Anthocyanins and their physiologically relevant metabolites alter the expression of IL-6 and VCAM-1 in CD40L and oxidized LDL challenged vascular endothelial cells

Scope In vitro and in vivo studies suggest that dietary anthocyanins modulate cardiovascular disease risk; however, given anthocyanins extensive metabolism, it is likely that their degradation products and conjugated metabolites are responsible for this reported bioactivity. Methods and results Human vascular endothelial cells were stimulated with either oxidized LDL (oxLDL) or cluster of differentiation 40 ligand (CD40L) and cotreated with cyanidin-3-glucoside and 11 of its recently identified metabolites, at 0.1, 1, and 10 μM concentrations. Protein and gene expression of IL-6 and VCAM-1 was quantified by ELISA and RT-qPCR. In oxLDL-stimulated cells the parent anthocyanin had no effect on IL-6 production, whereas numerous anthocyanin metabolites significantly reduced IL-6 protein levels; phase II conjugates of protocatechuic acid produced the greatest effects (>75% reduction, p ≤ 0.05). In CD40L-stimulated cells the anthocyanin and its phase II metabolites reduced IL-6 protein production, where protocatechuic acid-4-sulfate induced the greatest reduction (>96% reduction, p ≤ 0.03). Similarly, the anthocyanin and its metabolites reduced VCAM-1 protein production, with ferulic acid producing the greatest effect (>65% reduction, p ≤ 0.04). Conclusion These novel data provide evidence to suggest that anthocyanin metabolites are bioactive at physiologically relevant concentrations and have the potential to modulate cardiovascular disease progression by altering the expression of inflammatory mediators

Measurement of eta_c(1S), eta_c(2S) and non-resonant eta' pi+ pi- production via two-photon collisions

We report the measurement of gamma gamma to eta_c(1S), eta_c(2S) to eta' pi+ pi- with eta' decays to gamma rho and eta pi+ pi- using 941 fb^{-1} of data collected with the Belle detector at the KEKB asymmetric-energy e+e- collider. The eta_c(1S) mass and width are measured to be M = [2984.6\pm0.7 (stat.)\pm2.2 (syst.)] MeV/c^{2} and \Gamma = [30.8^{+2.3}_{-2.2}~(stat.) \pm 2.5~(syst.)] MeV, respectively. First observation of eta_c(2S) to eta' pi+ pi- with a significance of 5.5sigma including systematic error is obtained, and the eta_c(2S) mass is measured to be M = [3635.1\pm3.7~(stat.)\pm2.9~(syst.)] MeV/c^{2}. The products of the two-photon decay width and branching fraction (B) of decays to eta'pi+ pi- are determined to be \Gamma_{gamma gamma}B = [65.4\pm2.6~(stat.)\pm6.9~(syst.)] eV for eta_c(1S) and [5.6^{+1.2}_{-1.1}~(stat.)\pm1.1~(syst.)] eV for eta_c(2S). A new decay mode for the eta_c(1S) to eta'f_0(2080) with f_0(2080) to pi+ pi- is observed with a statistical significance of 20sigma. The f_0(2080) mass and width are determined to be M = [2083^{+63}_{-66}~(stat.)\pm 32~(syst.)] MeV/c^{2} and \Gamma = [178^{+60}_{-178}~(stat.) \pm 55~(syst.)] MeV. The cross sections for gamma gamma to eta' pi+ pi- and eta'f_{2}(1270) are measured for the first time.Comment: 19 pages, 14 figure

Measurement of the τ\tau lepton polarization and R(D∗)R(D^*) in the decay Bˉ→D∗τ−νˉτ\bar{B} \rightarrow D^* \tau^- \bar{\nu}_\tau with one-prong hadronic τ\tau decays at Belle

