非线性动力学分析方法在嗓音医学中的应用进展

言语交流是人类社会生存的基本功能,生活质量与嗓音功能密切相关。伴随着日趋频繁的社会交往活动,嗓音疾病的患病率也逐年增加,因此,在治疗嗓音疾病时重视嗓音功能的保护有重要意义。国家自然科学基金项目(NSFC81070773和NSF11174240

The Voice Effects of Sub-glottal Pressure in Excised Canine Larynx using Nonlinear Dynamics Method

目的探讨声门下压(Sub-glOTTAl PrESSurE,SgP)变化与离体狗喉声音质量变化之间的关系及非线性动力学和扰动分析方法在区别发声信号中的作用。方法收集6只离体狗喉分别在SgP为2kPA和4kPA时的发声信号,分别采用非线性动力学方法和扰动分析方法进行分析,比较非线性动力学指标:相空间重构、关联维d2及扰动分析方法指标:频率微扰(JITTEr)、振幅微扰(SHIMMEr)、基频(f0)、噪谐比(nHr)对SgP变化的敏感性。结果在SgP为4kPA时离体狗喉发声信号的相空间重构较SgP为2kPA时复杂,在SgP为4kPA时离体狗喉发声信号的d2和f0较SgP为2kPA时高,差异有统计学意义(P<0.05),在SgP为4kPA时离体狗喉发声信号的JITTEr、SHIMMEr和nHr较SgP为2kPA时低,差异有统计学意义(P<0.05);60次声学信号中有21次因不能提取稳定频率无法使用扰动方法进行分析,其中,SgP为4kPA时16次,SgP为2kPA时5次,差异有统计学意义(P<0.05)。结论在SgP为4kPA时离体狗喉的声音质量较SgP为2kPA时更好;离体狗喉发声信号的不规则性与SgP大小有关;非线性动力学方法分析声学信号较扰动方法更具敏感性。Objective To investigate the relationship between voice quality and sub-glottal pressure(SGP)in excised canine larynges by nonlinear dynamic method and perturbation.Methods Perturbation measures of jitter percent,shimmer percent,fundamental frequency(F0)and noise harmonic ratio(NHR),nonlinear dynamic measures of phase space reconstruction and correlation dimension(D2)were applied to analyze the voice from the study including six excised canine larynges under 2kPa and 4kPa sub-glottal pressure.Results There was a significant difference between 2kPa and 4kPa sub-glottal pressure in D2,jitter,shimmer,F0and NHR(P<0.05).However,21in 60voice signals could not be analyzed by perturbation methods,there was a significant difference in percent defective of analysis when SGP was 4kPa and 2kPa(P<0.05).Conclusion The voice quality when SGP was 4kPa may be better than that when SGP was 2kPa.The regulation of voice signal was relevant with SGP in the excised canine larynx.Nonlinear dynamic methods was applied more sensitive than perturbation methods for voice analysis.国家自然科学基金(81371080;NSF11174240); 厦门市科技局社会科技研究面上项目(3502220124035)联合资

Nonlinear Dynamic Analysis in Voices Signal from Patients with Vocal Polyps and Cysts

目的比较传统扰动方法与非线性动力学方法分析正常人、声带息肉和声带囊肿患者嗓音信号的结果,探讨非线性动力学方法的临床应用价值。方法对20例正常受试者、26例声带囊肿患者和29例声带息肉患者,分别应用传统扰动方法测量声学指标频率微扰(JITTEr)、振幅微扰(SHIMMEr)和应用非线性动力学方法重构相空间、计算关联维(d2)等,比较其结果。结果正常受试者嗓音信号的JITTEr、SHIMMEr和d2值均低于声带息肉和声带囊肿患者,差异有统计学意义(P0.05),声带息肉和声带囊肿患者嗓音信号的重构相空间复杂程度相似,但比正常人复杂。d2值在rOC曲线下的面积小于JITTEr和SHIMMEr值,其中5例患者嗓音信号不能应用扰动方法分析,而非线性动力学方法均可分析。结论扰动方法和非线性动力学方法对声带息肉和声带囊肿患者异常嗓音均有诊断价值,扰动方法的特异性优于非线性动力学方法,但其对信号的规则性要求较高,适用性较低,非线性动力学方法可作为扰动方法的重要补充。Objective To assess and compare the abilities of traditional perturbation methods and nonlinear dynamic methods to describe voice from normal subjects and patients with vocal polyps and vocal cysts.Methods Perturbation measures of jitter percent and shimmer percent,nonlinear dynamic measures of phase space reconstruction,and correlation dimension(D2) were applied to analyze the voices of 75 human subjects.Results There was a significant difference in jitter,shimmer,and D2 between normal and pathological voices(P0.05).The phase space reconstruction was similar between patients with vocal polyps and patients with vocal cysts,but it was more difficulty than that of normal subjects.The area under the ROC curves for D2 was less than the areas for jitter and shimmer.5 patients' voice signals could be analyzed by nonlinear dynamics methods but not by perturbation methods.Conclusion Both nonlinear dynamic and traditional perturbation measures could separate normal and pathological voice.Perturbation measures were superior to nonlinear dynamics in distinguishing pathologies but showed a higher rate of signal and lower adaptability.Nonlinear dynamics can be used as an important supplement to perturbation measures.国家自然科学基金项目资助(NSFC81070773

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel

JUNO sensitivity on proton decay p → ν K + searches*

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the $p\to \bar{\nu} K^+$ mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar{\nu} K^+$ is 36.9% ± 4.9% with a background level of $0.2\pm 0.05({\rm syst})\pm$$0.2({\rm stat})$ events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is $9.6 \times 10^{33}$ years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies