17 research outputs found
A Simple Data Relay Process and Turbo Code Application to Wireless Sensor Networks
In this study, we focus on relay process of intermediate node of wireless sensor networks. In conventional wireless sensor networks, the intermediate node performs the regenerative repeating process such that error correction, detection and reencoding are processed. This is reliable, but it requires a lot of processing effort and may take much energy. To reduce a burden of relay process, we propose to omit error decoding and/or reencoding process at the intermediate nodes. Further, we propose a method that realizes soft-decision decoding for hard-detected signals. With this method, we can employ Turbo code to wireless sensor networks. As results, we show that though omitting the decoding and re-encoding process at the intermediate node may not affect much to the performance.journal articl
Development of a Prognostic Scoring System using MYC Expression and Soluble Interleukin Receptor -2 level for Diffuse Large B-cell Lymphoma
Background: Diffuse large B-cell lymphoma, not otherwise specified (DLBCL-NOS), is the most frequent type of lymphoid neoplasm. Methods: We investigated the relationships between clinical factors of DLBCL-NOS and MYC immunohistochemistry (IHC) staining. Results: A total of 110 patients diagnosed with DLBCL-NOS from 2012 to 2020 at Tottori University Hospital and treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) chemotherapy were included. IHC staining of MYC in formalin-fixed, paraffin-embedded tumor specimens was performed, and ROC-curve analysis revealed the cut-off value of the MYC positive rate as 55%. The 2-year overall survival (OS) rates of the MYC-negative and -positive groups were 84.7% vs 57.7% (P = 0.0091), and the progression-free survival rates were 77.8% vs 54.7% (P = 0.016), respectively. Multivariate analysis for OS showed prognostic significance of MYC positivity [hazards ratio (HR): 2.496; P = 0.032], and serum levels of soluble interleukin-2 receptor (sIL-2R) > 2000 U/mL (HR: 3.950; P = 0.0019), as well as age > 75 (HR: 2.356; P = 0.068). The original scoring system was developed based on these findings. By assigning one point to each item, age (> 75), MYC positivity, and sIL-2R level (> 2000), all patients were classified into three risk categories: group 1 (0 points), group 2 (1 point), and group 3 (2–3 points). The 2-year survival rates were 100%, 83.0%, and 47.1% for the groups 1, 2, and 3, respectively (P < 0.0001). Conclusion: We suggest that a prognostic scoring system using MYC expression and soluble interleukin receptor -2 level is useful for the prediction of prognosis, contributing to further stratification in DLBCL-NOS.journal articl
A comparative study of Japanese and German composita (1)Compound noun
departmental bulletin pape
Protein Mutants Identified and Epistasis Tests
<div><p>(A) Alignment of a region of EGL-30 containing the M244I amino acid substitution with other G-proteins. The conserved methionine residue that is mutated to isoleucine in the <i>egl-30(ep271)</i> allele is indicated in bold text and underlined.</p><p>(B) Diagram showing the domain structure of the EAT-16 protein with relative locations of the E158K substitution found in the <i>eat-16(ep273)</i> allele, and the splice site mutation found in <i>eat16(ad702)</i> strains.</p><p>(C) Genetic interactions between mutations in G-αq and RGS. The G-αq/<i>egl-30(ep271)</i> and RGS<i>/eat-16(ad702)</i> mutations confer resistance to BMS-192364. The sensitivity of a G-αq/<i>egl-30(pk931)</i> strain to BMS-192364 is abrogated in the presence of the <i>eat-16(ad702)</i> mutation.</p></div
Amino Acid Substitutions in Mutants of the Yeast G-αq Protein Gpa1
<p>A theoretical three-dimensional structure of the yeast Gpa1 G-α protein in complex with the Ste4 protein (G-β) is shown. The position of four amino acid substitutions with phenotypes of interest is indicated by circles. Two alpha helices are indicated by yellow highlighting of the protein backbone. In higher eukaryotes, these helices are considered to form the interface with G-αq downstream effector proteins. Three mutations affecting adaptation to mating pheromone lie on this face: E355K and E364K both hyper-adapt while the M362I allele described in this work is hypo-adaptive. For reference, the position of a mutation affecting sensitivity to RGS GAP activity, G302S, is also shown.</p
Structure and Activity of BMS Small Molecules
<p>The effect of each compound on inhibition of carbachol-evoked tonicity of isolated rat bladder strips is shown in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0020057#pgen-0020057-t001" target="_blank">the table</a>.</p