With the full data sample of $772 \times 10^6$ $B{\bar B}$ pairs recorded by the Belle detector at the KEKB electron-positron collider, the decay $\bar{B} \rightarrow D^* \tau^- \bar{\nu}_\tau$ is studied with the hadronic $\tau$ decays $\tau^- \rightarrow \pi^- \nu_\tau$ and $\tau^- \rightarrow \rho^- \nu_\tau$. The $\tau$ polarization $P_\tau(D^*)$ in two-body hadronic $\tau$ decays is measured, as well as the ratio of the branching fractions $R(D^{*}) = \mathcal{B}(\bar {B} \rightarrow D^* \tau^- \bar{\nu}_\tau) / \mathcal{B}(\bar{B} \rightarrow D^* \ell^- \bar{\nu}_\ell)$, where $\ell^-$ denotes an electron or a muon. Our results, $P_\tau(D^*) = -0.38 \pm 0.51 {\rm (stat)} ^{+0.21}_{-0.16} {\rm (syst)}$ and $R(D^*) = 0.270 \pm 0.035{\rm (stat)} ^{+0.028}_{-0.025}{\rm (syst)}$, are consistent with the theoretical predictions of the Standard Model. The polarization values of $P_\tau(D^*) > +0.5$ are excluded at the 90\% confidence level.Comment: 17 pages, 11 figures, submitted to Physical Review

Measurement of Branching Fractions of Hadronic Decays of the Ωc0\Omega_c^0 Baryon

Using a data sample of 980 ${\rm fb}^{-1}$ of $e^+e^-$ annihilation data taken with the Belle detector operating at the KEKB asymmetric-energy $e^+e^-$ collider, we report the results of a study of the decays of the $\Omega_c^0$ charmed baryon into hadronic final states. We report the most precise measurements to date of the relative branching fractions of the $\Omega_c^0$ into $\Omega^-\pi^+\pi^0$, $\Omega^-\pi^+\pi^-\pi^+$, $\Xi^-K^-\pi^+\pi^+$, and $\Xi^0K^-\pi^+$, as well as the first measurements of the branching fractions of the $\Omega_c^0$ into $\Xi^-\bar{K}^0\pi^+$, $\Xi^0\bar{K}^0$, and $\Lambda \bar{K}^0\bar{K}^0$, all with respect to the $\Omega^-\pi^+$ decay. In addition, we investigate the resonant substructure of these modes. Finally, we present a limit on the branching fraction for the decay $\Omega_c^0\to\Sigma^+K^-K^-\pi^+$

Inclusive study of bottomonium production in association with an η\eta meson in e+e−e^+e^- annihilations near Υ(5S)\Upsilon(5S)

We study bottomonium production in association with an $\eta$ meson in $e^+e^-$ annihilations near the $\Upsilon(5S)$, at a center of mass energy of $\sqrt{s}=10.866\,$GeV. The results are based on the $121.4\,$fb$^{-1}$ data sample collected by the Belle experiment at the asymmetric energy KEKB collider. Only the $\eta$ meson is reconstructed and the missing-mass spectrum of $\eta$ candidates is investigated. We observe the $e^+e^-\to\eta\Upsilon_J(1D)$ process and find evidence for the $e^+e^-\to\eta\Upsilon(2S)$ process, while no significant signals of $\Upsilon(1S)$, $h_b(1P)$, nor $h_b(2P)$ are found. Cross sections for the studied processes are reported.Comment: Submitted to EPJ-

Measurements of the absolute branching fractions of B+→XccˉK+B^{+} \to X_{c\bar{c}} K^{+} and B+→Dˉ(∗)0π+B^{+} \to \bar{D}^{(\ast) 0} \pi^{+} at Belle

We present the measurement of the absolute branching fractions of $B^{+} \to X_{c\bar{c}} K^{+}$ and $B^{+} \to \bar{D}^{(\ast) 0} \pi^{+}$ decays, using a data sample of $772\times10^{6}$ $B\bar{B}$ pairs collected at the $\Upsilon(4S)$ resonance with the Belle detector at the KEKB asymmetric-energy $e^{+}e^{-}$ collider. Here, $X_{c\bar{c}}$ denotes $\eta_{c}$, $J/\psi$, $\chi_{c0}$, $\chi_{c1}$, $\eta_{c}(2S)$, $\psi(2S)$, $\psi(3770)$, $X(3872)$, and $X(3915)$. We do not observe significant signals for $X(3872)$ nor $X(3915)$, and set the 90$\%$ confidence level upper limits: ${\cal B}(B^{+} \to X(3872) K^{+} )<2.7 \times 10^{-4}$ and ${\cal B}(B^{+} \to X(3915) K^{+} )<2.9 \times 10^{-4}$. These represent the most stringent upper limit for ${\cal B}(B^{+} \to X(3872) K^{+} )$ to date and the first measurement for ${\cal B}(B^{+} \to X(3915) K^{+} )$. The measured branching fractions for $\eta_{c}$ and $\eta_{c}(2S)$ are the most precise to date: ${\cal B}(B^{+} \to \eta_{c} K^{+} )=(12.3\pm0.8\pm0.7) \times 10^{-4}$ and ${\cal B}(B^{+} \to \eta_{c}(2S)K^{+}) =(4.9\pm1.1\pm0.3) \times 10^{-4}$ , where the first and second uncertainties are statistical and systematic, respectively.Comment: 10 pages, 3 figure

New Zealand blackcurrant extract enhances fat oxidation during prolonged cycling in endurance-trained females.

PURPOSE: New Zealand blackcurrant (NZBC) extract has previously been shown to increase fat oxidation during prolonged exercise, but this observation is limited to males. We examined whether NZBC intake also increases fat oxidation during prolonged exercise in females, and whether this was related to greater concentrations of circulating fatty acids. METHODS: In a randomised, crossover, double-blind design, 16 endurance-trained females (age: 28 ± 8 years, BMI: 21.3 ± 2.1 kg·m-2, VO2max: 43.7 ± 1.1 ml·kg-1·min-1) ingested 600 mg·day-1NZBC extract (CurraNZ™) or placebo (600 mg·day-1microcrystalline cellulose) for 7 days. On day 7, participants performed 120 min cycling at 65% VO2max, using online expired air sampling with blood samples collected at baseline and at 15 min intervals throughout exercise for analysis of glucose, NEFA and glycerol. RESULTS: NZBC extract increased mean fat oxidation by 27% during 120 min moderate-intensity cycling compared to placebo (P = 0.042), and mean carbohydrate oxidation tended to be lower (P = 0.063). Pre-exercise, plasma NEFA (P = 0.034) and glycerol (P = 0.051) concentrations were greater following NZBC intake, although there was no difference between conditions in the exercise-induced increase in plasma NEFA and glycerol concentrations (P > 0.05). Mean fat oxidation during exercise was moderately associated with pre-exercise plasma NEFA concentrations (r = 0.45, P = 0.016). CONCLUSIONS: Intake of NZBC extract for 7 days elevated resting concentrations of plasma NEFA and glycerol, indicative of higher lipolytic rates, and this may underpin the observed increase in fat oxidation during prolonged cycling in endurance-trained females

Search for light tetraquark states in ϒ(1S) and ϒ(2S) decays

We search for the JPC=0−− and 1+− light tetraquark states with masses up to 2.46  GeV/c2 in Υ(1S) and Υ(2S) decays with data samples of (102±2) million and (158±4) million events, respectively, collected with the Belle detector. No significant signals are observed in any of the studied production modes, and 90% credibility level (C.L.) upper limits on their branching fractions in Υ(1S) and Υ(2S) decays are obtained. The inclusive branching fractions of the Υ(1S) and Υ(2S) decays into final states with f1(1285) are measured to be B(Υ(1S)→f1(1285)+anything)=(46±28(stat)±13(syst))×10−4 and B(Υ(2S)→f1(1285)+anything)=(22±15(stat)±6.3(syst))×10−4. The measured χb2→J/ψ+anything branching fraction is measured to be (1.50±0.34(stat)±0.22(syst))×10−3, and 90% C.L. upper limits for the χb0,b1→J/ψ+anything branching fractions are found to be 2.3×10−3 and 1.1×10−3, respectively. For B(χb1→ω+anything), the branching fraction is measured to be (4.9±1.3(stat)±0.6(syst))×10−2. All results reported here are the firs