Four-way regulation of mosquito yolk protein precursor genes by juvenile hormone-, ecdysone-, nutrient-, and insulin-like peptide signaling pathways.

Anautogenous mosquito females require a meal of vertebrate blood in order to initiate the production of yolk protein precursors by the fat body. Yolk protein precursor gene expression is tightly repressed in a state-of-arrest before blood meal-related signals activate it and expression levels rise rapidly. The best understood example of yolk protein precursor gene regulation is the vitellogenin-A gene (vg) of the yellow fever mosquito Aedes aegypti. Vg-A is regulated by (1) juvenile hormone signaling, (2) the ecdysone-signaling cascade, (3) the nutrient sensitive target-of-rapamycin signaling pathway, and (4) the insulin-like peptide (ILP) signaling pathway. A plethora of new studies have refined our understanding of the regulation of yolk protein precursor genes since the last review on this topic in 2005 (Attardo et al., 2005). This review summarizes the role of these four signaling pathways in the regulation of vg-A and focuses upon new findings regarding the interplay between them on an organismal level

Is This a Joke? Detecting Humor in Spanish Tweets

While humor has been historically studied from a psychological, cognitive and linguistic standpoint, its study from a computational perspective is an area yet to be explored in Computational Linguistics. There exist some previous works, but a characterization of humor that allows its automatic recognition and generation is far from being specified. In this work we build a crowdsourced corpus of labeled tweets, annotated according to its humor value, letting the annotators subjectively decide which are humorous. A humor classifier for Spanish tweets is assembled based on supervised learning, reaching a precision of 84% and a recall of 69%.Comment: Preprint version, without referra

International Glossina Genome Initiative 2004-2014: a driver for post-genomic era research on the African continent

Human African trypanosomiasis (HAT), also known as sleeping sickness, is a neglected disease that impacts 70 million people distributed over 1.55 million km2 in sub- Saharan Africa and includes at least 50% of the population of theDemocratic Republic of the Congo [1]. Trypanosoma brucei gambiense accounts for more than 98% of the infections in central and West Africa, the remaining infections being from Trypanosoma brucei rhodesiense in East Africa [2]. The parasites are transmitted to the hosts through the bite of an infected tsetse fly. Disease control is challenging as there are no vaccines, and effective, easily delivered drugs are still lacking. Treatment invariably involves lengthy hospitalization, with both medical and socioeconomic consequences.Web of Scienc

Live Imaging at the Onset of Cortical Neurogenesis Reveals Differential Appearance of the Neuronal Phenotype in Apical versus Basal Progenitor Progeny

The neurons of the mammalian brain are generated by progenitors dividing either at the apical surface of the ventricular zone (neuroepithelial and radial glial cells, collectively referred to as apical progenitors) or at its basal side (basal progenitors, also called intermediate progenitors). For apical progenitors, the orientation of the cleavage plane relative to their apical-basal axis is thought to be of critical importance for the fate of the daughter cells. For basal progenitors, the relationship between cell polarity, cleavage plane orientation and the fate of daughter cells is unknown. Here, we have investigated these issues at the very onset of cortical neurogenesis. To directly observe the generation of neurons from apical and basal progenitors, we established a novel transgenic mouse line in which membrane GFP is expressed from the beta-III-tubulin promoter, an early pan-neuronal marker, and crossed this line with a previously described knock-in line in which nuclear GFP is expressed from the Tis21 promoter, a pan-neurogenic progenitor marker. Mitotic Tis21-positive basal progenitors nearly always divided symmetrically, generating two neurons, but, in contrast to symmetrically dividing apical progenitors, lacked apical-basal polarity and showed a nearly randomized cleavage plane orientation. Moreover, the appearance of beta-III-tubulin–driven GFP fluorescence in basal progenitor-derived neurons, in contrast to that in apical progenitor-derived neurons, was so rapid that it suggested the initiation of the neuronal phenotype already in the progenitor. Our observations imply that (i) the loss of apical-basal polarity restricts neuronal progenitors to the symmetric mode of cell division, and that (ii) basal progenitors initiate the expression of neuronal phenotype already before mitosis, in contrast to apical progenitors

Plant Arrangement Effects on Dry Matter Production and Nitrogen Fixation of Berseem Clover: Annual Ryegrass Mixture

Agronomic factors affect the productivity and efficiency of cereal-legume intercropping systems (Ofori & Stern, 1987). This research aimed to determine the effects of different plant arrangement on hay yield, nitrogen (N) content and N fixation of berseem clover-annual ryegrass mixture in a Mediterranean semi-arid environment

Thermal frontal polymerization with a thermally released redox catalyst

We studied thermal frontal polymerization using a redox system in an attempt to lower the temperature of the frontally polymerizable system while increasing the front velocity so as to obtain a self-sustaining front in a thinner layer than without the redox components. A cobalt-containing polymer with a melting point of 63 °C (Intelimer 6050X11) and cumene hydroperoxide were used with a triacrylate. The use of the Intelimer decreased the front velocity but allowed fronts to propagate in thinner layers and with more filler while still having a pot life of days. Nonplanar modes of propagation occurred. Fronts propagated faster when 6-O-palmitoyl-L-ascorbic acid was used as a reductant. Interestingly, fronts were also faster with the reductant even without the Intelimer if kaolin clay was the filler; however, the pot life was significantly reduced. © 2012 Wiley Periodicals, Inc

