Mesozoic and Cenozoic deformation inferred from seismic stratigraphy in the southwestern intracontinental Palmyride fold-thrust belt, Syria

This paper was published in the Geological Society of America Bulletin. The Geological Society of America retains the copyright to this paper. Geological Society of America, P.O. Box 9140 , Boulder, CO 80301-9140 USA See also: http://www.geosociety.org/; http://atlas.geo.cornell.edu/syria/chaimov_gsa_bull_1992.htmlThe Palmyride fold belt in central Syria is an intracontinental northeast-trending, 400 by 100 km transpressive belt embedded in the northern Arabian platform. During the Late Paleozoic and most of the Mesozoic the region of the present-day mountains was a rift-like trough that collected over 5 km of sediments, for a total Phanerozoic thickness of over 10 km. The southwestern sector of the fold belt is bounded in the north by the Jhar fault and in the south by the south-vergent frontal thrust faults of the Palmyrides, with the broad Al-Daww depression in between. Structural features that characterize the southern and southwestern region of the Palmyrides include a short wavelength, typically 5-10 km, fold style controlled by a regional low-angle decollement within Triassic beds, and small inverted Jurassic and Early Cretaceous normal faults. Small intermontane basins (about 10 X 30 km) whose strata can be used to document the history of Palmyride deformation flank growth fault-bend folds and are mainly a product of Cenozoic shortening in the belt. These structures are elucidated by about 2000 km of newly available seismic reflection data in the Palmyrides. Synthetic seismic traces generated solely from forward modeling of outcrop information constrain seismic stratigraphic picks in two small basins about 100 km northeast of Damascus. There, minor Late Cretaceous uplift caused local onlap, marking the first inversion phase of the Palmyride trough. Tectonic quiescence throughout the Paleogene, interrupted only in the Middle Eocene by minor tectonism, resulted in monotonous deposition of about 2500 m of mostly limestone. Marked onlap and probable downlap of Lower Miocene strata onto an Oligocene angular unconformity indicate accelerated tectonism by Late Oligocene to Early Miocene time. This marks the beginning of the major phase of inversion and uplift of the Palmyrides. Recent seismicity indicates that transpression continues today. Despite its relative remoteness from convergent plate boundaries (the nearest, the Bitlis suture in southern Turkey, is about 300 km distant), the Late Cretaceous, Middle Eocene, and Neogene phases of deformation in the intraplate setting of the Palmyrides have a direct temporal relationship with major regional tectonism that occurred along the surrounding Arabian plate boundaries. The Palmyride trough was inverted in Late Cretaceous time and, subsequently, developed into a transpressive zone throughout Neogene and Quaternary times. Thus, the initiation of inversion in the Palmyrides, an integral part of the Syrian Arc, which extends from central Syria southward to central Sinai, apparently predates development of the Red Sea/Dead Sea plate boundary. In contrast, the intense Neogene through Quaternary deformational episode is clearly related to development of the Red Sea/Dead Sea fault system and to convergence along the northern boundary of the Arabian plate in southern Turkey

Clinical Classification of Acute Respiratory Symptoms in a Sample of Under Five Years Children in Erbil City

Background: Pneumonia is an important cause of morbidity and mortality in developing countries. They are responsible for the death of more than two million children under five year of age every year10, 11. Objective: To find out the proportions of clinical types of respiratory tract infections, also to find out the factors that might be associated with severity of pneumonia and to compare the proportions of pneumonia between the hospital and primary health care centers attendees. Patients and Methods: Case series study conducted among 300 children aged two months to five years in the outpatient clinic of Raperin Teaching Hospital / Erbil and six primary health care centers(PHCCs)from the first of march 2017 to thirty of march 2018. The questioner was completed through direct interview. A chi square test of association was used to compare proportions. A p value equal or less than 0.05 was considered as statistically significant. Results: The majority of cases 42% of the patients were infant and 59% were male. Sever pneumonia was diagnosed in 7%, pneumonia 5% and no pneumonia 88%. all of the patients presented with the cough, wheeze 100% in sever pneumonia 86% in pneumonia, and 35% in other group, fever are high in all groups, lethargy was higher among sever pneumonia patients (81%), chest indrawing also high among those with sever pneumonia 76.2% and those with pneumonia was 73.3% while only 1.5% among other groups. also unable to drink in sever pneumonia was 81%. No association between the diagnosis of pneumonia and sever pneumonia with age, gender and residence. The prevalence of sever pneumonia was 12.5% among low socioeconomic status (SES), 2.2% among those of moderate socioeconomic status and 0% among high socioeconomic status.The prevalence of pneumonia and sever pneumonia were higher among those with family history of asthma and higher among those whose father was smoker. Also 13.3% of the hospital cases had severe pneumonia compared with 0.7% of the cases of the PHCCs. Regarding pneumonia, 4% of the hospital cases had pneumonia compared with 6% of the cases of PHCCs. Conclusion: This study showed significant association with wheezes, immunization, history of chronic illness, SES, family history of asthma and smoking in father. The majority of cases with sever pneumonia was higher among hospital cases compared with PHCC. and pneumonia cases were lesser in hospital compared with PHCC

