511 research outputs found
Otolithic receptor mechanisms for vestibular-evoked myogenic potentials: A review
Air-conducted sound and bone-conduced vibration activate otolithic receptors and afferent neurons in both the utricular and saccular maculae, and trigger small electromyographic (EMG) responses [called vestibular-evoked myogenic potentials (VEMPs)] in various muscle groups throughout the body. The use of these VEMPs for clinical assessment of human otolithic function is built on the following logical steps: (1) that high-frequency sound and vibration at clinically effective stimulus levels activate otolithic receptors and afferents, rather than semicircular canal afferents, (2) that there is differential anatomical projection of otolith afferents to eye muscles and neck muscles, and (3) that isolated stimulation of the utricular macula induces short latency responses in eye muscles, and that isolated stimulation of the saccular macula induces short latency responses in neck motoneurons. Evidence supports these logical steps, and so VEMPs are increasingly being used for clinical assessment of otolith function, even differential evaluation of utricular and saccular function. The proposal, originally put forward by Curthoys in 2010, is now accepted: that the ocular vestibular-evoked myogenic potential reflects predominantly contralateral utricular function and the cervical vestibular-evoked myogenic potential reflects predominantly ipsilateral saccular function. So VEMPs can provide differential tests of utricular and saccular function, not because of stimulus selectivity for either of the two maculae, but by measuring responses which are predominantly determined by the differential neural projection of utricular as opposed to saccular neural information to various muscle groups. The major question which this review addresses is how the otolithic sensory system, with such a high density otoconial layer, can be activated by individual cycles of sound and vibration and show such tight locking of the timing of action potentials of single primary otolithic afferents to a particular phase angle of the stimulus cycle even at frequencies far above 1,000 Hz. The new explanation is that it is due to the otoliths acting as seismometers at high frequencies and accelerometers at low frequencies. VEMPs are an otolith-dominated response, but in a particular clinical condition, semicircular canal dehiscence, semicircular canal receptors are also activated by sound and vibration, and act to enhance the otolith-dominated VEMP responses
Optimizing the vertebrate vestibular semicircular canal: could we balance any better?
The fluid-filled semicircular canals (SCCs) of the vestibular system are used
by all vertebrates to sense angular rotation. Despite masses spanning seven
decades, all mammalian SCCs are nearly the same size. We propose that the SCC
represents a sensory organ that evolution has `optimally designed'. Four
geometric parameters are used to characterize the SCC, and `building materials'
of given physical properties are assumed. Identifying physical and
physiological constraints on SCC operation, we find that the most sensitive SCC
has dimensions consistent with available data.Comment: 4 pages, 3 figure
A mathematical model for top-shelf vertigo: the role of sedimenting otoconia in BPPV
Benign Paroxysmal Positional Vertigo (BPPV) is a mechanical disorder of the
vestibular system in which calcite particles called otoconia interfere with the
mechanical functioning of the fluid-filled semicircular canals normally used to
sense rotation. Using hydrodynamic models, we examine the two mechanisms
proposed by the medical community for BPPV: cupulolithiasis, in which otoconia
attach directly to the cupula (a sensory membrane), and canalithiasis, in which
otoconia settle through the canals and exert a fluid pressure across the
cupula. We utilize known hydrodynamic calculations and make reasonable
geometric and physical approximations to derive an expression for the
transcupular pressure exerted by a settling solid particle in
canalithiasis. By tracking settling otoconia in a two-dimensional model
geometry, the cupular volume displacement and associated eye response
(nystagmus) can be calculated quantitatively. Several important features
emerge: 1) A pressure amplification occurs as otoconia enter a narrowing duct;
2) An average-sized otoconium requires approximately five seconds to settle
through the wide ampulla, where is not amplified, which suggests a
mechanism for the observed latency of BPPV; and 3) An average-sized otoconium
beginning below the center of the cupula can cause a volumetric cupular
displacement on the order of 30 pL, with nystagmus of order /s, which
is approximately the threshold for sensation. Larger cupular volume
displacement and nystagmus could result from larger and/or multiple otoconia.Comment: 15 pages, 5 Figures updated, to be published in J. Biomechanic
Electrical vestibular stimulation in humans: a narrative review
Background: In patients with bilateral vestibulopathy, the
regular treatment options, such as medication, surgery, and/
or vestibular rehabilitation, do not always suffice. Therefore,
the focus in this field of vestibular research shifted to electrical vestibular stimulation (EVS) and the development of a
system capable of artificially restoring the vestibular function. Key Message: Currently, three approaches are being
investigated: vestibular co-stimulation with a cochlear implant (CI), EVS with a vestibular implant (VI), and galvanic
vestibular stimulation (GVS). All three applications show
promising results but due to conceptual differences and the
experimental state, a consensus on which application is the
most ideal for which type of patient is still missing. Summary: Vestibular co-stimulation with a CI is based on “spread of
excitation,” which is a phenomenon that occurs when the
currents from the CI spread to the surrounding structures
and stimulate them. It has been shown that CI activation can
indeed result in stimulation of the vestibular structures.
Therefore, the question was raised whether vestibular costimulation can be functionally used in patients with bilateral vestibulopathy. A more direct vestibular stimulation
method can be accomplished by implantation and activation of a VI. The concept of the VI is based on the technology
and principles of the CI. Different VI prototypes are currently
being evaluated regarding feasibility and functionality. So
far, all of them were capable of activating different types of
vestibular reflexes. A third stimulation method is GVS, which
requires the use of surface electrodes instead of an implanted electrode array. However, as the currents are sent through
the skull from one mastoid to the other, GVS is rather unspecific. It should be mentioned though, that the reported
spread of excitation in both CI and VI use also seems to induce a more unspecific stimulation. Although all three applications of EVS were shown to be effective, it has yet to be
defined which option is more desirable based on applicability and efficiency. It is possible and even likely that there is a
place for all three approaches, given the diversity of the patient population who serves to gain from such technologies
Resentment and Reluctance: Working with Everyday Diversity and Everyday Racism in Southern Sydney
A comparison of vestibular and auditory phenotypes in inbred mouse strains
The purposes of this research were to quantify gravity receptor function in inbred mouse strains and compare vestibular and auditory function for strain- and age-matched animals. Vestibular evoked potentials (VsEPs) were collected for 19 inbred strains at ages from 35 to 389 days old. On average, C57BL/6J (35 to 190 days), BALB/cByJ, C3H/HeSnJ, CBA/J, and young LP/J mice had VsEP thresholds comparable to normal. Elevated VsEP thresholds were found for elderly C57BL/ 6J, NOD.NONH2kb, BUB/BnJ, A/J, DBA/2J, NOD/LtJ, A/WySnJ, MRL/MpJ, A/HeJ, CAST/Ei, SJL/J, elderly LP/J, and CE/J. These results suggest that otolithic function varies among inbred strains and several strains displayed gravity receptor deficits by 90 days old. Auditory brainstem response (ABR) thresholds were compared to VsEP thresholds for 14 age-matched strains. C57BL/6J mice (up to 190 days) showed normal VsEPs with normal to mildly elevated ABR thresholds. Four strains (BUB/BnJ, NOD/LtJ, A/J, elderly LP/J) had significant hearing loss and elevated VsEP thresholds. Four strains (DBA/2J, A/WySnJ, NOD. NONH2kb, A/HeJ) had elevated VsEP thresholds (including absent VsEPs) with mild to moderate elevations in ABR thresholds. Three strains (MRL/MpJ, Ce/J, SJL/J) had significant vestibular loss with no concomitant hearing loss. These results suggest that functional change in one sensory system does not obligate change in the other. We hypothesize that genes responsible for early onset hearing loss may affect otolithic function, yet the time course of functional change may vary. In addition, some genetic mutations may produce primarily gravity receptor deficits. Potential genes responsible for selective gravity receptor impairment demonstrated herein remain to be identified. Originally published in Brain Research 1091(1), 2006
The rhesus protein RhCG: a new perspective in ammonium transport and distal urinary acidification
Urinary acidification is a complex process requiring the coordinated action of enzymes and transport proteins and resulting in the removal of acid and the regeneration of bicarbonate. Proton secretion is mediated by luminal H(+)-ATPases and requires the parallel movement of NH(3), and its protonation to NH(4)(+), to provide sufficient buffering. It has been long assumed that ammonia secretion is a passive process occurring by means of simple diffusion driven by the urinary trapping of ammonium. However, new data indicate that mammalian cells possess specific membrane proteins from the family of rhesus proteins involved in ammonia/μm permeability. Rhesus proteins were first identified in yeast and later also in plants, algae, and mammals. In rodents, RhBG and RhCG are expressed in the collecting duct, whereas in humans only RhCG was detected. Their expression increases with maturation of the kidney and accelerates after birth in parallel with other acid-base transport proteins. Deletion of RhBG in mice had no effect on renal ammonium excretion, whereas RhCG deficiency reduces renal ammonium secretion strongly, causes metabolic acidosis in acid-challenged mice, and impairs restoration of normal acid-base status. Microperfusion experiments or functional reconstitution in liposomes demonstrates that ammonia is the most likely substrate of RhCG. Similarly, crystal structures of human RhCG and the homologous bacterial AmtB protein suggest that these proteins may form gas channels.Kidney International advance online publication, 6 October 2010; doi:10.1038/ki.2010.386
Diminution of Voltage Threshold Plays a Key Role in Determining Recruitment of Oculomotor Nucleus Motoneurons during Postnatal Development
The size principle dictates the orderly recruitment of motoneurons (Mns). This principle assumes that Mns of different sizes have a similar voltage threshold, cell size being the crucial property in determining neuronal recruitment. Thus, smaller neurons have higher membrane resistance and require a lower depolarizing current to reach spike threshold. However, the cell size contribution to recruitment in Mns during postnatal development remains unknown. To investigate this subject, rat oculomotor nucleus Mns were intracellularly labeled and their electrophysiological properties recorded in a brain slice preparation. Mns were divided into 2 age groups: neonatal (1–7 postnatal days, n = 14) and adult (20–30 postnatal days, n = 10). The increase in size of Mns led to a decrease in input resistance with a strong linear relationship in both age groups. A well-fitted inverse correlation was also found between input resistance and rheobase in both age groups. However, input resistance versus rheobase did not correlate when data from neonatal and adult Mns were combined in a single group. This lack of correlation is due to the fact that decrease in input resistance of developing Mns did not lead to an increase in rheobase. Indeed, a diminution in rheobase was found, and it was accompanied by an unexpected decrease in voltage threshold. Additionally, the decrease in rheobase co-varied with decrease in voltage threshold in developing Mns. These data support that the size principle governs the recruitment order in neonatal Mns and is maintained in adult Mns of the oculomotor nucleus; but during postnatal development the crucial property in determining recruitment order in these Mns was not the modifications of cell size-input resistance but of voltage threshold
Constraining the Nature of Dark Energy using the SKA
We investigate the potential of the Square Kilometer Array Telescope (SKA) to
constrain the sound speed of dark energy. The Integrated Sachs Wolfe (ISW)
effect results in a significant power spectrum signal when CMB temperature
anisotropies are cross-correlated with galaxies detectable with the SKA in HI.
We consider using this measurement, the autocorrelation of HI galaxies and the
CMB temperature power spectrum to derive constraints on the sound speed. We
study the contributions to the cross-correlation signal made by galaxies at
different redshifts and use redshift tomography to improve the signal-to-noise.
We use a chi-square analysis to estimate the significance of detecting a sound
speed different from that expected in quintessence models, finding that there
is potential to distinguish very low sound speeds from the quintessence value.Comment: 8 pages, 8 figures; updated references for publication MNRA
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