Applying basic features from sentiment analysis on automatic irony detection

The final publication is available at Springer via http://dx.doi.org/10.1007/978-3-319-19390-8_38People use social media to express their opinions. Often linguistic devices such as irony are used. From the sentiment analysis perspective such utterances represent a challenge being a polarity reversor (usually from positive to negative). This paper presents an approach to address irony detection from a machine learning perspective. Our model considers structural features as well as, for the first time, sentiment analysis features such as the overall sentiment of a tweet and a score of its polarity. The approach has been evaluated over a set classifiers such as: Naïve Bayes, Decision Tree, Maximum Entropy, Support Vector Machine, and for the first time in irony detection task: Multilayer Perceptron. The results obtained showed the ability of our model to distinguish between potentially ironic and non-ironic sentences.The National Council for Science and Technology (CONACyT Mexico) has funded the research work of the first author (Grant No.218109/313683, CVU-369616). The research work of third author was carried out inthe framework of WIQ-EI IRSES (Grant No. 269180) within the FP 7 Marie Curie, DIANA-APPLICATIONS (TIN2012-38603-C02-01) projects and the VLC/CAMPUS Microcluster on Multimodal Interaction in Intelligent Systems.Hernández Farías, I.; Benedí Ruiz, JM.; Rosso, P. (2015). Applying basic features from sentiment analysis on automatic irony detection. En Pattern Recognition and Image Analysis: 7th Iberian Conference, IbPRIA 2015, Santiago de Compostela, Spain, June 17-19, 2015, Proceedings. Springer International Publishing. 337-344. https://doi.org/10.1007/978-3-319-19390-8_38S337344Alba-Juez, L.: Irony and the other off record strategies within politeness theory. J. Engl. Am. Stud. 16, 13–24 (1995)Attardo, S.: Irony markers and functions: towards a goal-oriented theory of irony and its processing. Rask 12, 3–20 (2000)Barbieri, F., Saggion, H.: Modelling Irony in Twitter, pp. 56–64. Association for Computational Linguistics (2014)Bosco, C., Patti, V., Bolioli, A.: Developing corpora for sentiment analysis: the case of irony and senti-tut. IEEE Intell. Syst. 28(2), 55–63 (2013)Buschmeier, K., Cimiano, P., Klinger, R.: An impact analysis of features in a classification approach to irony detection in product reviews. In: Proceedings of the 5th Workshop on Computational Approaches to Subjectivity, Sentiment and Social Media Analysis, pp. 42–49. Association for Computational Linguistics (2014)Ghosh, A., Li, G., Veale, T., Rosso, P., Shutova, E., Reyes, A., Barnden, J.: Sentiment analysis of figurative language in twitter. In: Proceedings of the International Workshop on Semantic Evaluation (SemEval-2015), Co-located with NAACL and *SEM (2015)Hu, M., Liu, B.: Mining and summarizing customer reviews. In: Proceedings of the Tenth ACM SIGKDD International Conference on Knowledge Discovery and Data Mining, KDD 2004, pp. 168–177(2004)Maynard, D., Greenwood, M.: Who cares about sarcastic tweets? investigating the impact of sarcasm on sentiment analysis. In: Proceedings of the Ninth International Conference on Language Resources and Evaluation (LREC-2014), European Language Resources Association (ELRA) (2014)Pedersen, T., Patwardhan, S., Michelizzi, J.: Wordnet::similarity: measuring the relatedness of concepts. In: Proceedings of the 9th National Conference on Artificial Intelligence, pp. 1024–1025. Association for Computational LinguisticsReyes, A., Rosso, P., Veale, T.: A multidimensional approach for detecting irony in twitter. Lang. Resour. Eval. 47(1), 239–268 (2013)Wallace, B.C.: Computational irony: a survey and new perspectives. Artif. Intell. Rev. 43, 467–483 (2013)Wang, A.P.: #irony or #sarcasm – a quantitative and qualitative study based on twitter. In: Proceedings of the PACLIC: the 27th Pacific Asia Conference on Language, Information, and Computation, pp. 349–356. Department of English, National Chengchi University (2013)Whissell, C.: Using the revised dictionary of affect in language to quantify the emotional undertones of samples of natural languages. Psychol. Rep. 2, 509–521 (2009)Wolf, A.: Emotional expression online: gender differences in emoticon use. CyberPsychology Behavior 3, 827–833 (2000

High-fidelity multimode fibre-based endoscopy for deep brain in vivo imaging

Progress in neuroscience constantly relies on the development of new techniques to investigate the complex dynamics of neuronal networks. An ongoing challenge is to achieve minimally-invasive and high-resolution observations of neuronal activity in vivo inside deep brain areas. A perspective strategy is to utilise holographic control of light propagation in complex media, which allows converting a hair-thin multimode optical fibre into an ultra-narrow imaging tool. Compared to current endoscopes based on GRIN lenses or fibre bundles, this concept offers a footprint reduction exceeding an order of magnitude, together with a significant enhancement in resolution. We designed a compact and high-speed system for fluorescent imaging at the tip of a fibre, achieving micron-scale resolution across a 50 um field of view, and yielding 7-kilopixel images at a rate of 3.5 frames/s. Furthermore, we demonstrate in vivo observations of cell bodies and processes of inhibitory neurons within deep layers of the visual cortex and hippocampus of anesthetised mice. This study forms the basis for several perspective techniques of modern microscopy to be delivered deep inside the tissue of living animal models while causing minimal impact on its structural and functional properties.Comment: 10 pages, 2 figures, Supplementary movie: https://drive.google.com/file/d/1Fm0G3TAIC49LVX6FaEiAtlefkWx1T2a5/vie