Identification of Important Sea Turtle Areas (ITAs) for hawksbill turtles in the Arabian Region

We present the first data on hawksbill turtle post-nesting migrations and behaviour in the Arabian region. Tracks from 90 post-nesting turtles (65 in the Gulf and 25 from Oman) revealed that hawksbills in the Arabian region may nest up to 6 times in a season with an average of 3 nests per turtle. Turtles from Qatar, Iran and the UAE generally migrated south and southwest to waters shared by the UAE and Qatar. A smaller number of turtles migrated northward towards Bahrain, Saudi Arabia and one reached Kuwait. Omani turtles migrated south towards Masirah island and to Quwayrah, staying close to the mainland and over the continental shelf. The widespread dispersal of hawksbill foraging grounds across the SW Gulf may limit habitat protection options available to managers, and we suggest these be linked to preservation of shallow water habitats and fishery management. In contrast, the two main foraging areas in Oman were small and could be candidates for protected area consideration. Critical migration bottlenecks were identified at the easternmost point of the Arabian Peninsula as turtles from Daymaniyat Islands migrate southward, and between Qatar and Bahrain. Overall, Gulf turtles spent 68% of the time in foraging ground with home ranges of 40–60km2 and small core areas of 6km2. Adult female turtles from Oman were significantly larger than Gulf turtles by ~11cm x¯=81.4CCL and spent 83% of their time foraging in smaller home ranges with even smaller core areas (~3km2), likely due to better habitat quality and food availability. Gulf turtles were among the smallest in the world x¯=70.3CCL and spent an average of 20% of time undertaking summer migration loops, a thermoregulatory response to avoid elevated sea surface temperatures, as the Gulf regularly experiences sustained sea surface temperatures >30°C. Fishery bycatch was determined for two of the 90 turtles. These spatio-temporal findings on habitat use will enable risk assessments for turtles in the face of multiple threats including oil and gas industries, urban and industrial development, fishery pressure, and shipping. They also improve our overall understanding of hawksbill habitat use and behaviour in the Arabian region, and will support sea turtle conservation-related policy decision-making at national and regional levels.Emirates Wildlife Society–World Wild Fund for Nature. 7Days, Abu Dhabi Urban Planning Council, Bridgestone, CASP, College of the North Atlantic-Qatar, Deutsche Bank, Dubai Electricity & Water Authority, Dubai Festival City, Emirates Palace, Environment & Protected Areas Authority, Sharjah, Environment Agency–Abu Dhabi, Fairmont, Géant, Gulftainer, HSBC, Intercontinental, Dubai Festival City, Jebel Ali Golf Resort & Spa, Jumeirah Etihad Towers, Linklaters, Momentum Logistics, Mubadala, Murjan Marinas, Nokia, Sheikha Salama bint Hamdan Al Nahyan Foundation, The Club, TimeOut Dubai, and the Young Presidents Organisation

Short-term behavioural responses to thermal stress by hawksbill turtles in the Arabian region

We present a previously unrecorded short-term behavioural response by hawksbill sea turtles to elevated sea surface temperatures in the Persian/Arabian Gulf. Surface waters typically exceed 30°C for sustained periods during the summer, and can be likened to a natural living laboratory for understanding thermoregulatory behaviour by marine species in the face of climate change and elevated global temperatures. We satellite-tracked 90 post-nesting hawksbill turtles between 2010 and 2013 as part of a larger programme to elucidate turtle foraging habitats and post-nesting behaviour. We used 66 of these datasets, where turtles clearly departed and returned to foraging grounds, for these analyses. Sea surface temperatures during the summer averaged 33.5°C and peaked at 34.9°C. During these elongated periods of elevated temperatures (June–August) the turtles temporarily migrated an average of 70km to deeper and cooler waters at northern latitudes, returning after 2–3months (September–October) back to original feeding grounds. Temperature differential T∆ between foraging and summer loop habitats was significantly different and approximated −2°C. Turtles undertaking summer migration loops generally moved in a north-easterly direction toward deeper water, returning in a south-westerly direction to the shallower foraging grounds. Swim speeds were significantly higher and orientation was less omnidirectional during the migrations than when foraging. The outbound migrations were significantly inversely correlated with temperature, but were not linked to chlorophyll-a, geostrophic currents or sea surface height. The turtles' preference for returning to the same foraging grounds suggests a lack of other substantial influences which might have precipitated the temporary summer migration loops. Our results indicate that Gulf hawksbills employ thermoregulatory responses which take them out of high temperature and potentially physiology-threatening conditions. These findings improve our overall understanding of hawksbill habitat use and behaviour in a climate-challenged environment, and support sea turtle conservation-related policy decision-making at national and regional levels.Emirates Wildlife Society—World Wild Fund for Nature Office. 7Days, Abu Dhabi Urban Planning Council, Bridgestone, CASP, College of the North Atlantic, Qatar, Deutsche Bank, Dubai Electricity & Water Authority, Dubai Festival City, Emirates Palace, Environment & Protected Areas Authority, Sharjah, Environment Agency—Abu Dhabi, Fairmont, Géant, Gulftainer, HSBC, Intercontinental, Dubai Festival City, Jebel Ali Golf Resort & Spa, Jumeirah Etihad Towers, Linklaters, Momentum Logistics, Mubadala, Murjan Marinas, Nokia, Sheikha Salama bint Hamdan Al Nahyan Foundation, The Club, TimeOut Dubai, and the Young Presidents Organisation

