Sweet Sorghum Planting Effects on Stalk Yield and Sugar Quality in Semi-Arid Tropical Environment

Sweet sorghum [Sorghum bicolor (L.) Moench] has potential as a bioenergy crop for producing food, fiber, and fermentable sugar. Unlike dryland grain sorghum, little information is available on the influence of staggered planting and genotypes, especially in semiarid tropical environments. The objectives of the present study were (i) to quantify the effects of planting time and genotype on stalk and biomass yields, juice sugar quality, and (ii) to identify the most productive genotypes and planting windows for sustainable feedstock supply. Four commercial sweet sorghum genotypes (SSV84, SSV74, CSV19SS, and CSH22SS) were planted on five planting dates (1 June, 16 June, 1 July, 16 July, and 1 August) during the rainy (June–October) season of 2008 and 2009 in Hyderabad (17°27´ N, 78°28´ E), India. Planting in early and mid-June produced significantly (P ≤ 0.05) higher fresh stalk yield and grain yield than later planting dates. Commercial hybrid CSH22SS produced significantly more stalk, grain, sugar, and ethanol yield over genotypes SSV84 or SSV74. Based on the stalk yield, juice sugar quality, sugar, and ethanol yields, the optimum planting dates for sweet sorghum in semiarid tropical climate is early June to early July. Planting sweet sorghum during this time allows more feedstock to be harvested and hence extends the period for sugar mill operation by about 1 mo, that is, from the first to the last week of October

Hypoxia Sensitive Metal β-Ketoiminate Complexes Showing Induced Single Strand DNA Breaks and Cancer Cell Death by Apoptosis

A series of ruthenium and iridium complexes have been synthesised and characterised with 20 novel crystal structures discussed. The library of β-ketoiminate complexes has been shown to be active against MCF-7 (human breast carcino-ma), HT-29 (human colon carcinoma), A2780 (human ovarian carcinoma) and A2780cis (cisplatin resistant human ovarian carcinoma) cell lines, with selected complexes being more than three times as active as cisplatin against the A2780cis cell line. Complexes have also been shown to be highly active under hypoxic conditions, with the activities of some complexes increasing with a decrease in O2 concentration. The enzyme thioredoxin reductase is over-expressed in cancer cells and complexes reported herein have the advantage of inhibiting this enzyme, with IC50 values measured in the nanomolar range. The anti-cancer activity of these complexes was further investigated to determine whether activity is due to effects on cellular growth or cell survival. The complexes were found to induce significant cancer cell death by apoptosis with levels induced correlating closely with activity in chemosensitivity studies. As a possible cause of cell death, the ability of the complexes to induce damage to cellular DNA was also assessed. The complexes failed to induce double strand DNA break or DNA crosslinking but induced significant levels of single DNA strand breaks indi-cating a different mechanism of action to cisplatin

Fertilization Strategies Based on Climate Information to Enhance Food Security Through Improved Dryland Cereals Production

Rainfall uncertainty and nutrient deficiency affect sorghum production in Sahel. This study aimed at (i) determining the responses (varieties*water*nitrogen) of various West-African sorghum (Sorghum bicolor L. Moench) varieties to the application of fertilizer (NPK and urea) at selected growing stages according to water regime (irrigated or not, different rainfall patterns) and (ii) simulating them to define alternative fertilization strategies. This chapter proposes alternative fertilization strategies in line with rainfall patterns. Split plot experiments with four replications were carried out in two locations (Senegal), with four improved sorghum varieties (Fadda, IS15401, Soumba and 621B). Treatments were T1, no fertilizer; T2 = 150 kg/ha of NPK (15-15-15) at emergence +50 kg/ha of urea (46%) at tillering +50 Kg/ha of urea at stem extension; T3 = half rate of T2 applied at the same stages; T4 = 150 kg/ha of NPK + 50 kg/ha of urea at stem extension +50 kg/ha of urea at heading, and T5 = half rate of T4 applied at the same stages. Plant height, leaf number, grain yield, and biomass were significantly affected by the timing and rate of fertilizers. Grain yield were affected by water*nitrogen and nitrogen*variety interactions. It varied from 2111 to 261 kg/ha at “Nioro du Rip” and from 1670 to 267 kg/ha at “Sinthiou Malème”. CERES-Sorghum model overestimated late fertilizer grain yields. To achieve acceptable grain yield, fertilizers application should be managed regarding weather

Contrasting anticancer activity of half-sandwich iridium(III) complexes bearing functionally diverse 2-phenylpyridine ligands

