Non-invasive single-bunch matching and emittance monitor

On-line monitoring of beam quality for high brightness beams is only possible using non-invasive instruments. For matching measurements, very few such instruments are available. One candidate is a quadrupole pick-up. Therefore, a new type of quadrupole pick-up has been developed for the 26 GeV Proton Synchrotron (PS) at CERN, and a measurement system consisting of two such pick-ups is now installed in this accelerator. Using the information from these pick-ups, it is possible to determine both injection matching and emittance in the horizontal and vertical planes, for each bunch separately. This paper presents the measurement method and some of the results from the first year of use, as well as comparisons with other measurement methods.Comment: 10 pages, 10 figures; added figure, minor textual additions; To be resubmitted to Phys. Rev. ST-A

Tune measurement for the CERN proton synchrotron booster rings using DSP in VME

The CERN PS Booster (PSB) consists of 4 superposed rings supplied with protons from a 50 MeV Linac The CERN PS Booster (PSB) consists of 4 superposed rings supplied with protons from a 50 MeV Linac. The proton beam is then accelerated to 1 GeV and sent either to the 26 GeV Proton Synchrotron (PS) or to the ISOLDE facility. This is carried out in a multi-cycle mode every 1.2 s. For high-intensity beams, the working-point in the tune diagram needs to be changed considerably during acceleration from 50 MeV to 1 GeV and the repeated measurement of the tunes throughout the cycle is an important requirement. Up to now, tune values were obtained through calculations based on quadrupole currents. However, practical experience has shown the need for a direct tune measurement system. For this purpose, a classical kick technique is used. A fixed amplitude kick of duration equal to one revolution period excites coherent betatron oscillations. For fast treatment, a Digital Signal Processing (DSP) module in a VME-standard crate was selected. It carries out the Fast Fourier Transform (FFT) analyses of signals from position-sensitive pickups in both planes and evaluates the tunes. These measurements are carried out every 10 ms during the 450 ms acceleration ramp. The paper presents the novel features of this system, particularly the beam-offset signal suppression as well as the peak-search algorithm which yields the tune values

Antiproton beam parameters measurement by a new digital-receiver-based system

The Antiproton Decelerator (AD) provides the users with very low intensity beams, in the 107 particles range, hence prompting the development of an innovative measuring system, which was completed in early 2000. This system measures antiproton beam intensity for bunched and debunched beams, together with momentum spread and mean momentum for debunched beams. It uses a state-of-the-art Digital Receiver board, which processes data obtained from two ultra-low-noise, wide-band AC beam transformers. These have a combined bandwidth in the range 0.02 MHz - 30 MHz and are used to measure AC beam current modulation. For bunched beams, the intensity is obtained by measuring the amplitude of the fundamental and second RF Fourier components. On the magnetic plateaus the beam is debunched for stochastic or electron cooling and longitudinal beam properties (intensity, momentum spread and mean momentum) are measured by FFT-based spectral analysis of Schottky signals. The system provides real-time information characterising the machine performance; it has been used for troubleshooting and to fine-tune the AD, thus allowing further improved performance. This system has been operating since May 2000 and providing beam intensity data to the users on a routine basis since late 2000. A dedicated software package was expressly developed to take care of the control, data acquisition and processing phases. It consists of three main codes, namely a GUI, a Real Time Task and a Low Level Code. This report gives an overview of both the hardware and software developed

4-[(E)-(5-Chloro-2-hydroxy­benzyl­idene)amino]benzene­sulfonamide

In the mol­ecule of title compound, C13H11ClN2O3S, the aromatic rings are oriented at a dihedral angle of 12.27 (3)°. An intra­molecular O—H⋯N hydrogen bond results in the formation of a planar (mean deviation 0.0083 Å) six-membered ring, which is nearly coplanar with the adjacent ring at a dihedral angle of 2.36 (13)°. In the sulfonamide group, the S atom is 0.457 (3) Å from the plane through the O and N atoms. In the crystal structure, inter­molecular N—H⋯O hydrogen bonds link the mol­ecules

Overview of the recent operation of the AAC and LEAR for the low-energy antiproton physics programme

This paper reviews the recent performance of the AAC and LEAR. Activities on the AAC include the successful exploitation of a magnetic horn as an antiproton collector lens and an energy-saving mode of operation, which has been possible since 1992, when LEAR became the only client of the AAC. LEAR worked in its full momentum range between 100 MeV/c and 2 GeV/c, with perform-ance (intensities, ejection modes and spill length) exceeding the design specifications. Improvements are described, which contributed to the quality of the beam delivered to experiments. The reliability and availability of the antiproton machines are also discussed

Has the 'Fast-Track' referral system affected the route of presentation and/or clinical outcomes in patients with colorectal cancer?

Background: The aim of this study is to determine whether the 'Fast-Track' referral system has changed the route by which patients present with colorectal cancer (CRC) and whether the route of presentation has any effect on clinical outcome. Methods: A retrospective cohort study of patients diagnosed with CRC under the care of two consultant colorectal surgeons between April 2006 and December 2012. The route by which patients presented was categorised as Fast-Track (FT), non-Fast-Track (non-FT) or acute. Outcome variables were operative intent, disease stage and 2- and 5-year survival. Results: A total of 558 patients were identified. One hundred ninety-seven patients (35.3%) were referred as FT, 108 (19.4%) presented acutely and 253 patients (45.3%) presented via other routes (non-FT). Over the study period, the route of presentation did not change significantly (P=0.135). There was no significant difference between FT and non-FT groups in terms of the proportion of patients undergoing potentially curative surgery (70.6 vs 74.3%, P=0.092) or with node-negative disease (48.2 vs 52.2%, P=0.796) nor was there any difference in 2-year or 5-year survival (74.1 vs 73.9%, P=0.837 and 52.3 vs 53.8%, P=0.889, respectively). Patients who presented acutely were less likely to undergo curative resection, had more advanced disease and had worse 2- and 5-year survival. Conclusions: The Fast-Track referral system has not affected the route by which patients present with CRC nor has it had any effect on clinical outcomes. Alternative strategies are required if the desired improvement in outcomes is to be achieved

Chronic HIV-1 Infection Frequently Fails to Protect against Superinfection

Reports of HIV-1 superinfection (re-infection) have demonstrated that the immune response generated against one strain of HIV-1 does not always protect against other strains. However, studies to determine the incidence of HIV-1 superinfection have yielded conflicting results. Furthermore, few studies have attempted to identify superinfection cases occurring more than a year after initial infection, a time when HIV-1-specific immune responses would be most likely to have developed. We screened a cohort of high-risk Kenyan women for HIV-1 superinfection by comparing partial gag and envelope sequences over a 5-y period beginning at primary infection. Among 36 individuals, we detected seven cases of superinfection, including cases in which both viruses belonged to the same HIV-1 subtype, subtype A. In five of these cases, the superinfecting strain was detected in only one of the two genome regions examined, suggesting that recombination frequently occurs following HIV-1 superinfection. In addition, we found that superinfection occurred throughout the course of the first infection: during acute infection in two cases, between 1–2 y after infection in three cases, and as late as 5 y after infection in two cases. Our results indicate that superinfection commonly occurs after the immune response against the initial infection has had time to develop and mature. Implications from HIV-1 superinfection cases, in which natural re-exposure leads to re-infection, will need to be considered in developing strategies for eliciting protective immunity to HIV-1

LHC Magnet Tests: Operational Techniques and Empowerment for Successful Completion

The LHC magnet tests operation team developed various innovative techniques, particularly since early 2004, to complete the superconductor magnet tests by Feb. 2007. Overall and cryogenic priority handling, rapid on-bench thermal cycling, rule-based goodness evaluation on round-the-clock basis, multiple, mashed web systems are some of these techniques applied with rigour for successful tests completion in time. This paper highlights these operation empowerment tools which had a pivotal role for success. A priority handling method was put in place to enable maximum throughput from twelve test benches, having many different constraints. For the cryogenics infrastructure, it implied judicious allocation of limited resources to the benches. Rapid On-Bench Thermal Cycle was a key strategy to accelerate magnets tests throughput, saving time and simplifying logistics. First level magnet appraisal was developed for 24 hr decision making so as to prepare a magnet further for LHC or keep it on standby. Web based systems (Tests Management and E-Traveller) were other essential ideas to track & coordinate various stages of tests handled by different teams

The antiproton decelerator: AD

A simplified scheme for the provision of antiprotons at 100 MeV/c based on fast extraction is described. The scheme uses the existing production target area and the modified Antiproton Collector Ring in their current location. The physics programme is largely based on capturing and storing antiprotons in Penning traps for the production and spectroscopy of antihydrogen. The machine modifications necessary to deliver batches of 1 107 /min at 100 MeV/c are described. Details of the machine layout and the experimental area in the existing AAC Hall are given

Hygienic quality of dehydrated aromatic herbs marketed in Southern Portugal

Dehydrated aromatic herbs are highly valued ingredients, widely used at home level and by food processing industry, frequently added to a great number of recipes in the Mediterranean countries. Despite being considered low-moisture products and classified as GRAS, during pre and post-harvesting stages of production they are susceptible of microbial contamination. In Europe an increasing number of food recalls and disease outbreaks associated with dehydrated herbs have been reported in recent years. In this study the microbial quality of 99 samples of aromatic herbs (bay leaves, basil, coriander, oregano, parsley, Provence herbs, rosemary and thyme) collected from retails shops in the region of Algarve (Southern Portugal) was assessed. All the samples were tested by conventional methods and were assayed for the total count of aerobic mesophilic microorganisms, Salmonella spp., Escherichia coli, coagulase-positive staphylococci and filamentous fungi. Almost 50 % of the herbs did not exceed the aerobic mesophilic level of 104 CFU/g. The fungi count regarded as unacceptable (106 CFU/g) was not found in any of the tested herbs, while 84 % of the samples ranged from ≤102 to 104 CFU/g. No sample was positive for the presence of Salmonella spp., Escherichia coli and staphylococci. The results are in compliance with the European Commission criteria although they point out to the permanent need of surveillance on the good standards of handling/cooking practices as well as the importance of avoiding contamination at production, retailing and distribution. The microbiological hazards associated with the pathogenic and toxigenic microbiota of dried herbs remain as a relevant public health issue, due to the fact that they are added to foods not submitted to any following lethal procedure. Control measures should be adopted in order to ensure that all phases of their supply chain respect the food safety standards.FCT: UID/BIA/04325/2019.info:eu-repo/semantics/publishedVersio