Sarilumab in patients admitted to hospital with severe or critical COVID-19: a randomised, double-blind, placebo-controlled, phase 3 trial

Background: Elevated proinflammatory cytokines are associated with greater COVID-19 severity. We aimed to assess safety and efficacy of sarilumab, an interleukin-6 receptor inhibitor, in patients with severe (requiring supplemental oxygen by nasal cannula or face mask) or critical (requiring greater supplemental oxygen, mechanical ventilation, or extracorporeal support) COVID-19. Methods: We did a 60-day, randomised, double-blind, placebo-controlled, multinational phase 3 trial at 45 hospitals in Argentina, Brazil, Canada, Chile, France, Germany, Israel, Italy, Japan, Russia, and Spain. We included adults (≥18 years) admitted to hospital with laboratory-confirmed SARS-CoV-2 infection and pneumonia, who required oxygen supplementation or intensive care. Patients were randomly assigned (2:2:1 with permuted blocks of five) to receive intravenous sarilumab 400 mg, sarilumab 200 mg, or placebo. Patients, care providers, outcome assessors, and investigators remained masked to assigned intervention throughout the course of the study. The primary endpoint was time to clinical improvement of two or more points (seven point scale ranging from 1 [death] to 7 [discharged from hospital]) in the modified intention-to-treat population. The key secondary endpoint was proportion of patients alive at day 29. Safety outcomes included adverse events and laboratory assessments. This study is registered with ClinicalTrials.gov, NCT04327388; EudraCT, 2020-001162-12; and WHO, U1111-1249-6021. Findings: Between March 28 and July 3, 2020, of 431 patients who were screened, 420 patients were randomly assigned and 416 received placebo (n=84 [20%]), sarilumab 200 mg (n=159 [38%]), or sarilumab 400 mg (n=173 [42%]). At day 29, no significant differences were seen in median time to an improvement of two or more points between placebo (12·0 days [95% CI 9·0 to 15·0]) and sarilumab 200 mg (10·0 days [9·0 to 12·0]; hazard ratio [HR] 1·03 [95% CI 0·75 to 1·40]; log-rank p=0·96) or sarilumab 400 mg (10·0 days [9·0 to 13·0]; HR 1·14 [95% CI 0·84 to 1·54]; log-rank p=0·34), or in proportions of patients alive (77 [92%] of 84 patients in the placebo group; 143 [90%] of 159 patients in the sarilumab 200 mg group; difference −1·7 [−9·3 to 5·8]; p=0·63 vs placebo; and 159 [92%] of 173 patients in the sarilumab 400 mg group; difference 0·2 [−6·9 to 7·4]; p=0·85 vs placebo). At day 29, there were numerical, non-significant survival differences between sarilumab 400 mg (88%) and placebo (79%; difference +8·9% [95% CI −7·7 to 25·5]; p=0·25) for patients who had critical disease. No unexpected safety signals were seen. The rates of treatment-emergent adverse events were 65% (55 of 84) in the placebo group, 65% (103 of 159) in the sarilumab 200 mg group, and 70% (121 of 173) in the sarilumab 400 mg group, and of those leading to death 11% (nine of 84) were in the placebo group, 11% (17 of 159) were in the sarilumab 200 mg group, and 10% (18 of 173) were in the sarilumab 400 mg group. Interpretation: This trial did not show efficacy of sarilumab in patients admitted to hospital with COVID-19 and receiving supplemental oxygen. Adequately powered trials of targeted immunomodulatory therapies assessing survival as a primary endpoint are suggested in patients with critical COVID-19. Funding: Sanofi and Regeneron Pharmaceuticals

Cabbage and fermented vegetables : From death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19

Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe, or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage have been associated with low death rates in European countries. SARS-CoV-2 binds to its receptor, the angiotensin-converting enzyme 2 (ACE2). As a result of SARS-CoV-2 binding, ACE2 downregulation enhances the angiotensin II receptor type 1 (AT(1)R) axis associated with oxidative stress. This leads to insulin resistance as well as lung and endothelial damage, two severe outcomes of COVID-19. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the most potent antioxidant in humans and can block in particular the AT(1)R axis. Cabbage contains precursors of sulforaphane, the most active natural activator of Nrf2. Fermented vegetables contain many lactobacilli, which are also potent Nrf2 activators. Three examples are: kimchi in Korea, westernized foods, and the slum paradox. It is proposed that fermented cabbage is a proof-of-concept of dietary manipulations that may enhance Nrf2-associated antioxidant effects, helpful in mitigating COVID-19 severity.Peer reviewe

Nrf2-interacting nutrients and COVID-19 : time for research to develop adaptation strategies

There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPAR gamma:Peroxisome proliferator-activated receptor, NF kappa B: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2 alpha:Elongation initiation factor 2 alpha). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT(1)R axis (AT(1)R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity