Vergleich der muttergebundenen und der künstlichen Aufzucht in Bezug auf Gesundheit, Gewichtsentwicklung und chronischen Stress bei Milchviehkälbern

In artificial rearing, calves are separated from their dam usually within 24h after birth and any further social contacts to the mother are prevented. Although this is common in practice we expect severe consequences on the health state, weight gain and stress response of the young calf. Two groups of calves suckled by their mother (unrestricted contact, n=14; contact twice daily for 15 minutes each before milking, n=15) were compared to two control groups that were both fed via automatic milk feeder (maximal six times daily, n=14; twice daily, n=14). The calves of the four treatment groups were kept in the same barn and cows were milked twice daily. All calves were weaned at 13 weeks of age. The calves were weighed weekly until 3 weeks after weaning. The health state of each animal was assessed daily and all veterinary treatments were recorded until weaning. Stress response to a long-term stressor (absence of the mother) was assessed by stimulation of the HPA axis by ACTH administration (at 11 weeks of age). For statistical analyses, linear mixed-effects models were used. The health state of both suckled groups was poorer (p=0.046, caused by diarrhoea), but the number of animals that had to be treated by a veterinarian did not differ. During the milk feeding period, weight gain was better in suckled calves (p<0.001). After weaning, the weight gain of all treatment groups was diminished, especially in suckled calves (p<0.001). Cortisol response to ACTH administration was reduced in calves fed via an automatic milk feeder (p<0.001). The higher weight gain in suckled calves before weaning can be explained by the large milk amounts the calves received. These results suggest that suckled calves show fewer signs of chronic stress. We conclude that rearing without contact with the mother causes chronic stress in young calves in terms of desensitization of the HPA axis

Der Verlust des Signaltransduktionsmoduls des Proteins p62 führt zu einem adipösen Phänotyp bei Mäusen

Das Protein p62 ist sowohl an der Signaltransduktion, als auch an der Proteindegradation beteiligt. In dieser Arbeit wird eine Mauslinie charakterisiert, die ein p62-Protein exprimiert, dem die Aminosäuren 69 bis 251 und damit das Signaltransduktionsmodul fehlen. Durch die Entkopplung von Signaltransduktion und Proteindegradation kommt es zu einer Anreicherung freier Sauerstoffradikale und einer gesteigerten Autophagozytose in primären Zellen. Diese beiden Phänomene sind sowohl als Folge, aber auch als Ursache von Adipositas beschrieben. Mäuse die diesen p62-Gendefekt tragen entwickeln einen altersbedingten adipösen Phänotyp und können als Modellorganismus zur Untersuchungen des Metabolischen Syndroms dienen. Darüber hinaus können Studien externer Faktoren Aufschluss über die Ursache von Folgeerkrankungen von Adipositas (z.B. Herzkreislauferkrankungen und Diabetes) geben

A Metadata Registry from Vocabularies Up: the NSDL Registry Project

The NSDL Metadata Registry is designed to provide humans and machines with the means to discover, create, access and manage metadata schemes, schemas, application profiles, crosswalks and concept mappings. This paper describes the general goals and architecture of the NSDL Metadata Registry as well as issues encountered during the first year of the project's implementation.This material is based upon work supported by the National Science Foundation under Grant No. DUE-0532828

The SASSCAL contribution to climate observation, climate data management and data rescue in Southern Africa

A major task of the newly established "Southern African Science Service Centre for Climate Change and Adaptive Land Management" (SASSCAL; www.sasscal.org) and its partners is to provide science-based environmental information and knowledge which includes the provision of consistent and reliable climate data for Southern Africa. Hence, SASSCAL, in close cooperation with the national weather authorities of Angola, Botswana, Germany and Zambia as well as partner institutions in Namibia and South Africa, supports the extension of the regional meteorological observation network and the improvement of the climate archives at national level. With the ongoing rehabilitation of existing weather stations and the new installation of fully automated weather stations (AWS), altogether 105 AWS currently provide a set of climate variables at 15, 30 and 60 min intervals respectively. These records are made available through the SASSCAL WeatherNet, an online platform providing near-real time data as well as various statistics and graphics, all in open access. This effort is complemented by the harmonization and improvement of climate data management concepts at the national weather authorities, capacity building activities and an extension of the data bases with historical climate data which are still available from different sources. These activities are performed through cooperation between regional and German institutions and will provide important information for climate service related activities

Effects of mesenchymal stromal cells versus serum on tendon healing in a controlled experimental trial in an equine model

Abstract Background Mesenchymal stromal cells (MSC) have shown promising results in the treatment of tendinopathy in equine medicine, making this therapeutic approach seem favorable for translation to human medicine. Having demonstrated that MSC engraft within the tendon lesions after local injection in an equine model, we hypothesized that they would improve tendon healing superior to serum injection alone. Methods Quadrilateral tendon lesions were induced in six horses by mechanical tissue disruption combined with collagenase application 3 weeks before treatment. Adipose-derived MSC suspended in serum or serum alone were then injected intralesionally. Clinical examinations, ultrasound and magnetic resonance imaging were performed over 24 weeks. Tendon biopsies for histological assessment were taken from the hindlimbs 3 weeks after treatment. Horses were sacrificed after 24 weeks and forelimb tendons were subjected to macroscopic and histological examination as well as analysis of musculoskeletal marker expression. Results Tendons injected with MSC showed a transient increase in inflammation and lesion size, as indicated by clinical and imaging parameters between week 3 and 6 (p < 0.05). Thereafter, symptoms decreased in both groups and, except that in MSC-treated tendons, mean lesion signal intensity as seen in T2w magnetic resonance imaging and cellularity as seen in the histology (p < 0.05) were lower, no major differences could be found at week 24. Conclusions These data suggest that MSC have influenced the inflammatory reaction in a way not described in tendinopathy studies before. However, at the endpoint of the current study, 24 weeks after treatment, no distinct improvement was observed in MSC-treated tendons compared to the serum-injected controls. Future studies are necessary to elucidate whether and under which conditions MSC are beneficial for tendon healing before translation into human medicine

Generalised Space-time and Gauge Transformations

We consider the generalised space-time introduced by the author in 2003 in the context of the non-linear realisation of the semi-direct product of E11 and its first fundamental representation. For all the fields we propose gauge transformations which are compatible with the underlying E11 structure. A crucial role is played by the generalised vielbein that the generalised space-time possess. We work out the explicit form of the gauge transformations, at low levels, in four, five and eleven dimensions.Comment: 33 page

Epidemiology, comorbidities, and healthcare utilization of patients with chronic urticaria in Germany

Abstract Background Comprehensive data on the epidemiology and comorbidities of chronic urticaria (CU) in Germany are either limited, or not contemporary. Objectives To investigate the epidemiology of CU, overall comorbidities and healthcare resource utilized by patients with CU in Germany, using an anonymized statutory health insurance (SHI) database. Methods Anonymized SHI claims research database of the Institute for Applied Health Research, Berlin [InGef] (01 January 2015–30 September 2018) was used to analyse insured individuals with a confirmed diagnosis of CU (ICD‐10‐GM codes). Twelve‐month diagnosed prevalence and incidence, comorbidities (vs. atopic dermatitis and psoriasis), and healthcare utilization by patients with CU were investigated. Results Of 4 693 772 individuals of all ages listed in the database, 3 538 540 were observable during 2017. Overall, 17 524 patients (˜0.5%) were diagnosed with CU; chronic spontaneous urticaria (CSU: 71.2%), chronic inducible urticaria (CIndU: 19.7%), CSU+CIndU (9.1%). Females, vs. males, had higher diagnosed prevalence (0.62% vs. 0.37%) and diagnosed incidence (0.18% vs. 0.11%) of CU among all patients. Patients most frequently visited general practitioners (41.3% of total visits). Hypertensive diseases (43.5%), lipoprotein metabolism disorders (32.1%) and affective disorders (26.0%) were the most frequently reported comorbidities of special interest. Rates of most comorbidities of special interests were similar to atopic dermatitis and psoriasis patients, and all higher vs. overall population. More than half (54.1%) of all CU patients were not prescribed any treatment. Second‐generation H 1 ‐antihistamines were the most commonly prescribed medication for adult (17.9%) and paediatric (27.9%) patients. Patients with CIndU (paediatric, 15.5%; adult, 7.8%) were more often hospitalized versus patients with CSU (paediatric, 9.9%; adult, 4.6%). Conclusions In Germany, prevalence of CU along with multiple comorbidities may pose increased burden on the healthcare system. Awareness of adhering to treatment guidelines, and aiming for complete control of urticaria, needs to be driven and may improve outcomes

Epidemiology, comorbidities, and healthcare utilization of patients with chronic urticaria in Germany

Background: Comprehensive data on the epidemiology and comorbidities of chronic urticaria (CU) in Germany are either limited, or not contemporary. Objectives: To investigate the epidemiology of CU, overall comorbidities and healthcare resource utilized by patients with CU in Germany, using an anonymized statutory health insurance (SHI) database. Methods: Anonymized SHI claims research database of the Institute for Applied Health Research, Berlin [InGef] (01 January 2015-30 September 2018) was used to analyse insured individuals with a confirmed diagnosis of CU (ICD-10-GM codes). Twelve-month diagnosed prevalence and incidence, comorbidities (vs. atopic dermatitis and psoriasis), and healthcare utilization by patients with CU were investigated. Results: Of 4 693 772 individuals of all ages listed in the database, 3 538 540 were observable during 2017. Overall, 17 524 patients (˜0.5%) were diagnosed with CU; chronic spontaneous urticaria (CSU: 71.2%), chronic inducible urticaria (CIndU: 19.7%), CSU+CIndU (9.1%). Females, vs. males, had higher diagnosed prevalence (0.62% vs. 0.37%) and diagnosed incidence (0.18% vs. 0.11%) of CU among all patients. Patients most frequently visited general practitioners (41.3% of total visits). Hypertensive diseases (43.5%), lipoprotein metabolism disorders (32.1%) and affective disorders (26.0%) were the most frequently reported comorbidities of special interest. Rates of most comorbidities of special interests were similar to atopic dermatitis and psoriasis patients, and all higher vs. overall population. More than half (54.1%) of all CU patients were not prescribed any treatment. Second-generation H1 -antihistamines were the most commonly prescribed medication for adult (17.9%) and paediatric (27.9%) patients. Patients with CIndU (paediatric, 15.5%; adult, 7.8%) were more often hospitalized versus patients with CSU (paediatric, 9.9%; adult, 4.6%). Conclusions: In Germany, prevalence of CU along with multiple comorbidities may pose increased burden on the healthcare system. Awareness of adhering to treatment guidelines, and aiming for complete control of urticaria, needs to be driven and may improve outcomes

Pure type I supergravity and DE(10)

We establish a dynamical equivalence between the bosonic part of pure type I supergravity in D=10 and a D=1 non-linear sigma-model on the Kac-Moody coset space DE(10)/K(DE(10)) if both theories are suitably truncated. To this end we make use of a decomposition of DE(10) under its regular SO(9,9) subgroup. Our analysis also deals partly with the fermionic fields of the supergravity theory and we define corresponding representations of the generalized spatial Lorentz group K(DE(10)).Comment: 28 page