進行胆嚢癌における膵頭十二指腸切除術：適応，手術成績，限界

新潟大学Niigata University博士（医学）新大院博(医)第1262

原発性脊髄神経膠腫の病理学的予後不良因子

新潟大学Niigata University博士（医学）Primary spinal cord gliomas are rare and are associated with high mortality. Unlike brain tumors, the clinicopathological features of spinal cord gliomas are not well defined. We analyzed clinical, histopathology, and immunohistochemical features and overall survival (OS) of 25 patients with primary spinal cord gliomas treated between 1994 and 2023 at 4 institutions. IDH1 R132H, H3K27M, and p53 were assessed by immunohistochemistry (IHC). Four (16%), 5 (20%), 2 (8%), and 13 (52%) patients were diagnosed as having grades 1, 2, 3, and 4 gliomas according to the World Health Organization (WHO) 2021 classification, respectively. One case (4%), with a circumscribed diffuse midline glioma, H3K27-altered, had a rare molecular profile and could not be graded. IHC demonstrated H3K27M positivity, indicative of H3F3A K27M or HIST1H3B K27M mutation, in 9 (36%) patients. H3K27me3-loss was evident in 13 (52%) patients. In one patient with a grade 1 tumor that showed negative staining for H3K27M and H3K27me3 loss, numbers of EZHIP-positive cells were increased, suggesting diffuse midline glioma, H3K27-altered (WHO grade 4). H3K27me3 loss, frequency of p53 positive cells (≥10%), MIB-1 index (≥10%), and high histopathological grades significantly correlated with poor OS. These results indicate the pathological and immunohistochemical characteristics of primary spinal cord gliomas that impact prognosis.Yuki Tanaka, Manabu Natsumeda, Masayuki Ohashi, Rie Saito, Nayuta Higa, Toshiaki Akahane, Hideki Hashidate, Junko Ito, Satoshi Fujii, Atsushi Sasaki, Akihide Tanimoto, Ryosuke Hanaya, Kei Watanabe, Makoto Oishi, Hiroyuki Kawashima, Akiyoshi Kakita, Primary spinal cord gliomas: Pathologic features associated with prognosis, Journal of Neuropathology & Experimental Neurology, Volume 83, Issue 12, December 2024, Pages 1010–1019, https://doi.org/10.1093/jnen/nlae084新大院博(医)第1266

自食時のスプーン操作と頭部・体幹姿勢の協調 : 小児と成人の比較

新潟大学博士（歯学）新大院博（歯）第598

中鎖脂肪酸油脂素材における嚥下特性の比較

新潟大学博士（歯学）新大院博（歯）第602

ファミリービジネスの事業承継における権限移行プロセス：事例比較を通じたパターンの導出

新潟大学博士（経済学）新大院博（経）第72

改質した西洋イラクサ粉末試料による水溶液中からの複数の重金属の同時除去法の開発と特性評

新潟大学博士（工学）新大院博（工）第588

気候変動が日本海地域の積雪量と季節流出量に及ぼす影響

新潟大学博士（農学）新大院博（農）第261

卓球選手の主観的感覚に焦点を当てたコーチングに関する研究

新潟大学Niigata University博士（学術）新大院博(学)第116

大学時代の正課内外を通じた学びの架橋経験の実態と効果 : 職業人へのトランジションまでを含めた影響の検討

新潟大学Niigata University博士（学術）新大院博(学)第115

環境水からのeDNAを用いた陸上植物群集評価に関する研究

新潟大学Niigata University博士（農学）新大院博(農)第254