Discussion of Treatment for Insomnia Based on Relationship between Melatonin and Yin-Yang

中医学认为,人是天地之气的产物,人体的构成及其生命活动与天地阴阳的变化相合相应,息息相关。褪黑素的分泌节律与光照周期变化关系密切,本文分别从昼夜阴阳变化、四时阴阳变化、生物体生命周期3个角度入手,探讨褪黑素与阴阳的关系,从而为失眠症发病机理及治疗方法的研究提供新思路。In traditional Chinese medicine(TCM) theory,human belonged to the product of vital breath in the universe,and human composition was in close correspondence between the changes of yin and yang.The rhythm of melatonin secretion has intimate connections with light cycles.In the review,in the sight of three aspects,yin-yang motivated changes in day and night,in four seasons and during the biological life cycle,relationships between melatonin and yin-yang were discussed,in order to provide a new method for the researches of mechanisms and treatments for insomnia.科学技术部国家科技支撑计划课题(2012BAF14B10):外配式经耳穴迷走神经刺激仪的研发,负责人:荣培晶;; 国家自然科学基金委面上项目(81473780):耳甲-迷走神经刺激治疗失眠症的临床及机制研究,负责人:荣培

基于局部一致性分析经皮耳迷走神经刺激治疗原发性失眠的中枢效应机制

目的:探讨经皮耳迷走神经刺激(taVNS)治疗原发性失眠(PI)的中枢效应机制。方法:纳入PI患者15例,采用治疗前后自身对照的原则,予以taVNS治疗4周,利用静息态功能磁共振技术,采集治疗前后患者的脑核磁数据,通过局部一致性(ReHo)的分析方法,观察taVNS对患者脑区局部一致性的调节作用。结果:PI患者经过taVNS治疗4周后,大脑多个脑区发生局部一致性的改变,其中左侧内侧额上回(t=5.36,P<0.01 )、右侧前扣带回(t=5.36, P<0.01) ReHo值升高,而右侧颞下回(t=-5.19, P<0.01)、双侧颞中回(t=-5.09,P<0.01)、右侧丘脑(t=-4.88,P<0.01 ReHo值降低。结论:taVNS对前额叶、前扣带回、颞叶、丘脑等相关区域功能的调节可能是其治疗PI的中枢效应机制

Central mechanism study of transcutaneous auricular vagus nerve stimulation based on ReHo in the treatment of primary insomnia

目的:探讨经皮耳迷走神经刺激(taVNS)治疗原发性失眠(PI)的中枢效应机制。方法:纳入PI患者15例,采用治疗前后自身对照的原则,予以taVNS治疗4周,利用静息态功能磁共振技术,采集治疗前后患者的脑核磁数据,通过局部一致性(ReHo)的分析方法,观察taVNS对患者脑区局部一致性的调节作用。结果:PI患者经过taVNS治疗4周后,大脑多个脑区发生局部一致性的改变,其中左侧内侧额上回(t=5.36,P&lt;0.01 )、右侧前扣带回(t=5.36, P&lt;0.01) ReHo值升高,而右侧颞下回(t=-5.19, P&lt;0.01)、双侧颞中回(t=-5.09,P&lt;0.01)、右侧丘脑(t=-4.88,P&lt;0.01 ReHo值降低。结论:taVNS对前额叶、前扣带回、颞叶、丘脑等相关区域功能的调节可能是其治疗PI的中枢效应机制。</p

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel

JUNO sensitivity on proton decay p → ν K + searches*

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the $p\to \bar{\nu} K^+$ mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar{\nu} K^+$ is 36.9% ± 4.9% with a background level of $0.2\pm 0.05({\rm syst})\pm$$0.2({\rm stat})$ events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is $9.6 \times 10^{33}$ years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies