Discussion on the Treatment of Hypertension from Retained Fluid

根据古代文献关于"饮病"和现代医学关于高血压病的认识,"饮病"与高血压病无论从临床表现还是从发病机制上都有着密切的相关性。近年来,"痰饮"成为高血压病发病的重要病因之一,并贯穿于高血压病发病的始终。五苓散、苓桂术甘汤等具有"化饮"功效的方剂在治疗高血压病的临床实践中已取得较好疗效,但始终缺乏从饮论治高血压病的辨治纲要。因此,将"饮邪"引入高血压病的致病因素之中,对其做系统性、理论性的探讨,并总结出一套治则治法,对指导临床实践具有一定的帮助。According to the ancient literature on the"retained fluid disease"and modern medicine on the understanding of hypertension,"retained fluid disease"and hypertension disease from clinical manifestations or from the pathogenesis are closely related. In recent years,"phlegm"has become one of the important causes of hypertension,and always runs through the occurrence of hypertension. Wuling Powder and Linggui Zhugan Decoction have"dispersing retained fluid"effect of the prescription in the treatment of hypertension in clinical practice to obtain good curative effect,but always a lack of debate on the treatment of hypertension from the theory of"retained fluid disease"treatment program. Therefore,put the"drink evil"into the category of hypertension disease,on the system,theoretical study,and sums up the prevention and treatment,to guide the clinical practice has certain help.2013~2015福建省中医药科研项目计划(课题名称:五苓散健脾-利水-温阳通脉多靶点途径调控高血压大鼠RAAS表达的机制研究)(编号:wzln201309);; 2013年夏门市科技局高校、科研院所科技创新项目(课题名称:柴苓降压剂的开发研究)(编号:3502Z20134052

产胞外布雷菲德菌素A青霉发酵条件的研究

通过正交设计试验,优化了青霉(Penicillium)属真菌SHZK-15产胞外布雷菲德菌素(B refeld in-A,简称BFA)的液体发酵条件。最佳的BFA发酵条件为:培养基含马铃薯200g(煮汁),葡萄糖20g,(NH4)2SO44.0g,KH2PO41.0g,MgSO4.7H2O 2.0g,CaCO35.0g,pH自然,瓶装量为100mL/250 mL,培养温度为28℃,转速为120 r/m in,培养时间为7d,BFA的最高产量可达151.6mg/L

α-羟基膦酸酯芳甲酸酯的合成、晶体结构和质谱裂解规律研究

α-羟基膦酸酯与各种取代苯甲酸或吡啶甲酸,通过酰氯或缩合剂的作用,合成了一系列的O,O-二烷基-α-苯基-α-(取代芳基甲酸酯基)-甲基膦酸酯的衍生物.它们的合成收率为61%～84%,这些化合物的结构经过核磁(1HNMR,13CNMR和31PNMR)、红外、质谱、元素分析或高分辨质谱确证,同时化合物C1的结构在晶体结构解析上进一步得到证实.利用多级质谱分析了化合物C2,C5和C8的质谱裂解规律,解释了重排离子的形成机制

Phytoplankton biomarkers in surface seawater from the northern South China Sea in summer 2009 and their potential as indicators of biomass/community structure

