with accelerometers. Analysis of thin sections of ice was performed on the place of the field works. Indentation tests were performed with the original hydraulic rig on natural ice and ice subjected to the action of vibrating plate. It was discovered that stroke rates tests were higher in the tests performed on the ice subjected to vibrations. Uniaxial compression tests were also performed on ice cores taken from the natural ice and from the ice subjected to the vibrations. Uniaxial compression strength of ice cores taken from the ice subjected to vibrations was higher than in the tests with natural ice

Have regional inequalities in life expectancy widened within the European Union between 1991 and 2008?

<b>BACKGROUND:</b> Health inequalities have widened within and between many European countries over recent decades, but Europe-wide sub-national trends have been largely overlooked. For regions across the European Union (EU), we assess how geographical inequalities (i.e., between regions) and sociospatial inequalities (i.e., between regions grouped by an area-level measure of average household income) in male and female life expectancy have changed between 1991 and 2008.<p></p> <b>METHODS:</b> Household income, life expectancy at birth and population count data were obtained for 129 regions (level 2 Nomenclature of Statistical Territorial Units, 'NUTS') in 13 European countries with 1991-2008 data (2008 population = 272 million). We assessed temporal changes in the range of life expectancies, for all regions and for Western and Eastern European regions separately.<p></p> <b>RESULTS:</b> Between 1991 and 2008, the geographical range of life expectancies found among European regions remained relatively constant, with the exception of life expectancy among male Eastern Europeans, for whom the range widened by 2.8 years. Sociospatial inequalities in life expectancy (1999-2008 data only) remained constant for all regions combined and for Western Europe, but more than doubled in size for male Eastern Europeans. For female Eastern Europeans, life expectancy was unrelated to regional household income.<p></p> <b>CONCLUSIONS:</b>Regional life-expectancy inequalities in the EU have not narrowed over 2 decades, despite efforts to reduce them. Household income differences across European regions may partly explain these inequalities. As inequalities transcend national borders, reduction efforts may require EU-wide coordination in addition to national efforts.<p></p&gt

Considerations for the design and conduct of human gut microbiota intervention studies relating to foods

With the growing appreciation for the influence of the intestinal microbiota on human health, there is increasing motivation to design and refine interventions to promote favorable shifts in the microbiota and their interactions with the host. Technological advances have improved our understanding and ability to measure this indigenous population and the impact of such interventions. However, the rapid growth and evolution of the field, as well as the diversity of methods used, parameters measured and populations studied, make it difficult to interpret the significance of the findings and translate their outcomes to the wider population. This can prevent comparisons across studies and hinder the drawing of appropriate conclusions. This review outlines considerations to facilitate the design, implementation and interpretation of human gut microbiota intervention studies relating to foods based upon our current understanding of the intestinal microbiota, its functionality and interactions with the human host. This includes parameters associated with study design, eligibility criteria, statistical considerations, characterization of products and the measurement of compliance. Methodologies and markers to assess compositional and functional changes in the microbiota, following interventions are discussed in addition to approaches to assess changes in microbiota–host interactions and host responses. Last, EU legislative aspects in relation to foods and health claims are presented. While it is appreciated that the field of gastrointestinal microbiology is rapidly evolving, such guidance will assist in the design and interpretation of human gut microbiota interventional studies relating to foods

Shortcomings in public health authorities’ videos on COVID-19: limited reach and a creative gap

Science Communication and Societ