We report the synthesis, characterization, and antiproliferative activity of 15 iridium(III) half-sandwich complexes of the type [(η5-Cp*)Ir(2-(R′-phenyl)-R-pyridine)Cl] bearing either an electron-donating (−OH, −CH2OH, −CH3) or electron-withdrawing (−F, −CHO, −NO2) group at various positions on the 2-phenylpyridine (2-PhPy) chelating ligand giving rise to six sets of structural isomers. The X-ray crystal structures of [(η5-Cp*)Ir(2-(2′-fluorophenyl)pyridine)Cl] (1) and [(η5-Cp*)Ir(2-(4′-fluorophenyl)pyridine)Cl] (2) exhibit the expected “piano-stool” configuration. DFT calculations showed that substituents caused only localized effects on the electrostatic potential surface of the chelating 2-PhPy ligand of the complexes. Hydrolysis of all complexes is rapid, but readily reversed by addition of NaCl. The complexes show preferential binding to 9-ethylguanine over 9-methyladenine and are active catalysts for the oxidation of NADH to NAD+. Antiproliferative activity experiments in A2780 ovarian, MCF-7 breast, A549 lung, and HCT116 colon cancer cell lines showed IC50 values ranging from 1 to 89 μM, with the most potent complex, [(η5-Cp*)Ir(2-(2′-methylphenyl)pyridine)Cl] (13) (A2780 IC50 = 1.18 μM), being 10× more active than the parent, [(η5-Cp*)Ir(2-phenylpyridine)Cl], and 2× more active than [(η5-CpxPh)Ir(2-phenylpyridine)Cl]. Intriguingly, contrasting biological activities are observed between structural isomers despite exhibiting similar chemical reactivity. For pairs of structural isomers both the nature and position of the functional group can affect the hydrophobicity of the complex. An increase in hydrophobicity resulted in enhanced cellular-iridium accumulation in A2780 ovarian cells, which generally gave rise to an increase in potency. The structural isomers [(η5-Cp*)Ir(2-(4′-fluorophenyl)pyridine)Cl] (2) and [(η5-Cp*)Ir(2-phenyl-5-fluoropyridine)Cl] (4) preferentially localized in the cytosol > membrane and particulate > nucleus > cytoskeleton. This work highlights the strong dependence of biological behavior on the nature and position of the substituent on the chelating ligand and shows how this class of organometallic anticancer complexes can be fine-tuned to increase their potency without using extended cyclopentadienyl systems

Effect of Increase in Plant Density on Stem Yield and Sucrose Content in Two Sweet Sorghum Cultivars

Abstract\ud In order to evaluate the effect of increase plant density on stalk yield and sucrose content in two sweet sorghum cultivars, an experiment was conducted at Research Farm of Isfahan University located at Zaghmar village. A split plot layout within a randomized complete block design with tree replication was used. Main plots were plant densities (100, 200, 300, 400, 500 and 600 thousand plant/ha) and subplots were cultivars (Rio and Keller). The effect of plant density at hard dough harvest stage on plant height, stem diameter, number of tillers, stem fresh weight and juice yield were significant but had no significant effect on brix, sucrose percentage and purity. The highest juice yield and purity were produced by 400 thousand plants/ha. Keller was significantly superior for plant height, stem diameter, stem fresh weight, juice yield and brix at hard dough harvest stage as compared to Rio. Number of tiller per plant of Rio was significantly more than Keller. There were no significant difference between two cultivars for sucrose percentage and purity but sucrose percentage in Keller had highest as compared to Rio. Maximum stem fresh weight, juice yield, sucrose percentage and purity were obtained at hard dough harvest stag. On the basis of the results obtained, 400 thousand plant/ha plant density, Keller cultivar and hard dough harvest stage might be suitable for sweet sorghum production under the condition similar to the present study. \ud \ud Keywords: Sweet sorghum, Stem yield, Sucrose percentage, Harvesting stage

Phytoremediation Efficiency of Sorghum bicolor (L.) Moench in Removing Cadmium, Lead and Arsenic

Heavy metals are a significant problem in municipal wastewater, in soil accumulation and are costly to remove in order to facilitate water use in irrigation. Wastewater, with three heavy metal cations and an anion, was employed in irrigation during the Sorghum bicolor (L.) Moench growth period. Results show that the absorption coefficient or bioaccumulation ability of Sorghum bicolor (L.) Moench is relegated to certain heavy metals and their concentrations, but not at all to plant tissues in dry ash weight (DAW) scale. Heavy metals absorption was determined in the following order: cadmium = lead &gt; arsenic, and while tissue accumulation based on DAW was equal for cadmium and lead, based on dry weight (DW) all three ions differed. The soil’s ability to accumulate heavy metal ranked as follows: cadmium &gt; lead&gt; arsenic by wastewater quality in this experimvent. These results change many previous ideas about decreasing the transportation of heavy metals from root to shoot or other organs in plants. With low cadmium and lead concentration in irrigation, sorghum is a good plant for remediation; however, in high concentration this plant benefits from arsenic remediation. Soil is a critical parameter for wastewater phytoremediation. This topic merits further research.</p