生物标志物已被广泛应用于重建浮游植物生产力和群落结构变化。该方法假设之一是生标的含量可以反映表层海水的浮游植物生物量,但这个假设还缺乏现场观测的充分验证。对2009年冬季南海北部表层海水颗粒物中主要生标做了分析,利用其含量及比值研究浮游植物的生物量及群落结构的分布。生标含量表明硅藻、甲藻、颗石藻的高值区位于珠江口南部及广东沿岸,在陆坡区也有高值。生标比值显示硅藻在3个类群中的相对比例最高。其中,甲藻/硅藻比值高值区位于陆坡区,这与大洋水(黑潮)的入侵,带来大量暖水性甲藻有很大关系;颗石藻/硅藻比值总体趋势与生物量的分布相反,在近岸少数站位有高值,向外海逐渐增加,主要是因为颗石藻更适于寡营养盐的环境。生标结果所指示的生物量及群落结构的空间分布与前人的调查结果类似,为利用生标重建此区域的浮游植物生产力和群落结构变化提供了依据。Biomarkers have been widely used to reconstruct phytoplankton productivity based on the assumption that biomarker contents could reflect phytoplankton productivity in the surface seawater.However,this hypothesis has not been validated with modern survey.In this study,the contents and ratios of three phytoplankton biomarkers in the surface seawater of the northern South China Sea in winter 2009 were analyzed,to indicate spatial distributions of phytoplankton biomass and community structure.The results show high values for diatoms,dinoflagellates and coccolithophorids near the Pearl River Estuary and Guangdong coastal areas.The community structure indicates diatoms are the dominant phytoplankton species in winter.High values of dinoflagellate/diatom ratio occur near the slope area owing to intrusion of the Kuroshio,which favors the growth of dinoflagellates.The coccolithophorid/diatom ratio displays an increasing trend from the Pearl River Estuary to offshore region due to the advantage of coccolithophorids in oligotrophic environment,which is opposite to the productivity pattern of all biomarkers.These results are consistent with previous studies using phytoplankton cell and pigments,which provides support for the use of biomarker to reconstruct phytoplankton productivity and community structure in the SCS.国家重点基础研究发展计划项目(2007CB815934、2009CB421201);国家自然科学基金项目(40776029

用HPLC-MS-MS快速分析和鉴定三尖杉植物内生真菌发酵液中的Brefeldin A

采用HPLC -MS -MS联用技术 ,分析了C56和C65两株具有抗肿瘤活性的三尖杉植物内生真菌发酵液抽提物 ,首次报道了这两株真菌都能产生BrefeldinA(BFA)。采用ESI-MS总离子流跟踪分析HPLC的洗脱液 ,并用低能量的CID -MS -MS(碰撞诱导裂解方式 )进一步确定目标离子峰为BFA分子离子峰 ,这为植物内生真菌发酵液中的有效成分的早期鉴别奠定了基

Synthesis and spectral characterization of {phenyl-[(pyridine-4carbonyl)amino]methyl}phosphonic acid dialkyl ester

alpha-Aminophosphonic acids and their derivates, as phosphorous analogs of amino acid, have attracted much attention because they show wide biological activities. In this paper, the title compounds, {phenyl-[(pyridine-4-carbonyl)amino]methyl}phosphonic acid dialkyl esters, were synthesized via Mannich reaction and peptide coupling reaction. Their structures were confirmed by elemental analysis, IR, H-1 NMR, C-13 NMR and MS spectra, and the antibacterial and antitumor activities of these compounds were given in this paper

The effect of phosphoryl oxygen on the intermolecular action of alanine and lysozyme

It was found that N-diisopropyloxyphosphoryl alanine (DIPP-Ala) could form adduct with hen egg white lysozyme (HEWL) as shown in electrospray ionization mass spectroscopy (ESI-MS), but the non-phosphorylated alanine couldn't. The capability for formation of DIPP-Ala dimmer was more stronger than that of alanine. It suggested that a specific non-covalent complex was formed in the solution phase and could be transferred to the gas phase via electrospray ionization (ESI). The results implied that phosphorylated alanine possessed relatively stronger affinities for protein and formed non-covalent complexes with protein more easily than alanine. Using Tripos force field, molecular mechanics calculation on DIPP-Ala dimmer showed that such non-covalent adduct formation was due to the intermolecular hydrogen bond

Theoretical Studies of Photodissociaiton Dynamics for Triatomic Molecules

光解反应动力学是光化学的一部分，也是分子反应动力学的一个重要分支。由于含时波包方法的简单性，容易实现，能够得到详细的动力学信息等优点，它被广泛地应用于光解动力学研究中。本论文中我们应用含时波包方法研究了三原子分子的光解过程。 为了解含时的Schrödinger方程，我们要给出初始条件，也就是初始波包。我们应用三维分离变量表象方法编写了求解三原子分子振动光谱的程序，应用到H2O和H2S体系，都得到了与实验结果符合的很好的振动能级..

明灯照耀传香火——中泰勉瑶挂灯仪式调查与比较研究

中泰勉瑶挂灯仪式涵盖着厚重的历史文化信息,体现了瑶族社会传递家族香火的核心宗旨和瑶人人生历程中的生命意义。中泰两国瑶人挂灯仪式存在异同,但都体现了中泰瑶族一脉相承的历史渊源关系与迁徙路线