The Aсquisition of a Wax Anatomical Model for Peter the Great in France: The Contract and Its Consequences

The article was submitted on 23.05.2016.Во время своей второй поездки в Европу, трехсотлетие которой отмечается в 2017 г., Петр I посетил Париж. Он осмотрел основные достопримечательности города и по нескольку раз побывал в тех из них, которые отвечали его интересу к естественным и техническим наукам. В частности, несколько визитов царь нанес в Королевский ботанический сад. Он познакомился там со знаменитым медиком, профессором анатомии и членом Парижской академии наук Жозефом-Гишаром Дюверне (в русской традиции его иногда именовавали Дювернеем; 1648–1730). Тот был известен по всей Европе, располагал обширным кругом знакомств среди ученых и славился изготовлением анатомических моделей из воска, а также «анатомическими демонстрациями» (публичными лекциями по анатомии). Среди прочих, Дюверне поддерживал знакомство с Робертом Арескином (иногда его фамилию транскрибируют как Эрскин), лейб-медиком Петра I шотландского происхождения. Свидетельством интереса, который Петр I проявил к талантам Дюверне, стал заказ на создание одной анатомической модели, которая предназначалась для Кунсткамеры. Непосредственным исполнителем воли царя стал Арескин, выступивший в роли заказчика. Анатомическая модель головного мозга и черепа и по сей день хранится в собрании Кунсткамеры, однако обстоятельства ее изготовления до нынешнего времени были неизвестны. На основе ранее не публиковавшегося документа из Национального архива Франции и иных французских и русских источников (в том числе архивных) в статье воссоздается история создания этой модели и вводятся в научный оборот данные, позволяющие судить о первоначальном замысле Петра I после его знакомства с Дюверне и об изменениях, которые подобный замысел претерпел по мере своего воплощения в жизнь.During his second tour of Europe, whose 300th anniversary is celebrated in 2017, Peter I visited Paris. He visited the main landmarks of the city, especially those related to his interest in the natural sciences and technology. For instance, he repeatedly visited the Royal Botanical Garden. There, he became acquainted with the renowned doctor, professor of anatomy, and member of the Paris Academy of Sciences Joseph-Guichard Duverney (1648–1730). He was well known in Europe, had a lot of connections with other scientists, and was famous for his wax anatomical models and ‘anatomical demonstrations’ (public lectures in anatomy). Among others, Duverney communicated with Robert Areskine, a physician of Scottish descent at Peter’s court. Peter ordered an anatomical model for his collection in the Kunstkamera, which proves the interest the tsar had in Duverney’s talents. Areskine represented Peter the Great in the purchase. The anatomical model of a human brain and skull is still kept in the Kunstkamera collection. However, until recently there was no information on how it was made. Referring to a previously unpublished document from the National Archive of France and other French and Russian sources (including archival ones), this article reconstructs the story of the model’s creation and provides new historical data that helps us to understand Peter’s initial idea after meeting Duverney and the changes the project underwent while it was being implemented

RNA editing regulates insect gamma-aminobutyric acid receptor function and insecticide sensitivity

A-to-I pre-mRNA editing by adenosine deaminase enzymes has been reported to enhance protein diversity in the nervous system. In Drosophila, the resistance to dieldrin (RDL) gamma-aminobutyric acid (GABA) receptor subunit displays an editing site (R122) that is close to the putative GABA-binding site. We assessed the functional effects of editing at this site by expressing homomeric RDL receptors in Xenopus oocytes. After replacement of arginine 122 with a glycine, both agonist and fipronil potencies were shifted to the right in either fipronil-sensitive receptors or mutated resistant receptors (A301G/T350M). These data provide the first insight on the influence of RNA editing on GABA receptor function

From Design to Production Control Through the Integration of Engineering Data Management and Workflow Management Systems

At a time when many companies are under pressure to reduce "times-to-market" the management of product information from the early stages of design through assembly to manufacture and production has become increasingly important. Similarly in the construction of high energy physics devices the collection of (often evolving) engineering data is central to the subsequent physics analysis. Traditionally in industry design engineers have employed Engineering Data Management Systems (also called Product Data Management Systems) to coordinate and control access to documented versions of product designs. However, these systems provide control only at the collaborative design level and are seldom used beyond design. Workflow management systems, on the other hand, are employed in industry to coordinate and support the more complex and repeatable work processes of the production environment. Commercial workflow products cannot support the highly dynamic activities found both in the design stages of product development and in rapidly evolving workflow definitions. The integration of Product Data Management with Workflow Management can provide support for product development from initial CAD/CAM collaborative design through to the support and optimisation of production workflow activities. This paper investigates this integration and proposes a philosophy for the support of product data throughout the full development and production lifecycle and demonstrates its usefulness in the construction of CMS detectors.Comment: 18 pages, 13 figure

Measurement of circulating 25-hydroxyvitamin D: A historical review

The constantly increasing requests for the measurement of serum 25-hydroxyvitamin D over the last years has led reagent manufacturers to market different automated and semi-automated methods, that being unfortunately not fully harmonized, yield different results. Liquid chromatography coupled to tandem mass spectrometry (LC/MS2) has more recently been introduced. This approach allows the distinction between the two forms of 25-hydroxyvitamin D and to measure other metabolites. This approach also requires harmonization to curtail the differences between the different analytical methods. To meet this requirement, the American National Institutes of Health (NIH), the CDC (Centre for Disease Control and Prevention) in Atlanta, the NIST (National Institute of Standards and Technology) and the vitamin D Reference laboratory of Ghent University have pooled their expertise to develop a standardization program. This article reviews the main elements and the difficulties of the automated and semi-automated methods for 25-hydroxyvitamin D, from sample preparation to the analytical phase, as well as those related to mass spectrometry. It also addresses the issues related to the clinical decision thresholds and the possibility of measurements in different biological liquids

Role of the Netrin-like Domain of Procollagen C-Proteinase Enhancer-1 in the Control of Metalloproteinase Activity

The netrin-like (NTR) domain is a feature of several extracellular proteins, most notably the N-terminal domain of tissue inhibitors of metalloproteinases (TIMPs), where it functions as a strong inhibitor of matrix metalloproteinases and some other members of the metzincin superfamily. The presence of a C-terminal NTR domain in procollagen C-proteinase enhancers (PCPEs), proteins that stimulate the activity of astacin-like tolloid proteinases, raises the possibility that this might also have inhibitory activity. Here we show that both long and short forms of the PCPE-1 NTR domain, the latter beginning at the N-terminal cysteine known to be critical for TIMP activity, show no inhibition, at micromolar concentrations, of several members of the metzincin superfamily, including matrix metalloproteinase-2, bone morphogenetic protein-1 (a tolloid proteinase), and different ADAMTS (a disintegrin and a metalloproteinase with thrombospondin motifs) proteinases from the adamalysin family. In contrast, we report that the NTR domain within PCPE-1 leads to superstimulation of bone morphogenetic protein-1 activity in the presence of heparin and heparan sulfate. These observations point to a new mechanism whereby binding to cell surface-associated or extracellular heparin-like sulfated glycosaminoglycans might provide a means to accelerate procollagen processing in specific cellular and extracellular microenvironments

Electromechanical, Thermal Properties And Radiation Hardness Tests Of Piezoelectric Actuators At Low Temperature

IPN Orsay participates, in the frame of the CARE project activities supported by EU, to the development of a fast cold tuning system for SRF cavities. The main task of IPN is the full characterization of piezoelectric actuators at low temperature T, and the study of their behaviour when subjected to fast neutrons radiation at T=4.2 K. In order to compare the performance of various industrial piezoelectric actuators, a new apparatus was developed and successfully used for measuring their electromechanical and thermal properties for T in the range 1.8 K-300 K. Different parameters were investigated as function of T: piezoelectric constant, dielectric and thermal properties including heating ΔT due to dielectric losses vs. modulating voltage Vmod and frequency f. We observed a decrease of the maximum displacement ΔX of the actuators tested from ΔX ~40μm @ 300K down to 1.8μm-3.5 μm @ 1.8K, depending on both material and fabrication process of the piezostacks. Besides, both material and fabrication process have a strong influence on the shape of the characteristics ΔX vs. T dependence. Finally a dedicated facility located at CERI institute (Orléans, France) for radiation hardness tests of actuators with fast neutrons at T=4.2 K was developed and the first beam tests results are summarized

Covalent grafting onto self-adhesive surfaces based on aryldiazonium salt seed layers

International audienceThe chemistry of aryldiazonium salts has been thoroughly used in recent years to graft in a very simple and robust way ultrathin polyphenylene-like films on a broad range of surfaces. We show here that the same chemistry can be used to obtain self-adhesive surfaces. This target was reached in a simple way by coating various surfaces with chemisorbed organic films containing active aryldiazonium salts. These self-adhesive surfaces are then put into contact with various species (molecules, polymers, nanoparticles, nanotubes, graphene flakes, etc.) that react either spontaneously or under activation with the immobilized aryldiazonium salts. Our self-adhesive surfaces were synthesized following a simple aqueous two-step protocol based on p-phenylenediamine diazotisation. The first diazotisation step results in the robust grafting of thin polyaminophenylene (PAP) layers onto the surface. The second diazotisation step changed the grafted PAP film into a poly-aryldiazonium polymer (PDP) film. The covalent grafting between those self-adhesive surfaces and the target species was achieved by direct contact or by immersion of the self-adhesive surfaces in solution. We present in this preliminary work the grafting of multi-wall carbon nanotubes (MWCNTs), flakes of highly oriented pyrolytic graphite (HOPG), various organic compounds and copper nanoparticles. We also tested these immobilized aryldiazonium salts as electropolymerization initiators for the grafting-to process